Patents by Inventor Nevenka Dimitrova

Nevenka Dimitrova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8561095
    Abstract: A system and method for collecting, analyzing, and using sensory reactions and involuntary or spontaneous movements by members of a television viewing (or listening) audience. While known programming is displayed on a television receiver, a plurality of sensors monitor the viewer or viewers for recognizable evidence of an emotional response that can be associated with a discrete program segment. Where positive (or negative) responses can be associated with a certain type of program content, the system monitors subsequent programs for the opportunity to notify the viewer or simply present (or avoid presenting) the program automatically.
    Type: Grant
    Filed: November 13, 2001
    Date of Patent: October 15, 2013
    Assignee: Koninklijke Philips N.V.
    Inventors: Nevenka Dimitrova, John Zimmerman, Lalitha Agnihotri
  • Patent number: 8528019
    Abstract: A method of selecting, storing and delivering desired audio/data/visual information includes the steps of determining viewing preferences of a viewer and receiving a first group of audio/data/visual signals, for example, broadcast and cable television signals or internet-based signals. Based on the first group of audio/data/visual signals, a second group of audio/data/visual signals, which is a subset of the first group of audio/data/visual signals, is identified. The second group of audio/data/visual signals is selected based on the association of EPG data for each signal with the viewing preferences of the viewer. Content data is then extracted from the second group of audio/data/visual signals and compared with the viewing preferences. The content data may include, for example, closed-captioned text, EPG data, audio information, visual information and transcript information.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: September 3, 2013
    Assignee: Koninklijke Philips N.V.
    Inventors: Nevenka Dimitrova, Thomas McGee, Jan Hermanus Elenbaas, Lalitha Agnihotri, Radu Jasinschi, Serhan Dagtas, Aaron S Mendelsohn
  • Publication number: 20130226621
    Abstract: A method comprises: recording an electronic record of diagnostic events including the performing of in-vitro diagnostic tests; during the recording, identifying the performing of a licensed in-vitro diagnostic test for which license information is stored in a licenses database; and computing license compensation due to a licensor for the performing of the licensed in-vitro diagnostic test based on royalty calculation information stored in the licenses database. The recording, identifying, and computing operations are performed by one or more computers. The method may further include remitting the computed license compensation to the licensor, the remitting also being performed by one or more computers.
    Type: Application
    Filed: October 24, 2011
    Publication date: August 29, 2013
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Pieter Jan Van Der Zaag, Nevenka Dimitrova, Anja Van De Stolpe, Hendrik Van Houten
  • Patent number: 8503808
    Abstract: A method for compression and/or decompression of bio-medical images such as DNA sequencing images is provided. The method comprises regeneration of a complete image using multiple distribution functions generated on the fly. The compression ratio achieved is in the order of 10 to 20 times, and is near lossless with respect to the clinically relevant information; which makes it well suited for these DNA sequencing images.
    Type: Grant
    Filed: May 11, 2009
    Date of Patent: August 6, 2013
    Assignee: Koninklijke Philips N.V.
    Inventors: Harsh Dhand, Nevenka Dimitrova, Hansraj Mishra
  • Publication number: 20130196877
    Abstract: The present invention relates to a method for identifying multi-modal associations between biomedical markers which allows for the determination of network nodes and/or high ranking network members or combinations thereof, indicative of having a diagnostic, prognostic or predictive value for a medical condition, in particular ovarian cancer. The present invention further relates to a biomedical marker or group of biomedical markers associated with a high likelihood of responsiveness of a subject to a cancer therapy, preferably a platinum based cancer therapy, wherein said bio-medical marker or group of biomedical markers comprises at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 8, 19, 20 or all markers selected from PKMYT1, SKIL, RAB8A, HIRIP3, CTNNB1, NGFR, ZCCHC11, LSP1, CD200, PAX8, CYBRD1, HOXC11, TCEAL1, FZD10,FZD1, BBS4, IRS2, TLX3, TSPAN2, TXN, and CFLAR.
