Abstract: The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds. The invention also relates to methods of modulating the function of protein tyrosine kinases using indolinone compounds and methods of treating diseases by modulating the function of protein tyrosine kinases and related signal transduction pathways.

Abstract: The present invention relates to novel 3-methylidenyl-2-indolinone compounds and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

Abstract: A midair collision avoidance system (MCAS) employs an existing design of Traffic Alert and Collision Avoidance System (TCAS) as a module and seamlessly integrates it with a customized tactical module which is capable of providing unique tactical avoidance guidance control and display. The tactical module handles all phases of a tactical mission, including formation flight (e.g., formation fall-in, arming formation flight, engaging formation flight following, and formation brake-away), and an air-refueling sequence (e.g., rendezvous, linkup, re-fueling, and disengaging air-refueling). The tactical module divides the air space around the aircraft into advisory, caution, and warning zones and for each provides display, tone and voice alerts to facilitate pop-up avoidance guidance commands. Military aircraft can thus effectively avoid mid air and near mid air collision situations in all three different operation modes: air traffic control (ATC) management mode, tactical mode, and a mixed mode.

Abstract: The present invention relates to novel geometrically restricted 2-indolinones and physiologically acceptable salts thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

Abstract: The present invention relates to novel geometrically restricted 2-indolinones and physiologically acceptable salts thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

Abstract: A midair collision avoidance system (MCAS) employs an existing design of Traffic Alert and Collision Avoidance System (TCAS) as a module and seamlessly integrates it with a customized tactical module which is capable of providing unique tactical avoidance guidance control and display. The tactical module handles all phases of a tactical mission, including formation flight (e.g., formation fall-in, arming formation flight, engaging formation flight following, and formation break-away), and an air-refueling sequence (e.g., rendezvous, linkup, re-fueling, and disengaging air-refueling). The tactical module divides the air space around the aircraft into advisory, caution, and warning zones and for each provides display, tone and voice alerts to facilitate pop-up avoidance guidance commands. Military aircraft can thus effectively avoid mid air and near mid air collision situations in all three different operation modes: air traffic control (ATC) management mode, tactical mode, and a mixed mode.

Abstract: The present invention relates to novel 3-methylidenyl-2-indolinone compounds and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

Abstract: A midair collision avoidance system (MCAS) employs an existing design of Traffic Alert and Collision Avoidance System (TCAS) as a module and seamlessly integrates it with a customized tactical module which is capable of providing unique tactical avoidance guidance control and display. The tactical module handles all phases of a tactical mission, including formation flight (e.g., formation fall-in, arming formation flight, engaging formation flight following, and formation break-away), and an air-refueling sequence (e.g., rendezvous, linkup, re-fueling, and disengaging air-refueling). The tactical module divides the air space around the aircraft into advisory, caution, and warning zones and for each provides display, tone and voice alerts to facilitate pop-up avoidance guidance commands. Military aircraft can thus effectively avoid mid air and near mid air collision situations in all three different operation modes: air traffic control (ATC) management mode, tactical mode, and a mixed mode.

Abstract: The present invention relates to novel geometrically restricted 2-indolinones and physiologically acceptable salts thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

Abstract: A midair collision avoidance system (MCAS) employs an existing design of Traffic Alert and Collision Avoidance System (TCAS) as a module and seamlessly integrates it with a customized tactical module which is capable of providing unique tactical avoidance guidance control and display. The tactical module handles all phases of a tactical mission, including formation flight (e.g., formation fall-in, arming formation flight, engaging formation flight following, and formation break-away), and an air-refueling sequence (e.g., rendezvous, linkup, re-fueling, and disengaging air-refueling). The tactical module divides the air space around the aircraft into advisory, caution, and warning zones and for each provides display, tone and voice alerts to facilitate pop-up avoidance guidance commands. Military aircraft can thus effectively avoid mid air and near mid air collision situations in all three different operation modes: air traffic control (ATC) management mode, tactical mode, and a mixed mode.

Abstract: A midair collision avoidance system (MCAS) employs an existing design of Traffic Alert and Collision Avoidance System (TCAS) as a module and seamlessly integrates it with a customized tactical module which is capable of providing unique tactical avoidance guidance control and display. The tactical module handles all phases of a tactical mission, including formation flight (e.g., formation fall-in, arming formation flight, engaging formation flight following, and formation break-away), and an air-refueling sequence (e.g., rendezvous, link-up, re-fueling, and disengaging air-refueling). The tactical module divides the air space around the aircraft into advisory, caution, and warning zones and for each provides display, tone and voice alerts to facilitate pop-up avoidance guidance commands. Military aircraft can thus effectively avoid mid air and near mid air collision situations in all three different operation modes: air traffic control (ATC) management mode, tactical mode, and a mixed mode.

Abstract: A midair collision avoidance system (MCAS) employs an existing design of Traffic Alert and Collision Avoidance System (TCAS) as a module and seamlessly integrates it with a customized tactical module which is capable of providing unique tactical avoidance guidance control and display. The tactical module handles all phases of a tactical mission, including formation flight (e.g., formation fall-in, arming formation flight, engaging formation flight following, and formation break-away), and an air-refueling sequence (e.g., rendezvous, linkup, re-fueling, and disengaging air-refueling). The tactical module divides the air space around the aircraft into advisory, caution, and warning zones and for each provides display, tone and voice alerts to facilitate pop-up avoidance guidance commands. Military aircraft can thus effectively avoid mid air and near mid air collision situations in all three different operation modes: air traffic control (ATC) management mode, tactical mode, and a mixed mode.

