Patents by Inventor Neil Smith

Neil Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210284653
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1a, R1b, R1c, R1d, R2, R2a, and A are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Application
    Filed: December 18, 2020
    Publication date: September 16, 2021
    Inventors: Graham BEATON, Mi CHEN, Timothy Richard COON, Todd EWING, Wanlong JIANG, Willy MOREE, Martin ROWBOTTOM, Warren WADE, Liren ZHAO, Richard LOWE, Nicole SMITH, Neil ASHWEEK, Yun-Fei ZHU
  • Patent number: 11119648
    Abstract: A computer-implemented a method for authenticating a user includes: displaying, by a computer device, a first user interface on a display; receiving, by the computer device, user input defining a first pattern; displaying, by the computer device, a second pattern on the display, wherein the second pattern is different than the first pattern; comparing, by the computer device, the first pattern to a predefined pattern; and based on the comparing, the computer device performing one of: re-displaying the first user interface when the first pattern does not match the predefined pattern; and displaying a second user interface when the first pattern does match the predefined pattern.
    Type: Grant
    Filed: November 7, 2019
    Date of Patent: September 14, 2021
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Chris R. Bean, Stephen R. F. Head, Sophie D. Green, Madeleine R. Neil Smith
  • Publication number: 20210269443
    Abstract: The present invention relates to new pharmaceutical salts and/or co-crystals of sepiapterin which exhibit improved properties. In particular, the invention relates to salts of sepiapterin with improved stability. The invention also relates to pharmaceutical compositions including a pharmaceutically effective amount of one or more salts and/or co-crystals of sepiapterin, as well as methods of treating tetrahydrobiopterin-related disorders including administration of a sepiapterin salt and/or co-crystal of the invention to a subject in need thereof.
    Type: Application
    Filed: May 30, 2019
    Publication date: September 2, 2021
    Inventors: Daniel E. LEVY, Neil SMITH, Jonathan REIS, Hiroshi YOSHINO, Taichi KOMODA, Yuichi SHIRO, Shunichi MURATA, Takayoshi MATSUMOTO, Kaito KISHIMOTO
  • Publication number: 20210260057
    Abstract: The present disclosure provides compositions, markers, and methods for diagnosing and treating cancer and other conditions. The method includes administering at least one androgen deprivation therapy to the subject; and administering a therapeutically effective amount of at least one inhibitor to the subject, wherein the at least one inhibitor is selected from the group including: at least one macropinocytosis inhibitor, at least one glutamine metabolism inhibitor, at least one glutaminase inhibitor, and any combinations thereof.
    Type: Application
    Filed: July 12, 2019
    Publication date: August 26, 2021
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Neil Bhowmick, Rajeev Mishra, Bethany Smith
  • Patent number: 11101983
    Abstract: A method of data transfer from a tenant to a service provider comprises encrypting the data with a public key of a key pair generated by a secure device within the service provider system. The data thus cannot be accessed by the service provider during transmission. The data is generated with a corresponding access control list, which specifies that a valid certificate must be presented in order to grant a particular use of the data once stored. The tenant can thus retain control of the use of the data even though it has been transferred out of the tenant system. A method of controlling use of data securely stored in the service provider system comprises issuing a use certificate having an expiry time to the party requesting use of the data. The use certificate must be validated before use of the stored data is granted. This enables the tenant to grant use of the stored data for a limited time period.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: August 24, 2021
    Assignee: NCIPHER SECURITY LIMITED
    Inventors: Ian Bygrave, Alec Edgington, Richard Kettlewell, David O'Doherty, Nicholas Smith, Neil Walker
  • Publication number: 20210220363
    Abstract: The present invention features compositions including sepiapterin, or a pharmaceutically acceptable salt thereof, and methods for the treatment of BH4-related disorders. In some embodiments, these compositions and methods result in an increase in plasma, CSF, and/or brain exposure of sepiapterin.
    Type: Application
    Filed: May 30, 2019
    Publication date: July 22, 2021
    Inventors: Neil SMITH, Jonathan REIS
  • Publication number: 20210169236
    Abstract: A collapsible carry cot includes a base member; first and second frame members, wherein the first and second frame members together at least partially define a side or end wall of the carry cot, and wherein the first and second frame members are pivotally coupled together such that pivoting the first and second frame members relative to one another changes a height of the side or end wall of the carry cot, and wherein the first frame member is pivotally movable relatively to the base member and the second frame member is pivotally and slidably movable relative to the base member; and a securing mechanism, the securing mechanism to releasable secure the second frame member relative to the base member, such that sliding of the second frame member relative to the base member is restricted, thereby restricting pivoting of the first frame member relative to the second frame member.
