Patents by Inventor Neil Aronin

Neil Aronin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • EXOSOMAL LOADING USING HYDROPHOBICALLY MODIFIED OLIGONUCLEOTIDES
    Publication number: 20170183686
    Abstract: In one aspect, the invention relates to a method of loading exosomes with oligonucleotide cargo, by incubating an oligonucleotide comprising one or more hydrophobic modifications with a population of exosomes for a period of time sufficient to allow loading of the exosomes with the oligonucleotide. Exosomes loaded with hydrophobic ally modified oligonucleotide cargo, and uses thereof, are also provided.
    Type: Application
    Filed: April 17, 2015
    Publication date: June 29, 2017
    Inventors: Anastasia Khvorova, Neil Aronin, Marie Cecile Didiot
  • RNA INTERFERENCE FOR THE TREATMENT OF GAIN-OF-FUNCTION DISORDERS
    Publication number: 20170051283
    Abstract: The present invention relates to the discovery of an effective treatment for a variety of gain-of-function diseases, in particular, Huntington's disease (HD). The present invention utilizes RNA Interference technology (RNAi) against polymorphic regions in the genes encoding various gain-of-function mutant proteins resulting in an effective treatment for the gain-of-function disease.
    Type: Application
    Filed: August 2, 2016
    Publication date: February 23, 2017
    Inventors: Neil Aronin, Phillip D. Zamore
  • BIOACTIVE CONJUGATES FOR OLIGONUCLEOTIDE DELIVERY
    Publication number: 20170043024
    Abstract: Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.
    Type: Application
    Filed: August 12, 2016
    Publication date: February 16, 2017
    Inventors: Anastasia Khvorova, Mehran Nikan, Matthew Hassler, Maire Osborn, Reka Haraszti, Andrew Coles, Anton Turanov, Neil Aronin
  • OLIGONUCLEOTIDE COMPOUNDS FOR TARGETING HUNTINGTIN mRNA
    Publication number: 20160355808
    Abstract: This disclosure relates to novel huntingtin targets. Novel oligonucleotides for the treatment of Huntington's disease are also provided.
    Type: Application
    Filed: April 1, 2016
    Publication date: December 8, 2016
    Inventors: Anastasia Khvorova, Neil Aronin, Julia Alterman
  • FULLY STABILIZED ASYMMETRIC SIRNA
    Publication number: 20160319278
    Abstract: Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.
    Type: Application
    Filed: April 1, 2016
    Publication date: November 3, 2016
    Inventors: Anastasia Khvorova, Neil Aronin, Matthew Hassler, Julia Alterman
  • RNA interference for the treatment of gain-of-function disorders
    Patent number: 9434943
    Abstract: The present invention relates to the discovery of an effective treatment for a variety of gain-of-function diseases, in particular, Huntington's disease (HD). The present invention utilizes RNA Interference technology (RNAi) against polymorphic regions in the genes encoding various gain-of-function mutant proteins resulting in an effective treatment for the gain-of-function disease.
    Type: Grant
    Filed: January 22, 2014
    Date of Patent: September 6, 2016
    Assignee: University of Massachusetts
    Inventors: Neil Aronin, Phillip D. Zamore
  • METHODS AND COMPOSITIONS FOR TREATING NEUROLOGICAL DISEASE
    Publication number: 20150232840
    Abstract: This invention relates to methods and compositions for treating neurological disease, and more particularly to methods of delivering iRNA agents to neural cells for the treatment of neurological diseases.
    Type: Application
    Filed: January 5, 2015
    Publication date: August 20, 2015
    Inventors: Neil Aronin, Phillip Zamore
  • Single nucleotide polymorphism (SNP) targeting therapies for the treatment of huntington'S disease
    Patent number: 8987222
    Abstract: The present invention relates to the discovery of (SNPs) significantly associated with Huntington's disease (HD). The present invention utilizes RNA silencing technology (e.g. RNAi) against such SNPs optimally combined with select additional SNP targeting silencing agents, thereby resulting in an effective treatment of significantly-sized patient populations. Silencing agents having enhanced discriminatory properties are also featured.
    Type: Grant
    Filed: April 8, 2010
    Date of Patent: March 24, 2015
    Assignee: University of Massachusetts
    Inventors: Neil Aronin, Edith Pfister, Phillip D. Zamore
  • RNA INTERFERENCE FOR THE TREATMENT OF GAIN-OF-FUNCTION DISORDERS
    Publication number: 20140370597
    Abstract: The present invention relates to the discovery of an effective treatment for a variety of gain-of-function diseases, in particular, Huntington's disease (HD). The present invention utilizes RNA Interference technology (RNAi) against polymorphic regions in the genes encoding various gain-of-function mutant proteins resulting in an effective treatment for the gain-of-function disease.
    Type: Application
    Filed: January 22, 2014
    Publication date: December 18, 2014
    Applicant: University of Massachusetts
    Inventors: Neil Aronin, Phillip D. Zamore
  • RNA interference for the treatment of gain-of-function disorders
    Patent number: 8680063
    Abstract: The present invention relates to the discovery of an effective treatment for a variety of gain-of-function diseases, in particular, Huntington's disease (HD). The present invention utilizes RNA Interference technology (RNAi) against polymorphic regions in the genes encoding various gain-of-function mutant proteins resulting in an effective treatment for the gain-of-function disease.
    Type: Grant
    Filed: December 13, 2010
    Date of Patent: March 25, 2014
    Assignee: University of Massachusetts
    Inventors: Neil Aronin, Phillip D. Zamore
  • METHODS AND COMPOSITIONS FOR TREATING NEUROLOGICAL DISEASE
    Publication number: 20130261166
    Abstract: This invention relates to methods and compositions for treating neurological disease, and more particularly to methods of delivering iRNA agents to neural cells for the treatment of neurological diseases.
