Abstract: A method in a computing device for quantitative surgical image registration includes: prior to a surgical procedure, obtaining, using a first imaging modality, a preoperative image of patient tissue and a plurality of preoperative measurements of a material property of the patient tissue. The preoperative measurements correspond to respective points in the preoperative image. The method includes storing the preoperative image and the preoperative measurements, and during the surgical procedure, using a second imaging modality, capturing an intraoperative image of the patient tissue and a second plurality of intraoperative measurements of the material property of the patient tissue. The intraoperative measurements correspond to respective points in the intraoperative image.

Abstract: A medical imaging system for illuminating tissue samples using three-dimensional structured illumination microscopy is port-based surgery is provided. The system comprises: an image sensor; a mirror device; zoom optics; a light modulator; a processor; and collimating optics configured to convey one or more images from the modulator to the mirror, the mirror configured to convey the images to the zoom optics, the zoom optics configured: to convey the image(s) from the mirror to a tissue sample; and convey one or more resulting images, formed by the image(s) illuminating the sample, back to the mirror, which conveys the resulting image(s) from the zoom optics to the image sensor, and, the processor configured to control the modulator to form the image(s), the image(s) including at least one pattern selected to interact with the sample to generate different depth information in each of resulting image(s).

Abstract: Systems and methods are provided for identifying a suitable surgical location and/or trajectory for proceeding with a surgical procedure based on local polarization-sensitive optical coherence tomography imaging (PS-OCT). PS-OCT images are obtained of a tissue region and are processed to provide a spatial map of anisotropic structure within the tissue region. The anisotropic structure is processed to determine one or more suitable surgical locations and/or trajectories for avoiding or reducing damage to local anisotropic tissue structure identified within the tissue region. The spatial map of the anisotropic structure is registered with pre-operative volumetric image data identifying anisotropic tissue structure within a second tissue region that is larger than the tissue region imaged by PS-OCT.

Abstract: System and methods are provided for adaptively and interoperatively configuring an automated arm used during a medical procedure. The automated arm is configured to position and orient an end effector on the automated arm a desired distance and orientation from a target. The end effector may be an external video scope and the target may be a surgical port. The positions and orientations of the end effector and the target may be continuously updated. The position of the arm may be moved to new locations responsive to user commands. The automated arm may include a multi-joint arm attached to a weighted frame. The weighted frame may include a tower and a supporting beam.

Abstract: Insertable imaging devices, and methods of use thereof in minimally invasive medical procedures, are described. In some embodiments, insertable imaging devices are described that can be introduced and removed from an access port without disturbing or risking damage to internal tissue. In some embodiments, imaging devices are integrated into an access port, thereby allowing imaging of internal tissues within the vicinity of the access port, while, for example, enabling manipulation of surgical tools in the surgical field of interest. In other embodiments, imaging devices are integrated into an imaging sleeve that is insertable into an access port.

Abstract: A system for illumination during a corridor based procedure is provided, comprising: a light source; and, an optical probe comprising: a tube having a distal end, a proximal end and one or more sidewalls there between, the optical probe and the light source arranged so that light from the light source is received by the one or more sidewalls, the one or more sidewalls configured to convey the light to the distal end, the distal end configured to receive the light and illuminate a sample adjacent thereto.

Abstract: Disclosed herein is a method for producing an evolvable tissue model of a patient and, using this model, modelling physical transformations of the tissue (e.g. deformation) of the tissue model by interacting the tissue model with influence models which model interactions with the tissue such as surgical instruments, pressure, swelling, temperature changes etc. The model is produced from a set of input data of the tissue which includes directional information of the tissue. The directional information is used to produce an oriented tissue map. A tissue model is then produced from the oriented tissue map such that the tissue model reflects the directionality of the tissue component. When the tissue model is subjected to an influence that causes tissue deformation over a period of time, the tissue model directionally deforms over the period of time in a manner which reflects a trajectory of the influence interacting with the directionality of the tissue component.

Abstract: Methods and systems for calculating dimensions for fabricating an artificial bone flap. Intra-operative data indicating dimensions of an opening in a portion of the patient's skull are obtained. 3D dimensions of the opening are calculated using the intra-operative data, registered to a reference image. The calculated 3D dimensions are provided for fabricating the artificial bone flap by a fabrication system.

Abstract: A method in a computing device for quantitative surgical image registration includes: prior to a surgical procedure, obtaining, using a first imaging modality, a preoperative image of patient tissue and a plurality of preoperative measurements of a material property of the patient tissue. The preoperative measurements correspond to respective points in the preoperative image. The method includes storing the preoperative image and the preoperative measurements, and during the surgical procedure, using a second imaging modality, capturing an intraoperative image of the patient tissue and a second plurality of intraoperative measurements of the material property of the patient tissue. The intraoperative measurements correspond to respective points in the intraoperative image.

Abstract: A method, system and apparatus for controlling a surgical navigation system are provided. The method 1 comprises receiving image data at a processor from a tracking system; receiving, at a processor, an identifier of a surgical instrument within a field of view of the tracking system; generating, at the processor, output data based on the identifier of the surgical instrument; and transmitting the output data to at least one output device connected to the processor, for controlling the output device.

Abstract: Insertable imaging devices, and methods of use thereof in minimally invasive medical procedures, are described. In some embodiments, insertable imaging devices are described that can be introduced and removed from an access port without disturbing or risking damage to internal tissue. In some embodiments, imaging devices are integrated into an access port, thereby allowing imaging of internal tissues within the vicinity of the access port, while, for example, enabling manipulation of surgical tools in the surgical field of interest. In other embodiments, imaging devices are integrated into an imaging sleeve that is insertable into an access port.

