Patents by Inventor Napoleone Ferrara

Napoleone Ferrara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 7390879
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: August 23, 2002
    Date of Patent: June 24, 2008
    Assignee: Genentech, Inc.
    Inventors: Avi J. Ashkenazi, Kevin P. Baker, David A. Botstein, Luc Desnoyers, Dan L. Eaton, Napoleone Ferrara, Sherman Fong, Wei-Qiang Gao, Hanspeter Gerber, Mary E. Gerritsen, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Ivar J. Kljavin, Jennie P. Mather, Mary A. Napier, James Pan, Nicholas F. Paoni, Margaret Ann Roy, Timothy A. Stewart, Daniel Tumas, Colin K. Watanabe, P. Mickey Williams, William I. Wood, Zemin Zhang
  • PRO217 polypeptides
    Patent number: 7378507
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: March 9, 2004
    Date of Patent: May 27, 2008
    Assignee: Genentech, Inc.
    Inventors: Napoleone Ferrara, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, William I. Wood
  • Antibodies to polypeptides homologous to VEGF and BMP1
    Patent number: 7371377
    Abstract: The present invention involves the identification and preparation of vascular endothelial growth factor-E (VEGF-E). VEGF-E is a novel polypeptide related to vascular endothelial growth factor (VEGF) and bone morphogenetic protein 1. VEGF-E has homology to VEGF including conservation of the amino acids required for activity of VEGF. VEGF-E can be useful in wound repair, as well as in the generation and regeneration of tissue.
    Type: Grant
    Filed: June 19, 2002
    Date of Patent: May 13, 2008
    Assignee: Genentech, Inc.
    Inventors: Napoleone Ferrara, Sophia S. Kuo
  • POLYPEPTIDES HOMOLOGOUS TO VEGF AND BMP1
    Publication number: 20080095773
    Abstract: The present invention involves the identification and preparation of vascular endothelial growth factor-E (VEGF-E). VEGF-E is a novel polypeptide related to vascular endothelial growth factor (VEGF) and bone morphogenetic protein 1. VEGF-E has homology to VEGF including conservation of the amino acids required for activity of VEGF. VEGF-E can be useful in wound repair, as well as in the generation and regeneration of tissue.
    Type: Application
    Filed: November 15, 2007
    Publication date: April 24, 2008
    Applicant: Genentech, Inc.
    Inventors: Napoleone Ferrara, Sophia Kuo
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 7355002
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: February 2, 2004
    Date of Patent: April 8, 2008
    Assignee: Genentech, Inc.
    Inventors: Napoleone Ferrara, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, William I. Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 7317092
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: February 1, 2002
    Date of Patent: January 8, 2008
    Assignee: Genentech, Inc.
    Inventors: Avi J. Ashkenazi, Kevin P. Baker, David A. Botstein, Luc Desnoyers, Dan L. Eaton, Napoleone Ferrara, Sherman Fong, Wei-Qiang Gao, Hanspeter Gerber, Mary E. Gerritsen, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Ivar J. Kljavin, Jennie P. Mather, Mary A. Napier, James Pan, Nicholas F. Paoni, Margaret Ann Roy, Timothy A. Stewart, Daniel Tumas, Colin K. Watanabe, P. Mickey Williams, William I. Wood, Zemin Zhang
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 7307152
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: October 20, 2004
    Date of Patent: December 11, 2007
    Assignee: Genentech, Inc.
    Inventors: Luc Desnoyers, Napoleone Ferrara, Ellen Filvaroff, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, William I. Wood
  • Production of vascular endothelial cell growth factor and DNA encoding same
    Patent number: 7300791
    Abstract: DNA isolates coding for a vascular endothelial cell growth factor may be used to produce the protein via recombinant expression systems. Such protein is useful therapeutically to treat conditions in which a selective action on the vascular endothelial cells, in the absence of excessive connective tissue proliferation, is desirable.
    Type: Grant
    Filed: May 17, 2002
    Date of Patent: November 27, 2007
    Assignee: Genentech, Inc.
