Abstract: Methods for clamping a tether about a spinal or other anatomical feature. In some implementations, a tether may be extended in a loop around an anatomical feature of a spine. A spinal fixation rod may be coupled with an inner coupling piece of a clamping assembly, such as by way of a slot formed in the inner coupling piece. The inner coupling piece may be nestably coupled within an outer coupling piece of the clamping assembly. A first end of the tether may be passed through a passage of the clamping assembly, the passage being is at least partially defined by an outer surface of the inner coupling piece and an inner surface of the outer coupling piece. The loop may be tightened about the anatomical feature with the tether clamped between the inner coupling piece and the outer coupling piece.

Abstract: Described herein are crystalline forms of Compound 1 useful for the prevention and treatment of angiogenic ocular conditions; methods of treating a disease comprising; processes for preparing; and kits comprising, the same.

Abstract: A system for caching includes an interface to receive a portion of a hypercube to evaluate. The hypercube includes cells with a set of the cells having a formula. The system includes a processor to determine term(s) in the formula for each cell of the set of cells; remove from consideration a time dimension and/or a primary dimension for the term(s) in the formula for each cell of the set of cells; determine a set of distinct terms using the term(s); determine whether a total number of terms in the set of cells is larger than a number of distinct terms in the set of distinct terms; and in response to determining that the total number of terms in the set of cells is larger than the number of distinct terms in the set of distinct terms, indicate to cache the set of distinct terms during evaluation.

Abstract: A solid polymer blend material comprising: (i) a lignin-acrylonitrile component containing a homogeneous blend of a lignin component and an acrylonitrile-containing rubber component; and (ii) a styrene-containing thermoplastic component that is non-elastomeric; wherein components (i) and (ii) are homogeneously dispersed in the polymer blend material. Methods for producing the blend material are also described. Methods for producing objects made of the blend material by melt extrusion are also described, comprising: (a) melt blending components (i) and (ii) to form a polymer blend in which components (i) and (ii) are homogeneously blended, wherein the polymer blend exhibits a melt viscosity of no more than 2000 Pa·s at a shear rate of 100-1000 s?1 and when heated to a temperature of no more than 240° C.; and (b) forming an object made of said polymer blend material.

Abstract: The present subject matter relates to scanning of objects. A device enabling scanning of objects includes an imaging unit to scan objects and a supporting unit to support the imaging unit on an electronic device. The supporting unit includes a supporting leg that forms a rotatable joint with the imaging unit to enable the imaging unit to fold over the supporting leg. The supporting unit also includes a coupling unit to detachably couple the device to the electronic device.

Abstract: A system and method for identification and location of user identified, feature specific printers works in conjunction with a user's smartphone or tablet computer. A user inputs their desired printer features into their device, and a listing of candidate printers within a search perimeter is rendered. A distance between the user device and each candidate printer is calculated from a determined location user device relative to locations of each of the candidate printers. The user selects their desired printer from the candidates, and directions for the user to walk to the selected printer are generated and displayed.

Abstract: An implantable prosthetic valve can include an annular frame comprising an inflow end and an outflow end and being radially collapsible and expandable between a radially collapsed configuration and a radially expanded configuration. A leaflet structure can be positioned within the frame and secured thereto. An annular sealing member can be positioned around an outer surface of the frame, wherein the sealing member has a periodic, undulating shape. An outer skirt can be positioned around an outer surface of the sealing member and secured to the frame.

Abstract: According to some examples, solutions are provided for power distribution of input alternating current (AC) power to at least one power outlet while the input AC power is available, charging of a set of batteries by the input AC power while the input AC power is available, and power distribution of direct current (DC) power from the set of batteries to the power outlet when the input AC power is not available. For such examples, the power outlet is capable of conducting AC power and DC power to a load that is coupled to the power outlet and that can receive either AC power or DC power.

Abstract: Described herein are crystalline forms of Compound 1 useful for the prevention and treatment of angiogenic ocular conditions; methods of treating a disease comprising; processes for preparing; and kits comprising, the same.

Abstract: A system and method for identification and location of user identified, feature specific printers works in conjunction with a user's smartphone or tablet computer. A user inputs their desired printer features into their device, and a listing of candidate printers within a search perimeter is rendered. A distance between the user device and each candidate printer is calculated from a determined location user device relative to locations of each of the candidate printers. The user selects their desired printer from the candidates, and directions for the user to walk to the selected printer are generated and displayed.