    Type: Application
    Filed: December 3, 2020
    Publication date: June 10, 2021
    Applicant: Mamas & Papas Limited
    Inventors: Peter Neil Smith, Graham John Martin
  • Patent number: 11031058
    Abstract: A spin-transfer torque (STT) magnetoresistive memory device includes a first electrode, a second electrode, and a magnetic tunnel junction located between the first electrode and the second electrode. The magnetic tunnel junpction includes a reference layer having a fixed magnetization direction, a free layer stack, and a nonmagnetic tunnel barrier layer located between the reference layer and the free layer stack. The free layer stack has a total thickness of less than 2 nm, and contains in order, a proximal ferromagnetic layer located proximal to the nonmagnetic tunnel barrier layer, a first non-magnetic metal sub-monolayer, an intermediate ferromagnetic layer, a second non-magnetic metal sub-monolayer, and a distal ferromagnetic layer.
    Type: Grant
    Filed: September 3, 2019
    Date of Patent: June 8, 2021
    Assignee: WESTERN DIGITAL TECHNOLOGIES, INC.
    Inventors: Tiffany Santos, Neil Smith
  • Publication number: 20210161901
    Abstract: The present invention features compositions including sepiapterin, or a pharmaceutically acceptable salt thereof, and methods for the treatment of BH4-related disorders. In some embodiments, these compositions and methods result in an increase in plasma exposure of BH4.
    Type: Application
    Filed: May 30, 2019
    Publication date: June 3, 2021
    Inventors: Neil SMITH, Jonathan REIS
  • Patent number: 11021581
    Abstract: Vulcanizable elastomeric formulation are disclosed. The formulations comprise at least one elastomer; a vulcanizing agent comprising cyclododecasulfur; and a prevulcanization inhibitor, present in an amount, for example, from about 0.01 phr to about 10 phr. The formulations, when vulcanized, provide articles that exhibit improved durability.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: June 1, 2021
    Assignee: Eastman Chemical Company
    Inventors: Scott Donald Barnicki, Frederick Ignatz-Hoover, Robert Thomas Hembre, Andrew Neil Smith, Henk Kreulen, Aruna M. Velamakanni, Chenchy Lin, Ronald H. Arthur
  • Publication number: 20210156201
    Abstract: Embodiments and methods relate to pulling and installing a product line along an underground arcuate path beneath an obstacle, including pulling the product line for an extended length (i.e. a length that might otherwise be deemed impracticable) along the underground arcuate path beneath the obstacle. Embodiments also relate to a pulling apparatus for installing a product line using a casing along an underground arcuate path beneath an obstacle, having a casing pull head connected to the casing, a product line pull head assembly connected to the product line, and a pull bracket connected to the product line pull head assembly and to the casing pull head sleeve frame.
    Type: Application
    Filed: February 3, 2021
    Publication date: May 27, 2021
    Inventors: Ronald G. HALDERMAN, Pablo Esteban GUERRA, Richard Neil SMITH, John Steven MEADERS, James WILLIAMS
  • Publication number: 20210065761
    Abstract: A spin-transfer torque (STT) magnetoresistive memory device includes a first electrode, a second electrode, and a magnetic tunnel junction located between the first electrode and the second electrode. The magnetic tunnel junpction includes a reference layer having a fixed magnetization direction, a free layer stack, and a nonmagnetic tunnel barrier layer located between the reference layer and the free layer stack. The free layer stack has a total thickness of less than 2 nm, and contains in order, a proximal ferromagnetic layer located proximal to the nonmagnetic tunnel barrier layer, a first non-magnetic metal sub-monolayer, an intermediate ferromagnetic layer, a second non-magnetic metal sub-monolayer, and a distal ferromagnetic layer.
    Type: Application
    Filed: September 3, 2019
    Publication date: March 4, 2021
    Inventors: Tiffany SANTOS, Neil SMITH
  • Patent number: 10914121
    Abstract: Embodiments and methods relate to pulling and installing a product line along an underground arcuate path beneath an obstacle, including pulling the product line for an extended length (i.e. a length that might otherwise be deemed impracticable) along the underground arcuate path beneath the obstacle. A sealing/locking mechanism is located at one end of an outer pipe and at an end of an inner pipe at a position within the underground arcuate path.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: February 9, 2021
    Assignee: Quanta Associates, L.P.
