Abstract: A method of optimizing a portfolio includes selecting an investment universe with a finite number of assets, forming a belief matrix based on one or more homogeneous inequality relationships among the expected returns of assets in the universe, selecting those asset returns that are consistent with the belief matrix to form a consistent set of return vectors, selecting a set of allowable weight vectors for the assets in the universe, determining a centroid vector of the consistent set of return vectors with respect to a probability measure, and finding an optimal portfolio by finding a weight vector on a boundary of the set of allowable weight vectors that maximizes an inner product with the centroid vector.

Abstract: The present invention relates to a 8-azabicyclo[3.2.1] octane derivative of Formula I, wherein each of the substituents is given the definition as set forth in the specification and claims, or a pharmaceutically acceptable salt thereof or solvate thereof. The present invention also relates to a pharmaceutical composition comprising an 8-azabicyclo [-3.2.1] octane derivative in admixture with one or more pharmaceutically acceptable auxiliaries and to the use of the 8-azabicyclo[3.2.1] octane derivative in therapy.

Abstract: This application relates to methods for modulating an immune response in a mammalian subject in need of prevention against or treatment of diabetes comprising the administration of EtxB and/or insulin.

Abstract: An expandable coupling arrangement for coupling first and second tubulars includes a male thread portion on an end of the first tubular and a female thread portion on an end of the second tubular. The thread portions comprise dovetail threads having flanks, roots and crests, wherein the flanks are inclined at an angle of greater than 10°.

Abstract: The invention relates generally to a system and method for creating custom multi-relational ontologies. The invention includes a system and method for creating a master ontology and the application of one or more customizing constraints to the master ontology. Also provided are methods for creating custom ontologies using path-finding and creation of custom ontologies by applying customizing constraints to extraction, assembly, curation, and publication processes.

Abstract: The invention relates to a system and method for parsing and/or exporting one or more multi-relational ontologies. The system may apply a set of export constraints to one or more master ontologies to produce a redacted data subset. The redacted data subset may then be exported to a specified location or application.

Abstract: A temporary load support intended in use to be supported from a fixed structure (10) to temporarily support an element (50) of the fixed structure, said load support comprising a pair of mountings (11) configured to, in use, be mounted to the fixed structure at spaced locations adjacent the element, a load bearing member (17) adapted to be fixed between the mountings, the load bearing member having a support element (23) located intermediate the mountings, wherein in use the mountings are fixed to the fixed structure proximate the element such that the support element is located in the region of the element, said support element being able to support the element.

Abstract: A method of lining a bore section, the method comprises providing a first tubing section and an expandable thin-walled second tubing section. The first tubing section is run into a section of a bore. The second tubing section is then run into the bore section, within the first tubing section, and expanded to a larger diameter, such that the bore section is lined by at least two tubing sections.

Abstract: A technique for detecting Trojans and worms within packed computer files uses fingerprint data derived from the unpacked resource data associated with the packed computer files. The number of entries, the position within the resource data and size of the resource that is the largest resource specified, a timestamp value of compilation and a checksum value derived from the whole of the resource data may be included within a fingerprint value as characteristic of a particular set of resource data. A library of such fingerprint values may be generated for known Trojans and worms, or other programs it is wished to detect, and then a suspect file compared against this library of fingerprints.

Abstract: A method of coupling first and second expandable tubulars comprises providing a male tubular connector portion and a female tubular connection portion having greater yield strength, coupling the connector portions together, and expanding the coupled connector portions. The coupled connector portions may be expanded downhole.

Abstract: Embodiments of the present invention provide an apparatus and method for expanding a tubular. In one aspect, embodiments of the prevent invention provide an expander tool having at least two expansion members radially extendable from the expander tool into contact with a surrounding inside surface of the tubular, the at least two expansion members radially extendable at different times and axially spaced after radially extending. In another aspect, embodiments include a method for isolating a first portion of a wellbore from a second portion of a wellbore comprising locating an expandable tubular within the wellbore between the first and second portions, the expandable tubular having a weakened portion therein, isolating the first portion from the second portion of the wellbore, and expanding the expandable tubular proximate to the weakened portion to sever the expandable tubular.

