Patents by Inventor Natalia AN

Natalia AN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7892787
    Abstract: A method of producing somatotropin encompassing the microbiological expression of a recombinant protein containing somatotropin and hybrid polypeptide containing the amino-acid sequence of ubiquitin and the amino-acid sequence of somatotropin.
    Type: Grant
    Filed: July 7, 2006
    Date of Patent: February 22, 2011
    Assignee: Instytut Biotechnologii I Antybiotykow
    Inventors: Andrzej Plucienniczak, Maria Ludwika Smorawinska, Renata Wolinowska, Diana Mikiewicz-Sygula, Iwona Sokolowska, Natalia Lukasiewicz, Luiza Chojnacka, Grazyna Plucienniczak, Jolanta Kuthan-Styczen, Krystyna Strzezek, Alina Marciniak-Rusek, Anna Kruszynska, Anna Wojtowicz, Anna Mazurkiewicz-Pisarek, Ewa Wojcik
  • Publication number: 20110033498
    Abstract: Viruses having an impaired ability to deISGylate ISG15 conjugates, in particular, viral mutants comprising a mutation in the viral genome that reduces or eliminates the ability of the viral OTU domain-containing protein encoded by the viral genome to deISGylate ISG15 conjugates and/or deubiquitinate ubiquitinated proteins and/or deNeddylate Neddylated proteins are disclosed. Such viral mutants may be used in the formulation of immunogenic compositions for inducing an immune response and preventing, managing and/or treating a viral infection. Also disclosed are methods for identifying anti-viral compounds, in particular, methods of identifying compounds that reduce or inhibit the deISGylation activity and/or deubiquitination and/or deNeddylation activity of a viral OTU domain-containing protein. The compounds identified using such methods may be used as antiviral agents for the prevention, treatment and/or management of viral infections.
    Type: Application
    Filed: April 7, 2008
    Publication date: February 10, 2011
    Inventors: Adolfo Garcia-Sastre, Natalia Frias-Staheli, Herbert W. Virgin, Nadia Giannakopoulos
  • Publication number: 20110033383
    Abstract: Provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing pattern recognition receptor activity, and CD40 activity. Also provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing CD40 activity without prostaglandin E2. Also provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing an inducible chimeric molecule comprising a region of a pattern recognition receptor or an adaptor thereof.
    Type: Application
    Filed: October 19, 2007
    Publication date: February 10, 2011
    Inventors: David Spencer, Natalia Lepteva
  • Publication number: 20110023313
    Abstract: A hanger locator for identifying the proper location for a hanger on a wall may include a first arm and a second arm extending from a central body. The central body may include a marker and/or a hook for engaging a suspension device. In some exemplary embodiments, the arms may include elastic bands. In some exemplary embodiments, the arms may include cords, and the central body may include a retractor coupled to the cords.
    Type: Application
    Filed: July 29, 2009
    Publication date: February 3, 2011
    Inventors: Natalia Johnson, Christian Scott Leyden, Robin E. Smith, Jackie Grant
  • Patent number: 7879221
    Abstract: The present invention relates to a process for preparing a porous metal organic framework comprising at least two organic compounds coordinated to at least one metal ion, which comprises the steps (a) oxidation of at least one anode comprising the metal corresponding to at least one metal ion in a reaction medium in the presence of at least one first organic compound which is an optionally substituted monocyclic, bicyclic or polycyclic saturated or unsaturated hydrocarbon in which at least two ring carbons have been replaced by heteroatoms selected from the group consisting of N, O and S to form a reaction intermediate comprising the at least one metal ion and the first organic compound; and (b) reaction of the reaction intermediate at a prescribed temperature with at least one second organic compound which coordinates to the at least one metal ion, with the second organic compound being derived from a dicarboxylic, tricarboxylic or tetracarboxylic acid.