Abstract: A dual radio frequency interferometer aided by laser rangefinder and terrain database system utilizes two linear rays of RFI sensors to determine the position of a source of RF energy. The dual RFI system is very attractive in that it is a passive system and cannot be detected by other sensors or systems while it is going through its position determination operation. Furthermore, use of two linear arrays of sensors allows for the elimination of chronic effects inherent in radio frequency interferometers. The two linear arrays can be placed anywhere on a vehicle as long as they are in the same common geometric plane and in-flight mechanisms are provided to transform the coordinate systems from the in-flight platform coordinates to the local geodetic coordinates. This provides positioning and source identification which can be beneficial to not only the present system but other systems in the area.

Abstract: A ground collision avoidance system that exhibits improved accuracy and performance by integrating with all other aircraft systems including guidance systems, navigation systems, digital terrain elevation databases, mission computers, and radar altimeters. The ground collision avoidance system fully utilizes active onboard sensors in combination with the knowledge of terrain and obstacle data contained in databases. Furthermore, the ground collision avoidance system provides a multiple processing path to determine numerous predicted flight paths based on a number of reasonable assumptions regarding the aircraft flight during a predetermined amount of time. By using predictive flight path schemes a realistic estimate of the predicted flight path envelope can be determined and then this information can be used in conjunction with accurate terrain elevation databases to determine whether a ground collision condition exists.

Abstract: An embedded mission avionics data link system is provided which allows an aircraft to receive, transmit, and process a variety of different types of information. The present system has the capability of generating and receiving video information for viewing by a pilot in the cockpit. The system also requests, receives and recognizes situation awareness data as well as mission update data and processes this information accordingly. Any video images received by the pilot either externally or internally may be annotated and either stored in memory or transmitted externally. The system allows multiple aircraft on a mission to stay in constant communication as to relative positions to each other and targets, provide up-to-date information as to the situation which exists at the target, and do this in a mostly automatic fashion which reduces the workload of the pilot and significantly enhance the mission capability.

Abstract: An apparatus and method for aircraft survivability equipment training. The disclosure is particularly directed to the use of such an apparatus and method for multiple player training aircraft with a central controller. The threats are simulated by the central controller and transmitted to each player aircraft via encoded data packets. Additionally, electronic counter measures, counter measures and weapons initiation are simulated. A predictive threat intervisibility engine provides a realistic training situation by predicting each player aircraft's "line of sight" to an updated threat list and local terrain data, as the aircraft travels. Defeated threats are determined by the central controller based on simulated electronic counter measure models, simulated weapon systems activated from weapon controls, simulated counter measures activated by counter measure controls and aircraft dynamic data from the player aircraft's navigation system.

Abstract: An integrated aircraft survivability equipment state machine. Aircraft survivability sensors provide aircraft survivability states that are routed to a finite state machine. Data processing, data generation, data representation, queueing tactical information and initiation of aircraft survivability counter measures are controlled by the state oriented approach. Systems state can be altered based on mission defined variables. Counter measures can be initiated based on correlated threat data and other functions such as failure recording and threat database generation functions. All individual aircraft survivability subsystems are integrated and controlled by the state machine. The state machine manages the ASE subsystem power as far as built-in testing and controls for the integrated ASE system. Overall threat data presentation is controlled and driven by the system state.

Abstract: Automatic countermeasures dispensing module controller for radio frequency countermeasures processes information generated by a missile approach detector and radio frequency receivers which is correlated to generate a radio frequency countermeasures dispensing command. A countermeasures module is connected to provide effective countermeasures against radio frequency guided missiles. Voice warning messages are generated and a threat display symbol is generated on a cockpit display system that provides an audio and visual monitor of the threat. The number of countermeasures employed is counted. If a radar warning receiver or pulsed radar jammer is in operation and a missile approaching event is detected, the region of missile approach is read from a missile approach detector. The missile threat is displayed and correlated with the radar warning receiver or pulsed radar jammer for the indicated region with a missile approach detector.

Abstract: An in-flight simulator for an integrated aircraft survivability equipment system controlling radar warning receiver and a radar jammer with countermeasures control provides a training module which emulates the existence of airborne threats. The airborne threats are provided in real time as if they were detected by a threat detection system such as a radar warning receiver or a radar jammer. A list of threats is provided for either a radar warning receiver or pulse radar jammer, a continuous radar jammer, an RF/IR missile approach detector or a laser that threat on a display, includes that threat in a candidate list and executes various threat proximity algorithms with the candidate list. The invention determines whether the threat is within the range hidden by terrain or beyond the horizon. The threat simulator performs aircraft survivability equipment sensor model simulation. Threats are also prioritized.

Abstract: Aircraft survivability system state management is based on system mode, time, altitude, aircraft position, reference radius, and manual aircraft survivability equipment configuration select. The system mode is used with a segment number to begin system configuration sequencing of a segment pointer. A mission aircraft survivability system configuration plan comprises a number of segments of a mission plan. Each segment contains information such as the time, altitude and position for each segment. The segment is displayed in an active configuration and a next configuration on an aircraft survivability equipment display. When the aircraft enters a detection window the segment pointer is updated by an aircraft survivability system mode control processor. The system may be placed in either automatic mode or manual mode.