Abstract: Described herein are crystalline forms of Compound 1 useful for the prevention and treatment of angiogenic ocular conditions; methods of treating a disease comprising; processes for preparing; and kits comprising, the same.

Abstract: The disclosure provides a bidet washing apparatus equipped with a backflow preventer and methods for using the apparatus for preventing backflow of potentially contaminate water into the bidet washing apparatus. The methods utilizing the apparatus include applying water pressure on a backflow preventer in-line with a reservoir dispenser outlet; and releasing the water pressure on the backflow preventer, thereby allowing air to enter the reservoir dispenser outlet, wherein any contaminated water cannot be pulled back into the apparatus by reduced pressure.

Abstract: Tether clamping assemblies, such as clamping assemblies used to clamp a tether about a spinal feature to assist in spinal fixation, and related methods and systems. In some embodiments, the assembly may comprise a tether configured to engage a bone or other anatomical feature, an inner coupling piece, and an outer coupling piece. A first passage may be at least partially defined by an inner surface of the outer coupling piece and an outer surface of the inner coupling piece. The first passage may be configured such that the tether can be clamped in between the inner surface and the outer surface to allow the tether to move through the first passage in a first direction and apply a force differential such that movement of the tether in a second direction opposite the first direction is made more difficult.

Abstract: The invention relates to heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.

Abstract: Tether clamping assemblies, such as clamping assemblies used to clamp a tether about a spinal feature to assist in spinal fixation, and related methods and systems. In some embodiments, the assembly may comprise a tether configured to engage a bone or other anatomical feature, an inner coupling piece, and an outer coupling piece. A first passage may be at least partially defined by an inner surface of the outer coupling piece and an outer surface of the inner coupling piece. The first passage may be configured such that the tether can be clamped in between the inner surface and the outer surface to allow the tether to move through the first passage in a first direction and lock the tether in place. The inner and outer surfaces preferably differ in surface roughness to facilitate automatic or self-locking of the tether in the assembly.

Abstract: Described herein are crystalline forms of Compound 1 useful for the prevention and treatment of angiogenic ocular conditions; methods of treating a disease comprising; processes for preparing; and kits comprising, the same.

Abstract: Described herein are certain crystalline forms of Compound 3, as well as pharmaceutical compositions employing the crystalline forms. Also provided are particles (e.g., nanoparticles) comprising such crystalline forms or pharmaceutical compositions. In certain examples, the particles are mucus penetrating particles (MPPs). The present invention further relates to methods of treating or preventing diseases using crystalline forms or pharmaceutical compositions.

Abstract: Tether tensioning instruments, such as instruments used to tension and/or lock a tether about a spinal feature to assist in spinal fixation, and related methods and systems. In some embodiments, the instrument may comprise a handle, a tensioner base coupled with the handle, at least a portion thereof being movably coupled to the handle, and a tether coupling member coupled with the tensioner base and configured to fixedly engage a tether. The instrument may further comprise a tensioner tip movably coupled with the tensioner base, wherein at least a portion of the tensioner base is biased away from the tensioner tip, and wherein the instrument is configured to allow for step-wise movement of the tensioner tip away from the tensioner base to increase tension between the tether and an element of the spinal fixation system.

Abstract: Provided herein is a compound, 1-(4-(3-amino-[1,2,3]triazolo[1,5-a]pyridin-4-yl)phenyl)-3-(3-chlorophenyl)urea, pharmaceutical compositions thereof, and crystal forms thereof. Also provided are particles (e.g., nanoparticles) comprising the compound, and pharmaceutical compositions thereof, that are mucus penetrating. Also provided herein are methods and kits for using the compound, and pharmaceutical compositions thereof, for treating and/or preventing diseases associated with abnormal or pathological angiogenesis and/or aberrant signaling of a growth factor (e.g., vascular endothelial growth factor (VEGF)), such as proliferative diseases (e.g., cancers, benign neoplasms, inflammatory diseases, autoimmune diseases) and ocular diseases (e.g., macular degeneration, glaucoma, diabetic retinopathy, retinoblastoma, edema, uveitis, dry eye, blepharitis, and post-surgical inflammation) in a subject in need thereof.