Patents by Inventor Natarajan Raju

Natarajan Raju has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240216900
    Abstract: Disclosed are perfluorinated SABRE catalysts comprising a d-block element and a perfluorinated ligand, wherein the perfluorinated ligand is of Formula (I): [Lm-(NHC)—(Y—Z)q] or a salt thereof. Also disclosed is a method of preparing a hyperpolarized substrate comprising a ½ spin nucleus or nuclei using the perfluorinated SABRE catalysts, and isolating the resulting hyperpolarized substrate for administration to an animal. Further disclosed is a method of imaging a tissue of an animal suspected of having a disease or condition.
    Type: Application
    Filed: January 11, 2024
    Publication date: July 4, 2024
    Applicant: The U.S.A., as represented by the Secretary, Department of Health and Human Services
    Inventors: Rolf E. Swenson, Jessica H. Ettedgui-Benjamini, Carolyn Woodroofe Hitko, Murali K. Cherukuri, Natarajan Raju
  • Publication number: 20210079225
    Abstract: The present disclosure provides reactive quencher dyes that can be used in the detection and/or quantification of desirable target molecules, such as proteins, nucleic acids and various cellular organelles. These dyes are essentially non-fluorescent but are efficient quenchers of various fluorescent dyes. Also, provided are methods of using the dyes, bio-probes incorporating dyes and methods of using the bio-probes. The quencher dyes described herein are modified to provide beneficial properties.
    Type: Application
    Filed: November 2, 2020
    Publication date: March 18, 2021
    Applicant: Enzo Biochem, Inc.
    Inventors: Zaiguo Li, Praveen Pande, Natarajan Raju
  • Patent number: 10865309
    Abstract: The present disclosure provides reactive quencher dyes that can be used in the detection and/or quantification of desirable target molecules, such as proteins, nucleic acids and various cellular organelles. These dyes are essentially non-fluorescent but are efficient quenchers of various fluorescent dyes. Also, provided are methods of using the dyes, bio-probes incorporating dyes and methods of using the bio-probes. The quencher dyes described herein are modified to provide beneficial properties.
    Type: Grant
    Filed: October 6, 2018
    Date of Patent: December 15, 2020
    Assignee: Enzo Biochem, Inc.
    Inventors: Zaiguo Li, Praveen Pande, Natarajan Raju
  • Patent number: 10683257
    Abstract: The invention provides methods for synthesizing the compound (2R,3S,4E)-N-methyl-5-(4?-pentylphenyl)-2-aminopent-4-ene-1,3-diol, also known as SK1-I, and intermediate compounds used in its synthesis.
    Type: Grant
    Filed: May 13, 2019
    Date of Patent: June 16, 2020
    Assignee: Enzo Biochem, Inc.
    Inventors: Zaiguo Li, Natarajan Raju, Praveen Pande
  • Publication number: 20200131113
    Abstract: The invention provides methods for synthesizing the compound (2R,3S,4E)-N-methyl-5-(4?-pentylphenyl)-2-aminopent-4-ene-1,3-diol, also known as SK1-I, and intermediate compounds used in its synthesis.
    Type: Application
    Filed: May 13, 2019
    Publication date: April 30, 2020
    Applicant: Enzo Biochem, Inc.
    Inventors: Zaiguo Li, Natarajan Raju, Praveen Pande
  • Publication number: 20190256453
    Abstract: The invention provides methods for synthesizing the compound (2R,3S,4E)-N-methyl-5-(4?-pentylphenyl)-2-aminopent-4-ene-1,3-diol, also known as SK1-I, and intermediate compounds used in its synthesis.
    Type: Application
    Filed: October 24, 2018
    Publication date: August 22, 2019
    Applicant: Enzo Biochem, Inc.
    Inventors: Zaiguo Li, Natarajan Raju, Praveen Pande
  • Patent number: 10364211
    Abstract: The invention provides methods for synthesizing the compound (2R,3S,4E)-N-methyl-5-(4?-pentylphenyl)-2-aminopent-4-ene-1,3-diol, also known as SK1-I, and intermediate compounds used in its synthesis.
    Type: Grant
    Filed: October 24, 2018
    Date of Patent: July 30, 2019
    Assignee: Enzo Biochem, Inc.
    Inventors: Zaiguo Li, Natarajan Raju, Praveen Pande
  • Publication number: 20190062560
    Abstract: The present disclosure provides reactive quencher dyes that can be used in the detection and/or quantification of desirable target molecules, such as proteins, nucleic acids and various cellular organelles. These dyes are essentially non-fluorescent but are efficient quenchers of various fluorescent dyes. Also, provided are methods of using the dyes, bio-probes incorporating dyes and methods of using the bio-probes. The quencher dyes described herein are modified to provide beneficial properties.
