Abstract: Systems and methods are provided for monitoring a subject, and particularly, for inferring an underlying brain state present in absence of current conditions. In some aspects, a method for monitoring the subject is provided including steps of receiving physiological feedback from at least one sensor configured to acquire physiological information from locations associated with a subject's brain, assembling a set of time-series data using the received physiological feedback, and identifying portions of the set of time-series data that indicate a burst suppression state. The method also includes identifying a burst characteristic profile associated with a burst pattern determined from the identified portions, and comparing the burst characteristic against a reference set of burst profiles.

Abstract: The present invention generally relates to compositions comprising anesthesia-reversing agents which facilitate or increase the time of awakening or reverse the effects of general anesthesia-induced unconsciousness. In some embodiments, the anesthesia reversing agent can be selected from any or a combination of methylphenidate (MPH), amphetamine, modafinil, amantadine, caffeine, or analogs or derivatives thereof. In some embodiments, compositions comprising at least one or more anesthesia-reversing agents can be used to facilitate awakening from anesthesia without or decreasing occurrence of delirium, and can be used in methods to treat or prevent the symptoms associated with emergence delirium, as well as treat a subject oversedated with general an esthesia. The invention also relates to methods for administering these compositions comprising anesthesia-reversing agents to subjects and for use.

Abstract: Systems and methods for determining a response of a patient to the administration of at least one drug having anesthetic properties are provided. In one aspect, a method includes receiving physiological data acquired from a patient, and analyzing the physiological data to determine at least one indicator of brain function. The method also includes determining, based on the at least one indicator of brain function, a response of the patient to the administration of at least one drug having anesthetic properties, and generating a report indicative of the response.

Abstract: A method and system for determining the state of a patients brain under anesthesia. The present invention recognizes that anesthesia compounds induce different signatures in physiological characteristics of the patient under anesthesia and aids interpretation of physiological characteristics and signatures therein based on a selected anesthesia compound. The present invention aids the monitoring and/or interpreting of the physiological characteristics to a state of the patient's brain.

Abstract: A seat system for a vehicle includes a seat having a seat bottom on which a person can sit. An intermediate support structure is secured to the seat and the vehicle which allows the seat to rotate relative to the vehicle. An actuator can interact with the seat to cause the seat to rotate relative to the vehicle. One or more sensors can each measure an aspect of motion. A processor can (i) receive input from each of the one or more sensors, (ii) determine from this input a measure of rotation of the vehicle away from a nominal, level horizontal orientation, and (iii) utilize the input to determine a desired rotation of the seat. An angle that the seat has been rotated away from a nominal, level orientation is more than insubstantially larger than an angle that the vehicle has rotated away from a nominal, level horizontal orientation.

Abstract: A self-locking guillotine door assembly and method for an animal enclosure is disclosed. The assembly includes a door, a locking mechanism attached to the door, and a cable attached to the locking mechanism. Pulling the cable releases the locking mechanism and lifts the locking mechanism and door. Pushing up on the bottom of the door locks the locking mechanism and resists lifting the door. The locking mechanism can include a post, a vertical slide with a slot, connector bars and cams such that when the cable is pulled, the cable lifts the vertical slide to lift proximal ends of the connector bars, which pivots the cams to release the locking mechanism. When the enclosure door is pushed up from the bottom, the locking mechanism pivots the cams towards the top of the enclosure door to lock the locking mechanism and resist lifting of the enclosure door.

Abstract: A new mandevilla plant particularly distinguished by pink flowers and vigorous upright growth, is disclosed.

Abstract: A seat system for a vehicle includes a seat having a seat bottom on which a person can sit. An intermediate support structure is secured to the seat and the vehicle which allows the seat to rotate relative to the vehicle. An actuator can interact with the seat to cause the seat to rotate relative to the vehicle. One or more sensors can each measure an aspect of motion. A processor can (i) receive input from each of the one or more sensors, (ii) determine from this input a measure of rotation of the vehicle away from a nominal, level horizontal orientation, and (iii) utilize the input to determine a desired rotation of the seat. An angle that the seat has been rotated away from a nominal, level orientation is more than insubstantially larger than an angle that the vehicle has rotated away from a nominal, level horizontal orientation.

