Patents by Inventor N. Brown

N. Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200261422
    Abstract: Disclosed herein are methods and compositions for reversing the effects of a sedation agent or general anesthetic agents. The methods are useful for example for assessing a patient during a surgical procedure or a patient's physiologic state during and/or after a surgical procedure. Other uses for the methods and compositions include modulating a circadian rhythm, treating cardiac arrest, hypotension and bradycardia, and preventing emergence delirium.
    Type: Application
    Filed: February 14, 2020
    Publication date: August 20, 2020
    Applicant: Massachusetts Institute of Technology
    Inventors: Jacob A. Donoghue, Emery N. Brown, Earl K. Miller, Noah D. Donoghue
  • Publication number: 20200237300
    Abstract: Systems and methods for monitoring a subject under, or suspected to be under, the influence of one or more drugs are provided. In one aspect, a method comprises controlling one or more sensors of a monitoring device to acquire physiological signals from a subject suspected to be under the influence of one or more drugs, and assembling a set of physiological data using the acquired physiological signals. The method also includes generating, using a processor of the monitoring device, physiological markers characteristic of the influence of the one or more drugs by analyzing the set of physiological data, and correlating the physiological markers with a drug profile characterizing the one or more drugs affecting the subject. The method further includes proving to a user a report indicating the drug profile characterizing the one or more drugs affecting the subject.
    Type: Application
    Filed: October 4, 2018
    Publication date: July 30, 2020
    Inventors: Jacob A. Donoghue, Kathleen J. Koenigs, Patrick L. Purdon, Emery N. Brown
  • Publication number: 20200239958
    Abstract: Described herein are methods for determining a Caucasian subject's susceptibility to having or developing a complement-mediated disease comprising determining in the Caucasian subject the identity of one or more haplotypes, wherein the presence of one or more of the haplotypes indicates the subject's susceptibility for having or developing a complement-mediated disease.
    Type: Application
    Filed: January 3, 2020
    Publication date: July 30, 2020
    Inventors: Gregory S. Hageman, Christian Matthew Pappas, Eric N. Brown, David Hutcheson
  • Publication number: 20200187853
    Abstract: Systems and method for age-compensated monitoring of a patient experiencing administration of at least one drug having anesthetic properties are provided. In one embodiment, a system includes a plurality of sensors configured to acquire physiological data from the patient and at least one processor configured to receive the physiological data from the plurality of sensors, and determine, from the physiological data, signal markers indicative of an apparent or likely patient age. The at least one processor is also configured to at least one of scale and regulate the physiological data using at least the apparent patient age to create age-compensated data, and generate a report including the age-compensated data.
    Type: Application
    Filed: February 27, 2020
    Publication date: June 18, 2020
    Inventors: Patrick L. Purdon, Emery N. Brown, Oluwasean Johnson-Akeju
  • Patent number: 10674956
    Abstract: A system and method for monitoring and/or controlling a state of consciousness of a subject experiencing anesthesia are provided. In some aspects, the system includes a plurality of sensors placed about the subject and configured to acquire electroencephalogram (“EEG”} data therefrom while the subject is receiving anesthesia, and at least one processor configured to receive the EEG data from the plurality of sensors, and perform a phase-amplitude coupling analysis using the received EEG data to determine a phase-amplitude frequency distribution. The at least one processor is also configured to identify a state of consciousness of the subject using the determined phase-amplitude frequency distribution, and generate a report indicative of the state of consciousness of the subject.
    Type: Grant
    Filed: January 14, 2015
    Date of Patent: June 9, 2020
    Assignee: The General Hospital Corporation
    Inventors: Patrick L. Purdon, Eran A. Mukamel, Emery N. Brown
  • Publication number: 20200170575
    Abstract: Systems and methods are provided for monitoring a subject, and particularly, for inferring an underlying brain state present in absence of current conditions. In some aspects, a method for monitoring the subject is provided including steps of receiving physiological feedback from at least one sensor configured to acquire physiological information from locations associated with a subject's brain, assembling a set of time-series data using the received physiological feedback, and identifying portions of the set of time-series data that indicate a burst suppression state. The method also includes identifying a burst characteristic profile associated with a burst pattern determined from the identified portions, and comparing the burst characteristic against a reference set of burst profiles.