    Type: Application
    Filed: October 6, 2018
    Publication date: February 28, 2019
    Applicant: Enzo Biochem, Inc.
    Inventors: Zaiguo Li, Praveen Pande, Natarajan Raju
  • Patent number: 10131789
    Abstract: The present disclosure provides reactive quencher dyes that can be used in the detection and/or quantification of desirable target molecules, such as proteins, nucleic acids and various cellular organelles. These dyes are essentially non-fluorescent but are efficient quenchers of various fluorescent dyes. Also, provided are methods of using the dyes, bio-probes incorporating dyes and methods of using the bio-probes. The quencher dyes described herein are modified to provide beneficial properties.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: November 20, 2018
    Assignee: Enzo Biochem, Inc.
    Inventors: Zaiguo Li, Praveen Pande, Natarajan Raju
  • Publication number: 20180215920
    Abstract: The present disclosure provides reactive quencher dyes that can be used in the detection and/or quantification of desirable target molecules, such as proteins, nucleic acids and various cellular organelles. These dyes are essentially non-fluorescent but are efficient quenchers of various fluorescent dyes. Also, provided are methods of using the dyes, bio-probes incorporating dyes and methods of using the bio-probes. The quencher dyes described herein are modified to provide beneficial properties.
    Type: Application
    Filed: March 22, 2018
    Publication date: August 2, 2018
    Applicant: ENZO BIOCHEM, INC.
    Inventors: ZAIGUO LI, PRAVEEN PANDE, NATARAJAN RAJU
  • Patent number: 9957393
    Abstract: The present disclosure provides reactive quencher dyes that can be used in the detection and/or quantification of desirable target molecules, such as proteins, nucleic acids and various cellular organelles. These dyes are essentially non-fluorescent but are efficient quenchers of various fluorescent dyes. Also, provided are methods of using the dyes, bio-probes incorporating dyes and methods of using the bio-probes. The quencher dyes described herein are modified to provide beneficial properties.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: May 1, 2018
    Assignee: Enzo Biochem, Inc.
    Inventors: Zaiguo Li, Praveen Pande, Natarajan Raju
  • Patent number: 9951227
    Abstract: The present disclosure provides reactive quencher dyes that can be used in the detection and/or quantification of desirable target molecules, such as proteins, nucleic acids and various cellular organelles. These dyes are essentially non-fluorescent but are efficient quenchers of various fluorescent dyes. Also, provided are methods of using the dyes, bio-probes incorporating dyes and methods of using the bio-probes. The quencher dyes described herein are modified to provide beneficial properties.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: April 24, 2018
    Assignee: Enzo Biochem, Inc.
    Inventors: Zaiguo Li, Praveen Pande, Natarajan Raju
  • Publication number: 20170369954
    Abstract: The present disclosure provides reactive quencher dyes that can be used in the detection and/or quantification of desirable target molecules, such as proteins, nucleic acids and various cellular organelles. These dyes are essentially non-fluorescent but are efficient quenchers of various fluorescent dyes. Also, provided are methods of using the dyes, bio-probes incorporating dyes and methods of using the bio-probes. The quencher dyes described herein are modified to provide beneficial properties.
    Type: Application
    Filed: September 7, 2017
    Publication date: December 28, 2017
    Applicant: Enzo Biochem, Inc.
    Inventors: Zaiguo Li, Praveen Pande, Natarajan Raju
  • Publication number: 20160289779
    Abstract: The present disclosure provides reactive quencher dyes that can be used in the detection and/or quantification of desirable target molecules, such as proteins, nucleic acids and various cellular organelles. These dyes are essentially non-fluorescent but are efficient quenchers of various fluorescent dyes. Also, provided are methods of using the dyes, bio-probes incorporating dyes and methods of using the bio-probes. The quencher dyes described herein are modified to provide beneficial properties.
    Type: Application
    Filed: March 30, 2015
    Publication date: October 6, 2016
    Applicant: Enzo Biochem, Inc.
    Inventors: ZAIGUO LI, PRAVEEN PANDE, NATARAJAN RAJU
  • Patent number: 8444954
    Abstract: New and improved compounds for use in diagnostic imaging or therapy having the formula M-N—O—P-G, wherein M is a metal chelator having the structure: wherein R1-R5 and FG are as defined herein (in the form complexed with a metal radionuclide or not), N—O—P is the linker containing at least one non-alpha amino acid with a cyclic group, at least one substituted bile acid or at least one non-alpha amino acid, and G is the GRP receptor targeting peptide. In the preferred embodiment, M is an Aazta metal chelator or a derivative thereof. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound is further provided. Methods and kits for preparing a radiotherapeutic agent are further provided.
