Abstract: Present invention discloses the stable pharmaceutical composition comprising premix of dapagliflozin with at least one pharmaceutically acceptable excipient(s) and process for preparation thereof. Dapagliflozin is highly hygroscopic and hence it is difficult to formulate dapagliflozin as stable pharmaceutical composition. Present invention discloses the stable pharmaceutical composition of dapagliflozin comprising premix of dapagliflozin with lactose.

Abstract: A method of dynamic adaptive authentication includes receiving a request from a user to access a resource of a network and determining whether the resource is protected. In response to determining that the resource is protected, a dynamic authentication chain is generated. The dynamic authentication chain includes a plurality of authentication schemes that are arranged in a particular order. The method also includes challenging the user with the dynamic authentication chain and receiving a set of credentials from the user based at least in part on the particular order of the dynamic authentication chain. The method includes determining whether the set of credentials satisfies the dynamic authentication chain. In response to determining that the set of credentials satisfies the dynamic authentication chain, the user is authenticated.

Abstract: The present invention relates to topical spray compositions and methods for the preparation of the same. The topical spray composition comprising Glycopyrrolate or its salts with specific class of excipients may be used to reduce various secretions in human body, specifically to control hyperhydrosis.

Abstract: Methods are provided for determining time and fuel efficient airport terminal area procedures for an aircraft. First, a series of departure clusters are generated for a departure airport based on standard instrument departure (SID) procedures. The time and fuel characteristics of the departure clusters are categorized by departure time. Next, a series of destination clusters is generated for a destination airport based on approach procedures and standard terminal arrival (STAR) procedures. The time and fuel characteristics of the destination clusters are categorized by arrival time. The clusters are stored in an electronic database and during planning a flight plan of the aircraft. Once retrieved, terminal area procedures for the flight plan of the aircraft are selected based upon weighted values assigned to the time and fuel characteristics of the departure clusters for a departure airport and the destination clusters for a destination airport.

Abstract: A system and method for determining an optimum flight slot for an aircraft are provided. The method, for example, may include, but is not limited to, receiving flight plan input data from a client device, generating a flight plan based upon the flight plan input data, the flight plan including a plurality of fixes, determining a plurality of time slots based upon the flight plan input data, determining a traffic density for each fix along the flight plan for each of the plurality of slots, the traffic density based upon a number of aircraft within a bounding area containing each respective fix, determining the optimum flight time slot from the plurality of time slots based upon a weighted summation of the traffic density for each fix along the flight plan for each of the plurality of slots, and transmitting the optimum flight time slot to the client device.

Abstract: Methods and systems are provided for classifying notice to airmen (NOTAM) alerts to a pilot of an aircraft. First, bundled NOTAMs are received during the flight planning process for the aircraft. A domain rules set for a filter engine on board the aircraft is created that prioritizes the bundled NOTAMs based on their criticality. The domain rules set is updated with weather data and day/night visibility analysis. The prioritized critical NOTAMs are stored on board in an electronic database and retrieved during the relevant phase of the flight path of the aircraft. The NOTAM messages are then displayed to the pilot on a graphical display device on board the aircraft.

Abstract: Embodiments include a resource allocation system for managing execution of a computing task by a hierarchically-arranged computing infrastructure. In embodiments, the resource allocation system can comprise a resource map, an index processor, and an allocation manager. The resource map can include data elements that are associated with each service provider, including parent-child relationships.

Abstract: Techniques for determining target system connectivity between service domains are disclosed herein. For each of multiple service domains configured as a distributed management system, a discovery unit identifies subnets having at least one target system component within the service domain. The discovery unit determines from among the identified subnets, subnets that each extend between two or more of the service domains. For each of the subnets that extend between two or more of the service domains, the discovery unit detects target system network connections between two or more of the service domains. The discovery unit reports the detected target system network connections to one or more entities within the distributed management system.

Abstract: A circuit may include control circuitry configured to determine a duty cycle error for a sample clock signal. Based on the duty cycle error the control circuitry may determine a corrective direction by which to alter the duty cycle to correct the duty cycle error. The control circuitry may indicate the corrective direction to selection circuitry via a selection signal. Responsive to the selection signal, the selection circuitry may select a leading phase signal and a lagging phase signal from among a plurality of relative phase signals. Output circuitry may combine the leading phase signal and a lagging phase signal to generate an output clock signal with a duty cycle corresponding the corrective direction.

Abstract: An apparatus includes first and second hardware components. The first component includes at least one first input configured to receive at least one first data or power signal, at least one voltage clamping circuit configured to limit a voltage of the at least one first data or power signal, and at least one first output configured to provide the at least one voltage-limited first data or power signal. The second component includes at least one second input configured to receive at least one second data or power signal, at least one limiter circuit configured to limit an amount of energy in the at least one second data or power signal, and at least one second output configured to provide the at least one energy-limited second data or power signal. The at least one second data or power signal comprises or is based on the at least one voltage-limited first data or power signal.

