Abstract: A continuous serpentine cooling circuit forming a progression of radial passages (44, 45, 46, 47A, 48A) between pressure and suction side walls (52, 54) in a MID region of a turbine airfoil (24). The circuit progresses first axially, then tangentially, ending in a last radial passage (48A) adjacent to the suction side (54) and not adjacent to the pressure side (52). The passages of the axial progression (44, 45, 46) may be adjacent to both the pressure and suction side walls of the airfoil. The next to last radial passage (47A) may be adjacent to the pressure side wall and not adjacent to the suction side wall. The last two radial passages (47A, 48A) may be longer along the pressure and suction side walls respectively than they are in a width direction, providing increased direct cooling surface area on the interiors of these hot walls.

Abstract: There are provided compounds of the formula wherein X, Y and R1 to R8 are as described herein and the enantiomers and pharmaceutically acceptable salts and esters thereof which compounds have anticancer activity.

Abstract: Disclosed is a relocatable vehicle inspection system. The relocatable vehicle inspection system includes a radiation source for radiating radials; a detection array for receiving the radials from the radiation source, so that an image of the cargo on the vehicle to be inspected may be obtained; a moving device on which the radiation source and the detection array are disposed; and a ramp-platform device. The ramp-platform device includes first and second intermediate parts (6a, 6b); first, second, third and fourth ramp parts (4a1, 4a2, 4b1, 4b2); first, second, third and fourth transitional parts (5a1, 5a2, 5b1, 5b2). The first and second transitional parts can be foldably or removably connected to the first intermediate part, and the third and fourth transitional parts can be foldably or removably connected to the second intermediate part. The said ramp-platform device can be placed onto or removed away from the moving device under disassembling and folding conditions.

Abstract: The invention relates to methods of correcting auto-correlated wave artifacts of array signal data based on the GC content of the nucleic acids under consideration without affecting signal variations due to copy number variations.

Abstract: In one embodiment, a method for detecting malicious software agents, such as domain-flux botnets. The method applies a co-clustering algorithm on a domain-name query failure graph, to generate a hierarchical grouping of hosts based on similarities between domain names queried by those hosts, and divides that hierarchical structure into candidate clusters based on percentages of failed queries having at least first- and second-level domain names in common, thereby identifying hosts having correlated queries as possibly being infected with malicious software agents. A linking algorithm is used to correlate the co-clustering results generated at different time periods to differentiate actual domain-flux bots from other domain-name failure anomalies by identifying candidate clusters that persist for relatively long periods of time.

Abstract: There are provided compounds of the formula wherein X, Y, R1, R1?, R2, R2?, R3, R4, R5 and R6 are as described herein and enantiomers or a pharmaceutically acceptable salt or ester thereof. The compounds are useful as anticancer agents.

Abstract: There are provided compounds of formula I or a pharmaceutically acceptable salt thereof, wherein X, Y, R1, R1?, R2, R2?, R3, R4, R5 are as defined herein. The compounds exhibit activity as anticancer agents.

Abstract: There are provided compounds of the formula and pharmaceutically acceptable salts and esters thereof wherein W, V, X, Y, A, R and R? are as described herein. The compounds are useful as anticancer agents.

Abstract: A ring segment for a gas turbine engine includes an outer panel defining a structural body for the ring segment. An outer side of an inner panel is attached to an inner side of the outer panel at an interface, and an inner side of the inner panel defines a portion of a hot gas path through the gas turbine engine. An outer side of the outer panel, opposite from the interface, is in communication with a source of cooling air. A plurality of impingement holes extend through the outer panel from the outer side to the inner side of the outer panel for directing impingement air to the outer side of the inner panel. The outer and inner panels define a plurality of flow channels at the interface for effecting convective cooling of the outer panel along the flow channels between the outer and inner panels.

Abstract: Compounds of formula and enantiomers and pharmaceutically acceptable salts thereof are described, as well as the pharmaceutical compositions containing said compounds and their pharmaceutically acceptable salts, and the use of said compounds and pharmaceutical compositions for the treatment, control, amelioration or prevention of cancer.

