Patents by Inventor Neil Aronin

Neil Aronin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BIOACTIVE CONJUGATES FOR OLIGONUCLEOTIDE DELIVERY
    Publication number: 20200339983
    Abstract: Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.
    Type: Application
    Filed: March 9, 2020
    Publication date: October 29, 2020
    Inventors: Anastasia Khvorova, Mehran Nikan, Matthew Hassler, Maire Osborn, Reka Haraszti, Andrew Coles, Anton Turanov, Neil Aronin
  • OLIGONUCLEOTIDE COMPOUNDS FOR TARGETING HUNTINGTIN MRNA
    Publication number: 20200308584
    Abstract: This disclosure relates to novel huntingtin targets. Novel oligonucleotides for the treatment of Huntington's disease are also provided.
    Type: Application
    Filed: March 6, 2020
    Publication date: October 1, 2020
    Inventors: Anastasia Khvorova, Neil Aronin, Julia Alterman
  • Oligonucleotide compounds for targeting huntingtin mRNA
    Patent number: 10774327
    Abstract: This disclosure relates to novel huntingtin targets. Novel oligonucleotides for the treatment of Huntington's disease are also provided.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: September 15, 2020
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Neil Aronin, Julia Alterman
  • EXOSOMAL LOADING USING HYDROPHOBICALLY MODIFIED OLIGONUCLEOTIDES
    Publication number: 20200283801
    Abstract: In one aspect, the invention relates to a method of loading exosomes with oligonucleotide cargo, by incubating an oligonucleotide comprising one or more hydrophobic modifications with a population of exosomes for a period of time sufficient to allow loading of the exosomes with the oligonucleotide. Exosomes loaded with hydrophobically modified oligonucleotide cargo, and uses thereof, are also provided.
    Type: Application
    Filed: December 13, 2019
    Publication date: September 10, 2020
    Inventors: Anastasia Khvorova, Neil Aronin, Marie Cecile Didiot, Reka Haraszti
  • Bioactive conjugates for oligonucleotide delivery
    Patent number: 10633653
    Abstract: Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: April 28, 2020
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Mehran Nikan, Matthew Hassler, Maire Osborn, Reka Haraszti, Andrew Coles, Anton Turanov, Neil Aronin
  • MODIFIED OLIGONUCLEOTIDES TARGETING SNPs
    Publication number: 20200123543
    Abstract: Novel oligonucleotides that enhance silencing of the expression of a gene containing a single nucleotide polymorphism (SNP) relative to the expression of the corresponding wild-type gene are provided. Methods of using novel oligonucleotides that enhance silencing of the expression of a gene containing a SNP relative to the expression of the corresponding wild-type gene are provided.
    Type: Application
    Filed: August 9, 2019
    Publication date: April 23, 2020
    Inventors: Anastasia Khvorova, Julia Alterman, Faith Conroy, Edith Pfister, Neil Aronin, Ken Yamada
  • AAV TREATMENT OF HUNTINGTON'S DISEASE
    Publication number: 20200087664
    Abstract: Aspects of the disclosure relate to compositions and methods useful for treating Huntington's disease. In some embodiments, the disclosure provides interfering nucleic acids (e.g., artificial miRNAs) targeting the huntingtin gene (HTT) and methods of treating Huntington's disease using the same.
    Type: Application
    Filed: September 17, 2019
    Publication date: March 19, 2020
    Applicant: University of Massachusetts
    Inventors: Christian Mueller, Neil Aronin, Edith L. Pfister
  • RNA INTERFERENCE FOR THE TREATMENT OF GAIN-OF-FUNCTION DISORDERS
    Publication number: 20200024599
    Abstract: The present invention relates to the discovery of an effective treatment for a variety of gain-of-function diseases, in particular, Huntington's disease (HD). The present invention utilizes RNA Interference technology (RNAi) against polymorphic regions in the genes encoding various gain-of-function mutant proteins resulting in an effective treatment for the gain-of-function disease.
    Type: Application
    Filed: May 17, 2019
    Publication date: January 23, 2020
    Inventors: Neil Aronin, Phillip D. Zamore
  • Exosomal loading using hydrophobically modified oligonucleotides
    Patent number: 10513710
    Abstract: In one aspect, the invention relates to a method of loading exosomes with oligonucleotide cargo, by incubating an oligonucleotide comprising one or more hydrophobic modifications with a population of exosomes for a period of time sufficient to allow loading of the exosomes with the oligonucleotide. Exosomes loaded with hydrophobic ally modified oligonucleotide cargo, and uses thereof, are also provided.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: December 24, 2019
    Assignee: University of Massachusetts
    Inventors: Anastasia Khvorova, Neil Aronin, Marie Cecile Didiot, Reka Haraszti
  • ARTIFICIAL EXOSOME COMPOSITION AND RELATED METHODS
    Publication number: 20190343767
    Abstract: Novel artificial exosomes and methods for producing novel artificial exosomes are provided. Methods of delivering cargo molecules to a cell using artificial exosomes are also provided.
