Patents by Inventor Natarajan Raju

Natarajan Raju has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20060153775
    Abstract: The present invention provides compounds for targeting endothelial cells, tumor cells or other cells that express the NP-1 receptor, compositions containing the same and methods for their use. Additionally, the present invention includes diagnostic, therapeutic and radiotherapeutic compositions useful for visualization, therapy or radiotherapy.
    Type: Application
    Filed: January 27, 2006
    Publication date: July 13, 2006
    Applicant: Bracco International B.V.
    Inventors: Mathew Von Wronski, Edmund Marinelli, Adrian Nunn, Radhakrishna Pillai, Kondareddiar Ramalingam, Michael Tweedle, Karen Linder, Palaniappa Nanjappan, Natarajan Raju
  • Publication number: 20060018830
    Abstract: New and improved compounds for use in diagnostic imaging or therapy having the formula M-N—O—P-G, wherein M is a metal chelator having the structure: wherein R1-R5 and FG are as defined herein (in the form complexed with a metal radionuclide or not), N—O—P is the linker containing at least one non-alpha amino acid with a cyclic group, at least one substituted bile acid or at least one non-alpha amino acid, and G is the GRP receptor targeting peptide. In the preferred embodiment, M is an Aazta metal chelator or a derivative thereof. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound is further provided. Methods and kits for preparing a radiotherapeutic agent are further provided.
    Type: Application
    Filed: June 24, 2005
    Publication date: January 26, 2006
    Applicant: Bracco Imaging S.p.A.
    Inventors: Enrico Cappelletti, Luciano Lattuada, Karen Linder, Edmund Marinelli, Palaniappa Nanjappan, Natarajan Raju, Kondareddiar Ramalingam, Rolf Swenson, Michael Tweedle
  • Publication number: 20040253225
    Abstract: New and improved compounds for use in diagnostic imaging or therapy having the formula M-N—O—P-G, wherein M is an optical label or a metal chelator (in the form complexed with a metal radionuclide or not), N—O—P is the linker, and G is the GRP receptor targeting peptide. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound is further provided. Methods and kits for preparing a radiotherapeutic agent are further provided.
    Type: Application
    Filed: April 20, 2004
    Publication date: December 16, 2004
    Inventors: Enrico Cappelleti, Luciano Lattuada, Karen E. Linder, Edmund Marinelli, Palaniappa Nanjappan, Natarajan Raju, Kondareddiar Ramalingam, Rolf E. Swenson, Michael Tweedle
  • Publication number: 20040136906
    Abstract: New and improved compounds for use in radiodiagnostic imaging or radiotherapy having the formula M-N—O—P-G, wherein M is the metal chelator (in the form complexed with a metal radionuclide or not), N—O—P is the linker, and G is the GRP receptor targeting peptide. Methods for imaging a patient and/or providing radiotherapy to a patient using the compounds of the invention are also provided. A method for preparing a diagnostic imaging agent from the compound is further provided. A method for preparing a radiotherapeutic agent is further provided.
    Type: Application
    Filed: January 13, 2003
    Publication date: July 15, 2004
    Inventors: Enrico Cappelletti, Luciano Lattuada, Karen E. Linder, Ed Marinelli, Palaniappa Nanjappan, Natarajan Raju, Rolf E. Swenson, Michael Tweedle
  • Publication number: 20020147136
    Abstract: The present invention provides compounds for targeting endothelial cells, tumor cells or other cells that express the NP-1 receptor, compositions containing the same and methods for their use. Additionally, the present invention includes diagnostic, therapeutic and radiotherapeutic compositions useful for visualization, therapy or radiotherapy.
    Type: Application
    Filed: June 4, 2001
    Publication date: October 10, 2002
    Inventors: Mathew A. Von Wronski, Edmund R. Marinelli, Adrian D. Nunn, Radhakrishna Pillai, Kondareddiar Ramalingam, Michael F. Tweedle, Karen Linder, Palaniappa Nanjappan, Natarajan Raju
  • Publication number: 20010004454
    Abstract: Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the &agr;, &ggr;, or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.
