Abstract: The present invention features a knock-in mouse comprising a mutation in an endogenous CRBN locus and methods of use thereof.

Abstract: Aspects of the disclosure relate to a data wrapper engine. A computing platform may receive a query comprising a request for data stored as a CLOB. The computing platform may obtain, from a data storage system, the data stored as a CLOB. The computing platform may generate a file wrapper for the data, wherein generating the file wrapper comprises converting the CLOB to a VARCHAR object and storing the VARCHAR object in the file wrapper. The computing platform may generate, using the VARCHAR object stored in the file wrapper, a SQL response to the query. The computing platform may execute the dynamic SQL response to generate a response to the query. The computing platform may send, to a user device, the response to the query and commands directing the user device to display the response to the query, which may cause the user device to display the response.

Abstract: Provided is a pharmaceutical composition comprising: N—((S)-5-((1R,2S)-2-(4-fluorophenyl)cyclopropylamino)-1-(4-methylpiperazin-1-yl)-1-oxopentan-2-yl)-4-(1H-1,2,3-triazol-1-yl)benzamide (Compound A), or a pharmaceutically acceptable salt thereof, and at least one stabilizer, pharmaceutical preparations thereof, and methods for the treatment a disease or disorder associated with KDM1A activity.

Abstract: A method for vehicle behavior prediction is described. The method includes detecting a vehicle entering an unmarked road segment. The method also includes determining a set of exit paths available for the detected vehicle to reach different exit lanes of the unmarked road segment. The method further includes predicting an exit path taken by the detected vehicle from the set of exit paths available for the detected vehicle to reach the different exit lanes of the unmarked road segment. The method also includes planning a trajectory of an ego vehicle according to the predicted exit path taken by the detected vehicle to reach an exit lane of the unmarked road segment.

Abstract: Systems, computer program products, and methods are described herein for continuous cognitive code logic detection and prediction using machine learning techniques. The present invention is configured to receive, from a user input device, source code scripts and target code scripts for functional code logic components of a full stack, wherein the source code scripts and the target code scripts are associated with one or more tiers; generate a training dataset based on at least the source code scripts, the target code scripts, and the functional code logic components of the full stack; train, using a machine learning algorithm, a machine learning model using the training dataset; determine a prediction accuracy associated with the machine learning model; determine that the prediction accuracy is greater than a predetermined threshold; and deploy the machine learning model on unseen source code scripts.

Abstract: Decalin derivative compounds of formula (I) are provided, including processes for preparation thereof, and pharmaceutical compositions including the decalin derivative compounds. Methods are provided for treating blood related disorders, such as sickle cell anemia, in a subject in need thereof using a compound of formula (I).

Abstract: A skill-gap analysis and recommender system and method is described that serves as a personalized education and skill (PES) map. It provides a comprehensive presentation of the opportunities afforded by the University along with a detailed analysis of trends for placements and career goals. It conducts a comprehensive analysis of past student data and current market trends to make recommendations that are adapted to each student's profile in line with their individual career goals. This is accomplished using an algorithm for adaptive association pattern mining with a built-in mechanism for creation of meta-categories and drill-down for specifics, so as to meet the needs of every student and not miss infrequent patterns or rare opportunities afforded by the system. For the recommendations generated, the system also provides an assessment of the time-sensitivity of a goal and a mechanism for students to track their progress through prioritizing short and long term goals.

Abstract: Mitigating bias in a machine learning-augmented threat disposition platform can include generating a group of alerts in response to determining a similarity among the alerts. The alerts are generated in real time by a threat monitoring tool in response to one or more potential threats to a networked computing system. One or more alert spikes can be determined by partitioning the group into one or more alert spike subgroups. Each alert spike subgroup corresponds to an alert spike and contains two or more similar alerts that were generated within a predetermined time interval of one another. Duplicate alerts in each alert spike can be eliminated and each non-discarded alert labeled. The labeled alerts are used for training a reduced-bias machine learning model.

Abstract: Water leakage detection is provided. One or more water sensing devices are placed at different locations with respect to a laundry treatment appliance. A computing device is in communication with the one or more water sensing devices. The computing device is programmed to receive sensor data from the one or more water sensing devices. Responsive to the sensor data indicating a leak, the computing device performs one or more corrective actions to address the leak.

Abstract: An eustachian tube (ET) drug eluting stent includes a plurality of longitudinal spars with spring-like elements between each of the plurality of longitudinal spars, creating smooth arcs between each of the plurality of longitudinal spars while minimizing impediment of mucociliary flow. The combination of the plurality of longitudinal spars with spring-like elements are configured to enter into the ET uncompressed.

Abstract: Storage level query processing may be implemented for processing database queries. Nodes that can access a database may perform parallel processing for at least a portion of a database query. An indication may be received that specifies parallel processing for the database query. The nodes can then be caused to perform the portion of the query as part of providing a result in response to the database query instead of a node, such as a query engine node, that received the database query.

Abstract: An eustachian tube (ET) drug eluting stent includes a plurality of longitudinal spars with spring-like elements between each of the plurality of longitudinal spars, creating smooth arcs between each of the plurality of longitudinal spars while minimizing impediment of mucociliary flow. The combination of the plurality of longitudinal spars with spring-like elements are configured to enter into the ET uncompressed.

