Patents by Inventor Nicholas A. Peppas

Nicholas A. Peppas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Delivery of small interfering RNA and micro RNA through nanogels containing hydrophobic pseudo-peptides
    Patent number: 11000602
    Abstract: Nanoscale, pH-responsive polycationic networks useful for the delivery of anionic biologic therapeutics and associated methods.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: May 11, 2021
    Assignee: Board of Regents, The University of Texas System
    Inventors: Nicholas Peppas, William Liechty
  • Hydrogels for delivery of therapeutic compounds
    Patent number: 10835609
    Abstract: In some aspects, methacrylate co-polymers crosslinked with an enzymatically cleavable peptide linker are provided and may be used for the oral delivery of a therapeutic. The peptide linker may be cleavable by an enzyme in the small intestine and may allow for the delivery of a therapeutic protein or nucleic acid to the small intestine. Also provided are methods of using the polymers for the treatment of a disease.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: November 17, 2020
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Jennifer M. Knipe, Laura E. Strong, Nicholas A. Peppas
  • Polymers for delivery of therapeutic proteins
    Patent number: 10500256
    Abstract: In some aspects, improved hydrogel copolymers (e.g., comprising itaconic acid and N-vinylpyrrolidone) are provided and may be used, e.g., for oral delivery of a therapeutic protein. In some embodiments, improved methods for loading a therapeutic protein (e.g., a high isoelectric point protein) into a hydrogel copolymer are provided, and may comprise incubating the therapeutic protein and the hydrogel in a reduced ionic strength loading solution. In some embodiments, use of the reduced ionic strength loading solution can result in hydrogel copolymer-therapeutic protein compositions that display improved pharmacokinetic attributes, e.g., improved loading and/or release of a therapeutic protein.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: December 10, 2019
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Michael Koetting, Nicholas Peppas
  • POLYMERS FOR DELIVERY OF FACTOR VIII AND/OR FACTOR IX
    Publication number: 20190275162
    Abstract: In some aspects, a composition comprising a pH-sensitive crosslinked copolymer of methacrylic acid and poly(ethylene glycol) monomethyl ether methacrylate and a therapeutic protein is provided. In some embodiments, the therapeutic protein is a high molecular weight protein such as factor VIII or factor IX. In some embodiments, the composition is orally administered to a patient to treat a disease or disorder such as, e.g., hemophilia.
    Type: Application
    Filed: March 13, 2019
    Publication date: September 12, 2019
    Inventors: Nicholas A. Peppas, Sarena D. Horava
  • Polymers for delivery of factor VIII and/or factor IX
    Patent number: 10265405
    Abstract: In some aspects, a composition comprising a pH-sensitive crosslinked copolymer of methacrylic acid and poly(ethylene glycol) monomethyl ether methacrylate and a therapeutic protein is provided. In some embodiments, the therapeutic protein is a high molecular weight protein such as factor VIII or factor IX. In some embodiments, the composition is orally administered to a patient to treat a disease or disorder such as, e.g., hemophilia.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: April 23, 2019
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Nicholas A. Peppas, Sarena D. Horava
  • Method of preparation of biodegradable nanoparticles with recognition characteristics
    Patent number: 10086091
    Abstract: The present disclosure relates to a novel type of recognitive biodegradable nanoparticles and their preparations. In particular, the present disclosure relates to combinations of MIPs and biodegradable nanoparticles.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: October 2, 2018
    Assignee: Board of Regents, The University of Texas System
    Inventors: Nicholas Peppas, Heidi Culver
  • HYDROGELS FOR DELIVERY OF THERAPEUTIC COMPOUNDS
    Publication number: 20180256724
    Abstract: In some aspects, methacrylate co-polymers crosslinked with an enzymatically cleavable peptide linker are provided and may be used for the oral delivery of a therapeutic. The peptide linker may be cleavable by an enzyme in the small intestine and may allow for the delivery of a therapeutic protein or nucleic acid to the small intestine. Also provided are methods of using the polymers for the treatment of a disease.
    Type: Application
    Filed: February 27, 2018
    Publication date: September 13, 2018
    Inventors: Jennifer M. KNIPE, Laura E. STRONG, Nicholas A. PEPPAS
  • Hydrogels for delivery of therapeutic compounds
    Patent number: 9937256
    Abstract: In some aspects, methacrylate co-polymers crosslinked with an enzymatically cleavable peptide linker are provided and may be used for the oral delivery of a therapeutic. The peptide linker may be cleavable by an enzyme in the small intestine and may allow for the delivery of a therapeutic protein or nucleic acid to the small intestine. Also provided are methods of using the polymers for the treatment of a disease.
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: April 10, 2018
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Jennifer M. Knipe, Laura E. Strong, Nicholas A. Peppas
  • DELIVERY OF SMALL INTERFERING RNA AND MICRO RNA THROUGH NANOGELS CONTAINING HYDROPHOBIC PSEUDO-PEPTIDES
    Publication number: 20170312372
    Abstract: Nanoscale, pH-responsive polycationic networks useful for the delivery of anionic biologic therapeutics and associated methods.