    Type: Grant
    Filed: May 11, 2007
    Date of Patent: February 1, 2011
    Assignee: BASF SE
    Inventors: Hermann Pütter, Markus Schubert, Ingo Richter, Ulrich Müller, Natalia Trukhan
  • Patent number: 7879988
    Abstract: The present invention provides nucleic acid compositions encoding a novel colorless GFP-like protein, acGFP, from Aequorea coerulscens and fluorescent and non-fluorescent mutants and derivatives thereof, as well as peptides and proteins encoded by these nucleic acid compositions. The subject protein and nucleic acid compositions of the present invention are colored and/or fluorescent and/or can be photoactivated, and can be used in a variety of different biological applications, particularly for labeling. Finally, kits for use in such biological applications are provided.
    Type: Grant
    Filed: August 28, 2008
    Date of Patent: February 1, 2011
    Assignee: Evrogen, IP
    Inventors: Nadejda G. Gurskaya, Arkadiy F. Fradkov, Sergey A. Lukyanov, Natalia I. Punkova
  • Publication number: 20110009977
    Abstract: A hip prosthesis is provided for insertion into a femur. In one exemplary embodiment, the hip prosthesis includes a stem having a proximal end, a distal end, and a longitudinal axis. This stem may include anterior and posterior locking surfaces which diverge away from the longitudinal axis. A shank portion may extend distally from the anterior and posterior locking surfaces and converge at an angle distally toward the longitudinal axis.
    Type: Application
    Filed: September 13, 2010
    Publication date: January 13, 2011
    Applicant: ZIMMER, INC.
    Inventors: Natalia Fridshtand, Douglas W. Gabel, Steven J. Charlebois, David L. Glass, Steven Zawadzki, Jeffrey P. Matney
  • Patent number: 7868169
    Abstract: Provided is a crystalline rosuvastatin intermediate and processes for preparation thereof.
    Type: Grant
    Filed: August 16, 2006
    Date of Patent: January 11, 2011
    Assignee: Teva Pharmaceutical Industries, Ltd.
    Inventors: Valerie Niddam-Hildesheim, Natalia Shenkar, Shlomit Wizel
  • Publication number: 20100330622
    Abstract: A method for manufacturing a product of a reaction catalyzed by a protein having 2-oxoglutarate-dependent enzyme activity such as (2S,3R,4S)-4-hydroxy-L-isoleucine or a salt thereof using a bacterium transformed with a DNA fragment containing a gene coding for a protein having 2-oxoglutarate-dependent enzyme activity such as L-isoleucine dioxygenase activity; and wherein said bacterium has the ability to produce a product such as (2S,3R,4S)-4-hydroxy-L-isoleucine.
    Type: Application
    Filed: June 21, 2010
    Publication date: December 30, 2010
    Inventors: Sergey Vasilievich Smirnov, Natalia Nikolaevna Samsonova, Veronika Aleksandrovna Kotliarova, Natalia Yurievna Rushkevich, Olga Sergeevna Beznoschenko, Tatyana Aleksandrovna Bachina, Yuki Imabayashi, Masakazu Sugiyama, Shunichi Suzuki
  • Patent number: 7858641
    Abstract: A variety of low molecular weight, guanidino-containing dihydroisoquinolinoines capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases. The compounds have the structure ID where the values of the variable are defined herein.
    Type: Grant
    Filed: October 11, 2005
    Date of Patent: December 28, 2010
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: Rustum S. Boyce, Natalia Aurrecoechea, Daniel Chu, Aaron Smith, Bryan Chang
  • Patent number: 7858377
    Abstract: A method is described for preparing a mixture for quality control of 0.1 g glycine tablets for sublingual application. The mixture for quality control includes a 100:1 ratio of water to porphyrized tablets, each tablet containing 0.101 g microcapsules of non-agglomerated crystals of amino-acetic acid covered with polymeric film of water-soluble methylcellulose, each tablet further comprising 0.001 g magnesium stearate. The process of dissolution takes 20 minutes and is carried out at a temperature of 37° C. in an apparatus using a paddle rotation speed of 150 revolutions per minute. After the mixture is dissolved, it is allowed to stand for 10 minutes, then a light transmission coefficient is measured at 700±2 nm for a 10 mm thick layer of the mixture. A transmission value within the range of 50% to 70% compared to purified water corresponds to the proper quality.
