Abstract: Provided herein are methods of enriching a retinal pigment epithelium (RPE) cell population derived from stem cells. Such a method may comprise removing contaminating cells through the depletion of CD24 positive cells, CD56 positive cells, and/or CD90 positive cells from a starting population of RPE cells.

Abstract: Mixing systems and methods that include a mixer housing and one or more disk assemblies for mixing and processing materials is disclosed. The disks rotate to mix an additive into the material and to carry agglomerated solids toward a discharge of the mixing system. The disks may have a plurality of fingers or lobes which extend from a central portion of the disks.

Abstract: Provided herein are methods of enriching a retinal pigment epithelium (RPE) cell population derived from stem cells. Such a method may comprise removing contaminating cells through the depletion of CD24 positive cells, CD56 positive cells, and/or CD90 positive cells from a starting population of RPE cells.

Abstract: A collection tank for a mobile vacuum excavator includes a front with a closed end, a rear with an open end, a door configured to be closed over the open end, and a linkage assembly having a first end attached to the door and a second end attached to the body. A first pivotal movement drives the first end and second end away from each other, and a second pivotal movement moves the first end and the second end toward each other. An actuator is attached to the first arm and to the second arm so that actuation of the actuator in a first direction drives the first pivotal movement and actuation of the actuator in a second direction drives the second arm the second pivotal movement.

Abstract: Provided herein is an adjustable implant configured to non-invasively guide bone growth in a patient. The adjustable implant includes a first portion configured to couple to a first bone segment and a second portion at least partially disposed within the first portion and configured to couple to a second bone segment. The adjustable implant includes a drive assembly configured to be transcutaneously actuated, and to drive rotation of a gear assembly configured to rotate about a first axis, and drive axial translation of the second portion along a second axis. Non-invasive actuation of the drive assembly therefore causes the adjustable implant to distract or retract along the second axis.

Abstract: Provided herein are methods of producing a photoreceptor precursor (PRP) cell population derived from stem cells. Further provided herein are methods of using the PRP cell populations, such as for therapeutics.

Abstract: One aspect of the disclosure relates to an extramedullary biocompatible implant for moving bone in a patient's body. In some cases, the implant includes: a first plate configured to be attached to bone at a first location; a second plate configured to be attached to bone at a second location; and a distractor extending from the first plate and being at least partially contained within the second plate, where the distractor houses a drive system including a driver and a gear system coupled with the driver, and where the drive system is configured to cause translation of the second plate relative to the first plate.

Abstract: A mixing apparatus is disclosed. The mixing apparatus includes a cradle assembly disposed within an enclosure wherein the cradle assembly is configured to receive a container for mixing. A crank is coupled to the enclosure is configured to rotate the cradle assembly by a rotational mechanism. The rotational mechanism may include a yoke coupled to a bottom portion of the cradle assemble and further coupled to the enclosure. The rotational mechanism may include a drive gear assembly for reducing force required on the crank.

Abstract: Mixing systems that include a mixer housing and one or more disk assemblies for mixing and processing materials is disclosed. The disks rotate to mix an additive into the material and to carry agglomerated solids toward a discharge of the mixing system. The disks may have a plurality of fingers or lobes which extend from a central portion of the disks.

Abstract: Provided herein are methods for producing quiescent cardiac fibroblast cells from pluripotent stem cells. Further provided herein are microtissue compositions comprising the cardiac fibroblast cells with endothelial cells and cardiomyocytes.

Abstract: One aspect of the disclosure relates to an extramedullary biocompatible implant for moving bone in a patient's body. In some cases, the implant includes: a first plate configured to be attached to bone at a first location; a second plate configured to be attached to bone at a second location; and a distractor extending from the first plate and being at least partially contained within the second plate, where the distractor houses a drive system including a driver and a gear system coupled with the driver, and where the drive system is configured to cause translation of the second plate relative to the first plate.

Abstract: Various implementations include implants and related methods for moving bone. Certain implementations include an implant for moving bone in a patient's body, the implant including: an implantable biocompatible housing; a first adjustment rod at least partially overlapping the implantable biocompatible housing; a driver configured to drive the first adjustment rod to enable movement of the first adjustment rod relative to the housing; and a load sensor positioned within the housing and configured to indicate a load applied by the driver on the first adjustment rod.

Abstract: Mixing systems that include a mixer housing and one or more disk assemblies for mixing and processing materials is disclosed. The disks rotate to mix an additive into the material and to carry agglomerated solids toward a discharge of the mixing system. The disks may have a plurality of fingers or lobes which extend from a central portion of the disks.

Abstract: A collection tank for a mobile vacuum excavator includes a front with a closed end, a rear with an open end, a door configured to be closed over the open end, and a linkage assembly having a first end attached to the door and a second end attached to the body. A first pivotal movement drives the first end and second end away from each other, and a second pivotal movement moves the first end and the second end toward each other. An actuator is attached to the first arm and to the second arm so that actuation of the actuator in a first direction drives the first pivotal movement and actuation of the actuator in a second direction drives the second arm the second pivotal movement.

Abstract: Various implementations include implants and related methods for moving bone. Certain implementations include an implant for moving bone in a patient's body, the implant including: an implantable biocompatible housing having a first cavity; a first adjustment rod at least partially contained within the first cavity; and a drive mechanism configured to drive the first adjustment rod to enable both translation axially relative to the housing and rotation about a primary axis of the housing.

Abstract: A collection tank for a mobile vacuum excavator includes a front with a closed end, a rear with an open end, a door configured to be closed over the open end, and a linkage assembly having a first end attached to the door and a second end attached to the body. A first pivotal movement drives the first end and second end away from each other, and a second pivotal movement moves the first end and the second end toward each other. An actuator is attached to the first arm and to the second arm so that actuation of the actuator in a first direction drives the first pivotal movement and actuation of the actuator in a second direction drives the second arm the second pivotal movement.

Abstract: Hydro excavation apparatus for excavating earthen material are disclosed. The hydro excavation apparatus includes a first reservoir for holding a base fluid therein, a second reservoir for holding an additive therein, a vacuum system for removing earthen material from an excavation site, and an additive dosing assembly. The additive dosing assembly includes at least one of a pump and a valve fluidly connected to the second reservoir. The additive dosing assembly is selectively controllable to introduce an additive into at least one of the base fluid and the removed earthen material.

Abstract: Provided herein are methods of enriching a retinal pigment epithelium (RPE) cell population derived from stem cells. Such a method may comprise removing contaminating cells through the depletion of CD24 positive cells, CD56 positive cells, and/or CD90 positive cells from a starting population of RPE cells.

Abstract: A collection tank for a mobile vacuum excavator includes a front with a closed end, a rear with an open end, a door configured to be closed over the open end, and a linkage assembly having a first end attached to the door and a second end attached to the body. A first pivotal movement drives the first end and second end away from each other, and a second pivotal movement moves the first end and the second end toward each other. An actuator is attached to the first arm and to the second arm so that actuation of the actuator in a first direction drives the first pivotal movement and actuation of the actuator in a second direction drives the second arm the second pivotal movement.

Abstract: Mixing systems that include a mixer housing and one or more disk assemblies for mixing and processing materials is disclosed. The disks rotate to mix an additive into the material and to carry agglomerated solids toward a discharge of the mixing system. The disks may have a plurality of fingers or lobes which extend from a central portion of the disks.