    Type: Grant
    Filed: December 2, 2010
    Date of Patent: May 21, 2013
    Assignee: Bracco Imaging S.p.A.
    Inventors: Enrico Cappelletti, Luciano Lattuada, Karen E. Linder, Edmund Marinelli, Palaniappa Nanjappan, Adrian Nunn, Natarajan Raju, Kondareddiar Ramalingam, Rolf E. Swenson, Michael Tweedle
  • Patent number: 8420050
    Abstract: Novel methods of treating prostate tumors or of delaying the progression of prostate tumors are also provided, including, methods of treating bone or soft tissue metastases of prostate cancer methods for treating hormone sensitive and hormone refractory prostate cancer, methods for delaying the progression of hormone sensitive prostate cancer, for facilitating combination therapy in patients with hormone sensitive prostate cancer and for decreasing aberrant vascular permeability in patients with hormone sensitive prostate cancer, said methods comprising the step of administering to a subject a dose comprising an amount of radioactively labeled L70, N-[4-[[[[[4,7,10-Tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]amino]acetyl]amino]benzoyl]-L-glutaminyl-L-tryptophyl-L-alanyl-L-valyl-glycyl-L-histidyl-L-leucyl-L-methioninamide.
    Type: Grant
    Filed: June 11, 2008
    Date of Patent: April 16, 2013
    Assignee: Bracco Imaging S.p.A.
    Inventors: Enrico Cappelletti, Luciano Lattuada, Karen E. Linder, Edmund R. Marinelli, Palaniappa Nanjappan, Adrian D. Nunn, Natarajan Raju, Kondareddiar Ramalingam, Rolf E. Swenson, Michael F. Tweedle, Mary Ellen Maddalena
  • Patent number: 8420053
    Abstract: Improved compounds for use in diagnostic imaging or therapy having the formula M-N-O-P-G, wherein M is an optical label or a metal chelator (in the form complexed with a metal radionuclide or not), N-O-P is the linker, and G is the GRP receptor targeting peptide. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound are further provided. Methods and kits for preparing a radiotherapeutic agent are further provided.
    Type: Grant
    Filed: August 31, 2009
    Date of Patent: April 16, 2013
    Assignee: Bracco Imaging S.p.A.
    Inventors: Enrico Cappelletti, Luciano Lattuada, Karen E. Linder, Edmund Marinelli, Palaniappa Nanjappan, Natarajan Raju, Kondareddiar Ramalingam, Rolf E. Swenson, Michael Tweedle
  • Patent number: 8414864
    Abstract: New and improved compounds for use in radiodiagnostic imaging or radiotherapy having the formula M-N—O—P-G, wherein M is the metal chelator (in the form complexed with a metal radionuclide or not), N—O—P is the linker, and G is the GRP receptor targeting peptide. Methods for imaging a patient and/or providing radiotherapy to a patient using the compounds of the invention are also provided. A method for preparing a diagnostic imaging agent from the compound is further provided. A method for preparing a radiotherapeutic agent is further provided.
    Type: Grant
    Filed: August 25, 2006
    Date of Patent: April 9, 2013
    Assignee: Bracco Imaging S.p.A.
    Inventors: Enrico Cappelletti, Luciano Lattuada, Karen E. Linder, Edmund R. Marinelli, Palaniappa Nanjappan, Natarajan Raju, Rolf E. Swenson, Michael Tweedle
  • Publication number: 20120315220
    Abstract: The present invention provides compounds for targeting endothelial cells, tumor cells or other cells that express the NP-1 receptor, compositions containing the same and methods for their use. Additionally, the present invention includes diagnostic, therapeutic and radiotherapeutic compositions useful for visualization, therapy or radiotherapy.
    Type: Application
    Filed: April 12, 2012
    Publication date: December 13, 2012
    Applicant: Bracco Suisse S.A.
    Inventors: Mathew A. Von Wronski, Edmund R. Marinelli, Adrian D. Nunn, Radhakrishna Pillai, Kondareddiar Ramalingam, Michael F. Tweedle, Karen E. Linder, Palaniappa Nanjappan, Natarajan Raju
  • Patent number: 8263739
    Abstract: The present invention provides compounds for targeting endothelial cells, tumor cells or other cells that express the NP-1 receptor, compositions containing the same and methods for their use. Additionally, the present invention includes diagnostic, therapeutic and radiotherapeutic compositions useful for visualization, therapy or radiotherapy.
    Type: Grant
    Filed: January 27, 2006
    Date of Patent: September 11, 2012
    Assignee: Bracco Suisse SA
    Inventors: Mathew A. Von Wronski, Edmund R. Marinelli, Adrian Nunn, Radhakrishna Pillai, Kondareddiar Ramalingam, Michael F. Tweedle, Karen E. Linder, Palaniappa Nanjappan, Natarajan Raju