    Inventors: Napoleone Ferrara, David Wai-Hung Leung
  • METHODS FOR TREATING KIDNEY DISORDERS
    Publication number: 20070264259
    Abstract: Provided are methods of treating kidney disorders in a subject by administering an effective amount of VEGFR agonist, e.g., a Flt1 agonist to a subject. The agonists are composed of compositions comprising VEGFR agonists, e.g., VEGF, antibodies directed to Flt1, Flt1 ligands, Flt1 small molecule activators, or Flt1 selective agents in a pharmaceutically acceptable carrier for use in activating Flt1.
    Type: Application
    Filed: March 26, 2007
    Publication date: November 15, 2007
    Applicant: Genentech, Inc.
    Inventors: Megan Baldwin, Hans-Peter Gerber, Napoleone Ferrara
  • DIAGNOSTICS AND TREATMENTS FOR TUMORS
    Publication number: 20070264193
    Abstract: Methods for the treatment of cancer with combination therapies that include anti-VEGF antibodies are provided. Methods for diagnosing resistant tumors are also provided.
    Type: Application
    Filed: March 28, 2007
    Publication date: November 15, 2007
    Applicant: Genentech, Inc.
    Inventors: Farbod Shojaei, Cuiling Zhong, Megan Baldwin, Hans-Peter Gerber, Napoleone Ferrara
  • VASCULAR ENDOTHELIAL CELL GROWTH FACTOR ANTAGONISTS AND USES THEREOF
    Publication number: 20070258980
    Abstract: The present invention provides vascular endothelial cell growth factor (VEGF) antagonists and methods of using VEGF antagonists. VEGF antagonists contemplated by the invention include VEGF antibodies and VEGF receptor fusion proteins. Methods of treating edema and stroke using VEGF antagonists are also provided.
    Type: Application
    Filed: September 29, 2006
    Publication date: November 8, 2007
    Applicant: Genentech, Inc.
    Inventors: NICHOLAS VAN BRUGGEN, Napoleone Ferrara
  • VASCULAR ENDOTHELIAL CELL GROWTH FACTOR ANTAGONISTS
    Publication number: 20070253959
    Abstract: The present invention provides human vascular endothelial cell growth factor (hVEGF) antagonists, including monoclonal antibodies, hVEGF receptors, and hVEGF variants that are useful for the treatment of age-related macular degeneration, and other diseases and disorders characterized by undesirable or excessive neovascularization.
    Type: Application
    Filed: June 20, 2007
    Publication date: November 1, 2007
    Applicant: Genentech, Inc.
    Inventors: Napoleone Ferrara, Kyung Kim
  • VEGF Receptor Conditional Knockout Animals and Methods of Use
    Publication number: 20070250941
    Abstract: Transgenic non-human animals and methods of producing non-human transgenic animals comprising within their genome a conditional targeted mutation in a VEGFR, e.g., VEGFR1 or VEGFR2, gene are provided along with methods and vectors used to produce such animals or cells.
    Type: Application
    Filed: March 26, 2007
    Publication date: October 25, 2007
    Applicant: Genentech, Inc.
    Inventors: Megan Baldwin, Hans-Peter Gerber, Napoleone Ferrara
  • BV8 NUCLEIC ACIDS AND POLYPEPTIDES WITH MITOGENIC ACTIVITY
    Publication number: 20070244063
    Abstract: The present invention provides methods of using Bv8 polypeptides to induce endothelial cell proliferation and to enhance endothelial cell survival. Also provided herein are methods of screening for modulators of Bv8 activity. Furthermore, methods of treatment using Bv8 polypeptides are provided.
    Type: Application
    Filed: September 29, 2006
    Publication date: October 18, 2007
    Applicant: Genentech, Inc.