    Inventors: Ronald G. Halderman, Pablo Esteban Guerra, Richard Neil Smith, John Steven Meaders, James Williams
  • Publication number: 20200410157
    Abstract: A system may use a machine-learned model to determine whether to classify a sequence of one or more words within a first document that is being edited as a candidate hyperlink based at least in part on context associated with the first document. In response to classifying the sequence of one or more words as the candidate hyperlink, the system may use the machine-learned model and based at least in part on the sequence of one or more words and the context to determine one or more candidate document to be hyperlinked from the sequence of one or more words. In response to receiving an indication of a second document being selected out of the one or more candidate documents, the system may modify the first document to associate the sequence of one or more words with a hyperlink to the second document.
    Type: Application
    Filed: March 14, 2019
    Publication date: December 31, 2020
    Inventors: Jan van de Kerkhof, Balint Miklos, Amr Abdelfattah, Tobias Kaufmann, László Lukács, Bjarke Ebert, Victor Anchidin, Brian Strope, Heeyoung Lee, Yun-hsuan Sung, Noah Constant, Neil Smith
  • Publication number: 20200333110
    Abstract: Trajectory estimate for a sub-sonic projectile can be derived from sampling a wake contribution of an acoustic signal detected at a multi-detector array. The wake contribution is sampled, in time, and the samples are processed to determine a bearing estimate for the projectile from which the acoustic wake derives.
    Type: Application
    Filed: July 24, 2019
    Publication date: October 22, 2020
    Inventor: Jonathan Neil SMITH
  • Patent number: 10787148
    Abstract: A transport system and method for securely transporting subjects such as prisoners or persons that include a belt and a slideably engagable channel positioned across a part of a vehicle seat or bench for securing the belt and subject within the vehicle.
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: September 29, 2020
    Assignee: SIRCHIE ACQUISITION COMPANY, LLC
    Inventors: John G Roby, Neil Smith, Jr., Dan Nichols
  • Patent number: 10777248
    Abstract: A magnetoresistive random access memory (MRAM) memory cell comprises a pinned layer having fixed direction of magnetization that is perpendicular to a plane of the pinned layer, a first free layer having a direction of magnetization that can be switched and is perpendicular to a plane of the first free layer, a tunnel barrier positioned between the pinned layer and the first free layer, a second free layer having a direction of magnetization that can be switched, and a spacer layer positioned between the first free layer and the second free layer. Temperature dependence of coercivity of the second free layer is greater than temperature dependence of coercivity of the first free layer.
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: September 15, 2020
    Assignee: Western Digital Technologies, Inc.
    Inventors: Goran Mihajlovic, Neil Smith, Michael Grobis, Michael Tran
  • Publication number: 20200176901
    Abstract: A frangible shunt link assembly includes a frangible link configured to conductively couple a current collector coupled with a vehicle and one or more components of the vehicle. The frangible link is configured to break responsive to the current collector being at least partially separated from the vehicle to interrupt a conductive connection between the current collector and the one or more components of the vehicle.
    Type: Application
    Filed: November 26, 2019
    Publication date: June 4, 2020
    Inventors: Joseph Mosher, William Golpe, Stacy Neil Smith
  • Publication number: 20200110147
    Abstract: Detection of a trajectory of a supersonic projectile is carried out derived from a plurality of acoustic detection signals. From these acoustic detection signals, two or more shockwave-derived trajectory estimates can be derived. Further, a wake derived trajectory bearing estimate can be derived, from which disambiguation of the shockwave-derived trajectory estimates can be effected.
    Type: Application
    Filed: July 24, 2019
    Publication date: April 9, 2020
    Inventor: Jonathan Neil Smith
  • Publication number: 20200073549
    Abstract: A computer-implemented a method for authenticating a user includes: displaying, by a computer device, a first user interface on a display; receiving, by the computer device, user input defining a first pattern; displaying, by the computer device, a second pattern on the display, wherein the second pattern is different than the first pattern; comparing, by the computer device, the first pattern to a predefined pattern; and based on the comparing, the computer device performing one of: re-displaying the first user interface when the first pattern does not match the predefined pattern; and displaying a second user interface when the first pattern does match the predefined pattern.
    Type: Application
    Filed: November 7, 2019
    Publication date: March 5, 2020
    Inventors: Chris R. Bean, Stephen R.F. Head, Sophie D. Green, Madeleine R. Neil Smith