Patents by Inventor Narasimhachari Narayanan

Narasimhachari Narayanan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 4,4-DISUBSTITUTED CYCLOHEXYL BRIDGED HEPTAMETHINE CYANINE DYES AND USES THEREOF
    Publication number: 20220178921
    Abstract: The invention relates to a family of compounds that comprise fluorescent cyanine dyes. The compounds are near infrared absorbing heptamethine cyanine dyes with a 4,4-disubstituted cyclohexyl ring as part of the polymethine chromophore. The compounds are generally hydrophilic and can be chemically linked to biomolecules, such as proteins, nucleic acids, and therapeutic small molecules. The compounds can be used for imaging in a variety of medical, biological and diagnostic applications.
    Type: Application
    Filed: November 10, 2021
    Publication date: June 9, 2022
    Inventor: Narasimhachari Narayanan
  • 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof
    Patent number: 11193932
    Abstract: The invention relates to a family of compounds that comprise fluorescent cyanine dyes. The compounds are near infrared absorbing heptamethine cyanine dyes with a 4,4-disubstituted cyclohexyl ring as part of the polymethine chromophore. The compounds are generally hydrophilic and can be chemically linked to biomolecules, such as proteins, nucleic acids, and therapeutic small molecules. The compounds can be used for imaging in a variety of medical, biological and diagnostic applications.
    Type: Grant
    Filed: October 16, 2019
    Date of Patent: December 7, 2021
    Assignee: VisEn Medical, Inc.
    Inventor: Narasimhachari Narayanan
  • 4,4-DISUBSTITUTED CYCLOHEXYL BRIDGED HEPTAMETHINE CYANINE DYES AND USES THEREOF
    Publication number: 20200049709
    Abstract: The invention relates to a family of compounds that comprise fluorescent cyanine dyes. The compounds are near infrared absorbing heptamethine cyanine dyes with a 4,4-disubstituted cyclohexyl ring as part of the polymethine chromophore. The compounds are generally hydrophilic and can be chemically linked to biomolecules, such as proteins, nucleic acids, and therapeutic small molecules. The compounds can be used for imaging in a variety of medical, biological and diagnostic applications.
    Type: Application
    Filed: October 16, 2019
    Publication date: February 13, 2020
    Inventor: Narasimhachari Narayanan
  • 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof
    Patent number: 10473658
    Abstract: The invention relates to a family of compounds that comprise fluorescent cyanine dyes. The compounds are near infrared absorbing heptamethine cyanine dyes with a 4,4-disubstituted cyclohexyl ring as part of the polymethine chromophore. The compounds are generally hydrophilic and can be chemically linked to biomolecules, such as proteins, nucleic acids, and therapeutic small molecules. The compounds can be used for imaging in a variety of medical, biological and diagnostic applications.
    Type: Grant
    Filed: February 7, 2018
    Date of Patent: November 12, 2019
    Assignee: VisEn Medical, Inc.
    Inventor: Narasimhachari Narayanan
  • Biocompatible N, N-disubstituted sulfonamide-containing fluorescent dye labels
    Patent number: 10442930
    Abstract: This invention relates to new fluorescent chemical entities, especially fluorescent molecules that comprise biocompatible N, N-disubstituted sulfonamide fluorochromes. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
    Type: Grant
    Filed: February 15, 2017
    Date of Patent: October 15, 2019
    Assignee: VisEn Medical, Inc.
    Inventors: Narasimhachari Narayanan, Kevin Groves, Jeffrey D. Peterson, Milind Rajopadhye
  • 4,4-DISUBSTITUTED CYCLOHEXYL BRIDGED HEPTAMETHINE CYANINE DYES AND USES THEREOF
    Publication number: 20180164312
    Abstract: The invention relates to a family of compounds that comprise fluorescent cyanine dyes. The compounds are near infrared absorbing heptamethine cyanine dyes with a 4,4-disubstituted cyclohexyl ring as part of the polymethine chromophore. The compounds are generally hydrophilic and can be chemically linked to biomolecules, such as proteins, nucleic acids, and therapeutic small molecules. The compounds can be used for imaging in a variety of medical, biological and diagnostic applications.
    Type: Application
    Filed: February 7, 2018
    Publication date: June 14, 2018
    Inventor: Narasimhachari Narayanan
  • 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof
    Patent number: 9897604
    Abstract: The invention relates to a family of compounds that comprise fluorescent cyanine dyes. The compounds are near infrared absorbing heptamethine cyanine dyes with a 4,4-disubstituted cyclohexyl ring as part of the polymethine chromophore. The compounds are generally hydrophilic and can be chemically linked to biomolecules, such as proteins, nucleic acids, and therapeutic small molecules. The compounds can be used for imaging in a variety of medical, biological and diagnostic applications.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: February 20, 2018
    Assignee: VisEn Medical, Inc.
    Inventor: Narasimhachari Narayanan
  • Biocompatible N, N-Disubstituted Sulfonamide-Containing Fluorescent Dye Labels
    Publication number: 20170283617
    Abstract: This invention relates to new fluorescent chemical entities, especially fluorescent molecules that comprise biocompatible N, N-disubstituted sulfonamide fluorochromes. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
    Type: Application
    Filed: February 15, 2017
    Publication date: October 5, 2017
    Inventors: Narasimhachari Narayanan, Kevin Groves, Jeffrey D. Peterson, Milind Rajopadhye
  • Biocompatible N, N-disubstituted sulfonamide-containing fluorescent dye labels
    Patent number: 9574085
    Abstract: This invention relates to new fluorescent chemical entities, especially fluorescent molecules that comprise biocompatible N,N-disubstituted sulfonamide fluorochromes. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
    Type: Grant
    Filed: September 1, 2006
    Date of Patent: February 21, 2017
    Assignee: VisEn Medical, Inc.
