Patents by Inventor Nader Fotouhi

Nader Fotouhi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cis-imidazolines
    Patent number: 7705007
    Abstract: There are provided compounds of the formula I wherein R, V1, V2 and Ring A are described herein. The compounds exhibit anticancer activity.
    Type: Grant
    Filed: January 17, 2007
    Date of Patent: April 27, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Nader Fotouhi, Gregory Jay Haley, Klaus B. Simonsen, Binh Thanh Vu, Stephen Evan Webber
  • Neuropeptide-2 receptor (Y-2R) agonists and uses thereof
    Patent number: 7642244
    Abstract: Provided herein are neuropeptide-2 receptor agonists of the formula (I): as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those disclosed in the specification. X is 4-oxo-6-(1-piperazinyl)-3(4H)-quinazoline-acetic acid (Pqa). These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity and diabetes.
    Type: Grant
    Filed: December 1, 2006
    Date of Patent: January 5, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Karin Conde-Knape, Waleed Danho, George Ehrlich, Nader Fotouhi, David Charles Fry, Wajiha Khan, Anish Konkar, Cristina Martha Rondinone, Joseph Swistok, Rebecca Anne Taub, Jefferson Wright Tilley
  • Pyrazolones as inhibitors of 11?-hydroxysteroid dehydrogenase
    Patent number: 7622492
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
    Type: Grant
    Filed: August 18, 2006
    Date of Patent: November 24, 2009
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Bruce Lester Banner, Joseph Anthony Bilotta, Nader Fotouhi, Paul Gillespie, Robert Alan Goodnow, Jr., Matthew Michael Hamilton, Nancy-Ellen Haynes, Agnieszka Kowalczyk, Alexander Mayweg, Michael Paul Myers, Sherrie Lynn Pietranico-Cole, Nathan Robert Scott, Kshitij Chhabilbhai Thakkar, Jefferson Wright Tilley, Kevin Richard Guertin
  • Cis-imidazolines
    Patent number: 7579368
    Abstract: There are presented compounds of the formula or pharmaceutically acceptable salts thereof, wherein Y1, Y2, X1, X2, X3 and R are as described in this application. These compounds are believed to inhibit MDM2-p53 interaction and as such the compounds will have anti-hyperproliferative cellular activity.
    Type: Grant
    Filed: March 13, 2006
    Date of Patent: August 25, 2009
    Assignee: Hoffman-La Roche Inc.
    Inventors: Nader Fotouhi, Gregory Jay Haley, Klaus B. Simonsen, Binh Thanh Vu, Stephen Evan Webber
  • CHIRAL CIS-IMIDAZOLINES
    Publication number: 20090143364
    Abstract: and the pharmaceutically acceptable salts and esters thereof, wherein X1, X2, X3, Y1, Y2 and R are described herein inhibit the interaction of MDM2 protein with a p53-like peptide and hence have anti proliferative activity.
    Type: Application
    Filed: February 5, 2009
    Publication date: June 4, 2009
    Inventors: Nader Fotouhi, Gregory Jay Haley, Klaus B. Simonsen, Binh Thanh Vu, Stephen Evan Webber
  • Thiazolyl-benzimidazoles
    Patent number: 7504513
    Abstract: The invention is directed to compounds of formula (1) and pharmaceutically acceptable salts thereof, methods for the preparation thereof, and methods of use thereof.
    Type: Grant
    Filed: February 7, 2007
    Date of Patent: March 17, 2009
    Assignee: Hoffman-La Roche Inc.
    Inventors: John Frederick Boylan, Jianping Cai, Nader Fotouhi, Paul Gillespie, Robert Alan Goodnow, Jr., Kang Le, Christophe Michoud
  • Leukotriene B4 Inhibitors
    Publication number: 20090054466
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification.
    Type: Application
    Filed: July 28, 2008
    Publication date: February 26, 2009
    Inventors: Romyr Dominique, Nader Fotouhi, Paul Gillespie, Robert Alan Goodnow, Agnieszka Kowalczyk, Qi Qiao, Achyutharao Sidduri
  • Diaminopropionic acid derivatives
    Patent number: 7491741
    Abstract: A compound of formula 1a which is useful for treating reperfusion injury, and salts, prodrugs, and related compounds.
    Type: Grant
    Filed: February 8, 2007
    Date of Patent: February 17, 2009
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Nader Fotouhi, Paul Gillespie, Robert William Guthrie, Sherrie Lynn Pietranico-Cole, Weiya Yun
  • Substituted hydantoins
    Patent number: 7427635
    Abstract: The present invention relates to compounds of the formula which are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as, cancer, cognative and CNS disorders and inflammatory/autoimmune diseases.
