Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.

Abstract: This invention relates to new fluorescent chemical entities, especially fluorescent molecules that comprise biocompatible N,N-disubstituted sulfonamide fluorochromes. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.

Abstract: A compound of the formula (I) wherein the variables are defined herein. Methods of dye-labeling biomolecules with the compound of formula (I) and dye-labeled biomolecules are also provided.

Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.

Abstract: A compound of the formula (I) wherein Z is O, S, or NR35 wherein R35 is H or alkyl; R1-R5 are each independently H, alkyl, halo, carboxyl, amino, or SO3?Cat+, wherein Cat+ is a cation and at least one of R1-R5 is SO3?Cat+; R6 and R7 are each H, alkyl, or optionally, together with the (a) group to which they are bonded, form a ring; m and n are each independently integers from 0 to 5; X and Y are each independently O, S, Se or CR19R20, wherein R19 and R20 are each independently alkyl, or optionally form a ring together with the carbon atom to which they are bonded; R8 and R13 are each independently alkyl, (CH2)rR25 or (CH2)rR18; wherein at least one of R8 and R13 (CH2)rR18 and wherein r is an integer from 1 to 50, and R25 is a functional group that does not directly react with a carboxyl, hydroxyl, amino, or a thiol group, and R18 is a functional group that can react with a carboxyl, hydroxyl, amino, or thiol group; and R9-R12 and R14-R17 are each independently H, alkyl, halo, amino, sulfonato, R21 COOH,

Abstract: A compound of the formula (I) wherein Z is O, S, or NR35 wherein R35 is H or alkyl; R1–R5 are each independently H, alkyl, halo, carboxyl, amino, or SO3?Cat+, wherein Cat+ is a cation and at least one of R1–R5 is SO3?Cat+; R6 and R7 are each H, alkyl, or optionally, together with the (a) group to which they are bonded, form a ring; m and n are each independently integers from 0 to 5; X and Y are each independently O, S, Se or CR19R20, wherein R19 and R20 are each independently alkyl, or optionally form a ring together with the carbon atom to which they are bonded; R8 and R13 are each independently alkyl, (CH2)rR25 or (CH2)rR18; wherein at least one of R8 and R13 (CH2)rR18 and wherein r is an integer from 1 to 50, and R25 is a functional group that does not directly react with a carboxyl, hydroxyl, amino, or a thiol group, and R18 is a functional group that can react with a carboxyl, hydroxyl, amino, or thiol group; and R9–R12 and R14–R17 are each independently H, alkyl, halo, amino, sulfonato, R21 COOH, R

Abstract: A compound of the formula (I) is provided: (I), wherein Z is O, S, or NR35 wherein R35 is H or alkyl; R1-R5 are each independently H, alkyl, halo, carboxyl, amino, or SO331 Cat+, wherein Cat+ is a cation and at least one of R1-R5 is SO3−Cat+; R6 and R7 are each H, alkyl, or optionally, together with the (a) group to which they are bonded, form a ring; m and n are each independently integers from 0 to 5; X and Y are each independently O, S, Se or CR19R20, wherein R19 and R20 are each independently alkyl, or optionally form a ring together with the carbon atom to which they are bonded; R8 and R13 are each independently alkyl, (CH2)rR25 or (CH2)rR18; wherein at least one of R8 and R13 (CH2)rR18 and wherein r is an integer from 1 to 50, and R25 is a functional group that does not directly react with a carboxyl, hydroxyl, amino or a thiol group, and R18 is a functional group that can react with 1

Abstract: A novel cyanine dye having the formula is useful for labeling biological and nonbiological molecules.

Abstract: To sequence DNA automatically, DNA marked with far infrared, near infrared, or infrared fluorescent dyes are electrophoresed in a plurality of channels through a gel electrophoresis slab or capillary tubes wherein the DNA samples are resolved in accordance with the size of DNA fragments in the gel electrophoresis slab or capillary tubes into fluorescently marked DNA bands. The separated samples are scanned photoelectrically with a laser diode and a sensor, wherein the laser scans with scanning light at a wavelength within the absorbance spectrum of said fluorescently marked DNA samples and light is sensed at the emission wavelength of the marked DNA.

Abstract: New fluorescent cyanine dyes are useful as reporter groups for labeling biomolecules.

Abstract: To sequence DNA automatically, DNA marked with far infrared, near infrared, or infrared fluorescent dyes are electrophoresed in a plurality of channels through a gel electrophoresis slab or capillary tubes wherein the DNA samples are resolved in accordance with the size of DNA fragments in the gel electrophoresis slab or capillary tubes into fluorescently marked DNA bands. The separated samples are scanned photoelectrically with a laser diode and a sensor, wherein the laser scans with scanning light at a wavelength within the absorbance spectrum of said fluorescently marked DNA samples and light is sensed at the emission wavelength of the marked DNA.

Abstract: To sequence DNA automatically, DNA marked with far infrared, near infrared, or infrared fluorescent dyes are electrophoresed in a plurality of channels through a gel electrophoresis slab or capillary tubes wherein the DNA samples are resolved in accordance with the size of DNA fragments in the gel electrophoresis slab or capillary tubes into fluorescently marked DNA bands. The separated samples are scanned photoelectrically with a laser diode and a sensor, wherein the laser scans with scanning light at a wavelength within the absorbance spectrum of said fluorescently marked DNA samples and light is sensed at the emission wavelength of the marked DNA.