Abstract: Disclosed are some implementations of systems, apparatus, methods and computer program products for executing process flows. A graphical representation of a flow is provided for presentation via a display device, where the flow includes a plurality of elements, each of the elements corresponding to a set of computer-readable instructions. A set of metrics associated with the flow is generated or updated, where the set of metrics indicates, for each of a plurality of paths of the flow, one or more metrics collected across a plurality of users of the database system that accessed the flow, each of the paths of the flow corresponding to a subset of the plurality of elements of the flow.

Abstract: The invention describes a kit for detection of a target polynucleotide using a CRISPR effector system that comprises CAS9 from Francisella novicida, a synthetic sgRNA and a detection scheme based on binding and subsequent enzymatic cleavage of the target polynucleotide. The invention also describes a method for detection of a target polynucleotide using the kit. The kit can be el applied to both pathogenic and non-pathogenic polynucleotides and can be used to distinguish polynucleotides different by a single mismatch without the need for sequencing. The kit can also be used for detection of COVID-19. The kit is economical, easy to assemble and provides a robust and rapid readout that can be appropriately adapted for point of care applications.

Abstract: Disclosed is a method of crosslinking hair or other keratin fibers by (i) providing a crosslinking agent comprising an oxidized sugar having at least two aldehyde groups; and (ii) infiltrating a plurality of non-crosslinked hair or other keratin fibers with the crosslinking agent under conditions effective to cause protein molecules contained in the non-crosslinked hair or other keratin fibers to become crosslinked, thereby yielding a population of crosslinked hair or other keratin fibers. The protein molecules include amine groups that react with the aldehyde groups of the oxidized sugar to yield the crosslinked hair or other keratin fibers. Also disclosed are formulations for crosslinking hair or other keratin fibers and methods of using the formulations to treat human hair to maintain a desired three dimensional structure. This formulation includes a crosslinking agent having a plurality of oxidized sugars having at least two aldehyde groups or mixture thereof.

Abstract: A flexible advance system allows users to request and receive advances instantly. The flexible advance system facilitates intra-system transfers between a third-party entity and employee accounts at a third-party system by generating and providing funding instructions to the third-party entity. Funding instructions include a funding amount that the flexible advance system predicts using one or more machine-learned models that account for seasonality and time delays. In executing the instructions from the flexible advance system, the third-party entity transfers funds to its entity account with the third-party system based on the funding amount. Once the flexible advance system receives an indication that the third-party entity has executed the instructions, the flexible advance system authorizes users of the flexible advance system to request short-term advances.

Abstract: A computer assesses device log entries. The computer receives a training log entry and an input log entry from a log entry corpus. The computer determines for the training log entry, status indicators respective to the group of log entries, The indicators are based on processing the training log entry with a group of unsupervised Machine Learning models calibrated to identify outliers. The computer assigns an outlier status based on the processing to the training log entry. The computer trains a supervised ML learning model with a data pair of the training log entry and an associated data label representing the assigned outlier status value. The computer processes the input log entry with the supervised ML model to predict an input log classification, and the log classification indicates whether the input log is anomaly. The computer generates an input log entry assessment report including the input log entry classification.

Abstract: A method of deriving a financial conscientiousness score from visual choices, using a machine learning model that is trained at a server is provided. The method includes (i) obtaining visual selection as an input from the user that is selected from one or more different visual choices that are displayed to the user, (ii) determining trait scores for a subset of traits based on the points that are attributed to the visual choices, (iii) training, a machine learning model by correlating the trait scores for the subset of traits with a previous credit history or a loan repayment record of the user to obtain a trained machine learning model, and (iv) determining, using the trained machine learning model, a financial conscientiousness score based on the trait scores for the subset of traits.

Abstract: Disclosed is a method of crosslinking protein fibers, including wool fibers, by (i) providing a crosslinking agent including an oxidized sugar mixture having a plurality of different oxidized sugars of different molecular lengths and having at least two aldehyde groups (e.g., oxidized soy flour sugars); and (ii) infiltrating a plurality of non-crosslinked protein fibers with the crosslinking agent under conditions effective to cause protein molecules contained in the non-crosslinked protein fibers to become crosslinked. This method yields a population of crosslinked protein fibers, where the protein molecules of the non-crosslinked protein fibers include amine groups that react with the aldehyde groups of the oxidized sugars to achieve the crosslinking of the protein molecules to yield the crosslinked protein fibers.

Abstract: This disclosure provides systems, methods, and apparatus for controlling transitions in an optically switchable device. In one aspect, a controller for a tintable window may include a processor, an input for receiving output signals from sensors, and instructions for causing the processor to determine a level of tint of the tintable window, and an output for controlling the level of tint in the tintable window. The instructions may include a relationship between the received output signals and the level of tint, with the relationship employing output signals from an exterior photosensor, an interior photosensor, an occupancy sensor, an exterior temperature sensor, and a transmissivity sensor. In some instances, the controller may receive output signals over a network and/or be interfaced with a network, and in some instances, the controller may be a standalone controller that is not interfaced with a network.