Abstract: A modified peptide or a modified polypeptide has the amino acid sequence of Thr-Val-Asp-Ser-Cys-Leu-Thr (SEQ ID NO: 1) and adhesiveness to a norbornene-based polymer. A ratio of the total number of amino acids constituting the modified peptide or the modified polypeptide to the number of oligopeptides consisting of the amino acid sequence of SEQ ID NO: 1 contained in the modified peptide or the modified polypeptide is 7 or more and 80 or less. The number of oligopeptides consisting of the amino acid sequence of SEQ ID NO: 1 is 1.

Abstract: A modified peptide or a modified polypeptide has the amino acid sequence of Thr-Val-Asp-Ser-Cys-Leu-Thr (SEQ ID NO: 1) and adhesiveness to a norbornene-based polymer. A ratio of the total number of amino acids constituting the modified peptide or the modified polypeptide to the number of oligopeptides consisting of the amino acid sequence of SEQ ID NO: 1 contained in the modified peptide or the modified polypeptide is 7 or more and 80 or less. The number of oligopeptides consisting of the amino acid sequence of SEQ ID NO: 1 is 1.

Abstract: Provided is a method for efficiently searching a peptide library for an oligopeptide that can be bound to the end of a protein or peptide of interest. Further, provided is an efficient and highly safe immunoassay.

Abstract: There is provided a wafer making it possible to stably break off the piezoelectric vibrator element. The wafer includes a piezoelectric vibrator element, a frame part, and a connection part adapted to connect the piezoelectric vibrator element and the frame part to each other, and the connection part is provided with a guide part adapted to guide force, which is applied to the connection part from one surface side in the thickness direction of the connection part when breaking off the piezoelectric vibrator element from the frame part at the connection part, to at least one side in the width direction of the connection part.

Abstract: Provided is a method for efficiently searching a peptide library for an oligopeptide that can be bound to the end of a protein or peptide of interest. Further, provided is an efficient and highly safe immunoassay.

Abstract: There is provided a method of manufacturing a piezoelectric vibrator element capable of preventing the piezoelectric vibrator element from being damaged when segmentallizing the piezoelectric vibrator element. The method of manufacturing a piezoelectric vibrator element includes the steps of providing the wafer with the piezoelectric plate and a frame part adapted to support the piezoelectric plate via a connection part, providing a pair of excitation electrodes to the piezoelectric plate, and forming a pair of extending electrodes extending from the piezoelectric plate to the frame part through the connection part and electrically connected respectively to the pair of excitation electrodes, and segmentallizing the piezoelectric plate by cutting the connection part. In the step of providing the pair of excitation electrodes, the pair of extending electrodes are formed on a side surface of the connection part.

Abstract: The invention is a method for promoting differentiation of cultured cells, including bringing a norbornene-based addition polymer formed article into contact with cells being cultured, and a cultured cell differentiation-promoting agent including a norbornene-based addition polymer formed article. The invention provides a method that can further promote the differentiation of cultured cells, and a cultured cell differentiation-promoting agent that may suitably be used for the method.

Abstract: The invention is a method for culturing adherent cells, culturing the adherent cells in a liquid medium in an alicyclic structure-containing polymer culture vessel, releasing the cells from the culture vessel by liquid flow without adding a protease, and suspending the cultured cells in a liquid medium. The cells can be easily released by a small force such as pipetting because the cells adhere loosely to the alicyclic structure-containing polymer culture vessel.

Abstract: Devices, systems, and methods for sensing one or more odorants are disclosed. The device may include an oscillator crystal coated with a polymer. The oscillator crystal may typically oscillate at a known first frequency. The coated crystal may respond to exposure to an odorant by oscillating at one or more alternative frequencies. The coated crystal response may depend on the polymer composition, polymer concentration, coating geometry, and/or odorant to which it may be exposed. The system may include one or more oscillator crystals, each coated with a different polymer composition, polymer concentration, and/or coating geometry. The system may include non-coated crystals. The system may also include additional electronics to measure the frequencies of the one or more coated or non-coated crystals and to analyze their frequencies. The method may include the use of such devices and/or systems to identify and/or determine the concentration of one or more odorants.

Abstract: There is provided a wafer making it possible to stably break off the piezoelectric vibrator element. The wafer includes a piezoelectric vibrator element, a frame part, and a connection part adapted to connect the piezoelectric vibrator element and the frame part to each other, and the connection part is provided with a guide part adapted to guide force, which is applied to the connection part from one surface side in the thickness direction of the connection part when breaking off the piezoelectric vibrator element from the frame part at the connection part, to at least one side in the width direction of the connection part.

Abstract: The piezoelectric vibrator element is miniaturized, and at the same time, the vibration leakage is suppressed. The piezoelectric vibrator element is formed so that the total length L1 of the piezoelectric vibrator element, the length L2 of the base, the width L3 of the connection part, the length L4 of the support arm part fulfill all of the following conditions A through C, Condition A: 0.1?L2/L1?0.2, Condition B: 0.4?L3/L2?0.6, Condition C: L4/L1?0.7. While the miniaturization is realized by shortening the base due to the condition A, the distance via the base can be elongated due to the condition B. Further, by increasing the length of the support arm parts due to the condition C, it is possible to increase the total mass of the path transmitting the vibration to absorb the vibration to thereby further suppress the vibration leakage.

