Patents by Inventor Nader Fotouhi

Nader Fotouhi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7504513
    Abstract: The invention is directed to compounds of formula (1) and pharmaceutically acceptable salts thereof, methods for the preparation thereof, and methods of use thereof.
    Type: Grant
    Filed: February 7, 2007
    Date of Patent: March 17, 2009
    Assignee: Hoffman-La Roche Inc.
    Inventors: John Frederick Boylan, Jianping Cai, Nader Fotouhi, Paul Gillespie, Robert Alan Goodnow, Jr., Kang Le, Christophe Michoud
  • Publication number: 20090054466
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification.
    Type: Application
    Filed: July 28, 2008
    Publication date: February 26, 2009
    Inventors: Romyr Dominique, Nader Fotouhi, Paul Gillespie, Robert Alan Goodnow, Agnieszka Kowalczyk, Qi Qiao, Achyutharao Sidduri
  • Patent number: 7491741
    Abstract: A compound of formula 1a which is useful for treating reperfusion injury, and salts, prodrugs, and related compounds.
    Type: Grant
    Filed: February 8, 2007
    Date of Patent: February 17, 2009
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Nader Fotouhi, Paul Gillespie, Robert William Guthrie, Sherrie Lynn Pietranico-Cole, Weiya Yun
  • Patent number: 7427635
    Abstract: The present invention relates to compounds of the formula which are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as, cancer, cognative and CNS disorders and inflammatory/autoimmune diseases.
    Type: Grant
    Filed: August 11, 2005
    Date of Patent: September 23, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Xin-Jie Chu, Nader Fotouhi, Nicholas J. S. Huby, Norman Kong, Lee Apostle McDermott, John Moliterni, Zhuming Zhang
  • Publication number: 20070225280
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
    Type: Application
    Filed: March 14, 2007
    Publication date: September 27, 2007
    Inventors: Kevin William Anderson, Nader Fotouhi, Paul Gillespie, Robert Alan Goodnow, Kevin Richard Guertin, Nancy-Ellen Haynes, Michael Paul Myers, Sherrie Lynn Pietranico-Cole, Lida Qi, Pamela Loreen Rossman, Nathan Robert Scott, Kshitij Chhabilbhai Thakkar, Jefferson Wright Tilley, Qiang Zhang
  • Publication number: 20070203210
    Abstract: The invention is directed to compounds of formula (1) and pharmaceutically acceptable salts thereof, methods for the preparation thereof, and methods of use thereof.
    Type: Application
    Filed: February 7, 2007
    Publication date: August 30, 2007
    Inventors: John Frederick Boylan, Jianping Cai, Nader Fotouhi, Paul Gillespie, Robert Alan Goodnow, Kang Le, Christophe Michoud
  • Publication number: 20070167437
    Abstract: There are provided compounds of the formula I wherein R, V1, V2 and Ring A are described herein. The compounds exhibit anticancer activity.
    Type: Application
    Filed: January 17, 2007
    Publication date: July 19, 2007
    Inventors: Nader Fotouhi, Gregory Haley, Klaus Simonsen, Binh Vu, Stephen Webber
  • Publication number: 20070155671
    Abstract: A compound of formula 1a which is useful for treating reperfusion injury, and salts, prodrugs, and related compounds.
    Type: Application
    Filed: February 8, 2007
    Publication date: July 5, 2007
    Inventors: Nader Fotouhi, Paul Gillespie, Robert Guthrie, Sherrie Pietranico-Cole, Weiya Yun
  • Publication number: 20070135351
    Abstract: Provided herein are neuropeptide-2 receptor agonists of the formula (I): as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity and diabetes.
    Type: Application
    Filed: December 1, 2006
    Publication date: June 14, 2007
    Inventors: Karin Conde-Knape, Waleed Danho, George Ehrlich, Nader Fotouhi, David Fry, Wajiha Khan, Anish Konkar, Cristina Rondinone, Joseph Swistok, Rebecca Taub, Jefferson Tilley
  • Patent number: 7217728
    Abstract: A compound of formula 1a which is useful for treating reperfusion injury, and salts, prodrugs, and related compounds.
