Patents by Inventor Nan-Horng Lin

Nan-Horng Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Farnesyltransferase inhibitors
    Patent number: 7211595
    Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: May 1, 2007
    Assignee: Abbott Laboratories
    Inventors: Akiyo K. Claiborne, Stephen L. Gwaltney, II, Lisa A. Hasvold, Qun Li, Tongmei Li, Nan-Horng Lin, Robert A. Mantei, Todd W. Rockway, Hing L. Sham, Gerard M. Sullivan, Yunsong Tong, Gary Wang, Le Wang, Xilu Wang, Wei-Bo Wang
  • Macrocyclic kinase inhibitors
    Patent number: 7163939
    Abstract: Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
    Type: Grant
    Filed: November 3, 2004
    Date of Patent: January 16, 2007
    Assignee: Abbott Laboratories
    Inventors: Nan-Horng Lin, Gaoquan Li, Magdalena K. Przytulinska, Thomas J. Sowin, Gerard M. Sullivan, Zhi-Fu Tao, Yunsong Tong, Le Wang
  • Farnesyltransferase Inhibitors
    Publication number: 20060264476
    Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
    Type: Application
    Filed: July 25, 2006
    Publication date: November 23, 2006
    Inventors: Akiyo Claiborne, Stephen Gwaltney, Lisa Hasvold, Qun Li, Tongmei Li, Nan-Horng Lin, Robert Mantei, Todd Rockway, Hing Sham, Gerard Sullivan, Yunsong Tong, Gary Wang, Le Wang, Xilu Wang, Wei-Bo Wang
  • Urea kinase inhibitors
    Patent number: 7056925
    Abstract: Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
    Type: Grant
    Filed: August 13, 2003
    Date of Patent: June 6, 2006
    Assignee: Abbott Laboratories
    Inventors: Gaoquan Li, Qun Li, Tongmei Li, Nan-Horng Lin, Robert A. Mantei, Hing L. Sham, Gary T. Wang
  • Macrocyclic kinase inhibitors
    Publication number: 20050215556
    Abstract: Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
    Type: Application
    Filed: November 3, 2004
    Publication date: September 29, 2005
    Inventors: Nan-Horng Lin, Gaoquan Li, Magdalenna Przytulinska, Thomas Sowin, Gerard Sullivan, Zhi-Fu Tao, Yunsong Tong, Le Wang
  • Macrocyclic kinase inhibitors
    Publication number: 20050096324
    Abstract: Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
    Type: Application
    Filed: November 5, 2003
    Publication date: May 5, 2005
    Inventors: Zhi-Fu Tao, Nan-Horng Lin, Le Wang, Thomas Sowin
  • Fused tri and tetra-cyclic pyrazole kinase inhibitors
    Publication number: 20040259904
    Abstract: Compounds having the formula (I) 1
    Type: Application
    Filed: March 3, 2004
    Publication date: December 23, 2004
    Inventors: Yunsong Tong, Akiyo K. Claiborne, Gaoquan Li, Nan-Horng Lin, Hing L. Sham, Thomas J. Sowin, Zhi-Fu Tao
  • Urea kinase inhibitors
    Publication number: 20040259885
    Abstract: Compounds having the formula 1
    Type: Application
    Filed: August 13, 2003
    Publication date: December 23, 2004
    Inventors: Gaoquan Li, Qun Li, Tongmei Li, Nan-Horng Lin, Robert A. Mantei, Hing L. Sham, Gary T. Wang
  • Heterocyclic kinase inhibitors
    Publication number: 20040254159
    Abstract: Compounds having the formula 1
    Type: Application
    Filed: February 25, 2004
    Publication date: December 16, 2004
    Inventors: Lisa A. Hasvold, Laura Hexamer, Gaoquan Li, Nan-Horng Lin, Hing Sham, Gerard M. Sullivan, Le Wang, Ping Xia
  • Protein kinase inhibitors
    Patent number: 6797825
    Abstract: Compounds having the formula or therapeutically acceptable salts thereof, are protein kinase inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.
    Type: Grant
    Filed: December 12, 2002
    Date of Patent: September 28, 2004
    Assignee: Abbott Laboratories
    Inventors: Nan-Horng Lin, Hing L. Sham, Ping Xia
  • Urea kinase inhibitors
    Publication number: 20040034038
    Abstract: Compounds having the formula 1
    Type: Application
    Filed: August 13, 2002
    Publication date: February 19, 2004
    Inventors: Goaquan Li, Qun Li, Tongmei Li, Nan-Horng Lin, Robert A. Mantei, Hing L. Sham, Gary T. Wang
  • Substituted pyridine compounds useful for controlling chemical synaptic transmission
    Patent number: 6656958
    Abstract: The present invention is directed to a series of substituted pyridine compounds, a method for selectively controlling neurotransmitter release in mammals using these compounds, and pharmaceutical compositions containing these compounds. Preferred compounds are 3′-(5′- and/or 6′-substituted) pyridyl ethers.
