Abstract: A shunt apparatus includes a mounting bracket assembly configured for connection to a vehicle, an actuator connected to the mounting bracket assembly, and a shoe unit connected to the actuator. The actuator is controllable to move the shoe unit to an extended position where a conductive shoe of the shoe unit is positioned to contact a conductive first running surface on which the vehicle travels. The shoe unit includes a resilient biasing assembly that is configured to exert a force on the shoe, to press the shoe against the running surface during movement of the vehicle. Two of the shunt apparatuses may be attached to opposite sides of the vehicle. The shoes of the two shunt apparatuses are electrically connected to one another by an electrical cable. When the shoes are brought into contact with respective running surfaces, the running surfaces are electrically shunted for vehicle signaling purposes or otherwise.

Abstract: The derail warning system may include a solar-powered LED indicator for derail or switch. The derail warning system may also include an orientation sensor that automatically turns on depending on the orientation of the derail (up or down), derail metal flag, or switch indicator flag. The derail warning system may bring more visibility with a 360-degree LED that is solar powered and may detect orientation and turn on based on the position of the derail, switch, or flag. The derail warning system may use a unique acceleration sensor or g-sensor that can detect orientation movement and automatically turn on or off and be fully charged to operate day or night. The derail warning system may also include a data-logging microprocessor to determine a time stamp of position and location.

Abstract: The present invention features compositions including sepiapterin, or a pharmaceutically acceptable salt thereof, and methods for the treatment of BH4-related disorders. In some embodiments, these compositions and methods result in an increase in plasma exposure of BH4.

Abstract: The present invention features compositions including sepiapterin, or a pharmaceutically acceptable salt thereof, and methods for the treatment of BH4-related disorders. In some embodiments, these compositions and methods result in an increase in plasma, CSF, and/or brain exposure of sepiapterin.

Abstract: A spin-transfer torque (STT) magnetoresistive memory device includes a first electrode, a second electrode, and a magnetic tunnel junction located between the first electrode and the second electrode. The magnetic tunnel junction includes a reference layer having a fixed magnetization direction, a free layer stack, and a nonmagnetic tunnel barrier layer located between the reference layer and the free layer stack. The free layer stack has a total thickness of less than 2 nm, and contains in order, a proximal ferromagnetic layer located proximal to the nonmagnetic tunnel barrier layer, a first non-magnetic metal sub-monolayer, an intermediate ferromagnetic layer, a second non-magnetic metal sub-monolayer, and a distal ferromagnetic layer.

Abstract: The present invention features compositions including sepiapterin, or a pharmaceutically acceptable salt thereof, and methods for the treatment of BH4-related disorders. In some embodiments, these compositions and methods result in an increase in plasma exposure of BH4.

Abstract: The derail warning system may include a solar-powered LED indicator for derail or switch. The derail warning system may also include an orientation sensor that automatically turns on depending on the orientation of the derail (up or down), derail metal flag, or switch indicator flag. The derail warning system may bring more visibility with a 360-degree LED that is solar powered and may detect orientation and turn on based on the position of the derail, switch, or flag. The derail warning system may use a unique acceleration sensor or g-sensor that can detect orientation movement and automatically turn on or off and be fully charged to operate day or night. The derail warning system may also include a data-logging microprocessor to determine a time stamp of position and location.

Abstract: A railcar fouling detection system is disclosed herein that is configured to monitor a railway foul zone between a switch and a foul line by detecting railway vehicles moving within or through the foul zone and determining whether railway vehicles are positioned within the foul zone based on information obtained by the one or more sensors. In some embodiments, the railcar fouling detection system may be configured to determine whether a railway vehicle is positioned within the foul zone by counting the number of wheels (or railway vehicles) entering and exiting the foul zone. The railcar fouling detection system may be configured to provide a visual indication of whether or not a railway vehicle is presently within the foul zone and/or provide a notification to locomotives in response to detecting a railway vehicle positioned within the foul zone.

Abstract: The invention features methods of treating a SARS-CoV-2 infection in a subject, the method comprising administering to the subject an effective amount of sepiapterin or a pharmaceutically acceptable salt thereof.

Abstract: The invention features methods of treating glioblastoma in a subject, the method comprising administering to the subject an effective amount of sepiapterin or a pharmaceutically acceptable salt thereof.

Abstract: The present invention features compositions including sepiapterin, or a pharmaceutically acceptable salt thereof, and methods for the treatment of BH4-related disorders. In some embodiments, these compositions and methods result in an increase in plasma, CSF, and/or brain exposure of sepiapterin.

Abstract: The derail warning system may include a solar-powered LED indicator for derail or switch. The derail warning system may also include an orientation sensor that automatically turns on depending on the orientation of the derail (up or down), derail metal flag, or switch indicator flag. The derail warning system may bring more visibility with a 360-degree LED that is solar powered and may detect orientation and turn on based on the position of the derail, switch, or flag. The derail warning system may use a unique acceleration sensor or g-sensor that can detect orientation movement and automatically turn on or off and be fully charged to operate day or night. The derail warning system may also include a data-logging microprocessor to determine a time stamp of position and location.

Abstract: The present invention features methods for treating Parkinson's disease using sepiapterin, or a pharmaceutically acceptable salt thereof.

Abstract: The present invention features compositions including sepiapterin, or a pharmaceutically acceptable salt thereof, and methods for the treatment of BH4-related disorders. In some embodiments, these compositions and methods result in an increase in plasma, CSF, and/or brain exposure of sepiapterin.

Abstract: Trajectory estimate for a sub-sonic projectile can be derived from sampling a wake contribution of an acoustic signal detected at a multi-detector array. The wake contribution is sampled, in time, and the samples are processed to determine a bearing estimate for the projectile from which the acoustic wake derives.

Abstract: A frangible shunt link assembly includes a frangible link configured to conductively couple a current collector coupled with a vehicle and one or more components of the vehicle. The frangible link is configured to break responsive to the current collector being at least partially separated from the vehicle to interrupt a conductive connection between the current collector and the one or more components of the vehicle.

Abstract: The invention features methods of reducing the blood phenylalanine concentration in a subject by administering sepiapterin, or a pharmaceutically acceptable salt thereof.

Abstract: Embodiments and methods relate to pulling and installing a product line along an underground arcuate path beneath an obstacle, including pulling the product line for an extended length (i.e. a length that might otherwise be deemed impracticable) along the underground arcuate path beneath the obstacle. Embodiments also relate to a pulling apparatus for installing a product line using a casing along an underground arcuate path beneath an obstacle, having a casing pull head connected to the casing, a product line pull head assembly connected to the product line, and a pull bracket connected to the product line pull head assembly and to the casing pull head sleeve frame.

Abstract: In one embodiment, the invention discloses a method for adapting educational content. The method comprises generating data for each of a plurality of students, the data pertaining to an aspect of the student's interaction with an educational system; combining the generated data to form a combined data set; analyzing the combined data set to identify clusters, each representing similar students according to a mathematical model; and adapting the educational system to provide a customized learning experience for a particular student based on an identified cluster.

Abstract: The invention provides methods for treating radiation exposure in a subject by administering sepiapterin, tetrahydrobiopterin, or dihydrobiopterin.