Abstract: The present invention is related to a process for the preparation of relugolix, a compound of formula I, also known as N-[4-[1-[(2,6-difluoro phenyl) methyl]-5-[(dimethyl amino]-methyl]-3-(6-methoxy-3-pyridazinyl]-2,4-dioxo-1,2,3,4-tetrahydro-thieno[2,3-d]pyrimidin-6-yl]phenyl]-N?-methoxyurea, or a pharmaceutically acceptable salt thereof. The present invention is also related to a process for the preparation of crystalline relugolix.

Abstract: Disclosed is a method of crosslinking hair or other keratin fibers by (i) providing a crosslinking agent comprising an oxidized sugar having at least two aldehyde groups; and (ii) infiltrating a plurality of non-crosslinked hair or other keratin fibers with the crosslinking agent under conditions effective to cause protein molecules contained in the non-crosslinked hair or other keratin fibers to become crosslinked, thereby yielding a population of crosslinked hair or other keratin fibers. The protein molecules include amine groups that react with the aldehyde groups of the oxidized sugar to yield the crosslinked hair or other keratin fibers. Also disclosed are formulations for crosslinking hair or other keratin fibers and methods of using the formulations to treat human hair to maintain a desired three dimensional structure. This formulation includes a crosslinking agent having a plurality of oxidized sugars having at least two aldehyde groups or mixture thereof.

Abstract: A method of manufacturing a three-dimensional lens comprises inputting a lens template into a controller, depositing a first layer of lens material onto a work surface according to the lens Template, and successively depositing additional filamentous layers of the lens material onto the first layer. The deposition of layers of lens material is done according to the lens template in order to build the three-dimensional lens with a particular transmission scattering profile for transmitted light.

Abstract: A self-powered microelectronic semiconductor device includes low temperature interconnection and encapsulation materials to enable integration of a battery with the microelectronics package during manufacture. The package includes a partially exposed leadframe or leads of a substrate for connecting the battery. The battery includes one or more terminal connectors that can either be manufactured by the battery vendor or externally attached using spot/laser or resistance welding. The steps of connecting the battery to the package are performed after the microelectronic package assembly to ensure the battery does not experience any high temperatures from the package assembly process. Cavities are formed in an overmolded molding compound to expose the leadframe or battery pads for electronic connection. A low temperature electrically conductive bonding agent is used to create the electrical and mechanical bond of the battery tabs to the leadframe.

Abstract: A method implemented on an electronic device detects and mitigates software attacks exploiting a zero-day vulnerability, such as Spring4Shell, against a computer server. At least one initial identifier, which indicates an attempt to extract a predetermined type of information on the computer server, is detected within an activity log of the computer server to thereby indicate occurrence of an initial stage. Then, prior to elapsing of a search window having a predetermined time duration, at least one subsequent identifier, which indicates an attempt to perform remote code execution on the computer server, is detected within the activity log of the computer server. Then, a source of network activity associated with the detected identifiers is detected, and a security response associated with the identified source of network activity is performed to mitigate the exploitation of the vulnerability.

Abstract: The present disclosed subject matter relates to assays, methods, and kits for determining protein-nucleic acid association and dissociation kinetics.

Abstract: The present invention relates to the formation of hydrogels from poly-amino acids designed from the ?-aggregation-prone region of functional amyloidogenic proteins that self-assemble to form a three-dimensional nanofibril matrix. Further, these water entrapped meshwork can be modulated by various physico-chemical cues. The present invention also explores the use of the designed hydrogels as cell and tissue adhesive biomaterial for tissue engineering applications. The present invention also relates to the application of functional amyloid hydrogel including but not limited to 3D tumoroid model for anticancer drug testing, optimization of drug dosage including drug-resistant tumors, repurposing of existing drugs, and patient-derived organoid. The present invention also describes the use of functional amyloid hydrogel as a depot for controlled and sustained release of therapeutics and biologic agents encapsulated within the same.

Abstract: An electronic package with a battery and method for producing the electronic package uses a bent leadframe having flanged ends that are physically and electrically connected to a substrate so that the battery is encircled by the bent leadframe and the substrate, and the substrate is positioned between the battery and an electronic component. A first terminal of the battery is physically and electrically connected to the substrate and a second terminal of the battery is physically and electrically connected to the bent leadframe, which provides an electrical connection between the battery and the electronic component.

Abstract: This disclosure provides systems, methods, and apparatus for controlling transitions in an optically switchable device. In one aspect, a controller for a tintable window may include a processor, an input for receiving output signals from sensors, and instructions for causing the processor to determine a level of tint of the tintable window, and an output for controlling the level of tint in the tintable window. The instructions may include a relationship between the received output signals and the level of tint, with the relationship employing output signals from an exterior photosensor, an interior photosensor, an occupancy sensor, an exterior temperature sensor, and a transmissivity sensor. In some instances, the controller may receive output signals over a network and/or be interfaced with a network, and in some instances, the controller may be a standalone controller that is not interfaced with a network.

Abstract: A set of incident records are received for a computing system. The incident records are analyzed to identify similar incident records which are then linked. Incident clusters are generated based upon the links and incident records in each cluster are ranked. A prompt is generated to an artificial intelligence (AI) model based on the ranked, related incidents and the AI model returns a response that identifies a root cause and mitigation steps corresponding to the ranked incidents.

Abstract: Methods, apparatus, and processor-readable storage media for automated image analysis using artificial intelligence techniques are provided herein. An example computer-implemented method includes obtaining image data associated with at least one event; characterizing a plurality of attributes of the image data by processing at least a portion of the image data using one or more artificial intelligence techniques and processing metadata associated with at least a portion of the image data using one or more rule-based techniques; generating a determination as to whether one or more portions of the image data have been modified based at least in part on the plurality of characterized attributes of the image data; and performing one or more automated actions, based at least in part on the determination, in connection with at least one user request related to the image data associated with the at least one event.

