Abstract: Provided is a crystal of a novel pyrido[3, 4-d]pyrimidine derivative having excellent CDK 4/6 inhibitory activity. A crystal of a compound represented by formula (I). In the formula, R1 represents a hydrogen atom or a C1-3 alkyl group; R2 represents a hydrogen atom or an oxo group; L represents a single bond or a C1-3 alkylene group; and X represents CH or N.

Abstract: This radiotherapy device comprises: an X-ray irradiation device and an X-ray camera for detecting the position of a specific landmark present in an irradiation target; a storage unit which, with one from among a plurality of time-lapse three-dimensional CT images including the landmark and obtained beforehand during treatment planning used as a reference images, stores the relationship between the displacement of the landmark position from that in the reference image to that in another three-dimensional CT image, and the deformation of each of the sites in the other CT image, obtained by analysis thereof; and an image processing unit, a deformation amount evaluation unit, and a display unit, that estimate the deformation of each of the sites and reproduce the estimated three-dimensional CT image, according to the position of the landmark detected and the relationship stored by the storage unit.

Abstract: A method of determining a cosmetic skin attribute of a person is provided. The method includes obtaining a color channel image of a person's skin, analyzing the color channel image with a computer using entropy statistics to obtain an entropy value, and then determining a cosmetic skin attribute for the person based on the entropy value.

Abstract: A method of visualizing at least one cosmetic skin attribute of a subject is provided. The method includes obtaining a digital image of the face of a person, defining a plurality of tiles across the image, analyzing each of the defined tiles for the at least one cosmetic skin attribute, assigning a single degree of indicium uniquely to each tile based on the analyzed at least one cosmetic skin attribute of the tile, and displaying at least some of the tiles so that a user can visualize the cosmetic skin attribute. The displayed tiles may be selected to indicate to user a cosmetic skin attribute condition that is better relative to the non-displayed tiles, based on the analyzed skin attribute.

Abstract: Provided are a moving body tracking apparatus that contributes to shortening treatment time and a radiation therapy system including the moving body tracking apparatus, a program, and a moving body tracking method. The moving body tracking apparatus includes a fluoroscopic apparatus that acquires fluoroscopic images including the target 2 from at least two directions, and the moving body tracking control apparatus 30A that obtains a position of the target 2 from the fluoroscopic images acquired by the fluoroscopic apparatus. The moving body tracking control apparatus 30A creates a simulated fluoroscopic image from the CT image including the target 2, creates a two-dimensional region including the target 2 from the simulated fluoroscopic image as a template, matches each of at least two fluoroscopic images with the template, and obtains a three-dimensional position of the target 2 from a plurality of matching results.

Abstract: A tumor tracking control device (41) performs windowing process on a captured image A (61) and a captured image B (62), measures a position of a marker (29) using the captured image A (61) and the captured image B (62) after performing the windowing process, and generates a signal capable of controlling irradiation with radiation based on the position of the marker (29). Accordingly, it is possible to provide a tumor tracking apparatus and an irradiation system which are capable of tracking an object to be tracked without erroneous detection, even in a case where a structure similar to the object to be tracked is in the vicinity of the object to be tracked, in tumor tracking.

Abstract: A method for identifying a pore color of at least one skin pore. The method includes obtaining at least one image of a subject, extracting a pore image from the obtained image, in which the extracted pore image identifies a boundary of the at least one skin pore, and superimposing the obtained image and the extracted pore image to identify the pore color within the identified boundary of the at least one skin pore.

Abstract: A fuel maintenance guide system is provided in a hybrid vehicle in which a shift to a fuel maintenance mode prioritizing consumption of fuel is automatically performed under a predetermined condition regardless of a driver's intention. The fuel maintenance guide system includes an information notification unit configured to perform notification of information urging consumption of the fuel, and a control unit configured to estimate a time to shift automatically to the fuel maintenance mode and to begin to perform notifying actuation of the information notification unit a predetermined period of time before the estimated time.

Abstract: Through the present invention, three-dimensional coordinates of a tracking object moving in an irradiation object can be calculated from fluoroscopic X-ray images captured and acquired from various angles in a single fluoroscopic X-ray device mounted to a radiation therapy apparatus. The three-dimensional coordinates of the tracking object are calculated on a straight tracking object presence line connecting an X-ray generating device for fluoroscopy and the position in an X-ray plane detector of the tracking object on the fluoroscopic X-ray image acquired by the X-ray generating device for fluoroscopy and the X-ray plane detector, and using line segment information included in a movement region of the tracking object set in advance (S104).

Abstract: In a hybrid vehicle including a front motor for driving front wheels, a rear motor for driving rear wheels, a generator for generating power by being driven by an internal combustion engine, and a step-up converter for stepping up the voltage from a battery and supplying power to the front motor, while stepping-down the generated power of the generator and supplying the power to the rear motor, a hybrid control unit decreases the power supplied from the generator to the rear motor, and increases the power supplied from the battery to the rear motor when input power of the step-up converter is limited based on a temperature condition of the step-up converter.

