Abstract: The present invention relates to water-soluble binuclear cationic nitrosyl iron complexes with natural aliphatic thiolyls of general formula [Fe2(SR)2(NO)4]SO4, wherein R is sulfur-containing aliphatic ligands of natural origin, preferably, cystamine or penicillamine, to a method for the preparation thereof, to use thereof as an anticancer agent, to an apoptosis inducer, to a pharmaceutical composition comprising said complexes in an effective amount, and to a kit useful for the treatment of cancer diseases.

Abstract: The present invention relates to polymers comprising one or more (repeating) unit(s) of the formula or a polymer of formula and their use as organic semiconductor in organic devices, especially in organic photovoltaics (solar cells) and photodiodes, or in a device containing a diode and/or an organic field effect transistor. The polymers according to the invention have excellent solubility in organic solvents and excellent film-forming properties. In addition, high efficiency of energy conversion, excellent field-effect mobility, good on/off current ratios and/or excellent stability can be observed, when the polymers according to the invention are used in organic field effect transistors, organic photovoltaics (solar cells) and photodiodes.

Abstract: Provided herein are methods for treating a solid tumor in a subject in need thereof by activating an immune response against a tumor antigen. Also provided are methods for treating a solid tumor in a subject in need thereof by activating antigen-presenting cells and eliciting an immune response against a tumor antigen. Also provided herein are optimized therapeutic treatments of solid tumors, which comprise determining the presence, absence or amount of a biomarker after the therapy has been administered, and determining whether a subsequent dose of the therapy should be maintained, increased, or decreased based on the biomarker assessment.

Abstract: The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.

Abstract: The present invention provides rosuvastatin and intermediates thereof having a low level of alkylether impurity and processes for the preparation thereof.

Abstract: A number of slot filling-compressing members are inserted from a framework into and across a slot-shaped excavation at ahead of a frontal face of a continuous, compacted slot filling being formed along the slot, and moved with a drive means connected to the members for intermittently forcing portions of the members against the filling to compress the filling adjacent to the members longitudinally against the face. The compacted filling is in this way formed by longitudinal pressure. The members can be mounted for forward or reciprocating movement in directions along and across the face.

Abstract: The present invention concerns a method for preparing polyanilines by oxidative polymerization of aniline in an aqueous acid medium, comprising at least one synthesis step carried out in the presence of a) a monomer with formula (An) RmRo—C6H3—NHR? in which Ro, Rm and R? independently of each other, represent H or a linear or branched alkyl, alkoxy, alkylcarboxy or alkylsulfonic group, containing 1 to 6 carbon atoms, b) an acid, c) an oxidizing agent and d) a salt, characterized in that the acid is formic acid. The PANI deposited and dried on a support provides films with 80% of crystalline phase, having a strong alignment of ?-? interactions parallel to the surface. The PANI and the films obtained may be used as semiconductors and/or conductors.

Abstract: The invention is directed to the elimination of changes of the chemical composition of a pumped liquid caused by introduction of strange components or by modification of original components. Another object of the invention is to provide the possibility of use of electrodes of the first order in order to increase productivity and decrease size and cost of the micropump. For this purpose, the electrokinetic micropump comprises a multichannel structure 810 made of non-conducting material, for example, a piece of a polycapillary column. The inlet and outlet end of this structure are adjacent to electrode sections 803, 804 having openings 821, 822 for inlet and outlet of the pumped liquid. These sections are divided by ion-exchange membranes 811, 812 into chambers 813, 814 for flow of the pumped liquid, communicating with the ends 841, 842 of the multichannel structure, and chambers 815, 816 filled with an auxiliary medium for transfer of electric charges. In the latter electrodes 817, 818 are located.

Abstract: The invention relates to pharmaceutical chemistry notably to new biologically active substances (BAS) and their properties. In particular, the invention relates to Creatine derivatives having a general formula: NH?C(NH2)—N(CH3)—CH2—CO—NH—R*X, wherein R—amino acid residue of aliphatic, aromatic or heteroaromatic L-amino acid or its derivative representing a salts of amino acid, amino acid esters, amino acid amides or peptides; X—lower organic or mineral acid or water. New substances are prepared by interaction of aforesaid amides of sarcosine having a general formula of HN(CH3)—CH2—CO—NH—R*X, wherein: R is amino acid residue or substituted amino acid residue; X is low-molecular-weight organic acid or mineral acid or water, with a guanidinylating agents with the in organic solvents at temperature not exceeding 50° C. New chemical compounds can be used as a remedy possessing a neuroprotective activity.