    Type: Grant
    Filed: February 1, 2001
    Date of Patent: December 2, 2003
    Assignee: Abbott Laboratories
    Inventors: Nan-Horng Lin, Liming Dong
  • Protein kinase inhibitors
    Publication number: 20030162785
    Abstract: Compounds having the formula 1
    Type: Application
    Filed: December 12, 2002
    Publication date: August 28, 2003
    Inventors: Nan-Horng Lin, Hing L. Sham, Ping Xia
  • Protein kinase inhibitors
    Publication number: 20030119839
    Abstract: Compounds having the formula 1
    Type: Application
    Filed: December 13, 2001
    Publication date: June 26, 2003
    Inventors: Nan-Horng Lin, Hing L. Sham, Ping Xia
  • Farnesyltransferase inhibitors
    Publication number: 20030087940
    Abstract: Substituted imidazoles and thiazoles having the formula 1
    Type: Application
    Filed: November 30, 2001
    Publication date: May 8, 2003
    Inventors: Akiyo K. Claiborne, Stephen L. Gwaltney, Lisa A. Hasvold, Qun Li, Tongmei Li, Nan-Horng Lin, Robert A. Mantei, Todd W. Rockway, Hing L. Sham, Gerard M. Sullivan, Yunsong Tong, Gary Wang, Le Wang, Xilu Wang, Wei-Bo Wang
  • 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission
    Publication number: 20020151712
    Abstract: A series of 3-pyrrolidinyloxy-3′-pyridyl ether compounds, a method for selectively controlling neurotransmitter release in mammals using these compounds, and pharmaceutical compositions including these compounds. Preferred compounds are 3-pyrrolidinylmethoxy-3′-(5′-and/or 6′-substituted) pyridyl ethers.
    Type: Application
    Filed: March 19, 2002
    Publication date: October 17, 2002
    Inventors: Nan-Horng Lin, Yihong Li, Irene Drizin, John F. Kincaid, Anwer Basha, Liming Dong, Ahmed A. Hakeem
  • Farnesyltransferase inhibitors
    Publication number: 20020115640
    Abstract: Substituted imidazoles and thiazoles having the formula 1
    Type: Application
    Filed: July 25, 2001
    Publication date: August 22, 2002
    Inventors: Akiyo K. Claiborne, Stephen L. Gwaltney,, Lisa A. Hasvold, Qun Li, Tongmei Li, Nan-Horng Lin, Robert A. Mantei, Todd W. Rockway, Hing L. Sham, Gerard M. Sullivan, Yunsong Tong, Gary Wang, Le Wang, Xilu Wang, Wei-Bo Wang
  • 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission
    Patent number: 6437138
    Abstract: Novel 3-pyridyloxymethyl heterocyclic ether compounds of the formula: or the pharmaceutically-acceptable salts or prodrugs thereof are selective and potent ligands at neuronal nicotinic cholinergic channel receptors, and are effective in controlling synaptic transmission. Key intermediates and processes using this key intermediates to produce compounds of formula I with the variables defined in the specification are also described.
    Type: Grant
    Filed: March 1, 2000
    Date of Patent: August 20, 2002
    Assignee: Abbott Laboratories
    Inventors: Nan-Horng Lin, Yun He, Mark W. Holladay, Keith Ryther, Yihong Li, Hao Bai
  • 3-Pyridyl enantiomers and their use as analgesics
    Patent number: 6403575
    Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula I: or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula I above which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.
    Type: Grant
    Filed: July 19, 2000
    Date of Patent: June 11, 2002
    Assignee: Abbott Laboratories
    Inventors: Mark W. Holladay, Stephen P. Arneric, Hao Bai, Michael J. Dart, Nan-Horng Lin, John K. Lynch, Yat Sun Or, Keith B. Ryther, James P. Sullivan, James T. Wasicak, Paul P. Ehrlich
  • Substituted pyridine compounds useful for controlling chemical synaptic transmission
    Publication number: 20020058646
    Abstract: The present invention is directed to a series of substituted pyridine compounds, a method for selectively controlling neurotransmitter release in mammals using these compounds, and pharmaceutical compositions containing these compounds. Preferred compounds are 3′-(5′- and/or 6′-substituted) pyridyl ethers.
    Type: Application
    Filed: February 1, 2001
    Publication date: May 16, 2002
    Inventors: Nan-Horng Lin, Liming Dong