Patents by Inventor Nader Fotouhi

Nader Fotouhi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chiral cis-imidazolines
    Publication number: 20050288287
    Abstract: and the pharmaceutically acceptable salts and esters thereof, wherein X1, X2, X3, Y1, Y2 and R are described herein inhibit the interaction of MDM2 protein with a p53-like peptide and hence have anti proliferative activity.
    Type: Application
    Filed: May 13, 2005
    Publication date: December 29, 2005
    Inventors: Nader Fotouhi, Gregory Haley, Klaus Simonsen, Binh Vu, Stephen Webber
  • Diaminopropionic acid derivatives
    Publication number: 20050080119
    Abstract: A compound of formula 1a which is useful for treating reperfusion injury, and salts, prodrugs, and related compounds.
    Type: Application
    Filed: September 21, 2004
    Publication date: April 14, 2005
    Inventors: Nader Fotouhi, Paul Gillespie, Robert Guthrie, Sherrie Pietranico-Cole, Weiya Yun
  • CIS-imidazoles
    Publication number: 20040259867
    Abstract: The present invention provides compounds according to formula I and pharmaceutically acceptable salts and esters thereof, having the designations provided herein and which inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity.
    Type: Application
    Filed: June 15, 2004
    Publication date: December 23, 2004
    Inventors: Nader Fotouhi, Emily Aijun Liu, Binh Thanh Vu
  • Diaminopropionic acid derivatives
    Patent number: 6803384
    Abstract: A compound of formula Id and pharmaceutically acceptable salts and esters thereof, wherein the substituent designations are as provided in the specification. Compounds of the invention are useful for treating reperfusion injury.
    Type: Grant
    Filed: January 22, 2003
    Date of Patent: October 12, 2004
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Nader Fotouhi, Paul Gillespie, Robert William Guthrie, Sherrie Lynn Pietranico-Cole, Weiya Yun
  • Diaminopropionic acid derivatives
    Publication number: 20040006236
    Abstract: A compound of formula 1a 1
    Type: Application
    Filed: January 22, 2003
    Publication date: January 8, 2004
    Inventors: Nader Fotouhi, Paul Gillespie, Robert William Guthrie, Sherrie Lynn Pietranico-Cole, Weiya Yun
  • Substituted pyrroles suitable for continuous infusion
    Patent number: 6559164
    Abstract: Disclosed are novel substituted pyrroles having the formula These compounds and their pharmaceutically acceptable salts are suitable for administration to patients as continuous infusion solution and are useful in the treatment and/or control of cell proliferative disorders, in particular cancer. Also disclosed are pharmaceutical compositions containing the foregoing compounds and methods for the treatment and/or control of cancer.
    Type: Grant
    Filed: October 3, 2000
    Date of Patent: May 6, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Nader Fotouhi, Norman Kong, Emily Aijun Liu, Allen John Lovey, John Guilfoyle Mullin, Jr.
  • Dehydroamino acids
    Patent number: 6515124
    Abstract: Aromatic dehydroamino acids are disclosed that are active as LFA-1 arnagonists This activity enables these compounds to prevent inflammation which is a consequence of T cell activation and accordingly reduce or eliminate inflammatory skin disease psoriasis.
    Type: Grant
    Filed: January 5, 2001
    Date of Patent: February 4, 2003
    Assignee: Hoffman-La Roche Inc.
    Inventors: Nader Fotouhi, Paul Gillespie, Robert William Guthrie, Sherrie Lynn Pietranico-Cole, Weiya Yun
  • Dehydroamino acids
    Publication number: 20020161237
    Abstract: Compounds of formula 1 and 1-1, 1
    Type: Application
    Filed: January 5, 2001
    Publication date: October 31, 2002
    Inventors: Nader Fotouhi, Paul Gillespie, Robert William Guthrie, Sherrie Lynn Pietranico-Cole, Weiya Yun
  • Diaminopropionic acid derivatives
    Publication number: 20020052512
    Abstract: A compound of formula 1a 1
    Type: Application
    Filed: June 12, 2001
    Publication date: May 2, 2002
    Inventors: Nader Fotouhi, Paul Gillespie, Robert W. Guthrie, Sherrie L. Pietranico-Cole, Weiya Yun
  • Diaminopropionic acid derivatives
    Patent number: 6331640
    Abstract: A compound of formula 1a which is useful for treating reperfusion injury, and salts, prodrugs, and related compounds.
    Type: Grant
    Filed: September 29, 1999
    Date of Patent: December 18, 2001
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Nader Fotouhi, Paul Gillespie, Robert William Guthrie, Sherrie Lynn Pietranico-Cole, Weiya Yun
  • Substituted pyrroles
    Patent number: 6313143
    Abstract: Disclosed are novel substituted pyrroles having the formula These compounds and their pharmaceutically acceptable salts are suitable for administration to patients as continuous infusion solution and are useful in the treatment and/or control of cell proliferative disorders, in particular cancer. Also disclosed are pharmaceutical compositions containing the foregoing compounds and methods for the treatment and/or control of cancer.
    Type: Grant
    Filed: November 7, 2000
    Date of Patent: November 6, 2001
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Nader Fotouhi, Emily Aijun Liu, Allen John Lovey, John Guilfoyle Mullin, Jr., Giuseppe Federico Weber
  • Substituted pyrroles
    Patent number: 6281356
    Abstract: Disclosed are substituted pyrroles having the formula These compounds and their pharmaceutically acceptable salts are useful in the treatment and/or control of cell proliferative disorders, in particular cancer. Also disclosed are pharmaceutical compositions containing the foregoing compounds.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: August 28, 2001
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Nader Fotouhi, Norman Kong, Allen John Lovey
  • Pyrrolidincarbonylamino cyclic disulfide anti-inflammatory agents
    Patent number: 6265572
    Abstract: Compounds of the formula: are described which have activity as anti-inflammatory agents. Cyclic disulfide compounds are provided which inhibit of binding of cells to endothelium. Such compounds are useful for treating inflammatory diseases, such as asthma, whose symptoms and/or damage are related to the binding of cell adhesion molecules to integrin expressing cells.
    Type: Grant
    Filed: April 14, 2000
    Date of Patent: July 24, 2001
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Li Chen, Nader Fotouhi, David Young Jackson, Jefferson Wright Tilley
  • St. John's Wort and methyl donor composition and uses thereof
    Patent number: 6096317
    Abstract: A therapeutic composition and method are provided for mood enhancement, regulation and the treatment of depression and anxiety, and the relief of PMS associated symptoms in mammals. The composition comprises St. John's Wort (Hypericum perforatum) and a methyl donor, such as S-adenosylmethionine.
    Type: Grant
    Filed: January 13, 1999
    Date of Patent: August 1, 2000
    Assignee: Rexall Sundown
    Inventors: Debbie A. Desantis, Nader Fotouhi