Abstract: Systems and methods are provided in which devices that are employed during a medical procedure are adaptively configured during the medical procedure, based on input or feedback that is associated with the current state, phase or context of the medical procedure. In some example embodiments, the input is obtained via the identification of one or more medical instruments present within a region of interest, and this input may be employed to determine configuration parameters for configuring the device. In other example embodiments, the input may be based on the image-based detection of a measure associated with the phase or context of the medical procedure, and this input may be employed to adaptively control the device based on the inferred context or phase of the medical procedure. In other embodiments, images from one imaging modality may be employed to adaptively switch to another imaging modality.

Abstract: A method in a computing device for quantitative surgical image registration includes: prior to a surgical procedure, obtaining, using a first imaging modality, a preoperative image of patient tissue and a plurality of preoperative measurements of a material property of the patient tissue. The preoperative measurements correspond to respective points in the preoperative image. The method includes storing the preoperative image and the preoperative measurements, and during the surgical procedure, using a second imaging modality, capturing an intraoperative image of the patient tissue and a second plurality of intraoperative measurements of the material property of the patient tissue. The intraoperative measurements correspond to respective points in the intraoperative image.

Abstract: Systems and methods are provided in which devices that are employed during a medical procedure are adaptively configured during the medical procedure, based on input or feedback that is associated with the current state, phase or context of the medical procedure. In some example embodiments, the input is obtained via the identification of one or more medical instruments present within a region of interest, and this input may be employed to determine configuration parameters for configuring the device. In other example embodiments, the input may be based on the image-based detection of a measure associated with the phase or context of the medical procedure, and this input may be employed to adaptively control the device based on the inferred context or phase of the medical procedure. In other embodiments, images from one imaging modality may be employed to adaptively switch to another imaging modality.

Abstract: System and methods are provided for adaptively and interoperatively configuring an automated arm used during a medical procedure. The automated arm is configured to position and orient an end effector on the automated arm a desired distance and orientation from a target. The end effector may be an external video scope and the target may be a surgical port. The positions and orientations of the end effector and the target may be continuously updated. The position of the arm may be moved to new locations responsive to user commands. The automated arm may include a multi-joint arm attached to a weighted frame. The weighted frame may include a tower and a supporting beam.

Abstract: An apparatus and method is provided for intraoperative tissue stimulation during port-based surgery. The apparatus includes an access port and electrical terminals attached to the access port for tissue stimulation. In an alternative embodiment, the apparatus may include an access port, with or without electrical terminals attached to the access port for tissue stimulation, and electrocorticography sensors attached to the access port. The method includes inserting an access port into a tissue, applying an electrical potential to the tissue using electrical terminals attached to the access port, and measuring consequent neural activity using electrocorticography sensors attached to the access port.

Abstract: A medical imaging system for illuminating tissue samples using three-dimensional structured illumination microscopy is port-based surgery is provided. The system comprises: an image sensor; a mirror device; zoom optics; a light modulator; a processor; and collimating optics configured to convey one or more images from the modulator to the mirror, the mirror configured to convey the images to the zoom optics, the zoom optics configured: to convey the image(s) from the mirror to a tissue sample; and convey one or more resulting images, formed by the image(s) illuminating the sample, back to the mirror, which conveys the resulting image(s) from the zoom optics to the image sensor, and, the processor configured to control the modulator to form the image(s), the image(s) including at least one pattern selected to interact with the sample to generate different depth information in each of resulting image(s).

Abstract: The present disclosure discloses anatomical phantoms having one or more distinct regions spectroscopically differentiated from each other by inclusion of spectroscopically active components each having a distinct fluorescence/emission/scattering spectrum. The distinct regions may represent different anatomical components of the corresponding real anatomical part and/or tumor mimics (or other diseased tissue) and different anatomical components of the corresponding real anatomical part, or just tumor mimics and a remainder of the anatomical part. The spectroscopically active materials may be dyes such as the cyanine dyes, or spectroscopically active nanoparticles.

Abstract: Systems and methods are provided in which local tissue diagnostic measurements are correlated with archival local tissue diagnostic data from prior tissue analyses to supplement diagnostic measurements with tissue analysis data from prior tissue analyses having similar local tissue diagnostic data. The tissue analysis data may include information such as pathology data, outcome data, and diagnosis data. The archived local tissue diagnostic data and the tissue analysis data may be stored in a database, and employed for a wide variety of methods, involving preoperative, intraoperative, and/or postoperative phases of a medical procedure. Methods and systems are also provided for displaying, on a medical image shown in a user interface, hyperlinked reference markers associated with tissue analyses, where the reference markers are shown at locations corresponding to local tissue analyses, and where associated diagnostic data and/or tissue analysis may be viewed by selecting a given reference marker.

Abstract: A method in a computing device for quantitative surgical image registration includes: prior to a surgical procedure, obtaining, using a first imaging modality, a preoperative image of patient tissue and a plurality of preoperative measurements of a material property of the patient tissue. The preoperative measurements correspond to respective points in the preoperative image. The method includes storing the preoperative image and the preoperative measurements, and during the surgical procedure, using a second imaging modality, capturing an intraoperative image of the patient tissue and a second plurality of intraoperative measurements of the material property of the patient tissue. The intraoperative measurements correspond to respective points in the intraoperative image image.