Patents by Inventor Naotsugu Onuma
Naotsugu Onuma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190120790Abstract: The present analysis method for analyzing a sample uses capillary electrophoresis by applying a voltage to a sample solution introduced to a micro flow path, performing separation analysis for a component contained in the sample solution, and measuring an optical measurement value at a measurement section of the micro flow path corresponding to an elapsed time after a start of measurement.Type: ApplicationFiled: October 17, 2018Publication date: April 25, 2019Applicant: ARKRAY, Inc.Inventors: Masao Kawano, Naotsugu Onuma
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Publication number: 20190041358Abstract: The disclosure provides an analysis chip that includes a microchip employing capillary electrophoresis and a cartridge.Type: ApplicationFiled: July 30, 2018Publication date: February 7, 2019Applicant: ARKRAY, Inc.Inventor: Naotsugu Onuma
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Patent number: 10018589Abstract: A method for analyzing a sample using capillary electrophoresis is provided. By the method, following steps are performed. First, an original sample and an anionic group-containing compound are fixed to form a mixed sample, where the original sample contains an analysis component to be analyzed and a sub component other than the analysis component. Then, an aggregate of the sub component and the anionic group-containing compound is removed from the mixed sample. Then, electrophoresis is performed in a capillary tube with respect to a complex in which the analysis component and the anionic group-containing compound are bound to each other, while the mixed sample is continuously supplied.Type: GrantFiled: September 4, 2015Date of Patent: July 10, 2018Assignee: ARKRAY, Inc.Inventor: Naotsugu Onuma
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Publication number: 20180164247Abstract: An analytical tool for use in analysis of a sample is provided. The analytical tool includes a first unit and a second unit. The first unit has an analysis portion where analysis is performed. The second unit, configured to be coupled with the first unit, has a liquid reservoir for confining a particular liquid used for the analysis of the sample. When the first unit and the second unit are coupled, a fluid passage for conducting the particular liquid from the liquid reservoir into the first unit is formed by only a part of the first unit, or only a part of the second unit, or a combination of respective parts of the first unit and the second unit.Type: ApplicationFiled: February 8, 2018Publication date: June 14, 2018Applicant: ARKRAY, Inc.Inventor: Naotsugu Onuma
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Patent number: 9989494Abstract: A method for manufacturing a chip that includes a microchannel is described, wherein the method includes the steps of: fixing a cationic polymer having a quaternary onium group to at least one surface of each of a pair of resin substrates; and joining the resin substrates together on the surfaces on which the cationic polymer has been fixed.Type: GrantFiled: February 13, 2015Date of Patent: June 5, 2018Assignee: ARKRAY, Inc.Inventor: Naotsugu Onuma
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Patent number: 9983170Abstract: A method is provided for analyzing a sample using capillary electrophoresis. According to the method, an electrophoretic liquid filling step is performed for filling a capillary tube with an electrophoretic liquid. In an introducing step, a predetermined amount of sample is introduced to an introducing tank linked to the capillary tube. In a flow step, performed after the introducing step, the sample is caused to flow in the introducing tank, thereby generating a shear flow at a link portion between the capillary tube and the introducing tank. In an electrophoresis step, electrophoresis is performed in the capillary tube while the sample is continuously supplied.Type: GrantFiled: September 10, 2015Date of Patent: May 29, 2018Assignee: ARKRAY, Inc.Inventor: Naotsugu Onuma
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Publication number: 20180113094Abstract: One embodiment of the invention provides: a microchip including a sample collection section and an analysis section, in which the sample collection section and the analysis section are imparted with both hydrophilicity and a positively-charged layer; an analysis system including the microchip; and a method of producing the microchip. The microchip includes: a sample collection section for collecting a sample; and an analysis section for analyzing the sample. In the microchip, a cationic polymer bonded with a hydrophilization substance is immobilized on inner walls of the sample collection section and the analysis section.Type: ApplicationFiled: October 19, 2017Publication date: April 26, 2018Applicant: ARKRAY, Inc.Inventors: Takanari Shigemitsu, Naotsugu Onuma