    Type: Application
    Filed: July 22, 2019
    Publication date: June 4, 2020
    Inventors: Patrick L. Purdon, Emery N. Brown, Laura D. Lewis, Brandon M. Westover, ShiNung Ching
  • Patent number: 10646165
    Abstract: Systems and a method for reducing periodic artifacts in an electrophysiologic signal are provided. The method includes receiving a time-series electrophysiologic signal acquired from a subject and providing a regression model that defines an interference signal caused by periodic artifacts using a harmonic representation. The method also includes applying the regression model using the time-series electrophysiologic signal to define a cost function and performing an iterative optimization process to estimate regression parameters that minimize the cost function. The method further includes determining, using the regression parameters, the interference signal, and generating a corrected time-series electrophysiologic signal by reducing the interference signal.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: May 12, 2020
    Assignee: The General Hospital Corporation
    Inventors: Pavitra Krishnaswamy, Patrick L. Purdon, Emery N. Brown
  • Publication number: 20200139518
    Abstract: A crimp tool includes a frame, a lead screw and a nut assembly connected to the lead screw. A spring member is connected to the frame and movable with rotation of the lead screw. A first transducer is connected to the nut assembly to measure a first force applied on the nut assembly. A second transducer is connected to the spring member to measure a second force applied thereon by the spring member.
    Type: Application
    Filed: December 23, 2019
    Publication date: May 7, 2020
    Inventors: John David Lefavour, Alan Douglas Beck, Robert Michael Poirier, Peter Matthew Wason, Lawrence N. Brown
  • Publication number: 20200129139
    Abstract: Methods and products for automated real-time ovarian follicular detection, monitoring and analysis are provided. The devices and methods allow for remote or local analysis, while minimizing or eliminating the need for technician review of the output images. The methods are useful in human and non-human subjects including companion animals and other animals such as endangered species.
    Type: Application
    Filed: July 7, 2017
    Publication date: April 30, 2020
    Applicants: Massachusetts Institute of Technology, The General Hospital Corporation
    Inventors: Rose T. Faghih, Emery N. Brown, Aaron K. Styer
  • Patent number: 10602978
    Abstract: Systems and method for age-compensated monitoring of a patient experiencing administration of at least one drug having anesthetic properties are provided. In one embodiment, a system includes a plurality of sensors configured to acquire physiological data from the patient and at least one processor configured to receive the physiological data from the plurality of sensors, and determine, from the physiological data, signal markers indicative of an apparent or likely patient age. The at least one processor is also configured to at least one of scale and regulate the physiological data using at least the apparent patient age to create age-compensated data, and generate a report including the age-compensated data.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: March 31, 2020
    Assignee: The General Hospital Corporation
    Inventors: Patrick L. Purdon, Emery N. Brown, Oluwaseun Johnson-Akeju
  • Publication number: 20200046229
    Abstract: A system and method for monitoring a patient suspected of experiencing a state of unconsciousness are provided. In certain aspects, the method includes assembling physiological data, obtained from a plurality of sensors placed on a subject, into sets of time-series data, separating, from the sets of time-series data, a plurality of electroencephalogram signals, and determining, from the plurality of electroencephalogram signals, at least one of frequency information and amplitude information. The method can also include identifying, using the at least one of the frequency information and the amplitude information, spatiotemporal signatures indicative of a likelihood of arousing the patient to consciousness by applying an external stimulus and generating a report indicating the likelihood of arousing the patient to consciousness by applying the external stimulus.
    Type: Application
    Filed: October 18, 2019
    Publication date: February 13, 2020
    Inventors: Patrick L. Purdon, Oluwaeseun Akeju, Emery N. Brown
  • Publication number: 20200040409
    Abstract: The present disclosure is in the field of plant breeding. The disclosure provides methods for breeding corn plants having a brachytic trait using marker-assisted selection. The disclosure further provides brachytic germplasm, markers associated with a brachytic trait for introgressing the trait into elite germplasm in a breeding program. This disclosure also provides brachytic or dwarf elite corn varieties having yield equal to or higher than conventional non-brachytic corn varieties.
    Type: Application
    Filed: October 1, 2019
    Publication date: February 6, 2020
    Applicant: Monsanto Technology LLC
    Inventors: Ty Jason Barten, Alana N. Brown, Edward James Cargill, Romain Fouquet, Jose Rafael Gomez, Matthew Sean Marengo, Manuel Oyervides Garcia, Jeanette M. Peevers, Dennis Hung Yang
  • Publication number: 20200029892
    Abstract: The present invention generally relates to compositions comprising anesthesia-reversing agents which facilitate or increase the time of awakening or reverse the effects of general anesthesia-induced unconsciousness. In some embodiments, the anesthesia reversing agent can be selected from any or a combination of methylphenidate (MPH), amphetamine, modafinil, amantadine, caffeine, or analogues or derivatives thereof. In some embodiments, compositions comprising at least one or more anesthesia-reversing agents can be used to facilitate awakening from anesthesia without or decreasing occurrence of delirium, and can be used in methods to treat or prevent the symptoms associated with emergence delirium, as well as treat a subject oversedated with general anesthesia. The invention also relates to methods for administering these compositions comprising anesthesia-reversing agents to subjects and for use.