    Type: Application
    Filed: October 4, 2011
    Publication date: August 1, 2013
    Applicants: COLD SPRING HARBOR LABORATORY, KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Nilanjana Banerjee, Angel Janevski, Sitharthan Kamalakaran, Vinay Varadan, Nevenka Dimitrova, Robert Lucito
  • Publication number: 20130102483
    Abstract: The present invention relates to methods, arrays and computer programs for assisting in classifying breast cancer diseases. In particular the invention relates to classifying breast cancer disorders by determining the methylation status of one or more sequences according to SEQ ID NO: 1-111. The classification may be further strengthened by also taking the expression levels of one or more proteins into account.
    Type: Application
    Filed: April 8, 2011
    Publication date: April 25, 2013
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Nevenka Dimitrova, Surabhi Khandige, Satyamoorthy Kapaettu, Aparna Gorthi, Shama Prasada Kabekkodu, Sanjiban Chakrabarty, Payal Keswarpu, Nilanjana Banerjee, Angel Janevski, Prashantha Hebbar
  • Publication number: 20130090257
    Abstract: A method for assigning ranking scores to pathways in a set of pathways for classifying patients is disclosed. The method comprises the steps of comparing biomolecular datasets from different groups of patients and performing an analysis in order to assign ranking scores to pathways in a set of pathways. Furthermore, a method for using cancer pathway evaluation to support clinical decision making is disclosed. This assessment is further used for stratifying ovarian cancer patients based on chemosensitivity to platinum based drugs, the standard chemotherapy. We present the method for evaluation and ranking of the most relevant pathways responsible for platinum sensitivity. Clinical decision support software system should be able to then visualize this information for a clinician, contextualize it within a patient data set and help make a final decision on the potential responsiveness.
    Type: Application
    Filed: June 21, 2011
    Publication date: April 11, 2013
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Nilanjana Banerjee, Nevenka Dimitrova, Robert Lucito
  • Patent number: 8357112
    Abstract: This invention relates to a method and an apparatus of controlling a release of a material carried by ultrasound sensitive particles, the release being caused by irradiating the ultrasound sensitive particles with an ultrasonic pulse having acoustic properties selected so as to interact with the ultrasound sensitive particles and thus causing the release of the material. The ultrasound sensitive particles comprise sub-groups of ultrasound sensitive particles, the ultrasound sensitive particles within the same sub-group having their respective acoustic property causing each respective sub-group to interact independently with the sound wave.
    Type: Grant
    Filed: March 3, 2008
    Date of Patent: January 22, 2013
    Assignee: Koninklijke Philips Electronics N.V.
    Inventors: Nevenka Dimitrova, Christopher S. Hall, Chien T. Chin
  • Patent number: 8261306
    Abstract: A system and method for providing information to television viewers in order to assist them in shopping from an apparently conventional media, such as a television program, as well as making better and more educated shopping decisions are provided. The user selects the product of interest, and if desired, indicates the price, quantity and time frame within which he/she wants to buy the product. The system then acts as an agent on the user's behalf to get the best product under best price and shortest time frame as may be desired. When a user sees a product he wants while watching television, he simply can press a point on the screen, talk, or press a button on a remote control or similar keypad and the system shows the current price and availability. If the user wants the product, he can buy it instantly. If the user determines it to be too expensive, he can add the product to his wish-list with a price he would be willing to pay.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: September 4, 2012
    Assignee: Koninklijke Philips Electronics N.V.
    Inventors: Nevenka Dimitrova, John D. Zimmerman, Radu Serban Jasinschi
  • Patent number: 8204317
    Abstract: Method and device for providing a summary of a plurality of images, e.g. a video sequence. The method includes dividing the video sequence into a plurality of segments. The segments are analyzed with respect to content and a set of content descriptors are associated to the segments. Preferably, additional textual information about the segments, screenplay etc., is used to determine the content descriptors. A graph representing relations between the segments is constructed indicating relations between segments. Weights are associated to the relations so as to represent a measure of relation, e.g. a logical correlation, between segments. The weights are based on the calculated content descriptors. A relevance measure for a segment is determined based on all weights associated with relations to said segment. Finally, a summary is generated by selecting the most relevant segments.
