Patents by Inventor Nathalie Scholler

Nathalie Scholler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10266580
    Abstract: The invention provides compositions and methods for adoptive T cell therapy in treating a variety of disorders including cancer, infections, and autoimmune disorders. In one embodiment, the invention provides a universal immune receptor (UnivIR) that comprises an extracellular label binding domain, a transmembrane domain, and a cytoplasmic domain or otherwise an intracellular domain.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: April 23, 2019
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Nathalie Scholler, Katarzyna Urbanska, Daniel J. Powell, Jr.
  • Patent number: 10259849
    Abstract: The present invention relates to B7-H4-specific compositions and methods of use thereof.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: April 16, 2019
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Nathalie Scholler, Denarda Dangaj, Aizhi Zhao, Daniel J. Powell
  • Patent number: 10160809
    Abstract: The invention relates to Anti-TEM 1 antibodies or antigen-binding fragments thereof, yeast libraries comprising the same, and prophylactic, diagnostic, and therapeutic methods using the same.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: December 25, 2018
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Nathalie Scholler, Aizhi Zhao, Donald Siegel, George Coukos
  • Publication number: 20180002439
    Abstract: The present disclosure provides isolated nanobodies based on camelid VHH domains that specifically bind to mesothelin with high affinity. Also disclosed are conjugate constructs comprising the isolated nanobodies derivatized to allow conjugation to or that are conjugated to accessory moieties, such as biologically active moieties (e.g., a cytotoxin, a non-cytotoxic drug, a radioactive agent, a protein, or an enzyme) or detectable markers (e.g., a fluorescent label or biotin). Nucleic acid molecules encoding the nanobodies and conjugate constructs, expression vectors, host cells and methods for expressing the nanobodies and conjugate constructs are also provided. Pharmaceutical compositions comprising the nanobodies and conjugate-constructs as described herein are also provided. The present invention is also directed to methods for detecting mesothelin, as well as methods for diagnosis, treating, preventing and ameliorating mesothelin-associated diseases and conditions (e.g.
    Type: Application
    Filed: June 28, 2017
    Publication date: January 4, 2018
    Inventors: Daniel BATY, Patrick CHAMES, Brigitte KERFELEC, Nathalie SCHOLLER
  • Publication number: 20170342124
    Abstract: The invention provides compositions and methods for adoptive T cell therapy in treating a variety of disorders including cancer, infections, and autoimmune disorders. In one embodiment, the invention provides a universal immune receptor (UnivIR) that comprises an extracellular label binding domain, a transmembrane domain, and a cytoplasmic domain or otherwise an intracellular domain.
    Type: Application
    Filed: May 10, 2017
    Publication date: November 30, 2017
    Inventors: Nathalie Scholler, Katarzyna Urbanska, Daniel J. Powell, Jr.
  • Publication number: 20170281793
    Abstract: The invention relates to Anti-TEM 1 antibodies or antigen-binding fragments thereof, yeast libraries comprising the same, and prophylactic, diagnostic, and therapeutic methods using the same.
    Type: Application
    Filed: January 20, 2017
    Publication date: October 5, 2017
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Nathalie SCHOLLER, Aizhi Zhao, Donald Siegel, George Coukos
  • Publication number: 20170267755
    Abstract: Embodiments in accordance with the present disclosure include antibody binding domains that specifically bind to mesothelin. A nanobody or conjugate construct thereof can comprise the antibody binding domain comprising complementary determining region (CDR)1 of SEQ ID NO:05 or SEQ ID NO:08, CDR2 of SEQ ID NO:06 or SEQ ID NO:09, and/or CDR3 of SEQ ID NO:07 or SEQ ID NO:10. The nanobody or conjugate constructs of the nanobody can be used for diagnosis or treatment of diseases or conditions associated with overexpression of mesothelin.
    Type: Application
    Filed: March 16, 2017
    Publication date: September 21, 2017
    Inventor: Nathalie Scholler
  • Patent number: 9708384
    Abstract: The invention provides compositions and methods for adoptive T cell therapy in treating a variety of disorders including cancer, infections, and autoimmune disorders. In one embodiment, the invention provides a universal immune receptor (UnivIR) that comprises an extracellular label binding domain, a transmembrane domain, and a cytoplasmic domain or otherwise an intracellular domain.
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: July 18, 2017
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Nathalie Scholler, Katarzyna Urbanska, Daniel J. Powell, Jr.
