Abstract: A unit-type strain wave gearing device provided with a cross roller bearing that supports an internally toothed gear and an externally toothed gear in a state in which both gears can rotate relative to each other, and a meshing section of both gears is lubricated with grease. A gap by which the meshing section and the cross roller bearing raceway groove communicate is formed between the inner ring of the cross roller bearing and the external gear. Due to the pump effect caused by deflection of the external gear, grease is pushed from the meshing section to the gap. Some grease is returned to the inner space of the externally toothed gear via a grease-flowing hole that penetrates the diaphragm of the external gear. Thus, leakage of grease from an oil seal of the cross roller bearing to the unit side can be controlled.

Abstract: This unit-type strain wave gearing is provided with a cross-roller bearing that supports an internally toothed gear and an externally toothed gear in a relatively rotatable manner, wherein a meshing portion between the two gears is lubricated by a grease. In the outer circumference of the externally toothed gear, a gap is formed which communicates with the meshing portion and a raceway groove of the cross-roller bearing. A portion of the grease pressed out from the meshing portion to the gap flows out through a through-hole formed in the internally toothed gear, and flows back to the meshing portion. The grease can be suppressed from leaking to the outside of the unit from an oil seal of the cross-roller bearing.

Abstract: A unit-type strain wave gearing device provided with a cross roller bearing that supports an internally toothed gear and an externally toothed gear in a state in which both gears can rotate relative to each other, and a meshing section of both gears is lubricated with grease. A gap by which the meshing section and the cross roller bearing raceway groove communicate is formed between the inner ring of the cross roller bearing and the external gear. Due to the pump effect caused by deflection of the external gear, grease is pushed from the meshing section to the gap. Some grease is returned to the inner space of the externally toothed gear via a grease-flowing hole that penetrates the diaphragm of the external gear. Thus, leakage of grease from an oil seal of the cross roller bearing to the unit side can be controlled.

Abstract: A wave generator of a wave gear device flexes an externally toothed gear into a shape along an elliptical closed curve to form engaging portions of the externally toothed gear with an internally toothed gear at two places, namely at both ends of the major axis, and to move the engaging portions in the circumferential direction. The elliptical closed curve has a non-point symmetric shape. For example, the elliptical closed curve is a line symmetric closed curve that is not symmetric about the minor axis, and is symmetric about only the major axis. In the non-point symmetric state, the engaging portions are formed at both ends in the major axis direction. By selecting different shapes for the engaging portions at the two locations of the major axis, vibration attributed to a secondary angular transmission error component generated along with the rotation of the wave generator can be reduced.

Abstract: A strain wave gearing has a wave generator for generating a wave motion that repeatedly flexes each part in the circumferential direction of an externally toothed gear in the radial direction. The wave generator is provided with a plurality of wave-generating members arranged at positions at a prescribed angular interval along the circumferential direction of the externally toothed gear. Each of the wave-generating members is provided with an outer circumferential cam surface, rotates centered on a rotation center line that is parallel to the device center axis line, and repeatedly flexes each part of the externally toothed gear in the radial direction with a prescribed amplitude. A strain wave gearing, which is suitable for forming a large device hollow part, can be obtained.

Abstract: A magnetic type rotation transmitting mechanism has a rotating plate made of a magnetic material, and a magnet to which the rotational movement of the rotating plate is transmitted through a magnetic coupling between the magnet and the rotating plate. When the rotating plate is rotated, a plurality of oblique edge portions formed on the outer peripheral edge of the rotating plate rotate while sequentially passing through a magnet-facing area. The oblique edge portions move in the direction of the rotation centerline of the rotating plate, the rotation centerline being perpendicular to the center axis line of the magnet. The magnet is rotated about the center axis line by a magnetic force occurring between the magnet and the oblique edge portions passing through the magnet-facing area. It is possible to realize a small and compact mechanism for extracting rotation.

