Patents by Inventor Napoleone Ferrara

Napoleone Ferrara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 6946263
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptide of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: September 20, 2005
    Assignee: Genentech, Inc.
    Inventors: Napoleone Ferrara, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Colin K. Watanabe, William I. Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 6936436
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: August 30, 2005
    Assignee: Genentech, Inc.
    Inventors: Kevin P. Baker, David Botstein, Luc Desnoyers, Dan L. Eaton, Napoleone Ferrara, Sherman Fong, Wei-Qiang Gao, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, Kenneth J. Hillan, James Pan, Nicholas F. Paoni, Margaret Ann Roy, Victoria Smith, Timothy A. Stewart, Daniel Tumas, Colin K. Watanabe, P. Mickey Williams, William I. Wood
  • Method of inducing fetal hemoglobin synthesis
    Patent number: 6936254
    Abstract: The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: August 31, 2001
    Date of Patent: August 30, 2005
    Assignee: Genentech, Inc.
    Inventors: Kevin P. Baker, David Botstein, Dan L. Eaton, Napoleone Ferrara, Ellen Filvaroff, Mary E. Gerritsen, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, Kenneth J. Hillan, Ivar J. Kljavin, Mary A. Napier, Margaret Ann Roy, Daniel Tumas, William I. Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20050187382
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: September 23, 2004
    Publication date: August 25, 2005
    Applicant: Genentech, Inc.
    Inventors: Avi Ashkenazi, Kevin Baker, David Botstein, Luc Desnoyers, Dan Eaton, Napoleone Ferrara, Sherman Fong, Hanspeter Gerber, Mary Gerritsen, Audrey Goddard, Paul Godowski, J. Grimaldi, Austin Gurney, Ivar Kljavin, Mary Napier, James Pan, Nicholas Paoni, Margaret Roy, Timothy Stewart, Daniel Tumas, Colin Watanabe, P. Williams, William Wood, Zemin Zhang
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20050181478
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: December 28, 2004
    Publication date: August 18, 2005
    Inventors: Kevin Baker, David Botstein, Luc Desnoyers, Dan Eaton, Napoleone Ferrara, Sherman Fong, Wei-Qiang Gao, Audrey Goddard, Paul Godowski, J. Grimaldi, Austin Gurney, Kenneth Hillan, James Pan, Nicholas Paoni, Margaret Roy, Victoria Smith, Timothy Stewart, Daniel Tumas, Colin Watanabe, P. Williams, William Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 6930172
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: December 27, 2001
    Date of Patent: August 16, 2005
    Assignee: Genentech, Inc.
    Inventors: Napoleone Ferrara, Wei-Qiang Gao, Audrey Goddard, Austin L. Gurney, Colin K. Watanabe, William I. Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20050170458
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: February 2, 2005
    Publication date: August 4, 2005
    Applicant: GENENTECH, INC.
    Inventors: Napoleone Ferrara, Audrey Goddard, Paul Godowski, Austin Gurney, William Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20050170465
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: March 15, 2005
    Publication date: August 4, 2005
    Applicant: GENENTECH, INC.
    Inventors: Napoleone Ferrara, Audrey Goddard, Paul Godowski, Austin Gurney, Kenneth Hillan, William Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20050170467
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: February 2, 2005
    Publication date: August 4, 2005
    Applicant: GENENTECH, INC.
    Inventors: Napoleone Ferrara, Audrey Goddard, Paul Godowski, Austin Gurney, William Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20050158830
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those peptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to herologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: March 14, 2005
    Publication date: July 21, 2005
    Applicant: GENENTECH, INC.
    Inventors: Luc Desnoyers, Napoleone Ferrara, Audrey Goddard, Paul Godowski, Austin Gurney, Kenneth Hillan, William Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20050124789
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: October 16, 2001
    Publication date: June 9, 2005
    Inventors: Avi Ashkenazi, Kevin Baker, David Botstein, Luc Desnoyers, Dan Eaton, Napoleone Ferrara, Ellen Filvaroff, Sherman Fong, Wei-Qiang Gao, Hanspeter Gerber, Mary Gerritsen, Audrey Goddard, Paul Godowski, J. Christopher Grimaldi, Austin Gurney, Kenneth Hillan, Ivar Kljavin, Sophia Kuo, Mary Napier, James Pan, Nicholas Paoni, Margaret Roy, David Shelton, Timothy Stewart, Daniel Tumas, P. Mickey Williams, William Wood
  • Endothelial cell growth factor methods of isolation and expression
    Patent number: 6899882
    Abstract: A novel growth factor specific for vascular endothelial cells has been identified in conditioned medium of bovine pituitary derived folliculo stellate cells. This factor, named folliculo stellate derived growth facto (FSdGF) or vascular endothelial growth factor (VEGF), was purified to homogeneity by a combination of heparin sepharose affinity chromatography, Bio Gel P-60 exclusion chromatography, Mono S ion exchange chromatography and hydrophobic chromatography on a C4 reverse phase HPLC column. The factor is also found in the murine AtT-20 cell line.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: May 31, 2005
    Assignee: The Regents of the University of California
    Inventors: Napoleone Ferrara, Denis Gospodarowicz, Jean Plouet
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20050112725
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: October 29, 2004
    Publication date: May 26, 2005
    Applicant: Genentech, Inc.