Abstract: The present invention is directed to methods and compositions for blocking the effect of the intronic inhibitory splicing region of intron 7 of the SMN2 gene. The compositions and methods of the instant invention include short oligonucleotide reagents (e.g., oligoribonucleotides) that effectively target sites in the SMN2 pre-mRNA, thereby modulating the splicing of SMN2 pre-mRNA to include exon 7 in the processed transcript. The short target regions are 8-mers and 5-mers and also include the identification of a single nucleotide base that is essential for initiating a long distance stearic inhibitory interactions as well as novel targets distant from intron 7 which block the intronic inhibitory splicing of the same. These short target regions and concomitant inhibitory blocking oligonucleotides are less expensive and easier to manufacture and are small enough to cross the blood brain barrier.

Abstract: System and method of distribution of printed advertising informational messages when money transfers and payments is related to the sphere of electronic distribution of advertising informational materials and can be used by the systems of international and local money transfer and/or systems of payments collecting and/or technical provider which functions include save, rout, sort and distribute information among the systems of transfers and payments rendering services to the companies and individuals.

Abstract: The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.

Abstract: Subject of the present invention is an in vitro-method for classifying a foodstuff and/or beverage and/or diet and/or nutrition regimen and/or medicament in view of an effect on the cardiovascular system of a subject, comprising determining the relative level of one or more cardiovascular markers.

Abstract: Described is an electrode material which is suitable for a lithium ion accumulator and comprises a porous metal-organic framework, wherein the framework comprises lithium ions and optionally at least one further metal ion and at least one bidentate organic compound and the at least one bidentate organic compound is based on a dihydroxydicarboxylic acid which can be reversibly oxidized to a quinoid structure. Also described is a porous metalorganic framework, the use thereof and also lithium ion accumulators comprising such electrode materials.

Abstract: The invention relates to the field of medicine, namely to new biologically active compounds, particularly to 2,4,6-trimethyl-3-hydroxypyridine derivatives and salts thereof (compound 1) having antioxidant, geroprotective and anti-ischemic action. The salts of compound (1) are prepared by reacting equimolecular quantities of 2,4,6-trimethyl-3-hydroxypyridine and dicarboxylic in solution of a lower alcohol at a temperature of 60-100° C. with following treatment of the reaction mass with an organic solvent and maintaining for 2-5 h at 10-15 ° C.

Abstract: Disclosed are compositions and methods useful for labeling and detection of analytes. The compositions generally are associations of three components: reporter binding agents, amplification target circles, and DNA polymerase. The compositions are assembled prior to their use in a rolling circle amplification reaction and can be stored and transported prior to use without substantial loss of activity. The reporter binding agents generally are composed of a specific binding molecule and a rolling circle replication primer. The specific binding molecule can be specific for a target molecule. The rolling circle replication primer has sequence complementary to the amplification target circle. The DNA polymerase can interact with the rolling circle replication primer and amplification target circle. For use as a general reagent, the specific binding molecule is not bound to the target molecule until the composition is used in an assay.

Abstract: The invention provides RGD-containing cyclic peptidomimetics; conjugates of said peptidomimetics and a moiety of a payload selected from fluorescent probes, photosensitizers, chelating agents, or cytotoxic agents; and pharmaceutical compositions comprising these conjugates. The conjugates of the invention are useful both for diagnostic purposes and treatment of various diseases, disorders and conditions. More specifically, conjugates comprising fluorescent probes can be used for diagnostic purposes, e.g., visualization of organs and tissues, and diagnosis of tumors; conjugates comprising photosensitizers can be used for photodynamic therapy of both tumors and nonneoplastic tissues; conjugates comprising chelating agents can be used in radio imaging or radiotherapy; and conjugates comprising cytotoxic agents can be used for in targeted chemotherapy.

Abstract: A method is provided for producing a purine nucleoside, such as inosine and guanosine, and a method for producing a 5?-purine nucleotide such as 5?-inosinic acid or 5?-guanylic acid, using a bacterium belonging to the either genus Escherichia or genus Bacillus, wherein purine nucleoside productivity of said bacterium is enhanced by enhancing an activity of a protein encoded by the yeaS (leuE) gene.

Abstract: The invention concerns the production of filter materials for the purification and disinfection of water, water solutions and other liquids, as well as for sterilizing filtration of injections and other solutions, for concentration of biomolecules in physiological liquids, concentration and extraction of viruses, preparation of apyrogenic water, in biocatalytic diaphragm reactors. The invention solves the problems of a new filter material production, characterized by high sorption properties, high retention efficiency of submicron electronegative particles, microorganisms, submicron non-polar particles and chemical contaminations, and, at the same time, characterized by low hydrodynamic resistance. A base of filter material is the nonwoven organic synthetic polymeric fabric, modified by the aluminum hydroxide particles, fixed to the surface of base fibers for improvement of its sorption properties and for making it positively charged.

Abstract: The present invention provides nucleotide sequences encoding an insecticidal protein exhibiting lepidopteran inhibitory activity, as well as a novel insecticidal protein referred to herein as a Cry1A.105 insecticide, transgenic plants expressing the insecticide, and methods for detecting the presence of the nucleotide sequences or the insecticide in a biological sample.