Abstract: The use of an agent in the manufacture of a medicament to affect an allergic condition and/or a hypersensitivity condition is described. The agent is capable of modulating a ganglioside associated activity. The agent is not coupled to an antigen. The modulation of the ganglioside activity affects an allergic condition and/or a hypersensitivity condition.

Abstract: A method of sealing an expandable tubular within a bore comprises the steps of providing an expandable tubular describing a first diameter and having a sealing medium on its outer surface, running the tubular into a bore and expanding the tubular within the bore to describe a second larger diameter, and activating the sealing medium to facilitate provision of a seal between the tubular and the bore.

Abstract: Malware definition data for mobile computing devices 2 is generated from master malware definition data 44 by selecting those classes of malware threat to which the mobile computing device is vulnerable and then selecting the matching malware items from within the master malware definition data. A PC 6 to which the mobile computing device may be connected is responsible for downloading an updated version of the master malware definition data for its own use and generates appropriate mobile computing device malware definition data for transfer to the mobile computing device when it is connected to the PC. The scanner programs of both the PC and the mobile computing device may be similarly updated.

Abstract: There is disclosed an expandable centraliser for locating a body within a borehole, and a method of centralising tubing in a borehole. In an embodiment of the invention, an expandable centraliser (10) is disclosed, the centraliser (10) comprising a deformable body (12), and at least one abutment portion in the form of a shoulder (14) on the body (12), the shoulder (14) adapted to be urged radially outwardly on deformation of the body (12), to centralise tubing (28) coupled to the centraliser (10) within a borehole (15).

Abstract: Embodiments of the present invention provide an apparatus and method for expanding a tubular. In one aspect, embodiments of the prevent invention provide an expander tool having at least two expansion members radially extendable from the expander tool into contact with a surrounding inside surface of the tubular, the at least two expansion members radially extendable at different times and axially spaced after radially extending. In another aspect, embodiments include a method for isolating a first portion of a wellbore from a second portion of a wellbore comprising locating an expandable tubular within the wellbore between the first and second portions, the expandable tubular having a weakened portion therein, isolating the first portion from the second portion of the wellbore, and expanding the expandable tubular proximate to the weakened portion to sever the expandable tubular.

Abstract: A seal arrangement comprises an expandable inner tubular and an outer tubular. The inner tubular comprises an axially extending lip seal. Expansion of the inner tubular serves to energise the lip seal, a free end of which will be urged into contact with the outer tubular.

Abstract: A method of forming a seal between two tubular members comprising providing a first tubular member having an internal surface and an external surface describing a first diameter, with a recess in the external surface at a seal portion of the first tubular member. A deformable circumferentially extending sealing member is located in the recess, the sealing member describes an external diameter no greater than the first diameter. The first tubular member is located within a second tubular member and the seal portion of the first tubular member is expanded such that the sealing member engages an inner surface of the second tubular member.

Abstract: The invention relates to apparatus for use in wellbores and particularly, but not exclusively, to circulating subs used during downhole drilling operations. The apparatus includes a control groove and a pin received within the control groove for determining whether or not a longitudinal movement of a piston in a given direction relative to the apparatus body will move the apparatus between open and closed configurations. The apparatus further includes a control member located between and movable relative to the body and the piston. The control groove is defined in one of the piston and control member, and the pin is provided on the other of the piston and control member. Means are also provided for constraining movement of the piston relative to the body to longitudinal movement only. The invention thus provides an apparatus which has improved reliability in moving between open and closed configurations.

Abstract: There is disclosed an expandable seal for sealing at least part of a wall of a well borehole, an expandable seal assembly comprising at least two such expandable seals, and a method of sealing at least part of a well borehole using such a seal. In one embodiment, the expandable seal (32) comprises an expandable tubular support member (34) and an inflatable seal element (36) mounted externally of the expandable tubular support member (34) for inflation radially outwardly into sealing engagement with at least part of a wall (50) of a well borehole (10). There is also disclosed a sealing apparatus for sealing at least one flow port in an expandable downhole tubular, in one embodiment, the sealing apparatus (332) comprising a sealing member (384) coupled to an expandable tubular (334), the sealing member (384) including a deformable portion (387) movable between a closed position preventing fluid flow through a flow port (356) and an open position permitting fluid flow through the flow port (356).