Patents by Inventor Nghe Nguyen-Ba

Nghe Nguyen-Ba has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antiviral compounds
    Patent number: 5955610
    Abstract: Nucleotide analogues having the general formula (I) and pharmaceutically acceptable derivatives: ##STR1## wherein n is 0 or an integer; X is O or S, CH.sub.2, CH-halogen, CH--N.sub.3, or C.dbd.CH.sub.2 ;Q and U are independently selected from: O, S, and CH(R.sub.a) wherein R.sub.a is hydrogen, OH, halogen, N.sub.3, NH.sub.2, SH, carboxyl, C.sub.1-6 alkyl or R.sub.a is CH.sub.2 (R.sub.b) wherein R.sub.b is hydrogen, OH, SH, NH.sub.2, C.sub.1-6 alkyl or carboxyl; or both Q and U are CH when Q and U are linked by a double bond;Z is selected from: O, a C.sub.1-6 alkoxy, a C.sub.1-6 thioalkyl, a C.sub.1-6 aminoalkyl, (CH.sub.2).sub.m wherein m is 0 or an integer, and N(R.sub.c).sub.2 wherein both R.sub.c are independently hydrogen or a C.sub.1-6 alkyl; andR2 is a purine or pyrimidine base or an analogue or derivative thereof. Members of this series of analogues possess anti-viral activity.
    Type: Grant
    Filed: June 4, 1997
    Date of Patent: September 21, 1999
    Assignee: Biochem Pharma, Inc.
    Inventors: Nghe Nguyen-Ba, Miguel Quimpere, Laval Chan Chun Kong, William L. Brown, Gervais Dionne
  • Anti-viral compounds
    Patent number: 5789394
    Abstract: Nucleotide analogues having the general formula (I) and pharmaceutically acceptable derivatives: ##STR1## wherein n is 0 or an integer; X is O or S, CH.sub.2, CH-halogen, CH--N.sub.3, or C.dbd.CH.sub.2 ;Q and U are independently selected from: O, S, and CH(R.sub.a) wherein R.sub.a is hydrogen, OH, halogen, N.sub.3, NH.sub.2, SH, carboxyl, C.sub.1-6 alkyl or R.sub.a is CH.sub.2 (R.sub.b) wherein R.sub.b is hydrogen, OH, SH, NH.sub.2, C.sub.1-6 alkyl or carboxyl; or both Q and U are CH when Q and U are linked by a double bond;Z is selected from: O, a C.sub.1-6 alkoxy, a C.sub.1-6 thioalkyl, a C.sub.1-6 aminoalkyl, (CH.sub.2).sub.m wherein m is 0 or an integer, and N(R.sub.c).sub.2 wherein both R.sub.c are independently hydrogen or a C.sub.1-6, alkyl; andR2 is a purine or pyrimidine base or an analogue or derivative thereof are disclosed. Members of this series of analogues possess anti-viral activity.
    Type: Grant
    Filed: April 29, 1996
    Date of Patent: August 4, 1998
    Inventors: Nghe Nguyen-Ba, Miguel Quimpere, Laval Chan Chung Kong, William L. Brown, Gervais Dionne
  • Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
    Patent number: 5684164
    Abstract: Disclosed are processes for preparing compounds of the formula (I) and pharmaceutically acceptable salts or esters thereof: ##STR1## wherein R.sub.2 is a purine or pyrimidine base or an analogue or derivative thereof; and Z is S, S.dbd.O or SO.sub.2. The invention also relates to intermediates of use in the preparation of these compounds.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: November 4, 1997
    Assignee: BioChem Pharma Inc.
    Inventors: Bernard Belleau, deceased, Tarek Mansour, Allan Tse, Colleen A. Evans, Haolun Jin, Boulos Zacharie, Nghe Nguyen-Ba
  • Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties
    Patent number: 5587480
    Abstract: This invention relates to novel substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes or pharmaceutically acceptable salts and esters thereof, of the formula: ##STR1## wherein X is S, S.dbd.O, or SO.sub.2 ;Y is O, S, S.dbd.O, or SO.sub.2 ;R.sub.1 is hydrogen, trisubstituted silyl, C.sub.1-6 alkyl, aralkyl, or C.sub.1-6 acyl, and R.sub.2 is a pyrimidine base or an analogue or derivative thereof.This invention also relates to processes for preparing these compounds, intermediates useful in their preparation, to pharmaceutical compositions containing them and to the use of these compounds as antiviral agents.
