Abstract: It is an object of the present invention to provide drugs which are effective for treatment of hypertension, cardiac disease (cardiac hypertrophy, cardiac failure, myocardial infarction, etc.), cerebral apoplexy, nephritis and the like. The invention also provides circulatory disease treatment agents in forms that allow combined use of chymase inhibitors and ACE inhibitors, and circulatory disease treatment methods which produce simultaneous chymase inhibition and ACE inhibition.

Abstract: The present invention provides acid salts, such as sulfate, hydrochloride, and methanesulfonate, of 4-(1-((4-methylbenzothiophen-3-yl)methyl)benzimidazol-2-ylthio)butanoic acid and the crystals thereof. These benzimidazole derivatives and the crystals thereof have an in vivo chymase inhibitory activity and can be used as a preventive or therapeutic agent for inflammatory diseases, allergic diseases, respiratory diseases, circulatory diseases, or bone/cartilage metabolic diseases.

Abstract: A benzimidazole derivative or its medically acceptable salt, represented by the following formula (1), that is a human chymase activity inhibitor capable of being applied clinically: wherein, R1 and R2 represent a hydrogen atom, an alkyl group or an alkoxy group, etc., A represents an alkylene group or an alkenylene group, E represents —COOR3, —SO3R3, —CONHR3 or —SO2NHR3, etc., G represents an alkylene group, M represents a single bond or —S(O)m—, J represents a heterocyclic group, and X represents —CH? or a nitrogen atom.

Abstract: The present invention provides drugs containing chymase inhibitors as active ingredients for improving glucose intolerance or preventing and/or treating diseases caused by glucose intolerance. The diseases caused by glucose intolerance are diabetes and/or diabetes complications, wherein the diabetes complications include diabetic nephropathy, diabetic retinopathy, diabetic peripheral neuropathy, hyperinsulinism, insulin resistance syndrome, arteriosclerosis, acute coronary syndrome, arteriosclerosis obliterans, angitis, stroke, hypertension, renal insufficiency, nephropathy, nephritis, renal artery aneurysm, renal infarction, obesity and the like.

Abstract: Various crystal forms of 4-(1-((4-methylbenzothiophen-3-yl)methyl)benzimidazol-2-ylthio)butanoic acid from a solvent, and a process for production thereof are provided.

Abstract: A fan of an aircraft engine is provided with a rotating fan rotor for feeding air aftward as a spiral flow and a stator vane for rectifying the spiral flow to be an axial flow. The fan stator vane is provided with a hub end portion extending radially relative to a rotating axis of the fan rotor and a tip end portion leaning toward a suction side. Leading edges of the hub end portion and the tip end portion have sweepback angles of from 27 degrees to 33 degrees relative to a radial direction defined by the rotating axis.

Abstract: Systems, methods, and programs for updating map data create differential data in a server by comparing an old version of map data stored in the server with a new version of map data and transmit the differential data from the server to a relay device. The systems, methods and programs create updated map data by combining the differential data received from the server with map data previously stored in the relay device. The relay device may then be connected to an updated data storing device that disconnectably connects to both the relay device and the navigation system. The systems, methods, and programs, may then transfer the updated map data from the relay device to the updated data storing device and from the updated data storing device to the navigation system.

Abstract: The present invention is a thiobenzimidazole derivative represented by the following formula (1) or a medically acceptable salt thereof wherein said thiobenzimidazole derivative and a medically acceptable salt thereof have a potent activity of inhibiting human chymase. Thus, they are potential preventive and/or therapeutic agents clinically applicable to various diseases in which human chymase is involved.

Abstract: The present invention relates to an anthranilic acid derivative expressed by the following formula (1) or the following formula (2), or its pharmacologically permissible salt or solvate.

Abstract: The present invention is 3,4-disubstituted-benzo[b]thiophene derivatives represented by general formula (I) and processes for preparing compounds represented by general formula (V) from compounds represented by general formula (IV), preparing a mixture of compounds represented by the following formula (II) and the following formula (III) and preparing the benzo[b]thiophene derivatives represented by the above formula (I): wherein, R1 and R2 represent each a halogen atom, a trihalomethyl group, a C1-4 alkyl group or a C1-4 alkoxy group; X represents a hydroxy group or a halogen atom; R3 and R4 represent each a hydrogen or a halogen atom, a trihalomethyl group, a C1-4 alkyl group or a C1-4 alkoxy group; and R5 represents a C1-3 alkyl group or a trifluoromethyl group.