    Type: Application
    Filed: December 30, 2000
    Publication date: June 21, 2001
    Inventors: Paul W. Wedeking, Ruth E. Wager, Thangavel Arunachalam, Kondareddiar Ramalingam, Karen E. Linder, Ramachandran S. Ranganathan, Adrian D. Nunn, Natarajan Raju, Michael F. Tweedle
  • Patent number: 6221334
    Abstract: Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the &agr;, &ggr;, or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.
    Type: Grant
    Filed: January 3, 2000
    Date of Patent: April 24, 2001
    Assignee: Bracco Research USA, Inc.
    Inventors: Paul W. Wedeking, Ruth E. Wager, Thangavel Arunachalam, Kondareddiar Ramalingam, Karen E. Linder, Ramachandran S. Ranganathan, Adrian D. Nunn, Natarajan Raju, Michael F. Tweedle
  • Patent number: 6093382
    Abstract: Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the .alpha., .gamma., or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.
    Type: Grant
    Filed: May 16, 1998
    Date of Patent: July 25, 2000
    Assignee: Bracco Research USA Inc.
    Inventors: Paul W. Wedeking, Ruth E. Wager, Thangavel Arunachalam, Kondareddiar Ramalingam, Karen E. Linder, Ramachandran S. Ranganathan, Adrian D. Nunn, Natarajan Raju, Michael F. Tweedle
  • Patent number: 5907036
    Abstract: Novel procedures for obtaining ribo-C-nucleosides, including especially 2-.beta.-D-ribofuranosylthiazole-4-carboxylamide (tiazofirin) and 2-.beta.-D-ribofuranosylselenazole-4-carboxylamide (sylenazofurin) and synthesis intermediates thereof. The novel procedures involve introducing a cyano group at the 1' position of a ribose, directly or indirectly converting the cyano group to HN.dbd.C--OR.sub.1 or thicarboxylamide wherein R.sub.1 is a lower alkyl, forming the group which substituted for the cyano group into a heterocyclic ring containing an ester, and converting the ester into an amide.
    Type: Grant
    Filed: February 20, 1996
    Date of Patent: May 25, 1999
    Assignee: ICN Pharmaceuticals, Inc.
    Inventors: Kandasamy Ramasamy, Arthur F Lewis, Roland K Robins, deceased, Natarajan Raju, Ramesh Bharadwaj, Vjera Pejanovic
  • Patent number: 5741912
    Abstract: Novel compounds containing a heteroatom-bearing bridge and novel complexes of these compounds with metals. The novel compounds and complexes are useful in diagnostic and therapeutic methods.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: April 21, 1998
    Assignee: Bracco International B.V.
    Inventors: Kondareddiar Ramalingam, Natarajan Raju
  • Patent number: 5665329
    Abstract: Novel compounds containing a heteroatom-bearing bridge and novel complexes of these compounds with metals. The novel compounds and complexes are useful in diagnostic and therapeutic methods.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: September 9, 1997
    Assignee: Bracco International B.V.
    Inventors: Kondareddiar Ramalingam, Natarajan Raju
  • Patent number: 5656254
    Abstract: Novel compounds containing a heteroatom-bearing bridge and novel complexes of these compounds with metals. The novel compounds and complexes are useful in diagnostic and therapeutic methods.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: August 12, 1997
    Assignee: Bracco International B.V.
    Inventors: Kondareddiar Ramalingam, Natarajan Raju
  • Patent number: 5627286
    Abstract: Novel compounds containing a heteroatom-bearing bridge and novel complexes of these compounds with metals. The novel compounds and complexes are useful in diagnostic and therapeutic methods.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: May 6, 1997
    Assignee: Bracco International B.V.
    Inventors: Kondareddiar Ramalingam, Natarajan Raju
  • Patent number: 5608110
    Abstract: Novel compounds containing a heteroatom-bearing bridge and novel complexes of these compounds with metals. The novel compounds and complexes are useful in diagnostic and therapeutic methods.
    Type: Grant
    Filed: May 18, 1994
    Date of Patent: March 4, 1997
    Assignee: Bracco International B.V.
    Inventors: Kondareddiar Ramalingam, Natarajan Raju