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Publication number: 20170350857Abstract: An analysis chip for capillary electrophoresis includes a capillary tube, and a filter that is provided upstream of the capillary tube. The chip can also include an introducing tank connected to one end of the capillary tube, and a discharging tank connected to another end of the capillary tube.Type: ApplicationFiled: August 24, 2017Publication date: December 7, 2017Inventor: Naotsugu ONUMA
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Publication number: 20170168013Abstract: An analytical tool is provided for analysis of a sample by capillary electrophoresis. The analytical tool includes an inlet reservoir into which a sample is introduced, a capillary tube in communication with the inlet reservoir, a filter through which a liquid from the inlet reservoir passes, an enlarged portion undergoing a sudden increase in a cross-sectional area and being in communication with the inlet reservoir and the capillary tube, and a pressure fluctuation reducer for preventing pressure fluctuation at the enlarge portion from affecting a liquid in the capillary tube.Type: ApplicationFiled: December 9, 2016Publication date: June 15, 2017Inventors: Takanari SHIGEMITSU, Naotsugu ONUMA
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Patent number: 9618478Abstract: Provided are a sample analysis method using capillary electrophoresis capable of enhancing analysis accuracy, a solution for capillary electrophoresis, and a sample analysis kit. The sample analysis method includes separating and/or detecting a substance to be analyzed in a sample through capillary electrophoresis, in which the substance to be analyzed is separated and/or detected in the presence of a pH buffer substance and a non-surfactant-type zwitterionic substance. Further, the solution for capillary electrophoresis contains a pH buffer substance, a non-surfactant-type zwitterionic substance, and water.Type: GrantFiled: January 16, 2014Date of Patent: April 11, 2017Assignee: ARKRAY, Inc.Inventor: Naotsugu Onuma
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Patent number: 9551723Abstract: A liquid reagent of a stabilized thyroid hormone-immobilized carrier, by which a thyroid hormone can be measured easily in a short time and at low cost, is provided. The liquid reagent of a thyroid hormone-immobilized carrier according to the present invention includes: a thyroid hormone-immobilized carrier; and a solvent, and a pH of the solvent containing the thyroid hormone-immobilized carrier is in a range from 8.7 to 11.5. The detection of a thyroid hormone using the liquid reagent of the present invention can be carried out by competitively binding a thyroid hormone in a sample and the thyroid hormone-immobilized carrier in the liquid reagent with an anti-thyroid hormone antibody and detecting a composite of the thyroid hormone-immobilized carrier and the anti-thyroid hormone antibody.Type: GrantFiled: February 2, 2012Date of Patent: January 24, 2017Assignee: ARKRAY, Inc.Inventor: Naotsugu Onuma
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Patent number: 9528963Abstract: Provided is a buffer composition capable of suppressing temperature dependency of the pH of a buffer solution, and a specimen analysis method and a specimen analysis system using the buffer composition, wherein the buffer composition contains a buffer substance A showing a positive correlation between temperature and pH and a buffer substance B showing a negative correlation between temperature and pH.Type: GrantFiled: July 7, 2015Date of Patent: December 27, 2016Assignee: ARKRAY, Inc.Inventors: Naotsugu Onuma, Miho Fukuda
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Publication number: 20160334367Abstract: An analytical tool for use in analysis of a sample is provided. The analytical tool includes a first unit and a second unit. The first unit has an analysis portion where analysis is performed. The second unit, configured to be coupled with the first unit, has a liquid reservoir for confining a particular liquid used for the analysis of the sample. When the first unit and the second unit are coupled, a fluid passage for conducting the particular liquid from the liquid reservoir into the first unit is formed by only a part of the first unit, or only a part of the second unit, or a combination of respective parts of the first unit and the second unit.Type: ApplicationFiled: May 12, 2016Publication date: November 17, 2016Applicant: ARKRAY, Inc.Inventor: Naotsugu Onuma
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Publication number: 20160209359Abstract: A sample analysis method capable of improving separation accuracy of at least one of hemoglobin A2 and hemoglobin S and downsizing an analysis device is provided. The method includes separating hemoglobin in a sample in an alkaline solution containing a cationic polymer by capillary electrophoresis.Type: ApplicationFiled: January 8, 2016Publication date: July 21, 2016Inventors: Naotsugu Onuma, Takanari Shigemitsu