    Type: Grant
    Filed: February 27, 2007
    Date of Patent: June 19, 2012
    Assignee: Koninklijke Philips Electronics N.V.
    Inventors: Mauro Barbieri, Lalitha Agnihotri, Nevenka Dimitrova
  • Patent number: 8199991
    Abstract: A method of automatically identifying the microarray chip corners and probes, even if there are no probes at the corners, in a high density and high resolution microarray scanned image having an image space, wherein the method minimizes the error distortions in the image arising in the scanning process by applying to the image a multipass corner finding algorithm comprising: (a) applying a Radon transform to an input microarray image to project the image into an angle and distance space where it is possible to find the orientation of the straight lines; (b) applying a fast Fourier transform to the projected image of (a) to find the optimal tilting angle of the projected image; (c) determining the optimal first and last local maxima for the optimal tilting angle; (d) back projecting the determined first and last local maxima to the image space to find the first approximation of the first and last column lines of the image; (e) rotating the image and repeating steps (a) through (d) to find the first approximati
    Type: Grant
    Filed: December 3, 2007
    Date of Patent: June 12, 2012
    Assignee: Koninklijke Philips Electronics N.V.
    Inventors: Lalitha Agnihotri, James David Schaffer, Nevenka Dimitrova
  • Publication number: 20120053071
    Abstract: The present invention relates to a method for the detection of a DNA methylation signature associated with the presence of or the predisposition to develop a disorder, the method comprising the identification of one or more candidate genes exhibiting differential DNA methylation in target and reference samples as well as the respective determination of the nucleic acid sites in said candidate genes that are differentially methylated and the recognition sites for DNA binding factors, said DNA binding factors each recognizing such a differentially methylated nucleic acid site, wherein the patterns of differentially methylated nucleic acid sites and of DNA binding factor recognition sites obtained together represent a DNA methylation signature that is indicative for the presence of or the predisposition to develop a disorder in a target sample.
    Type: Application
    Filed: December 14, 2009
    Publication date: March 1, 2012
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Nevenka Dimitrova, Chetan Mittal, Sitharthan Kamalakaran
  • Patent number: 8126763
    Abstract: This invention relates to a method and computer system for automatic generation of trailers. More specifically it relates to a method for generating revenues from providers of content data. The method generally comprises the steps of finding product placement data in a super set of data. When these product placements have been found they are preferably matched with a user profile and segments, of the superset comprising these product placements with a positive match, are selected and merged into a subset of data. A counter may keep track of which product placement that has been chosen and how many times a product placement has been chosen and viewed. Based on the value of the counter an invoice is created.
    Type: Grant
    Filed: January 17, 2006
    Date of Patent: February 28, 2012
    Assignee: Koninklijke Philips Electronics N.V.
    Inventors: Lalitha Agnihotri, Mauro Barbieri, Nevenka Dimitrova
  • Publication number: 20120036116
    Abstract: The present invention discloses a method for DNA sequence analysis based on DNA spectrogram database. Furthermore, a use, a device and a computer-readable medium related to the method are disclosed.
    Type: Application
    Filed: November 11, 2009
    Publication date: February 9, 2012
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Srinivas Rao Kudavelly, Nevenka Dimitrova
  • Publication number: 20120016826
    Abstract: The invention relates to selecting a set of candidate genes from a pool of genes. The method comprising receiving a set of gene data; arranging the set of gene data into a set of clusters with similar profiles by use of a clustering algorithm; and inputting the set of clusters into a genetic algorithm to select a set of candidate genes from the set of clusters. The method thus relates to hybrid between selection by clustering computation and selection by evolutionary computation. This hybrid is also referred to as an evolutionary clustering algorithm (ECA).