Abstract: A cancer remedy comprising a compound represented by the following formula as an active ingredient: wherein, X represents a group represented by either of the following formulae: wherein, R1 and R2 represent each a hydrogen atom, a hydroxy group, a trihalomethyl group, a C1-C12 alkoxy group or alkylthio group, a (substituted) C7-C11 aralkyloxy group or a (substituted) C3-C10 alkenyloxy group; R4 and R5 represent each a hydrogen atom, a halogen atom, a C1-C4 alkyl group or a C1-C4 alkoxy group; A represents —O—, —S—, —S(?O)—, —S(?O)2—, —CH2—, —OCH2—, —SCH2, —C(?O)— or —CH(OR6)—; Y represents a hydrogen atom, a halogen atom, a nitro group, a nitrile group, an amino group, —COOR7, —NHCOR8 or —NHSO2R9?; E represents —C(?O)—, —CR10R11C(?O)—, —CH2CH2C(?O)— or —CH?CHC(?O)—; G represents a hydrogen atom, a hydroxy group, —SO2NH2, —COOR3, —CN or a tetrazol-5-yl group; and Z represents a hydrogen atom, a halogen atom, a nitro group or a methyl group.

Abstract: A fan of an aircraft engine is provided with a rotating fan rotor for feeding air aftward as a spiral flow and a stator vane for rectifying the spiral flow to be an axial flow. The fan stator vane is provided with a hub end portion extending radially relative to a rotating axis of the fan rotor and a tip end portion leaning toward a suction side. Leading edges of the hub end portion and the tip end portion have sweepback angles of from 27 degrees to 33 degrees relative to a radial direction defined by the rotating axis.

Abstract: A benzimidazole derivative or its medically acceptable salt, represented by the following formula (1), that is a human chymase activity inhibitor capable of being applied clinically: 1

Abstract: The present invention is a method of producing a 3-hydroxymethyl-benzo[b]thiophene derivative without the possible concomitant formation of isomers, which comprises selectively cyclizing a sulfoxide having X shown in the reaction scheme below: wherein R1 to R3 are, same or independently, a hydrogen atom, an alkyl group having 1 to 4 carbons, a trihalomethyl group, an alkoxy group having 1 to 4 carbons, an alkylthio group having 1 to 4 carbons, or a trihalomethoxy group; R4 is an acyl group; X is a halogen atom, a hydroxy group, an amino group, a mercapto group, an alkylthio group having 1 to 9 carbons, an acyloxy group having 1 to 9 carbons, an acylamino group having 1 to 9 carbons, or a trihalomethoxy group.

Abstract: It is an object of the present invention to provide drugs which are effective for treatment of hypertension, cardiac disease (cardiac hypertrophy, cardiac failure, myocardial infarction, etc.), cerebral apoplexy, nephritis and the like. The invention also provides circulatory disease treatment agents in forms that allow combined use of chymase inhibitors and ACE inhibitors, and circulatory disease treatment methods which produce simultaneous chymase inhibition and ACE inhibition.

Abstract: A low noise fan stationary blade, wherein a negative lean angle &thgr;L in the reverse direction of a rotating direction is provided near a hub and a positive lean angle &thgr;L in the rotating direction is provided on the other tip side, the negative lean angle &thgr;L is −10°±3° in a high loss area near the hub and the positive lean angle &thgr;L is 30°±3° on the tip side, a positive sweep angle &thgr;s is provided, and the positive sweep angle &thgr;s is 20°±3° on the hub side and 20°±3° also on the tip side, whereby a total pressure loss on both hub and tip sides can be reduced, noise can be reduced on both hub and tip sides, and thus noise can be reduced without lowering an aerodynamic performance.

Abstract: A benzimidazole derivative or its medically acceptable salt, represented by the following formula (1), that is a human chymase activity inhibitor capable of being applied clinically: 1

Abstract: The present invention relates to an anthranilic acid derivative expressed by the following formula (1) or the following formula (2), or its pharmacologically permissible salt or solvate.

Abstract: A cancer remedy comprising a compound represented by the following formula as an active ingredient: 1

Abstract: There are provided a negative lean angle &thgr;L of a direction opposite to a rotation direction in the vicinity of a hub, and a positive lean angle &thgr;L of the rotation direction in other regions on a chip side. The negative lean angle &thgr;L is −10°±3° in a high loss region in the vicinity of the hub, and the positive lean angle &thgr;L is 30°±3° on the chip side. Moreover, there is provided a positive sweep angle &thgr;s. The positive sweep angle &thgr;s is 20°±3° on the hub side, and is also 20°±3° on the chip side. Total pressure losses on both the hub and chip sides are reduced, noises can be reduced on both the hub and chip sides, and thereby noise reduction can be achieved without deteriorating aerodynamic capabilities.