  • Patent number: 9556272
    Abstract: The invention relates to Anti-TEM 1 anti-bodies or antigen-binding fragments thereof, yeast libraries comprising the same, and prophylactic, diagnostic, and therapeutic methods using the same.
    Type: Grant
    Filed: November 12, 2010
    Date of Patent: January 31, 2017
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Nathalie Scholler, Aizhi Zhao, Donald Siegel, George Coukos
  • Patent number: 9422351
    Abstract: The present invention relates to B7-H4-specific chimeric antigen receptor compositions and methods of use thereof.
    Type: Grant
    Filed: November 5, 2012
    Date of Patent: August 23, 2016
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Nathalie Scholler, Denarda Dangaj, Aizhi Zhao, Daniel J. Powell
  • Publication number: 20160222119
    Abstract: The present invention relates to B7-H4-specific compositions and methods of use thereof.
    Type: Application
    Filed: January 28, 2016
    Publication date: August 4, 2016
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Nathalie SCHOLLER, Denarda DANGAJ, Aizhi ZHAO, Daniel J. POWELL
  • Patent number: 9345785
    Abstract: Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of CD70-expressing a cancer, comprising administering to a subject the disclosed pharmaceutical compositions.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: May 24, 2016
    Assignee: Seattle Genetics, Inc.
    Inventors: Che-Leung Law, Alan F. Wahl, Nathalie Scholler, Linda A. Pestano
  • Patent number: 9279008
    Abstract: The present invention relates to B7-H4-specific compositions and methods of use thereof.
    Type: Grant
    Filed: February 17, 2014
    Date of Patent: March 8, 2016
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Nathalie Scholler, Denarda Dangaj, Aizhi Zhao, Daniel J. Powell
  • Patent number: 9272002
    Abstract: The present invention relates to compositions and methods for treating diseases, disorders or conditions associated with dysregulated expression of mesothelin. In one embodiment, the invention relates to a fully human chimeric antigen receptor (CAR) wherein the CAR is able to target mesothelin.
    Type: Grant
    Filed: October 26, 2012
    Date of Patent: March 1, 2016
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Daniel J. Powell, Jr., Nathalie Scholler
  • Publication number: 20140308259
    Abstract: The present invention relates to B7-H4-specific chimeric antigen receptor compositions and methods of use thereof.
    Type: Application
    Filed: November 5, 2012
    Publication date: October 16, 2014
    Inventors: Nathalie Scholler, Denarda Dangaj, Aizhi Zhao, Daniel J. Powell
  • Publication number: 20140301993
    Abstract: The present invention relates to compositions and methods for treating diseases, disorders or conditions associated with dysregulated expression of mesothelin. In one embodiment, the invention relates to a fully human chimeric antigen receptor (CAR) wherein the CAR is able to target mesothelin.
    Type: Application
    Filed: October 26, 2012
    Publication date: October 9, 2014
    Inventors: Daniel J. Powell, JR., Nathalie Scholler
  • Publication number: 20140294861
    Abstract: The present invention relates to B7-H4-specific compositions and methods of use thereof.
    Type: Application
    Filed: February 17, 2014
    Publication date: October 2, 2014
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Nathalie Scholler, Denarda Dangaj, Aizhi Zhao, Daniel J. Powell
  • Publication number: 20140234348
    Abstract: The invention provides compositions and methods for adoptive T cell therapy in treating a variety of disorders including cancer, infections, and autoimmune disorders. In one embodiment, the invention provides a universal immune receptor (UnivIR) that comprises an extracellular label binding domain, a transmembrane domain, and a cytoplasmic domain or otherwise an intracellular domain.
    Type: Application
    Filed: September 24, 2012
    Publication date: August 21, 2014
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Nathalie Scholler, Katarzyna Urbanska, Daniel J. Powell, JR.
  • Patent number: 8609104
    Abstract: Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of a CD70-expressing cancer, comprising administering to a subject the disclosed pharmaceutical compositions.
    Type: Grant
    Filed: June 7, 2012
    Date of Patent: December 17, 2013
    Assignee: Seattle Genetics, Inc.
    Inventors: Che-leung Law, Alan F. Wahl, Nathalie Scholler, Linda A. Pestano
  • Patent number: 8535678
    Abstract: Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, immunosuppressive, or other therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the disclosed pharmaceutical compositions.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: September 17, 2013
    Assignee: Seattle Genetics, Inc.
    Inventors: Cheu-leung Law, Alan F. Wahl, Nathalie Scholler, Linda A. Pestano