    Type: Grant
    Filed: April 20, 1994
    Date of Patent: December 24, 1996
    Assignee: BioChem Pharma, Inc.
    Inventors: Bernard Belleau, deceased, Nghe Nguyen-Ba, Laval C. C. Kong, Tarek Mansour, Haolun Jin, Livio Brasili
  • Use of 1,3-oxathiolane nucleoside analogues in the treatment of hepatitis B
    Patent number: 5532246
    Abstract: Use of a compound of formula (I) or a pharmaceutically acceptable derivative thereof in the manufacture of a medicament for the treatment of hepatitis B is disclosed.
    Type: Grant
    Filed: August 9, 1993
    Date of Patent: July 2, 1996
    Assignee: BioChem Pharma, Inc.
    Inventors: Bernard Belleau, deceased, Nghe Nguyen-Ba
  • 1,3-oxathiolanes useful in the treatment of hepatitis
    Patent number: 5486520
    Abstract: The present invention relates to the use of nucleoside analogues in the treatment of viral infections. More specifically it is concerned with the use of 1,3-oxathiolane nucleoside analogues in the treatment of hepatitis, in particular hepatitis B.
    Type: Grant
    Filed: December 10, 1993
    Date of Patent: January 23, 1996
    Assignee: BioChemPharma, Inc.
    Inventors: Bernard Belleau, deceased, Nghe Nguyen-Ba
  • Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
    Patent number: 5466806
    Abstract: Disclosed are processes for preparing compounds of the formula (I) and pharmaceutically acceptable salts or esters thereof: ##STR1## wherein R.sub.2 is a purine or pyrimidine base or an analogue or derivative thereof; and Z is S, S.dbd.O or SO.sub.2. The invention also relates to intermediates of use in the preparation of these compounds.
    Type: Grant
    Filed: March 29, 1993
    Date of Patent: November 14, 1995
    Assignee: Biochem Pharma Inc.
    Inventors: Bernard Belleau, deceased, Tarek Mansour, Allan Tse, Colleen A. Evans, Haolun Jin, Boulos Zacharie, Nghe Nguyen-Ba
  • 4-(purinyl bases)-substituted-1,3-dioxlanes
    Patent number: 5270315
    Abstract: There is provided novel 2-substituted-4-substituted-1,3-dioxolanes which are particularly useful as antiviral agents.
    Type: Grant
    Filed: March 7, 1991
    Date of Patent: December 14, 1993
    Assignee: BioChem Pharma Inc.
    Inventors: Bernard Belleau, Dilip Dixit, Nghe Nguyen-Ba
  • 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
    Patent number: 5151426
    Abstract: Methods and compositions for preventing or treating human immunodeficiency virus (HIV) infections characterized by 2-substituted-5-substituted-1,3-oxathiolanes.
    Type: Grant
    Filed: June 17, 1991
    Date of Patent: September 29, 1992
    Assignee: BioChem Pharma Inc.
    Inventors: Bernard Belleau, Nghe Nguyen-Ba
  • 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
    Patent number: 5047407
    Abstract: Methods and compositions for preventing or treating human immunodeficiency virus (HIV) infections characterized by 2-substituted-5-substituted-1,3-oxathiolanes.
    Type: Grant
    Filed: February 8, 1989
    Date of Patent: September 10, 1991
    Assignee: IAF BioChem International, Inc.
    Inventors: Bernard Belleau, Nghe Nguyen-Ba
  • 4-(nucleoside base)-substituted-1,3-dioxolanes useful for treatment of retroviral infections
    Patent number: 5041449
    Abstract: There are provided novel 2-substituted-4-substituted-1,3-dioxolanes which are particularly useful as antiviral agents.
    Type: Grant
    Filed: June 29, 1990
    Date of Patent: August 20, 1991
    Assignee: IAF BioChem International, Inc.
    Inventors: Bernard Belleau, Dilip Dixit, Nghe Nguyen-Ba