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Publication number: 20160077053Abstract: A method is provided for analyzing a sample using capillary electrophoresis. According to the method, an electrophoretic liquid filling step is performed for filling a capillary tube with an electrophoretic liquid. In an introducing step, a predetermined amount of sample is introduced to an introducing tank linked to the capillary tube. In a flow step, performed after the introducing step, the sample is caused to flow in the introducing tank, thereby generating a shear flow at a link portion between the capillary tube and the introducing tank. In an electrophoresis step, electrophoresis is performed in the capillary tube while the sample is continuously supplied.Type: ApplicationFiled: September 10, 2015Publication date: March 17, 2016Inventor: Naotsugu Onuma
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Publication number: 20160069835Abstract: A method for analyzing a sample using capillary electrophoresis is provided. By the method, following steps are performed. First, an original sample and an anionic group-containing compound are fixed to form a mixed sample, where the original sample contains an analysis component to be analyzed and a sub component other than the analysis component. Then, an aggregate of the sub component and the anionic group-containing compound is removed from the mixed sample. Then, electrophoresis is performed in a capillary tube with respect to a complex in which the analysis component and the anionic group-containing compound are bound to each other, while the mixed sample is continuously supplied.Type: ApplicationFiled: September 4, 2015Publication date: March 10, 2016Inventor: Naotsugu Onuma
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Publication number: 20160011150Abstract: Provided is a buffer composition capable of suppressing temperature dependency of pH of a buffer solution, and a specimen analysis method and a specimen analysis system using the buffer composition, wherein the buffer composition comprises a buffer substance A showing a positive correlation between temperature and pH and a buffer substance B showing a negative correlation between temperature and pH.Type: ApplicationFiled: July 7, 2015Publication date: January 14, 2016Applicant: ARKRAY, Inc.Inventors: Naotsugu Onuma, Miho Fukuda
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Publication number: 20150233865Abstract: A method for manufacturing a chip that includes a microchannel is described, wherein the method includes the steps of: fixing a cationic polymer having a quaternary onium group to at least one surface of each of a pair of resin substrates; and joining the resin substrates together on the surfaces on which the cationic polymer has been fixed.Type: ApplicationFiled: February 13, 2015Publication date: August 20, 2015Applicant: ARKRAY, Inc.Inventor: Naotsugu Onuma
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Publication number: 20140202858Abstract: Provided are a sample analysis method using capillary electrophoresis capable of enhancing analysis accuracy, a solution for capillary electrophoresis, and a sample analysis kit. The sample analysis method includes separating and/or detecting a substance to be analyzed in a sample through capillary electrophoresis, in which the substance to be analyzed is separated and/or detected in the presence of a pH buffer substance and a non-surfactant-type zwitterionic substance. Further, the solution for capillary electrophoresis contains a pH buffer substance, a non-surfactant-type zwitterionic substance, and water.Type: ApplicationFiled: January 16, 2014Publication date: July 24, 2014Applicant: ARKRAY, INC.Inventor: Naotsugu Onuma
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Publication number: 20120202230Abstract: A liquid reagent of a stabilized thyroid hormone-immobilized carrier, by which a thyroid hormone can be measured easily in a short time and at low cost, is provided. The liquid reagent of a thyroid hormone-immobilized carrier according to the present invention includes: a thyroid hormone-immobilized carrier; and a solvent, and a pH of the solvent containing the thyroid hormone-immobilized carrier is in a range from 8.7 to 11.5. The detection of a thyroid hormone using the liquid reagent of the present invention can be carried out by competitively binding a thyroid hormone in a sample and the thyroid hormone-immobilized carrier in the liquid reagent with an anti-thyroid hormone antibody and detecting a composite of the thyroid hormone-immobilized carrier and the anti-thyroid hormone antibody.Type: ApplicationFiled: February 2, 2012Publication date: August 9, 2012Applicant: ARKRAY, Inc.Inventor: Naotsugu Onuma