    Type: Application
    Filed: January 23, 2013
    Publication date: October 3, 2013
    Inventors: Muthiah Manoharan, Neil Aronin
  • METHODS AND COMPOSITIONS FOR TREATING NEUROLOGICAL DISEASE
    Publication number: 20120214861
    Abstract: This invention relates to methods and compositions for treating neurological disease, and more particularly to methods of delivering iRNA agents to neural cells for the treatment of neurological diseases.
    Type: Application
    Filed: September 21, 2011
    Publication date: August 23, 2012
    Applicant: UNIVERSITY OF MASSACHUSETTS
    Inventors: Neil ARONIN, Phillip D. ZAMORE
  • SINGLE NUCLEOTIDE POLYMORPHISM (SNP) TARGETING THERAPIES FOR THE TREATMENT OF HUNTINGTON'S DISEASE
    Publication number: 20120136039
    Abstract: The present invention relates to the discovery of (SNPs) significantly associated with Huntington's disease (HD). The present invention utilizes RNA silencing technology (e.g. RNAi) against such SNPs optimally combined with select additional SNP targeting silencing agents, thereby resulting in an effective treatment of significantly-sized patient populations. Silencing agents having enhanced discriminatory properties are also featured.
    Type: Application
    Filed: April 8, 2010
    Publication date: May 31, 2012
    Applicant: UNIVERSITY OF MASSACHUSETTS
    Inventors: Neil Aronin, Edith Pfister, Phillip D. Zamore
  • METHODS AND COMPOSITIONS FOR TREATING NEUROLOGICAL DISEASE
    Publication number: 20110251257
    Abstract: This invention relates to methods and compositions for treating neurological disease, and more particularly to methods of delivering iRNA agents to neural cells for the treatment of neurological diseases.
    Type: Application
    Filed: October 8, 2010
    Publication date: October 13, 2011
    Inventors: Muthiah Manoharan, Neil Aronin
  • RNA INTERFERENCE FOR THE TREATMENT OF GAIN-OF-FUNCTION DISORDERS
    Publication number: 20110172291
    Abstract: The present invention relates to the discovery of an effective treatment for a variety of gain-of-function diseases, in particular, Huntington's disease (HD). The present invention utilizes RNA Interference technology (RNAi) against polymorphic regions in the genes encoding various gain-of-function mutant proteins resulting in an effective treatment for the gain-of-function disease.
    Type: Application
    Filed: December 13, 2010
    Publication date: July 14, 2011
    Applicant: UNIVERSITY OF MASSACHUSETTS
    Inventors: Neil ARONIN, Phillip D. ZAMORE
  • RNA interference for the treatment of gain-of-function disorders
    Patent number: 7947658
    Abstract: The present invention relates to the discovery of an effective treatment for a variety of gain-of-function diseases, in particular, Huntington's disease (HD). The present invention utilizes RNA Interference technology (RNAi) against polymorphic regions in the genes encoding various gain-of-function mutant proteins resulting in an effective treatment for the gain-of-function disease.
    Type: Grant
    Filed: September 13, 2004
    Date of Patent: May 24, 2011
    Assignee: University of Massachusetts
    Inventors: Neil Aronin, Phillip D. Zamore
  • Methods and Compositions for Treating Neurological Disease
    Publication number: 20110027882
    Abstract: This invention relates to methods and compositions for treating neurological disease, and more particularly to methods of delivering iRNA agents to neural cells for the treatment of neurological diseases.
    Type: Application
    Filed: January 29, 2010
    Publication date: February 3, 2011
    Inventors: Muthiah Manoharan, Neil Aronin
  • METHODS AND COMPOSITIONS FOR TREATING NEUROLOGICAL DISEASE
    Publication number: 20100267810
    Abstract: This invention relates to methods and compositions for treating neurological disease, and more particularly to methods of delivering iRNA agents to neural cells for the treatment of neurological diseases.
    Type: Application
    Filed: June 25, 2010
    Publication date: October 21, 2010
    Applicant: UNIVERSITY OF MASSACHUSETTS
    Inventors: NEIL ARONIN, PHILLIP D. ZAMORE
  • METHODS AND COMPOSITIONS FOR LOCATING SNP HETEROZYGOSITY FOR ALLELE SPECIFIC DIAGNOSIS AND THERAPY
    Publication number: 20100151470
    Abstract: The present invention provides methods for the rapid and cost effective identification of the presence of a disease-associated mutation and a particular SNP in the same allele of a gene without the need to clone and sequence the entire gene. The compositions and methods of the invention are useful for identification of patient to subpopulations amenable to treatment as part of a therapeutic strategy for treating genetic disorders, for example, dominant, gain-of-function gene mutations, for example, Huntington's Disease (HD).
    Type: Application
    Filed: October 30, 2009
    Publication date: June 17, 2010
    Applicant: UNIVERSITY OF MASSACHUSETTS
    Inventors: PHILLIP D. ZAMORE, NEIL ARONIN
  • RNA SILENCING COMPOSITIONS AND METHODS FOR THE TREATMENT OF HUNTINGTON'S DISEASE
    Publication number: 20090186410
    Abstract: The present invention relates to the discovery of an effective treatment for a variety of Huntington's disease (HD). The present invention utilizes RNA silencing technology (e.g. RNAi) against single nucleotide polymorphisms (SNPs) in the Huntingtin (htt) gene encoding the dominant, gain-of-function mutant Huntington protein, thereby resulting in an effective treatment for the gain-of-function disease.
    Type: Application
    Filed: January 5, 2009
    Publication date: July 23, 2009
    Applicant: UNIVERSITY OF MASSACHUSETTS
    Inventors: Neil Aronin, Phillip D. Zamore