Abstract: Provided are water-based fuel additive compositions that, when combusted with a fuel containing vanadium in a gas turbine, inhibit vanadium hot corrosion in the gas turbine. The water-based fuel additive compositions include at least one rare earth element compound or alkaline earth element compound that retards vanadium corrosion resulting from combustion of vanadium rich fuel.

Abstract: Provided are oil-based fuel additive compositions that, when combusted with a fuel containing vanadium in a gas turbine, inhibit vanadium hot corrosion in the gas turbine. The oil-based fuel additive compositions include at least one rare earth element compound or alkaline earth element compound that retards vanadium corrosion resulting from combustion of vanadium rich fuel.

Abstract: An interface device for providing Intrinsic Safety to a Smart Identity Module (SIM) card includes a buffer circuit including a voltage regulator and a voltage level translator including drivers. Baseband processor side pins include at least an input/output (IO) pin for receiving data signals, first SIM reset (RST) pin, core power supply (VCC) pin, a clock (CLK) pin, a battery power supply (VBAT) pin, and SIM side pins include at least a VCC pin, a SIM CLK pin, second SIM RST pin, and a SIM IO pin. There is at least one series resistor (R1, R2, R3, R4 and R5) in series with each of the baseband processor side pins.

Abstract: Systems and methods for automated decentralized multilateral transaction processing are disclosed. According to one embodiment, in an information processing apparatus comprising at least one computer processor, a method for automated decentralized multilateral transaction processing may include: (1) receiving a plurality of transaction requests to conduct a plurality of transactions; (2) determining that a party to a first transaction of the plurality of transactions does not meet a liquidity requirement to conduct the first transaction; (3) executing a netting algorithm to identify a second transaction of the plurality of transactions that when executed allows the first transaction to execute; and (4) executing the first and second transactions.

Abstract: A cleaning method and a cleaning fluid are provided. The cleaning method includes accessing a plurality of turbine components attached to a turbine assembly, the turbine assembly being a portion of a turbomachine, positioning at least one cleaning vessel over at least one of the turbine components, forming a liquid seal with a sealing bladder, providing a cleaning fluid to the cleaning vessel, and draining the cleaning fluid from the cleaning vessel. The cleaning fluid includes a carrier fluid and a solvent additive for removing fouling material from the turbine component. An alternative cleaning method is also provided.

Abstract: The invention relates to (among other things) a method of administering to a patient suffering from a cancer, the method comprising the steps of: (a) administering an IL-2R?-activating amount of a long acting, IL-2R?-selective agonist; and (b) administering a CTLA-4 pathway-inhibiting amount of an anti-CTLA-4 antibody or a PD-1 pathway-inhibiting amount of an anti-PD-1 antibody.

Abstract: A system includes a back plane having at least one primary module and at least one secondary module that is redundant to the at least one primary module. The back plane is configured to limit energy from the at least one primary module and the at least one secondary module to a field device. The at least one primary module includes a first plurality of channels and is configured to provide channel to channel isolation among the first plurality of channels. The at least one secondary module includes a second plurality of channels and is configured to provide channel to channel isolation among the second plurality of channels.

Abstract: According to examples, a storage node may include storage devices and a controller that may determine whether all of a plurality of data chunks of a first intra-node portion of a stripe have been stored on the storage node. Based on a determination that all of the data chunks have been stored, a first intra-node parity chunk may be stored at a second one of the storage devices, in which the first intra-node parity chunk may be determined from at least one of the data chunks of the first intra-node portion. Based on a determination that at least one of the data chunks has not been stored, storage of a first intra-node parity chunk of the stripe on the storage node may be delayed until a determination is made that all of the data chunks of the first intra-node portion have been stored at the storage node.

Abstract: A monitor can be installed in the terminal block having a monitor access opening. The installed monitor allows for current measurement without having to disconnect a wire from the terminal block. Similar monitors can measure voltage, detect ground loops, and provide continuous readings of circuit parameters. Embodiments can positively hold probe tips, transmit data over wires, or transmit data wirelessly. Make-before-break monitors allow parameters to be measured without ever breaking the monitored circuit. Break-before-make monitors allow the monitored circuit to be interrupted and then reconnected with a monitor in place.

Abstract: In an all-flash storage array, write requests can take about 9 to 10 times longer than a read request of the same size. There could be several problems when reading or writing from all-flash storage, such as a large write request slowing down small read requests, or other write requests. Also, a large read request may slow down smaller read requests by filling the incoming requests queue. In one implementation, a determination is made on what is the maximum size of a request to flash storage that improves the throughput of a flash chip (e.g., write requests beyond a certain size do not improve throughput). A chunklet is defined as a block of data having the calculated maximum size. As write requests come in, the write requests are broken into chunklets, and then the chunklets are queued for processing by the flash chip. One chunklet is processed at a time per write request.