    Type: Grant
    Filed: August 11, 2005
    Date of Patent: September 23, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Xin-Jie Chu, Nader Fotouhi, Nicholas J. S. Huby, Norman Kong, Lee Apostle McDermott, John Moliterni, Zhuming Zhang
  • Adamantyl-pyrazole carboxamides as inhibitors of 11B-hydroxysteroid dehydrogenase
    Publication number: 20070225280
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
    Type: Application
    Filed: March 14, 2007
    Publication date: September 27, 2007
    Inventors: Kevin William Anderson, Nader Fotouhi, Paul Gillespie, Robert Alan Goodnow, Kevin Richard Guertin, Nancy-Ellen Haynes, Michael Paul Myers, Sherrie Lynn Pietranico-Cole, Lida Qi, Pamela Loreen Rossman, Nathan Robert Scott, Kshitij Chhabilbhai Thakkar, Jefferson Wright Tilley, Qiang Zhang
  • Thiazolyl-benzimidazoles
    Publication number: 20070203210
    Abstract: The invention is directed to compounds of formula (1) and pharmaceutically acceptable salts thereof, methods for the preparation thereof, and methods of use thereof.
    Type: Application
    Filed: February 7, 2007
    Publication date: August 30, 2007
    Inventors: John Frederick Boylan, Jianping Cai, Nader Fotouhi, Paul Gillespie, Robert Alan Goodnow, Kang Le, Christophe Michoud
  • Cis-imidazolines
    Publication number: 20070167437
    Abstract: There are provided compounds of the formula I wherein R, V1, V2 and Ring A are described herein. The compounds exhibit anticancer activity.
    Type: Application
    Filed: January 17, 2007
    Publication date: July 19, 2007
    Inventors: Nader Fotouhi, Gregory Haley, Klaus Simonsen, Binh Vu, Stephen Webber
  • Diaminopropionic acid derivatives
    Publication number: 20070155671
    Abstract: A compound of formula 1a which is useful for treating reperfusion injury, and salts, prodrugs, and related compounds.
    Type: Application
    Filed: February 8, 2007
    Publication date: July 5, 2007
    Inventors: Nader Fotouhi, Paul Gillespie, Robert Guthrie, Sherrie Pietranico-Cole, Weiya Yun
  • Neuropeptide-2 receptor (Y-2R) agonists and uses thereof
    Publication number: 20070135351
    Abstract: Provided herein are neuropeptide-2 receptor agonists of the formula (I): as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity and diabetes.
    Type: Application
    Filed: December 1, 2006
    Publication date: June 14, 2007
    Inventors: Karin Conde-Knape, Waleed Danho, George Ehrlich, Nader Fotouhi, David Fry, Wajiha Khan, Anish Konkar, Cristina Rondinone, Joseph Swistok, Rebecca Taub, Jefferson Tilley
  • Diaminopropionic acid derivatives
    Patent number: 7217728
    Abstract: A compound of formula 1a which is useful for treating reperfusion injury, and salts, prodrugs, and related compounds.
    Type: Grant
    Filed: September 21, 2004
    Date of Patent: May 15, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Nader Fotouhi, Paul Gillespie, Robert William Guthrie, Sherrie Lynn Pietranico-Cole, Weiya Yun
  • MCH receptor antagonists
    Publication number: 20070078165
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of obesity, hyperphagia, anxiety, depression and related disorders and diseases.
    Type: Application
    Filed: September 25, 2006
    Publication date: April 5, 2007
    Inventors: Steven Berthel, Shawn Erickson, Nader Fotouhi, Robert Kester, Kyungjin Kim, Steven Mischke, Yimin Qian, Kshitij Thakkar, Jefferson Tilley, Hong Wang
  • Pyrazolones as inhibitors of 11B-hydroxysteroid dehydrogenase
    Publication number: 20070049632
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
    Type: Application
    Filed: August 18, 2006
    Publication date: March 1, 2007
    Inventors: Bruce Banner, Joseph Bilotta, Nader Fotouhi, Paul Gillespie, Robert Goodnow, Matthew Hamilton, Nancy-Ellen Haynes, Agnieszka Kowalczyk, Alexander Mayweg, Michael Myers, Sherrie Pietranico-Cole, Nathan Scott, Kshitij Thakkar, Jefferson Tilley
  • CIS-imidazoles
    Patent number: 7132421
    Abstract: The present invention provides compounds according to formula I and pharmaceutically acceptable salts and esters thereof, having the designations provided herein and which inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity
    Type: Grant
    Filed: June 15, 2004
    Date of Patent: November 7, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Nader Fotouhi, Emily Aijun Liu, Binh Thanh Vu
  • Cis-imidazolines
    Publication number: 20060211693
    Abstract: There are presented compounds of the formula or pharmaceutically acceptable salts thereof, wherein Y1, Y2, X1, X2, X3 and R are as described in this application. These compounds are believed to inhibit MDM2-p53 interaction and as such the compounds will have anti-hyperproliferative cellular activity.
    Type: Application
    Filed: March 13, 2006
    Publication date: September 21, 2006
    Inventors: Nader Fotouhi, Gregory Haley, Klaus Simonsen, Binh Vu, Stephen Webber
  • Substituted hydantoins
    Publication number: 20060041146
    Abstract: The present invention relates to compounds of the formula which are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as, cancer, cognative and CNS disorders and inflammatory/autoimmune diseases.
    Type: Application
    Filed: August 11, 2005
    Publication date: February 23, 2006
    Inventors: Xin-Jie Chu, Nader Fotouhi, Nicholas Huby, Norman Kong, Lee McDermott, John Moliterni, Zhuming Zhang