Abstract: A wave generator of a wave gear device flexes an externally toothed gear into a shape along an elliptical closed curve to form engaging portions of the externally toothed gear with an internally toothed gear at two places, namely at both ends of the major axis, and to move the engaging portions in the circumferential direction. The elliptical closed curve has a non-point symmetric shape. For example, the elliptical closed curve is a line symmetric closed curve that is not symmetric about the minor axis, and is symmetric about only the major axis. In the non-point symmetric state, the engaging portions are formed at both ends in the major axis direction. By selecting different shapes for the engaging portions at the two locations of the major axis, vibration attributed to a secondary angular transmission error component generated along with the rotation of the wave generator can be reduced.

Abstract: A magnetic type rotation transmitting mechanism has a rotating plate made of a magnetic material, and a magnet to which the rotational movement of the rotating plate is transmitted through a magnetic coupling between the magnet and the rotating plate. When the rotating plate is rotated, a plurality of oblique edge portions formed on the outer peripheral edge of the rotating plate rotate while sequentially passing through a magnet-facing area. The oblique edge portions move in the direction of the rotation centerline of the rotating plate, the rotation centerline being perpendicular to the center axis line of the magnet. The magnet is rotated about the center axis line by a magnetic force occurring between the magnet and the oblique edge portions passing through the magnet-facing area. It is possible to realize a small and compact mechanism for extracting rotation.

Abstract: The roller insertion groove of the inner ring of a crossed roller bearing is provided with an outer circumferential surface-side groove opening that is exposed to an inner rings-side V-groove. The groove opening is defined by circumferential direction opening edge that extends in the circumferential direction along the inner ring-side V-groove and side opening edges that extend from both ends of the circumferential direction opening to the ring-shaped end face of the inner ring. Concentration of stress occurs in the corners between the circumferential direction opening edges and the side opening edges. The circumferential direction opening edge is formed so as not to coincide with the minimum outer diameter section of the inner ring-side V-groove.

Abstract: A strain wave gearing has a wave generator for generating a wave motion that repeatedly flexes each part in the circumferential direction of an externally toothed gear in the radial direction. The wave generator is provided with a plurality of wave-generating members arranged at positions at a prescribed angular interval along the circumferential direction of the externally toothed gear. Each of the wave-generating members is provided with an outer circumferential cam surface, rotates centered on a rotation center line that is parallel to the device center axis line, and repeatedly flexes each part of the externally toothed gear in the radial direction with a prescribed amplitude. A strain wave gearing, which is suitable for forming a large device hollow part, can be obtained.

Abstract: The roller insertion groove of the inner ring of a crossed roller bearing is provided with an outer circumferential surface-side groove opening that is exposed to an inner rings-side V-groove. The groove opening is defined by circumferential direction opening edge that extends in the circumferential direction along the inner ring-side V-groove and side opening edges that extend from both ends of the circumferential direction opening to the ring-shaped end face of the inner ring. Concentration of stress occurs in the corners between the circumferential direction opening edges and the side opening edges. The circumferential direction opening edge is formed so as not to coincide with the minimum outer diameter section of the inner ring-side V-groove.

Abstract: In a non-excitation operative brake, a friction plate faces the inner disk part of an attraction plate made from a magnetic material, and an electromagnet faces the outer disk part of the attraction plate. A part for generating a brake force acting on a hollow shaft is located on an inner circumferential side in a radial direction of the attraction plate, while a part for magnetically attracting the attraction plate so as to release the brake force is located on an outer circumferential side in the radial direction of the attraction plate. A flat non-excitation operative brake having a reduced length in the direction of an axis line can be realized.

Abstract: In a non-excitation operative brake, a friction plate faces the inner disk part of an attraction plate made from a magnetic material, and an electromagnet faces the outer disk part of the attraction plate. A part for generating a brake force acting on a hollow shaft is located on an inner circumferential side in a radial direction of the attraction plate, while a part for magnetically attracting the attraction plate so as to release the brake force is located on an outer circumferential side in the radial direction of the attraction plate. A flat non-excitation operative brake having a reduced length in the direction of an axis line can be realized.

