Abstract: A method of gastric reduction is disclosed that includes the steps of: inserting an oral-gastric device into the interior volume of the stomach of a subject; and inserting through the esophagus at least one barbed suture in proximity to the muscularis of the stomach of a subject. The barbed suture has a first end having a pointed configuration, and a second end. The muscularis comprise at least first and second surfaces that are in at least partially interfacing relationship to one another in the interior volume. The method also includes inserting the first and/or the second end of the barbed suture through the muscularis to form at least first and second pull regions; and pulling the ends to cause the first pull region to move the first surface towards the interior volume and to cause the second pull region to move the second surface towards the interior volume.

Abstract: Methods for producing biocompatible compositions are provided. The biocompatible compositions include an aliphatic polyester macromer produced without the use of solvents or catalysts. The resulting aliphatic polyester macromer may be reacted with a polyisocyanate to form an end-capped aliphatic polyester macromer which, in turn, may be reacted with a polyol to produce a polyurethane. The polyurethane, in turn, may be reacted with a second polyisocyanate to produce an isocyanate-functional polyurethane. The compositions prepared by the methods of the present disclosure may be used as adhesives or sealants for medical/surgical uses.

Abstract: Novel silver-triclosan salts are provided which have antimicrobial properties and may be used as pharmaceutical compositions or to treat articles such as medical devices, packaging materials, and textiles.

Abstract: Compounds are provided which can form bioabsorbable compositions useful as adhesives or sealants for medical/surgical applications.

Abstract: The present disclosure relates to crosslinked polymer compositions comprising an inclusion complex functionalized with one or more reactive groups and a polymer functionalized with one or more complimentary reactive groups.

Abstract: The present disclosure provides methods for purifying p-dioxanone. In embodiments, crude p-dioxanone may be contacted with at least one isocyanate-functionalized scavenger. The at least one isocyanate-functionalized scavenger may react with hydroxyl compounds present with the crude p-dioxanone to form reaction products, in embodiments polyurethanes and/or polyureas, which may then be removed. The p-dioxanone thus obtained is of greater purity than the starting crude p-dioxanone.

Abstract: Compounds are provided which can form bioabsorbable compositions useful as adhesives or sealants for medical/surgical applications.

Abstract: The present disclosure provides compositions which may be utilized as adhesives or sealants in medical and surgical applications. The compositions may, in embodiments, be formed from the cycloaddition reaction of a first component possessing at least one azide group with a second component possessing at least one alkyne group.

Abstract: Compounds are provided which can form bioabsorbable compositions useful as adhesives or sealants for medical/surgical applications.

Abstract: Methods are provided for isolating and purifying components useful, either alone or in combination with other components, as adhesives or sealants for medical/surgical applications.

Abstract: A kit for storing and applying an adhesive removing device comprising an enclosure which includes a base portion and a removable top layer releasably secured to the base portion; an adhesive removing device including at least one wiping mechanism which includes at least one absorbent portion; and a biocompatible composition including a solvent and a moisturizing agent embedded in the absorbent portion of the wiping mechanism. A method for storing and applying an adhesive removing device comprises a series of steps for using the adhesive removing device to remove an adhesive from a surface.

Abstract: Novel biodegradable phosphoester polyamines are disclosed. The biodegradable phosphoester polyamines may be utilized as cross-linkers for sprayable compositions which may be used as tissue adhesives or sealants.

Abstract: The present disclosure is directed to polymers having hydroxyl containing bioactive agents incorporated into the backbone of the polymer or attached thereto by pendant linkages. Hydroxyl containing bioactive agents which may be attached to these polymers include antimicrobial agents such as triclosan. The polymers may be utilized to form medical devices or coatings for such devices. The hydroxyl containing bioactive agent may be released from the polymer upon hydrolysis of the polymeric backbone or pendant linkage in vivo.

Abstract: Antimicrobial medical devices are prepared with a complexed antimicrobial agent which enhances the adherence of the antimicrobial agent to the medical device.

Abstract: The present disclosure provides sprayable compositions having reduced viscosity which may be used as adhesives or tissue sealants.

Abstract: Biocompatible compositions are provided including a first polymer component including an isocyanate-functional polyalkylene oxide combined with at least one multi-isocyanate functional polyether-polyurethane, and a second component including at least one diamine.

Abstract: Biocompatible macromer compositions are provided including an isocyanate-functional polyalkylene oxide combined with at least one multi-functional isocyanate as a first component, and a multi-amino functional compound possessing multiple primary amines as a second component. The isocyanate-functional polyalkylene oxide has pendant polyalkylene oxide groups. The resulting biocompatible macromer composition can be employed as an adhesive or sealant for medical/surgical uses.

Abstract: Bioabsorbable macromer compositions are provided including a diisocyanate-functional bioabsorbable polymer. In some embodiments, the diisocyanate-functional bioabsorbable polymer can be combined with a functionalized polyol. The resulting bioabsorbable macromer composition can be employed as an adhesive or sealant for medical/surgical uses.

Abstract: The disclosure relates to compositions for medical/surgical synthetic adhesives and sealants. Adhesive compositions include a functionalized triol and functionalized diol, while sealant compositions further include a multifunctionalized polyol and at least one amine cross linker.

Abstract: Flowable bioabsorbable compounds are provided which are useful in producing surgical adhesive or sealant compositions.