Abstract: A seat system for a vehicle includes a seat having a seat bottom on which a person can sit. An intermediate support structure is secured to the seat and the vehicle which allows the seat to rotate relative to the vehicle. An actuator can interact with the seat to cause the seat to rotate relative to the vehicle. One or more sensors can each measure an aspect of motion. A processor can (i) receive input from each of the one or more sensors, (ii) determine from this input a measure of rotation of the vehicle away from a nominal, level horizontal orientation, and (iii) utilize the input to determine a desired rotation of the seat. An angle that the seat has been rotated away from a nominal, level orientation is more than insubstantially larger than an angle that the vehicle has rotated away from a nominal, level horizontal orientation.

Abstract: A hydraulic tool cutting dies including first and second cutting dies. The first cutting die has a first mounting section and a first cutting edge. The first mounting section is sized and shaped to removably attached to a hydraulic tool. The second cutting die has a second mounting section and a second cutting edge. The second mounting section is sized and shaped to removably attached to the hydraulic tool. The first cutting die includes a post extending past the first cutting edge and the second cutting die includes a post receiving area which has a different cross-sectional shape than the post.

Abstract: Described herein are methods for determining a Caucasian subject's susceptibility to having or developing a complement-mediated disease comprising determining in the Caucasian subject the identity of one or more haplotypes, wherein the presence of one or more of the haplotypes indicates the subject's susceptibility for having or developing a complement-mediated disease.

Abstract: Systems and methods for analyzing electrophysiological signals acquired from a subject are provided. In some aspects, a method includes receiving electrophysiological signals acquired from a subject using one or more sensors, and assembling a set of time-series data using the acquired electrophysiological signals. The method also includes analyzing the set of time-series data using a state-space multi-taper framework to generate spectral information describing the electrophysiological signals, and determining a brain state of the subject using the spectral information. The method further includes generating a report indicative of the determined brain state.

Abstract: Provided herein are methods of making a cell growth scaffold from adipose tissue, cell growth scaffolds having low lipid content and methods of using the cell growth scaffold.

Abstract: Provided herein are compositions and medical devices, and in particular, biodegradable scaffolds capable of repairing and replacing cartilagenous meniscuses. Also provided herein are methods of using scaffolds for treating degenerative tissue disorders. In certain embodiments, such scaffolds can promote tissue regeneration of a temporal mandibular joint (TMJ) meniscus.

Abstract: Provided herein are methods of making a cell growth scaffold from adipose tissue, cell growth scaffolds having low lipid content and methods of using the cell growth scaffold.

Abstract: A seat system for a vehicle includes a seat having a seat bottom on which a person can sit. An intermediate support structure is secured to the seat and the vehicle which allows the seat to rotate relative to the vehicle. An actuator can interact with the seat to cause the seat to rotate relative to the vehicle. The combined motion of the vehicle relative to the earth and the seat relative to the vehicle results in motion of the seat moving about a virtual pivot point. A user control is provided for adjustment of the location of the virtual pivot point.

Abstract: Systems and methods for discovery and characterization of neuroactive drugs are provided. In some aspects, a method for evaluating an effectiveness of a drug administered to a subject includes receiving neurophysiological data acquired from a subject under an administration of a drug, and analyzing the neurophysiological data to generate signatures indicative of brain states induced by the drug. The method also includes correlating the generated signatures with a database comprising information associated with a plurality of drug profiles, and determining, using the information, a molecular activity profile for the drug. The method further includes generating a report indicative of the effectiveness of the drug using the molecular activity profile.

Abstract: Systems and methods for inducing natural sleep in a subject is provided. In some aspects, the method includes inducing a first sleep state; monitoring a first plurality of characteristics of a brain of the subject to verify the subject is in the first sleep state; inducing a second sleep state after the subject has been in the first sleep state for a predetermined amount of time; and monitoring a second plurality of characteristics of the brain of the subject to verify the subject is in the second sleep state.

Abstract: A system and method for monitoring a patient suspected of experiencing a state of unconsciousness are provided. In certain aspects, the method includes assembling physiological data, obtained from a plurality of sensors placed on a subject, into sets of time-series data, separating, from the sets of time-series data, a plurality of electroencephalogram signals, and determining, from the plurality of electroencephalogram signals, at least one of frequency information and amplitude information. The method can also include identifying, using the at least one of the frequency information and the amplitude information, spatiotemporal signatures indicative of a likelihood of arousing the patient to consciousness by applying an external stimulus and generating a report indicating the likelihood of arousing the patient to consciousness by applying the external stimulus.

Abstract: A new mandevilla plant particularly distinguished by pink flowers and vigorous upright growth, is disclosed.