Abstract: Provided is a method for preparing B cells which produce a human-type antibody, comprising substituting an antibody gene of B cells with a human antibody gene, wherein the B cells are non-human vertebrate B cells capable of inducing or halting AID (activation induced cytidine deaminase) expression with the induction of the expression of an exogenous Cre recombinase gene through extracellular stimulation followed by the inversion of the direction of the exogenous AID gene by expressed Cre recombinase.

Abstract: An objective of the present invention is to provide methods for introducing DNAs encoding a desired amino acid sequence into a region comprising a DNA encoding an antibody variable region of antibody-producing cells. The present inventors developed methods for efficiently introducing DNAs encoding a desired amino acid sequence into the antibody variable region gene locus of DT40-SW, which is a mutant line of the DT40 chicken B cell line which has the ability to spontaneously introduce mutations. This allows mutagenesis of introduced DNAs to modify the polypeptides to have superior functions. In particular, the present inventors revealed the nucleotide sequence of the antibody H chain variable region gene locus of the DT40 cell line. Based on this finding, the present inventors successfully constructed targeting vectors that allow efficient substitution of the antibody H chain variable region gene locus of the DT40 cell line with a gene encoding a desired polypeptide.

Abstract: Methods are provided for selecting B cells that produce a desired antibody, comprising a step of culturing B cells, which have the properties of cell death being induced under specific conditions and that cell death being suppressed by a signal generated as a result of the binding between an antigen and an antibody expressed on B cell surface (B cell antigen receptor on the B cell surface), with an antigen under conditions in which cell death is induced, and selecting antibody-producing B cells that bind with the antigen as viable cells.

Abstract: A geared motor assembly has a rotation-transmitting shaft for transferring output rotation of a reducer on the front side of a motor to an output shaft sensor on the rear side of the motor. A front end portion of the rotation-transmitting shaft is securely bonded to a rotation output member of the reducer by an adhesive that exhibits flexibility or elasticity after hardening, and a rear end portion of the rotation-transmitting shaft is rotatably supported by a sensor cover via a bearing in a position adjacent to the output shaft sensor. The rotation-transmitting shaft can be supported in a state free of axial runout by deformation of the adhesive and by the bearing. Consequently, the rotation angle position of the rotation output member can be detected with precision by the output shaft sensor in a position adjacent to the bearing.

Abstract: The invention provides block copolymers formed of poly(ethylene glycol) segments and poly(amino acid derivative) segments having side chains of at least one kind of specific amine residue. The invention also provides polyion complexes of such copolymers with polynucleotides and the like. These block copolymers are useful as carriers for in vivo delivery of active substances such as DNA.

Abstract: A geared motor assembly comprises a rotation-transmitting shaft for transferring output rotation of a reducer on the front side of a motor to an output shaft sensor on the rear side of the motor. A front end portion of the rotation-transmitting shaft is securely bonded to a rotation output member of the reducer by an adhesive that exhibits flexibility or elasticity after hardening, and a rear end portion of the rotation-transmitting shaft is rotatably supported by a sensor cover via a bearing in a position adjacent to the output shaft sensor. The rotation-transmitting shaft can be supported in a state free of axial runout by deformation of the adhesive and by the bearing. Consequently, the rotation angle position of the rotation output member can be detected with precision by the output shaft sensor in a position adjacent to the bearing.

Abstract: A relay connector is secured to a hollow hole forming member provided with a hollow hole in a hollow rotator so as to be coaxially located in the hollow hole in order to draw out an electric wire group from the side of one end surface in the direction of a rotation central axis line of the hollow rotator to the side of the other end surface by using the hollow hole passing through in the direction of the rotation central axis line in the hollow rotator. A first connection section is formed on one end of the direction of the rotation central axis line of the relay connector and a second connection section is formed on the other end thereof. A first electric wire side connector attached to the end of a first electric wire group is electrically and detachably connected to the first connection section and a second electric wire side connector attached to the end of a second electric wire group is electrically and detachably connected to the second connection section.