Abstract: An anomaly diagnosis system obtains a plurality of anomaly signals corresponding to a plurality of sensor signals of a physical system and segments one or more anomaly signals into a plurality of time segments. The system determines an anomaly score for each time segment based on anomaly values of the one or more anomaly signals during the time segment and identifies an anomaly time interval corresponding to at least one consecutive time segment within the plurality of time segments. The system clusters the plurality of anomaly signals within the anomaly time interval to identify an anomaly group of sensor signals associated with the anomaly time interval and determines an aggregate anomaly score for the anomaly group. The system generates a graphical user interface presenting a representation of the anomaly group of sensor signals and the aggregate anomaly scores and causes the graphical user interface to be displayed on a user device.

Abstract: A computer-implemented method, according to one approach includes having a historical risk score generated for a current cybersecurity event in response to detecting the current cybersecurity event. A sigma rule detection score is also generated for the current cybersecurity event, in addition to an anomaly risk score that is generated for the current cybersecurity event. An IoC score is further generated for the current cybersecurity event. A machine learning model is used to evaluate the historical risk score, the sigma rule detection score, the anomaly risk score, and the IoC score. The machine learning model is also used to create a consolidated risk score corresponding to: the current cybersecurity event, the consolidated risk score incorporating the historical risk score, the sigma rule detection score, the anomaly risk score, and the IoC score.

Abstract: Automated determination of web page rendering performance techniques and systems are described. In one example, a web page including multiple user-interactive elements that can be selected or navigated via user input is received. A frame rendering system is employed to automatically identify the user-interactive elements and generate scripts to simulate user input at the user-interactive elements. The generated scripts are then used to simulate user input at the user-interactive elements. The scripts may be generated to simulate user interaction via a variety of different device types, and under a variety of different network conditions. During the simulation, a rendering performance score for the web page is generated by monitoring rendering performance relative to a threshold rendering rate.

Abstract: Methods and systems for detecting systemwide service issues by using anomaly localization. In an example, a method includes receiving time-series monitoring data for multiple services, the time-series monitoring data including multiple dimensions and an error metric; for the monitoring data from each service, evaluating scopes within the monitoring data based on an objective function for a time-series of the error metric to identify at least one anomalous scope, each scope including at least one dimension and a value for the dimension; based on evaluating the scopes, generating a ranked list of scopes for each service based on objective function scores for the scopes; correlating the ranked lists of scopes across the multiple services to identify a cross-service anomaly; and generating an alert for the services based on the cross-service anomaly, the alert indicating at least one scope as a potential root cause for the cross-service anomaly.

Abstract: A method, a network device, and a non-transitory computer-readable storage medium are described in relation to an agnostic-based end device management service. The agnostic-based end device management service may include a network-side service that hosts persona information associated with a user and end devices. The persona information may include executable end device applications, end device application data, context information pertaining to the user and the end devices, end device application session data, and business logic. The end devices of the user may not store and execute the end device applications yet have access and use of end device functionality across varying types of end devices. The network-side service may also simulate the executable environment of an end device when providing an application service to the end device. An end device-side service of the end device may render application data and provide sensory data and input data to the network-side service.

Abstract: Methods and apparatus for extending OpenvSwitch (OVS) megaflow offloads to hardware to address hardware pipeline limitations. Under a method implemented on a compute platform including a Network Interface Controller (NIC) having one or more ports and running software including OVS software and a Linux operating system having a kernel including a TC-flower module and a NIC driver a new megaflow is created with a mask in the OVS software employing a subset of microflow fields for a packet. The microflow fields and the megaflow mask is sent to the NIC driver. A new megaflow is implemented in the NIC driver employing a subset of the microflow fields and the NIC driver creates a new hardware flow on the NIC employing a packet match scheme using all the microflow fields. The NIC also programs a NIC hardware pipeline with the new hardware flow using a match scheme that may depend on the available hardware resources, such as the size of a TCAM.

Abstract: The technology disclosed teaches systems and methods for self-service installation of monitoring operations in an area of real space, the method including scanning the area of real space to generate a 3D representation of the area of real space, placing a camera at an initial location and orientation for monitoring a zone within the area of real space, configuring a computing device to be connected to a cloud network hosting an image processing service and couplable to the camera, coupling the camera to the computing device via a local connection using a unique identifier associated with the camera, and finetuning the camera placement to a calibrated location and orientation, wherein the finetuning is assisted by information received from a cloud-based application associated with the image processing service.

Abstract: Examples described herein relate to a Transport Layer Security (TLS) offload engine to: based on detection of encrypted data unassociated with a previously detected data header: search for one or more data headers; identify at least two candidate data headers for validation; and based on receipt of an indication that the at least two candidate data headers are valid, perform decryption of received data in one or more packets. In some examples, the TLS offload engine is to: based on receipt of an indication that one or more of the at least two candidate data headers is not a valid header, search for two or more other candidate data headers.

Abstract: A system may include one or more devices configured to register a camera device with a core network; assign the camera device to a subscription of a user equipment (UE) device registered with the core network; and assign the camera device to an uplink streaming network slice. The one or more devices may be further configured to assign an uplink streaming video Quality of Service (QOS) class to a data flow sent from the camera device to the core network, wherein the uplink streaming video QoS class guarantees at least one video streaming QoS parameter; and establish the data flow from the camera device to a destination device via the uplink streaming network slice based on the uplink streaming video QoS class.