    Type: Grant
    Filed: December 15, 2006
    Date of Patent: December 28, 2010
    Assignee: Nekommercheskoe Uchrezhdenie “Nauchno-Issledovateljskiyj Institut Citokhimii I Molekulyarnoyj Farmakologii”
    Inventors: Irina Alekseevna Komissarova, Tatyana Dmitrievna Soldatenkova, Yulia Vasilievna Gudkova, Tatyana Tikhonovna Kondrashova, Natalia Mikhaylovna Burbenskaya
  • Patent number: 7858631
    Abstract: A variety of low molecular weight, guanidino-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases. The compounds have the structure of Formulas (IA), (IB), or (IC): where the values of the variable are defined herein.
    Type: Grant
    Filed: May 23, 2003
    Date of Patent: December 28, 2010
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: Rustum S. Boyce, Natalia Aurrecoechea, Daniel Chu, Aaron Smith, Bryan Chang
  • Publication number: 20100321633
    Abstract: The invention provides a progressive ophthalmic lens suitable to be worn by a person engaged in a sporting activity. For this purpose the lens has a far vision region which is enlarged, and a peripheral field of vision which is separated and whose mean sphere gradients are gentle. When a progressive lens of this kind is allocated to a wearer, the lens can have an addition value that is approximately equal to a prescribed value, or an addition value that is less than the prescribed value.
    Type: Application
    Filed: December 9, 2008
    Publication date: December 23, 2010
    Applicant: Essilor Intenational (compagnie Generale D'optique
    Inventors: Helene De Rossi, Natalia Dobrescu, Sara Marie
  • Publication number: 20100323957
    Abstract: The invention provides methods and compositions for screening for modulators of EGFR activity. In particular, an assay for such modulators is provided, which includes methods of screening for modulators using models of the three dimensional structure of EGFR kinase domains.
    Type: Application
    Filed: November 19, 2008
    Publication date: December 23, 2010
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA THE OFFICE OF THE PRESIDENT
    Inventors: John Kuriyan, Xuewu Zhang, Natalia Jura
  • Publication number: 20100323409
    Abstract: A method for manufacturing (2S,3R,4S)-4-hydroxy-L-isoleucine or a salt thereof using an L-isoleucine-producing bacterium transformed with a DNA fragment containing a gene coding for a protein having L-isoleucine dioxygenase activity; and having the ability to produce (2S,3R,4S)-4-hydroxy-L-isoleucine.
    Type: Application
    Filed: June 21, 2010
    Publication date: December 23, 2010
    Inventors: Sergey Vasilievich Smirnov, Natalia Nikolaevna Samsonova, Veronika Aleksandrovna Kotliarova, Natalia Yurievna Rushkevich, Olga Sergeevna Beznoschenko
  • Patent number: 7855255
    Abstract: Disclosed is a polyethylene composition. The composition comprises single-site multimodal resin A and single-site multimodal resin B, wherein resin A differs from resin B in molecular weight, in monomeric composition, in density, in long chain branch concentration or distribution, or in combinations thereof. Disclosed is also a method for making the polyethylene composition. The method comprises polymerizing, in the presence of two or more single-site catalysts, ethylene or its mixture with a C3-C10 ?-olefin to form a first multimodal resin and continuing the polymerization in the presence of the same catalysts but in a different hydrogen concentration, in a different monomer composition, or at a different temperature to form a second multimodal resin.