Abstract: Provided is a lesion identification marker for use in radiation therapy that enables pure gold microparticles which absorb X-rays to be placed, with extremely low invasive potential, in any site in the body in an arbitrary amount appropriate for the type of radiation therapy and the therapeutic target site, and that enables the placement site to be identified over a long period of time by radiation therapy equipment. The lesion identification marker for use in radiation therapy includes a mixture of pure gold particles and a substance containing a calcium phosphate-based bone reinforcing material, or a mixture of pure gold particles, a mixing solution, and a substance containing a calcium phosphate-based bone reinforcing material. The volume mean diameter (MV) of the particles of the substance containing a calcium phosphate-based bone reinforcing material is in the range of 3-12 ?m.

Abstract: The present invention makes it possible to provide a radiation therapy system capable of not only inhibiting treatment time from increasing more effectively than before but also reducing the loads of fluoroscopic radiation photographing apparatuses.

Abstract: A template matching is performed on two fluoroscopic images by using a template image prepared in advance and a position corresponding to a high matching score is listed as a candidate for the position of a marker 29. From two lists of the candidates of the position of the marker 29, the lengths of common vertical lines for all combinations are calculated. Then, the position of the marker 29 is detected based on the matching score and the common vertical line. Then, based on the detected position of the marker 29, an amount of a proton beam to be irradiated to a target is controlled. Therefore, a tracking target can be accurately detected even when the conditions for X-ray fluoroscopy is severe, e.g., a thick object.

Abstract: A tumor tracking control device (41) performs windowing process on a captured image A (61) and a captured image B (62), measures a position of a marker (29) using the captured image A (61) and the captured image B (62) after performing the windowing process, and generates a signal capable of controlling irradiation with radiation based on the position of the marker (29). Accordingly, it is possible to provide a tumor tracking apparatus and an irradiation system which are capable of tracking an object to be tracked without erroneous detection, even in a case where a structure similar to the object to be tracked is in the vicinity of the object to be tracked, in tumor tracking.

Abstract: A controller of a hybrid vehicle includes: a control unit configured to activate a starter device for starting any one of a drive motor and an engine by stepping up electric power from a battery by a voltage transformer. The control unit includes a limitation part that limits passing power of the voltage transformer when the temperature of the voltage transformer rises, and a calculation part that obtains a maximum electric power that can be supplied to the drive motor when the starter device is activated, by subtracting a consumed power of the starter device from limited power during limitation of passing power by the limitation part. The control unit activates the starter device and starts the engine, when required power of the drive motor reaches the maximum electric power calculated by the calculation part during limitation of passing power by the limitation part.

Abstract: A fuel maintenance guide system in hybrid vehicles in which a shift to the fuel maintenance mode giving priority to consuming fuel is executed automatically under a predetermined condition regardless of intention of a driver, the fuel maintenance guide system including: a residual fuel detecting unit detecting a residual amount of the fuel; a cancel condition determining unit determining a cancel condition for cancelling the shift to the fuel maintenance mode, based on the residual amount detected by the residual fuel detecting unit; and a displaying unit displaying the cancel condition determined by the cancel condition determining unit from a predetermined time period before the shift to the fuel maintenance mode.

Abstract: A fuel maintenance guide system for a vehicle includes a user-notification-information generating part capable of generating user notification information including duration, and free capacity, based on duration calculated in a fuel-maintenance-execution-date calculation part and free capacity calculated in a fuel-tank-free-capacity computing part, and a user notification part capable of receiving the user notification information, generated in the user-notification-information generating part, from the user-notification-information generating part and displaying the user notification information on a screen.

Abstract: A power controller of a hybrid vehicle includes: a first drive motor that drives any one of a front wheel and a rear wheel of a vehicle; an engine that drives the one wheel or the corresponding other one of the front wheel and the rear wheel of the vehicle through a clutch; a generator that is driven by the engine; and a voltage transformer that steps down generated electric power supplied to the first drive motor and a battery from the generator. The power controller limits passing power of the voltage transformer according to the temperature of the voltage transformer, and connects the clutch when the passing power of the voltage transformer is limited.

Abstract: In a hybrid vehicle including a front motor for driving front wheels, and a step-up converter for stepping up voltage from a battery to supply power to the front motor, in which power regenerated by rotational force of the front wheel during vehicle deceleration is stepped down by a step-up converter and can be supplied to a battery, the hybrid vehicle includes a hybrid control unit which computes maximum input power of the step-up converter and regenerated power of the front motor during vehicle deceleration, and sets a difference obtained by subtracting regenerated power of the front motor from the maximum input power of the step-up converter to the maximum generated power of the generator.