    Type: Grant
    Filed: September 21, 2004
    Date of Patent: May 15, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Nader Fotouhi, Paul Gillespie, Robert William Guthrie, Sherrie Lynn Pietranico-Cole, Weiya Yun
  • Publication number: 20070078165
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of obesity, hyperphagia, anxiety, depression and related disorders and diseases.
    Type: Application
    Filed: September 25, 2006
    Publication date: April 5, 2007
    Inventors: Steven Berthel, Shawn Erickson, Nader Fotouhi, Robert Kester, Kyungjin Kim, Steven Mischke, Yimin Qian, Kshitij Thakkar, Jefferson Tilley, Hong Wang
  • Publication number: 20070049632
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
    Type: Application
    Filed: August 18, 2006
    Publication date: March 1, 2007
    Inventors: Bruce Banner, Joseph Bilotta, Nader Fotouhi, Paul Gillespie, Robert Goodnow, Matthew Hamilton, Nancy-Ellen Haynes, Agnieszka Kowalczyk, Alexander Mayweg, Michael Myers, Sherrie Pietranico-Cole, Nathan Scott, Kshitij Thakkar, Jefferson Tilley
  • Patent number: 7132421
    Abstract: The present invention provides compounds according to formula I and pharmaceutically acceptable salts and esters thereof, having the designations provided herein and which inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity
    Type: Grant
    Filed: June 15, 2004
    Date of Patent: November 7, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Nader Fotouhi, Emily Aijun Liu, Binh Thanh Vu
  • Publication number: 20060211693
    Abstract: There are presented compounds of the formula or pharmaceutically acceptable salts thereof, wherein Y1, Y2, X1, X2, X3 and R are as described in this application. These compounds are believed to inhibit MDM2-p53 interaction and as such the compounds will have anti-hyperproliferative cellular activity.
    Type: Application
    Filed: March 13, 2006
    Publication date: September 21, 2006
    Inventors: Nader Fotouhi, Gregory Haley, Klaus Simonsen, Binh Vu, Stephen Webber
  • Publication number: 20060041146
    Abstract: The present invention relates to compounds of the formula which are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as, cancer, cognative and CNS disorders and inflammatory/autoimmune diseases.
    Type: Application
    Filed: August 11, 2005
    Publication date: February 23, 2006
    Inventors: Xin-Jie Chu, Nader Fotouhi, Nicholas Huby, Norman Kong, Lee McDermott, John Moliterni, Zhuming Zhang
  • Publication number: 20050288287
    Abstract: and the pharmaceutically acceptable salts and esters thereof, wherein X1, X2, X3, Y1, Y2 and R are described herein inhibit the interaction of MDM2 protein with a p53-like peptide and hence have anti proliferative activity.
    Type: Application
    Filed: May 13, 2005
    Publication date: December 29, 2005
    Inventors: Nader Fotouhi, Gregory Haley, Klaus Simonsen, Binh Vu, Stephen Webber
  • Publication number: 20050080119
    Abstract: A compound of formula 1a which is useful for treating reperfusion injury, and salts, prodrugs, and related compounds.
    Type: Application
    Filed: September 21, 2004
    Publication date: April 14, 2005
    Inventors: Nader Fotouhi, Paul Gillespie, Robert Guthrie, Sherrie Pietranico-Cole, Weiya Yun
  • Publication number: 20040259867
    Abstract: The present invention provides compounds according to formula I and pharmaceutically acceptable salts and esters thereof, having the designations provided herein and which inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity.
    Type: Application
    Filed: June 15, 2004
    Publication date: December 23, 2004
    Inventors: Nader Fotouhi, Emily Aijun Liu, Binh Thanh Vu
  • Patent number: 6803384
    Abstract: A compound of formula Id and pharmaceutically acceptable salts and esters thereof, wherein the substituent designations are as provided in the specification. Compounds of the invention are useful for treating reperfusion injury.
    Type: Grant
    Filed: January 22, 2003
    Date of Patent: October 12, 2004
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Nader Fotouhi, Paul Gillespie, Robert William Guthrie, Sherrie Lynn Pietranico-Cole, Weiya Yun
  • Publication number: 20040006236
    Abstract: A compound of formula 1a 1
    Type: Application
    Filed: January 22, 2003
    Publication date: January 8, 2004
    Inventors: Nader Fotouhi, Paul Gillespie, Robert William Guthrie, Sherrie Lynn Pietranico-Cole, Weiya Yun