    Type: Grant
    Filed: December 4, 2008
    Date of Patent: December 21, 2010
    Assignee: Equistar Chemicals, LP
    Inventors: Venki Chandrashekar, Mark P. Mack, Charles H. Gates, Jr., Charles S. Holland, Natalia Nagy, Sandor M. Nagy, Edward S. Vargas, Jean A. Merrick-Mack
  • Publication number: 20100311645
    Abstract: The Present invention relates to molecules isolated from the nucleic acid that encodes spider web proteins or fragments of these or other derivatives of these. The invention also refers to a chimerical gene and an expression vector containing molecules isolated from the nucleic acid that codes for proteins related to the webs of Nephilengys, Cruentata, Avicularia Juruensis and Parawixia Bistriata spiders. Another embodiment of the present invention are transformed cells containing a chimerical gene or an expression vector of the present invention. Yet another embodiment of the present invention relates to a method for obtaining genetically modified organisms containing inventive chimerical genes or expression vectors and a method for obtaining recombinant proteins from the silks of Nephilengys, Cruentata, Aviculana Juruensis and Parawixia Bistriata spiders. Finally, the invention describes products, such as biofilaments and compositions, using the recombinant proteins of the present invention.
    Type: Application
    Filed: March 13, 2008
    Publication date: December 9, 2010
    Applicants: Empresa Brasileira de Pesquisa Agropecuaria- EMBRAPA, Fundacao Universidade de Brasilia
    Inventors: Elibio Leopoldo Rech Filho, Natalia Cristina Verza Ferreira, Giovanni Rodrigues Vianna, Felipe Rodrigues Da Silva, Francisco Jose Lima Aragao, Luiz Alberto Colnago, Alan Carvalho Andrade, Daniela Matias De Carvalho Bittencourt, Pedro Ismael Da Silva Junior, Betulia De Morais Souto, Luisa De Moraes Madeira, Paulo Cesar Motta
  • Publication number: 20100308583
    Abstract: A floatable surface vessel comprises a vessel hull having a circular sector-shaped cross-section and a ballast filling with a controllable position of a centre of mass disposed remote from the circular centre and adapted to come into resonance with rocking action of water waves being induced a rocking motion of the hull about the circular centre and a frame being supported on the hull for rotation about the circular centre to be isolated from the rocking.
    Type: Application
    Filed: June 28, 2010
    Publication date: December 9, 2010
    Inventors: Vladimir Anatol Shreider, Natalia Shreider
  • Publication number: 20100303868
    Abstract: The present invention relates to an ex vivo, fast and efficient process to obtain activated antigen-presenting cells that are useful for therapies against cancer and immune system-related diseases. At the same time, it is related to a cellular composition that contributes to stimulate the activated antigen-presenting cells to induce a specific immune response against tumors in patients with cancer or other pathologies involving immune responses.
    Type: Application
    Filed: September 26, 2008
    Publication date: December 2, 2010
    Applicants: UNIVERSIDAD DE CHILE, ONCOBIOMED
    Inventors: Flavio Andrés Salazar Onfray, Mercedes Natalia López Nitsche, Cristián Javier Pereda Ramos, Raquel Elvira Aguilera Insunza, Alejandro Felipe Escobar Álvarez
  • Publication number: 20100303762
    Abstract: Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include novel amino acid sequences, and variants and fragments thereof, for antipathogenic polypeptides that were isolated from microbial fermentation broths. Nucleic acid molecules comprising nucleotide sequences that encode the antipathogenic polypeptides of the invention are also provided. A method for inducing pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant an expression cassette comprising a promoter operably linked to a nucleotide sequence that encodes an antipathogenic polypeptide of the invention. Compositions comprising an antipathogenic polypeptide or a transformed microorganism comprising a nucleic acid of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided.
    Type: Application
    Filed: June 8, 2010
    Publication date: December 2, 2010
    Applicants: Pioneer Hi-Bred International, Inc., E.I. du Pont de Nemours and Company, The Regents of the University of California
    Inventors: Daniel J. Altier, Glen Dahlbacka, Irina Ellanskaya, Natalia Ellanskaya, Rafael Herrmann, Jennie Hunter-Cevera, Billy F. McCutchen, James K. Presnail, Janet A. Rice, Eric Schepers, Carl R. Simmons, Tamas Torok, Nasser Yalpani