    Inventors: Avi Ashkenazi, Kevin Baker, David Botstein, Luc Desnoyers, Dan Eaton, Napoleone Ferrara, Sherman Fong, Hanspeter Gerber, Mary Gerritsen, Audrey Goddard, Paul Godowski, J. Grimaldi, Austin Gurney, Ivar Kljavin, Mary Napier, James Pan, Nicholas Paoni, Margaret Roy, Timothy Stewart, Daniel Tumas, Colin Watanabe, P. Williams, William Wood, Zemin Zhang
  • Inhibitors of vascular endothelial growth factor activity, their uses and processes for their production
    Patent number: 6897294
    Abstract: The present invention is directed to novel chimeric VEGF receptor proteins comprising amino acid sequences derived from the vascular endothelial growth factor (VEGF) receptors flt-1 and KDR, including the murine homologue to the human KDR receptor FLK-1, wherein said chimeric VEGF receptor proteins bind to VEGF and antagonize the endothelial cell proliferative and angiogenic activity thereof. The present invention is also directed to nucleic acids and expression vectors encoding these chimeric VEGF receptor proteins, host cells harboring such expression vectors, pharmaceutically acceptable compositions comprising such proteins, methods of preparing such proteins and to methods utilizing such proteins for the treatment of conditions associated with undesired vascularization.
    Type: Grant
    Filed: March 20, 2002
    Date of Patent: May 24, 2005
    Assignee: Genentech, Inc.
    Inventors: Terri Lynn Davis-Smyth, Helen Hsifei Chen, Leonard Presta, Napoleone Ferrara
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20050084935
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 21, 2004
    Publication date: April 21, 2005
    Inventors: Avi Ashkenazi, Kevin Baker, David Botstein, Luc Desnoyers, Dan Eaton, Napoleone Ferrara, Ellen Filvaroff, Sherman Fong, Wei-Qiang Gao, Hanspeter Gerber, Mary Gerritsen, Audrey Goddard, Paul Godowski, J. Grimaldi, Austin Gurney, Kenneth Hillan, Ivar Kljavin, Sophia Kuo, Mary Napier, James Pan, Nicholas Paoni, Margaret Roy, David Shelton, Timothy Stewart, Daniel Tumas, P. Williams, William Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20050079582
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: October 11, 2004
    Publication date: April 14, 2005
    Applicant: GENENTECH, INC.
    Inventors: Avi Ashkenazi, David Botstein, Luc Desnoyers, Dan Eaton, Napoleone Ferrara, Ellen Filvaroff, Sherman Fong, Wei-Qiang Gao, Hanspeter Gerber, Mary Gerritsen, Audrey Goddard, Paul Godowski, Christopher Grimaldi, Austin Gurney, Kenneth Hillan, Ivar Kljavin, Jennie Mather, James Pan, Nicholas Paoni, Margaret Roy, Timothy Stewart, Daniel Tumas, P. Williams, William Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20050079577
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 16, 2004
    Publication date: April 14, 2005
    Inventors: Avi Ashkenazi, Kevin Baker, David Botstein, Luc Desnoyers, Dan Eaton, Napoleone Ferrara, Ellen Filvaroff, Sherman Fong, Wei-Qiang Gao, Hanspeter Gerber, Mary Gerritsen, Audrey Goddard, Paul Godowski, J. Grimaldi, Austin Gurney, Kenneth Hillan, Ivar Kljavin, Sophia Kuo, Mary Napier, James Pan, Nicholas Paoni, Margaret Roy, David Shelton, Timothy Stewart, Daniel Tumas, P. Williams, William Wood
  • EG-VEGF nucleic acids and polypeptides and methods of use
    Publication number: 20050064522
    Abstract: The present invention is directed to novel polypeptides designated herein as EG-VEGF and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Also provided herein are methods of screening for modulators of EG-VEGF. Furthermore, methods and related methods of treatment are described herein which pertain to regulating cellular proliferation and chemotaxis.
    Type: Application
    Filed: October 22, 2003
    Publication date: March 24, 2005
    Applicant: Genentech, Inc.
    Inventors: Napoleone Ferrara, Colin Watanabe, William Wood
  • Vascular endothelial cell growth factor antagonists and uses thereof
    Publication number: 20050053599
    Abstract: The present invention provides vascular endothelial cell growth factor (VEGF) antagonists and methods of using VEGF antagonists. VEGF antagonists contemplated by the invention include VEGF antibodies and VEGF receptor fusion proteins. Methods of treating edema and stroke using VEGF antagonists are also provided.
    Type: Application
    Filed: October 9, 2003
    Publication date: March 10, 2005
    Applicant: Genentech, Inc.
    Inventors: Nicholas Van Bruggen, Napoleone Ferrara
  • SECRETED AND TRANSMEMBRANE POLYPEPTIDES AND NUCLEIC ACIDS ENCODING THE SAME
    Publication number: 20050043520
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: December 7, 2001
    Publication date: February 24, 2005
    Inventors: Kevin Baker, David Botstein, Luc Desnoyers, Dan Eaton, Napoleone Ferrara, Sherman Fong, Wei-Qiang Gao, Audrey Goddard, Paul Godowski, J. Grimaldi, Austin Gurney, Kenneth Hillan, James Pan, Nicholas Paoni, Margaret Roy, Victoria Smith, Timothy Stewart, Daniel Tumas, Colin Watanabe, P. Williams, William Wood