Abstract: There are provided compounds of the formula wherein X, Y and R1 to R8 are described herein along with the enantiomers, pharmaceutically acceptable salts and esters thereof. The compounds are useful as anticancer agents.

Abstract: Graphite aluminum composites for use in thermal management applications, such as heat sinks, are manufactured using pressure molds. The materials may be mixed previous to insertion into the mold, or can be mixed within the mold. Further, graphitic particles, such as graphitic needle coke surfaces, can be coated with the aluminum before the mold process is performed. Further, ceramic sheets can be inserted into the mixture before the mold process is performed so that the molded material can then be sliced to provide a carbon aluminum composite plate with a ceramic sheet on one of its surfaces.

Abstract: Disclosed is a ramp-platform device for an on-board relocatable small vehicle inspection system. The ramp-platform device includes a connection frame having a rectangular shape and defining therein an inner space, first and second intermediate parts which are disposed in parallel with each other and at two opposite sides of the connection frame, first to fourth ramp parts having a substantially triangle shaped longitudinal section. The first and second ramp parts are removably connected to the two opposite ends of the first intermediate part separately, and the third and fourth ramp parts are removably connected to the two opposite ends of the second intermediate part separately. The height of a top end of the first to the fourth ramp parts is substantially equal to the height of the first and second intermediate parts.

Abstract: Disclosed is a relocatable vehicle inspection system. The relocatable vehicle inspection system includes a radiation source for radiating radials; a detection array for receiving the radials from the radiation source, so that an image of the cargo on the vehicle to be inspected may be obtained; a moving device on which the radiation source and the detection array are disposed; and a ramp-platform device. The ramp-platform device includes first and second intermediate parts (6a, 6b); first, second, third and fourth ramp parts (4a1, 4a2, 4b1, 4b2); first, second, third and fourth transitional parts (5a1, 5a2, 5b1, 5b2). The first and second transitional parts can be foldably or removably connected to the first intermediate part, and the third and fourth transitional parts can be foldably or removably connected to the second intermediate part. The said ramp-platform device can be placed onto or removed away from the moving device under disassembling and folding conditions.

Abstract: There are provided compounds of the formula wherein X, Y and R1 to R8 are as described herein and the enantiomers and pharmaceutically acceptable salts and esters thereof which compounds have anticancer activity.

Abstract: Novel isolated DNA sequences which comprise all or part of a gene cluster encoding sanglifehrin synthase, processing and regulatory genes involved in the biosynthesis of a mixed non-ribosomal peptide/polyketide compound, or mutants having altered biosynthetic capability, polypeptides or mutants thereof encoded by DNA or the mutants, vectors containing the DNA or the mutants thereof, host cells transformed with the DNA, the mutants thereof, or the vector, and a method for producing sanglifehrin compounds. Compounds with cyclophilin inhibition activity used as immunosuppressants, antivirals or cardiac protection agents.

Abstract: An article of manufacture comprises a carbon-containing matrix. The carbon-containing matrix may comprise at least one type of carbon material selected from the group comprising graphite crystalline carbon materials, carbon powder, carbon fibers, artificial graphite powder, or combinations thereof. In addition, the carbon-containing matrix comprises a plurality of pores. The article of manufacture also comprises an additive that is not a metal pressure disposed within at least a portion of the plurality of pores.

Abstract: There are provided compounds of the formula wherein X, Y and R1 to R8 are described herein along with the enantiomers, pharmaceutically acceptable salts and esters thereof. The compounds are useful as anticancer agents.

Abstract: There are provided compounds of the formula wherein R1, R2, R3, R3, R4, R5 are as described herein and enantiomers, pharmaceutically acceptable salts and esters thereof. The compounds are useful as anticancer agents.

Abstract: The instant article of manufacture is made by applying optical energy to one or more layers of nanoparticulate materials under predetermined conditions to produce a nanostructure. The nanostructure has layers of optically fused nanoparticles including a predetermined pore density, a predetermined pore size, or both. The predetermined conditions for applying the optical energy may include a predetermined voltage, a predetermined duration, a predetermined power density, or combinations thereof.