Abstract: A piezoelectric vibrator element includes a pair of vibrating arms extending from a base, and having a groove on each of opposing principal surfaces in the longitudinal direction of the vibrating arms. Two systems of excitation electrodes are included on the side surfaces and the opposing principal surfaces, and in the grooves of the vibrating arms. A width of a bank part formed by a side surface of the vibrating arms and a side surface of the groves is W0, and the separation distance between the excitation electrodes on the opposing principal surfaces is W1, such that 1 ?m<W1<3 ?m and W0>W1.

Abstract: The piezoelectric vibrator element is miniaturized, and at the same time, the vibration leakage is suppressed. The piezoelectric vibrator element is formed so that the total length L1 of the piezoelectric vibrator element, the length L2 of the base, the width L3 of the connection part, the length L4 of the support arm part fulfill all of the following conditions A through C, Condition A: 0.1?L2/L1?0.2, Condition B: 0.4?L3/L2?0.6, Condition C: L4/L1?0.7. While the miniaturization is realized by shortening the base due to the condition A, the distance via the base can be elongated due to the condition B. Further, by increasing the length of the support arm parts due to the condition C, it is possible to increase the total mass of the path transmitting the vibration to absorb the vibration to thereby further suppress the vibration leakage.

Abstract: In the piezoelectric vibrator element, a larger area of the electrode part making a contribution to the vibration of the piezoelectric vibrator element is ensured. The piezoelectric vibrator element is a tuning-fork piezoelectric vibrator element, provided with a pair of vibrating arm parts extending from a base, and a groove part constant in width is formed on each of principal surfaces (reverse and obverse surfaces) in the longitudinal direction of the vibrating arm part. On the side surfaces and the principal surfaces, and in the groove part of the vibrating arm part, there are formed two systems of excitation electrodes.

Abstract: The present invention is a method for culturing adherent cells that can allow adherent cells to survive and grow even in a suspended state, a culture vessel that is formed using an alicyclic structure-containing polymer, and includes a liquid medium, and adherent cells that survive in the liquid medium in a suspended state, and a method for producing a protein. The adhesive cells can be grown in a method for culturing adherent cells comprising bringing adherent cells into contact with an alicyclic structure-containing polymer formed article to grow the adherent cells in a state in which the adherent cells are suspended in a liquid medium.

Abstract: The present invention is a method that can promote the differentiation of cultured cells, and a cultured cell differentiation promoter that may suitably be used for the method. The differentiation of cultured cells is induced by bringing an alicyclic structure-containing polymer formed article into contact with cells that are being cultured.

Abstract: There is provided a method of manufacturing a piezoelectric vibrator element capable of preventing the piezoelectric vibrator element from being damaged when segmentallizing the piezoelectric vibrator element. The method of manufacturing a piezoelectric vibrator element includes the steps of providing the wafer with the piezoelectric plate and a frame part adapted to support the piezoelectric plate via a connection part, providing a pair of excitation electrodes to the piezoelectric plate, and forming a pair of extending electrodes extending from the piezoelectric plate to the frame part through the connection part and electrically connected respectively to the pair of excitation electrodes, and segmentallizing the piezoelectric plate by cutting the connection part. In the step of providing the pair of excitation electrodes, the pair of extending electrodes are formed on a side surface of the connection part.

Abstract: A pair of vibrating arm portions are disposed lined up in a second direction perpendicular to a first direction and are configured such that base end sides thereof in the first direction are fixed to a base portion. A pair of inclined surfaces are formed on both sides in the second direction on the base end side of the vibrating arm portion so that a width of the vibrating arm portion in the second direction is gradually widened from the distal end side to the base end side. A length of a region, having the pair of inclined surfaces formed therein, in the first direction is set to equal to or greater than 0.25 times and equal to or less than 0.5 times of a total length of the vibrating arm portion from the base end to the distal end.

Abstract: A pair of vibrating arms are arranged side by side in a second direction crossing the first direction, base end sides of which in the first direction are fixed to the base, a pair of inclined surfaces are formed in both sides of the base end of the vibrating arm in the second direction, an end portion in the base end side of an inner inclined surface is connected to an end surface in the tip end side of the base, and an end portion in the base end side of an outer inclined surface is connected to an end surface of the base in the second direction, and the base-end side end portion of the outer inclined surface is arranged closer to the tip end side than the base-end side end portion of the inner inclined surface.

Abstract: Crystal oscillators and methods for fabricating the crystal oscillators are disclosed. Also disclosed are sensors comprising the crystal oscillators, and methods for detecting an analyte using the sensors. In some embodiments, a crystal oscillator can include a convex crystal resonator having a first surface and a second surface, wherein the first surface comprises at least one convex-shaped portion and the second surface is substantially planar; at least one pair of first electrodes disposed on the first surface; and at least one second electrode disposed on the second surface.