    Type: Application
    Filed: April 24, 2019
    Publication date: November 14, 2019
    Inventors: Reka Agnes Haraszti, Anastasia Khvorova, Neil Aronin
  • AAV treatment of Huntington's disease
    Patent number: 10457940
    Abstract: Aspects of the disclosure relate to compositions and methods useful for treating Huntington's disease. In some embodiments, the disclosure provides interfering nucleic acids (e.g., artificial miRNAs) targeting the huntingtin gene (HTT) and methods of treating Huntington's disease using the same.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: October 29, 2019
    Assignee: University of Massachusetts
    Inventors: Christian Mueller, Neil Aronin, Edith L. Pfister
  • Oligonucleotide compounds for targeting huntingtin mRNA
    Patent number: 10435688
    Abstract: This disclosure relates to novel huntingtin targets. Novel oligonucleotides for the treatment of Huntington's disease are also provided.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: October 8, 2019
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Neil Aronin, Julia Alterman
  • OLIGONUCLEOTIDE COMPOUNDS FOR TARGETING HUNTINGTIN MRNA
    Publication number: 20190225965
    Abstract: This disclosure relates to novel huntingtin targets. Novel oligonucleotides for the treatment of Huntington's disease are also provided.
    Type: Application
    Filed: January 31, 2019
    Publication date: July 25, 2019
    Inventors: Anastasia Khvorova, Neil Aronin, Julia Alterman
  • RNA interference for the treatment of gain-of-function disorders
    Patent number: 10344277
    Abstract: The present invention relates to the discovery of an effective treatment for a variety of gain-of-function diseases, in particular, Huntington's disease (HD). The present invention utilizes RNA Interference technology (RNAi) against polymorphic regions in the genes encoding various gain-of-function mutant proteins resulting in an effective treatment for the gain-of-function disease.
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: July 9, 2019
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Neil Aronin, Phillip D. Zamore
  • CONJUGATED OLIGONUCLEOTIDES
    Publication number: 20190185855
    Abstract: Provided herein are conjugated oligonucleotides that are characterized by efficient and specific tissue distribution.
    Type: Application
    Filed: August 11, 2017
    Publication date: June 20, 2019
    Inventors: Anastasia KHVOROVA, Mehran NIKAN, Matthew HASSLER, Maire OSBORN, Reka HARASZTI, Andrew COLES, Anton TURANOV, Neil ARONIN, Annabelle BISCANS
  • OLIGONUCLEOTIDE COMPOUNDS FOR TARGETING HUNTINGTIN MRNA
    Publication number: 20180094263
    Abstract: This disclosure relates to novel huntingtin targets. Novel oligonucleotides for the treatment of Huntington's disease are also provided.
    Type: Application
    Filed: September 6, 2017
    Publication date: April 5, 2018
    Inventors: Anastasia Khvorova, Neil Aronin, Julia Alterman
  • AAV TREATMENT OF HUNTINGTON'S DISEASE
    Publication number: 20180094264
    Abstract: Aspects of the disclosure relate to compositions and methods useful for treating Huntington's disease. In some embodiments, the disclosure provides interfering nucleic acids (e.g., artificial miRNAs) targeting the huntingtin gene (HTT) and methods of treating Huntington's disease using the same.
    Type: Application
    Filed: September 15, 2017
    Publication date: April 5, 2018
    Applicant: University of Massachusetts
    Inventors: Christian Mueller, Neil Aronin, Edith L. Pfister
  • Methods and compositions for treating neurological disease
    Patent number: 9914924
    Abstract: This invention relates to methods and compositions for treating neurological disease, and more particularly to methods of delivering iRNA agents to neural cells for the treatment of neurological diseases.
    Type: Grant
    Filed: January 5, 2015
    Date of Patent: March 13, 2018
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Neil Aronin, Phillip Zamore
  • FULLY STABILIZED ASYMMETRIC SIRNA
    Publication number: 20170369882
    Abstract: Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.
    Type: Application
    Filed: August 30, 2017
    Publication date: December 28, 2017
    Inventors: Anastasia Khvorova, Neil Aronin, Matthew Hassler, Julia Alterman
  • Oligonucleotide compounds for targeting huntingtin mRNA
    Patent number: 9809817
    Abstract: This disclosure relates to novel huntingtin targets. Novel oligonucleotides for the treatment of Huntington's disease are also provided.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: November 7, 2017
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Neil Aronin, Julia Alterman