    Type: Application
    Filed: December 23, 2009
    Publication date: January 19, 2012
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Narayan Behera, Shruti Sinha, Rakesh Gupta, Ann Geoncy, Nevenka Dimitrova
  • Publication number: 20110281756
    Abstract: The present invention relates compositions and methods for microRNA (miRNA) expression profiling of colorectal cancer. In particular, the invention relates to a diagnostic kit of molecular markers for identifying one or more mammalian target cells exhibiting or having a predisposition to develop colorectal cancer, the kit comprising a plurality of nucleic acid molecules, each nucleic acid molecule encoding a miRNA sequence, wherein one or more of the plurality of nucleic acid molecules are differentially expressed in the target cells and in one or more control cells, and wherein the one or more differentially expressed nucleic acid molecules together represent a nucleic acid expression signature that is indicative for the presence of or the predisposition to develop colorectal cancer.
    Type: Application
    Filed: November 13, 2009
    Publication date: November 17, 2011
    Inventors: Ying Wu, Hongguang Zhu, Jian Li, Liang Xu, Wilhelmus F.J. Verhaegh, Yiping Ren, Angel Janevski, Vinay Varadan, Zhaoyong Li, Nevenka Dimitrova
  • Publication number: 20110246082
    Abstract: The present invention relates a method for analyzing a DNA sequence. The DNA sequence by converting the DNA sequence into a plurality of binary indicator sequences (BIS), and applying short term Fourier transform (STFT) on the binary indicator sequences. A binning function (BF) is applied to the Fourier coefficients (Usk_X(k)) and thereby modifying the corresponding Fourier coefficients (Usk_X(k)). Finally, substantially equal modified Fourier coefficients (Usk_X(k)) is found. The invention provides the user with a much improved ability to see unique strong patterns in vast amount of DNA sequence data.
    Type: Application
    Filed: June 12, 2009
    Publication date: October 6, 2011
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Anca Ioana Daniela Bucur, Jasper Johannes Adrianus Van Leeuwen, Nevenka Dimitrova, Chetan Mittal
  • Publication number: 20110224103
    Abstract: A method is provided allowing for automatic selection of enzymes to be used in protocols such as methylation profiling, chip-on-chip, and comparative genomic hybridization experiments. The method may also maximize the space on a micro array for a given experiment. This means that the results from the micro array are improved. The method also improves zero-in and focus of significant patterns on a micro array. This enhances the ability to distinguish two separate classes of samples, e.g. tumour vs. normal, aggressive vs. non-aggressive, male vs. female, etc. Furthermore, a computer readable medium and a device are also provided.
    Type: Application
    Filed: May 14, 2009
    Publication date: September 15, 2011
    Applicants: KONINKLIJKE PHILIPS ELECTRONICS N.V., COLD SPRING HARBOR LABORATORY
    Inventors: Nevenka Dimitrova, Sitharthan Kawalakaran, Robert Lucito
  • Publication number: 20110189098
    Abstract: The present invention relates to a method of non-invasively monitoring the expression of a gene of interest in a cell when contacting said cell with a compound influencing the expression of said gene of interest. The present invention is also concerned with different isolated nucleic acid molecules comprising a coding sequence. Said coding sequence comprises a gene of interest-sequence encoding a gene of interest-polypeptide fused to a reporter sequence encoding a fluorescent reporter polypeptide and is operatively coupled to a promoter sequence. The present invention is also concerned with the use of a method and a nucleic acid molecule of the invention for delivering a compound influencing the expression of a gene of interest in a cell, monitoring the delivery of said compound as well as monitoring the influence on the expression of said gene fluorescence of interest induced by said compound at the same time.
    Type: Application
    Filed: May 14, 2009
    Publication date: August 4, 2011
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Nevenka Dimitrova, Chetan Mital
  • Patent number: 7934233
    Abstract: A method for providing complementary information 226 for a video program is provided that includes receiving complementary information 226 for a video program. A query is received from a consumer. The query is related to a specified portion of the complementary information 226. A query response is provided to the consumer based on the specified portion of the complementary information 226.
    Type: Grant
    Filed: April 1, 2003
    Date of Patent: April 26, 2011
    Assignee: Koninklijke Philips Electronics N.V.
    Inventors: John Zimmerman, Nevenka Dimitrova, Dongge Li, Johanna Maria Bont, Andreas Henricus Elisabeth Lamers, Angel Janevski, Lira Nikolovska