    Inventors: Narasimhachari Narayanan, Kevin Groves, Jeffrey D. Peterson, Milind Rajopadhye
  • 4,4-DISUBSTITUTED CYCLOHEXYL BRIDGED HEPTAMETHINE CYANINE DYES AND USES THEREOF
    Publication number: 20140348746
    Abstract: The invention relates to a family of compounds that comprise fluorescent cyanine dyes. The compounds are near infrared absorbing heptamethine cyanine dyes with a 4,4-disubstituted cyclohexyl ring as part of the polymethine chromophore. The compounds are generally hydrophilic and can be chemically linked to biomolecules, such as proteins, nucleic acids, and therapeutic small molecules. The compounds can be used for imaging in a variety of medical, biological and diagnostic applications.
    Type: Application
    Filed: March 17, 2014
    Publication date: November 27, 2014
    Applicant: VisEn Medical, Inc.
    Inventor: Narasimhachari Narayanan
  • Nicotinic acid and picolinic acid derived near-infrared fluorophores
    Patent number: 8771646
    Abstract: This invention relates to new fluorescent chemical entities, including fluorescent molecules that comprise a carboxyl or carbonyl functionalized pyridine moiety. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: July 8, 2014
    Assignee: VisEn Medical, Inc.
    Inventors: Milind Rajopadhye, Narasimhachari Narayanan, Jeffrey D. Peterson
  • Nicotinic Acid and Picolinic Acid Derived Near-Infrared Fluorophores
    Publication number: 20130272967
    Abstract: This invention relates to new fluorescent chemical entities, including fluorescent molecules that comprise a carboxyl or carbonyl functionalized pyridine moiety. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
    Type: Application
    Filed: March 14, 2013
    Publication date: October 17, 2013
    Inventors: Milind Rajopadhye, Narasimhachari Narayanan, Jeffrey D. Peterson
  • Nicotinic acid and picolinic acid derived near-infrared fluorophores
    Patent number: 8455651
    Abstract: This invention relates to new fluorescent chemical entities, including fluorescent molecules that comprise a carboxyl or carbonyl functionalized pyridine moiety. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
    Type: Grant
    Filed: April 18, 2012
    Date of Patent: June 4, 2013
    Assignee: VisEn Medical, Inc.
    Inventors: Milind Rajopadhye, Narasimhachari Narayanan
  • OPTICAL FLUORESCENT IMAGING IN HISTOLOGY
    Publication number: 20130052637
    Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.
    Type: Application
    Filed: August 29, 2012
    Publication date: February 28, 2013
    Applicant: LI-COR, INC.
    Inventors: Joy Kovar, Jiyan Chen, Daniel R. Draney, D. Michael Olive, William M. Volcheck, Xinshe Xu, Ananda G. Lugade, Narasimhachari Narayanan
  • NICOTINIC ACID AND PICOLINIC ACID DERIVED NEAR-INFRARED FLUOROPHORES
    Publication number: 20120321562
    Abstract: This invention relates to new fluorescent chemical entities, including fluorescent molecules that comprise a carboxyl or carbonyl functionalized pyridine moiety. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
    Type: Application
    Filed: April 18, 2012
    Publication date: December 20, 2012
    Inventors: Milind Rajopadhye, Narasimhachari Narayanan, Jeffrey D. Peterson
  • Optical fluorescent imaging
    Patent number: 8303936
    Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: November 6, 2012
    Assignee: Li-Cor, Inc.
    Inventors: Daniel R. Draney, Ananda G. Lugade, Narasimhachari Narayanan, Joy Kovar, D. Michael Olive
  • OPTICAL FLUORESCENT IMAGING
    Publication number: 20120258048
    Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.
    Type: Application
    Filed: June 15, 2012
    Publication date: October 11, 2012
    Applicant: LI-COR, INC.
    Inventors: Joy Kovar, Jiyan Chen, Daniel R. Draney, D. Michael Olive, William M. Volcheck, Xinshe Xu, Ananda G. Lugade, Narasimhachari Narayanan
  • Polycyclo dyes and use thereof
    Patent number: 8221721
    Abstract: The invention relates to a family of fluorescent compounds of Formula (I). The compounds can be chemically linked to biomolecules, such as proteins, nucleic acids, and therapeutic small molecules. The compounds can be used for imaging in a variety of medical, biological and diagnostic applications, and are particularly useful for the in vivo imaging of regions of interest within a mammal.
    Type: Grant
    Filed: February 8, 2008
    Date of Patent: July 17, 2012
    Assignee: VisEn Medical, Inc.
    Inventor: Narasimhachari Narayanan
  • Nicotinic and picolinic acid derived near-infrared fluorophores
    Patent number: 8173819
    Abstract: This invention relates to new fluorescent chemical entities, including fluorescent molecules that comprise a carboxyl or carbonyl functionalized pyridine moiety. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
    Type: Grant
    Filed: September 1, 2006
    Date of Patent: May 8, 2012
    Assignee: VisEn Medical, Inc.
    Inventors: Milind Rajopadhye, Narasimhachari Narayanan, Jeffrey D. Peterson
  • OPTICAL FLUORESCENT IMAGING
    Publication number: 20100080758
    Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.
    Type: Application
    Filed: October 2, 2009
    Publication date: April 1, 2010
    Applicant: LI-COR,INC.
    Inventors: Daniel R. Draney, Ananda G. Lugade, Narasimhachari Narayanan