    Inventors: NAPOLEONE FERRARA, Jennifer Le Couter
  • VARIANTS OF VASCULAR ENDOTHELIAL CELL GROWTH FACTORS HAVING ANTAGONISTIC PROPERTIES, NUCLEIC ACIDS ENCODING THE SAME AND HOST CELLS COMPRISING THOSE NUCLEIC ACIDS
    Publication number: 20070238659
    Abstract: The present invention involves the preparation of vascular endothelial growth factor (VEGF) antagonist molecules comprising variant VEGF polypeptides which are capable of binding to and occupying cell surface VEGF receptors without inducing a VEGF response, thereby antagonizing the biological activity of the native VEGF protein. Specifically, the variant VEGF polypeptides of the present invention comprise modifications of at least one cysteine residue in the native VEGF sequence, thereby inhibiting the ability of the variant polypeptide to dimerize through the formation of disulfide bonds. The present invention is further directed to methods for preparing such variant VEGF antagonists and to methods, compositions and assays utilizing such variants for producing pharmaceutically active materials having therapeutic and pharmacologic properties that differ from the native VEGF protein.
    Type: Application
    Filed: September 28, 2006
    Publication date: October 11, 2007
    Applicant: Genentech, Inc.
    Inventors: Bruce Keyt, Francis Nguyen, Napoleone Ferrara
  • Production of Vascular Endothelial Cell Growth Factor and DNA Encoding Same
    Publication number: 20070238642
    Abstract: DNA isolates coding for a vascular endothelial cell growth factor may be used to produce the protein via recombinant expression systems. Such protein is useful therapeutically to treat conditions in which a selective action on the vascular endothelial cells, in the absence of excessive connective tissue proliferation, is desirable.
    Type: Application
    Filed: September 22, 2006
    Publication date: October 11, 2007
    Applicant: Genentech, Inc.
    Inventors: Napoleone Ferrara, David Leung
  • EG-VEGF NUCLEIC ACIDS AND POLYPEPTIDES AND METHODS OF USE
    Publication number: 20070213268
    Abstract: The present invention is directed to novel polypeptides designated herein as EG-VEGF and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Also provided herein are methods of screening for modulators of EG-VEGF. Furthermore, methods and related methods of treatment are described herein which pertain to regulating cellular proliferation and chemotaxis.
    Type: Application
    Filed: September 29, 2006
    Publication date: September 13, 2007
    Applicant: Genentech, Inc.
    Inventors: Napoleone Ferrara, Colin Watanabe, William Wood, Theresa Shek
  • Composition comprising and method of using angiopoietin-like protein 3 Angptl3
    Patent number: 7267819
    Abstract: The present invention is directed to methods and means for making and using Angptl3 polypeptides. The invention specifically concerns the use of Angptl3 polypeptides in inducing liver regeneration and angiogenesis. Further methods include the use of Angptl3 polypeptides in the diagnosis and treatment of liver disease. Also provided herein are antibodies which bind to the polypeptides of the present invention.
    Type: Grant
    Filed: November 15, 2002
    Date of Patent: September 11, 2007
    Assignee: Genentech, Inc.
    Inventors: Napoleone Ferrara, Hans-Peter Gerber, Joe Kowalski, Maria Teresa Pisabarro, Daniel Eric Sherman
  • EG-VEGF nucleic acids and polypeptides and method of use
    Patent number: 7264801
    Abstract: The present invention is directed to novel polypeptides designated herein as EG-VEGF and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Also provided herein are methods of screening for modulators of EG-VEGF. Furthermore, methods and related methods of treatment are described herein which pertain to regulating cellular proliferation and chemotaxis.
    Type: Grant
    Filed: December 19, 2001
    Date of Patent: September 4, 2007
    Assignee: Genentech, Inc.
    Inventors: Napoleone Ferrara, Colin Watanabe, William I. Wood, Theresa Shek
  • Production of Vascular Endothelial Cell Growth Factor and DNA Encoding Same
    Publication number: 20070161558
    Abstract: DNA isolates coding for a vascular endothelial cell growth factor may be used to produce the protein via recombinant expression systems. Such protein is useful therapeutically to treat conditions in which a selective action on the vascular endothelial cells, in the absence of excessive connective tissue proliferation, is desirable.
    Type: Application
    Filed: September 27, 2006
    Publication date: July 12, 2007
    Applicant: Genentech, Inc.
    Inventors: Napoleone Ferrara, David Leung