    Type: Application
    Filed: September 20, 2019
    Publication date: January 30, 2020
    Inventors: Emery N. Brown, Patrick L. Purdon
  • Patent number: 10513015
    Abstract: A crimp tool includes a frame, a lead screw and a nut assembly connected to the lead screw. A spring member is connected to the frame and movable with rotation of the lead screw. A first transducer is connected to the nut assembly to measure a first force applied on the nut assembly. A second transducer is connected to the spring member to measure a second force applied thereon by the spring member.
    Type: Grant
    Filed: September 7, 2016
    Date of Patent: December 24, 2019
    Assignee: Hubbell Incorporated
    Inventors: John David Lefavour, Alan Douglas Beck, Robert Michael Poirier, Peter Matthew Wason, Lawrence N. Brown
  • Publication number: 20190374158
    Abstract: Systems and methods for monitoring and controlling anesthesia are provided. In some aspects, a method includes receiving data corresponding to EEG signals acquired from a patient and an indication of at least one characteristic of the patient and the at least one drug having anesthetic properties, and assembling, using the data received, one or more sets of EEG time-series. The method also includes selecting alpha frequency signals from the one or more sets of EEG time-series, and analyzing the alpha frequency signals to determine signatures particular to the at least one drug administered. The method further includes identifying at least one of a current state and a predicted future state of the patient induced by the at least one drug based on the signatures and the indication, and generating a report indicative of the at least one of the current state and the predicted future state of the patient.
    Type: Application
    Filed: March 5, 2019
    Publication date: December 12, 2019
    Inventors: Emery N. Brown, Patrick L. Purdon
  • Patent number: 10472684
    Abstract: The present disclosure is in the field of plant breeding. The disclosure provides methods for breeding corn plants having a brachytic trait using marker-assisted selection. The disclosure further provides brachytic germplasm, markers associated with a brachytic trait for introgressing the trait into elite germplasm in a breeding program. This disclosure also provides brachytic or dwarf elite corn varieties having yield equal to or higher than conventional non-brachytic corn varieties.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: November 12, 2019
    Assignee: Monsanto Technology LLC
    Inventors: Ty Jason Barten, Alana N. Brown, Edward James Cargill, Romain Fouquet, Jose Rafael Gomez, Matthew Sean Marengo, Manuel Oyervides Garcia, Jeanette M. Peevers, Dennis Hung Yang
  • Publication number: 20190290196
    Abstract: The present invention generally relates to compositions comprising anesthesia-reversing agents which facilitate or increase the time of awakening or reverse the effects of general anesthesia-induced unconsciousness. In some embodiments, the anesthesia reversing agent can be selected from any or a combination of methylphenidate (MPH), amphetamine, modafinil, amantadine, caffeine, or analogues or derivatives thereof. In some embodiments, compositions comprising at least one or more anesthesia-reversing agents can be used to facilitate awakening from anesthesia without or decreasing occurrence of delirium, and can be used in methods to treat or prevent the symptoms associated with emergence delirium, as well as treat a subject oversedated with general an esthesia. The invention also relates to methods for administering these compositions comprising anesthesia-reversing agents to subjects and for use.
    Type: Application
    Filed: April 2, 2019
    Publication date: September 26, 2019
    Inventors: Emery N. Brown, Patrick L. Purdon
  • Publication number: 20190283634
    Abstract: A seat system for a vehicle includes a seat having a seat bottom on which a person can sit. An intermediate support structure is secured to the seat and the vehicle which allows the seat to rotate relative to the vehicle. An actuator can interact with the seat to cause the seat to rotate relative to the vehicle. The combined motion of the vehicle relative to the earth and the seat relative to the vehicle results in motion of the seat moving about a virtual pivot point. A user control is provided for adjustment of the location of the virtual pivot point.
    Type: Application
    Filed: March 16, 2018
    Publication date: September 19, 2019
    Applicant: ClearMotion Acquistion I LLC
    Inventors: Robert Preston Parker, Lawrence D. Knox, Travis Lee Hein, Steven N. Brown, Brian Alexander Selden
  • Patent number: PP30867
    Abstract: A new mandevilla plant particularly distinguished by pink flowers and a vigorous upright growth habit, is disclosed.
    Type: Grant
    Filed: August 10, 2018
    Date of Patent: September 3, 2019
    Assignee: Klemm+Sohn GmbH & Co. KG
    Inventor: Graham N. Brown
  • Patent number: PP30891
    Abstract: A new mandevilla plant particularly distinguished by red flowers and vigorous vining upright growth, is disclosed.
    Type: Grant
    Filed: August 10, 2018
    Date of Patent: September 24, 2019
    Assignee: KLEMM+SOHN GMBH & CO. KG
    Inventor: Graham N. Brown