    Type: Application
    Filed: May 5, 2017
    Publication date: November 2, 2017
    Inventors: Nicholas Peppas, William Liechty
  • HYDROGELS FOR DELIVERY OF THERAPEUTIC COMPOUNDS
    Publication number: 20160206741
    Abstract: In some aspects, methacrylate co-polymers crosslinked with an enzymatically cleavable peptide linker are provided and may be used for the oral delivery of a therapeutic. The peptide linker may be cleavable by an enzyme in the small intestine and may allow for the delivery of a therapeutic protein or nucleic acid to the small intestine. Also provided are methods of using the polymers for the treatment of a disease.
    Type: Application
    Filed: January 13, 2016
    Publication date: July 21, 2016
    Inventors: Jennifer M. Knipe, Laura E. Strong, Nicholas A. Peppas
  • METHOD OF PREPARATION OF BIODEGRADABLE NANOPARTICLES WITH RECOGNITION CHARACTERISTICS
    Publication number: 20160199516
    Abstract: The present disclosure relates to a novel type of recognitive biodegradable nanoparticles and their preparations. In particular, the present disclosure relates to combinations of MIPs and biodegradable nanoparticles.
    Type: Application
    Filed: March 24, 2016
    Publication date: July 14, 2016
    Inventors: Nicholas Peppas, Heidi Culver
  • POLYMERS FOR DELIVERY OF FACTOR VIII AND/OR FACTOR IX
    Publication number: 20160136291
    Abstract: In some aspects, a composition comprising a pH-sensitive crosslinked copolymer of methacrylic acid and poly(ethylene glycol) monomethyl ether methacrylate and a therapeutic protein is provided. In some embodiments, the therapeutic protein is a high molecular weight protein such as factor VIII or factor IX. In some embodiments, the composition is orally administered to a patient to treat a disease or disorder such as, e.g., hemophilia.
    Type: Application
    Filed: November 17, 2015
    Publication date: May 19, 2016
    Inventors: Nicholas A. Peppas, Sarena D. Horava
  • POLYMERS FOR DELIVERY OF THERAPEUTIC PROTEINS
    Publication number: 20160106846
    Abstract: In some aspects, improved hydrogel copolymers (e.g., comprising itaconic acid and N-vinylpyrrolidone) are provided and may be used, e.g., for oral delivery of a therapeutic protein. In some embodiments, improved methods for loading a therapeutic protein (e.g., a high isoelectric point protein) into a hydrogel copolymer are provided, and may comprise incubating the therapeutic protein and the hydrogel in a reduced ionic strength loading solution. In some embodiments, use of the reduced ionic strength loading solution can result in hydrogel copolymer-therapeutic protein compositions that display improved pharmacokinetic attributes, e.g., improved loading and/or release of a therapeutic protein.
    Type: Application
    Filed: September 30, 2015
    Publication date: April 21, 2016
    Inventors: Michael KOETTING, Nicholas PEPPAS
  • METHOD AND PROCESS FOR THE PRODUCTION OF MULTI-COATED RECOGNITIVE AND RELEASING SYSTEMS
    Publication number: 20160095820
    Abstract: The present invention includes compositions, methods, systems and kits for the controlled delivery of an active agent within a polymeric network upon the binding of a molecule that decreases the structural integrity of the polymeric network at one or more micro- or nanovacuoles.
    Type: Application
    Filed: August 31, 2015
    Publication date: April 7, 2016
    Inventor: Nicholas A. PEPPAS
  • Method and process for the production of multi-coated recognitive and releasing systems
    Patent number: 9155703
    Abstract: The present invention includes compositions, methods, systems and kits for the controlled delivery of an active agent within a polymeric network upon the binding of a molecule that decreases the structural integrity of the polymeric network at one or more micro- or nanovacuoles.
    Type: Grant
    Filed: March 12, 2008
    Date of Patent: October 13, 2015
    Assignee: Board of Regents, the University of Texas System
    Inventor: Nicholas A. Peppas
  • DELIVERY OF SMALL INTERFERING RNA AND MICRO RNA THROUGH MEMBRANE-DISRUPTIVE, RESPONSIVE NANOSCALLE HYDROGELS
    Publication number: 20150216814
    Abstract: Nanoscale, pH-responsive polycationic networks useful for the delivery of anionic biologic therapeutics and associated methods.
    Type: Application
    Filed: April 14, 2015
    Publication date: August 6, 2015
    Inventors: NICHOLAS PEPPAS, WILLIAM LIECHTY
  • Protein imprinting by means of alginate-based polymers
    Patent number: 8940394
    Abstract: Methods of preparing molecularly imprinted polymers are provided. In one embodiment, a method comprises providing a solution comprising a template molecule; and forming a product comprising calcium alginate in the presence of the template molecule so that the template molecule is imprinted in the product.
    Type: Grant
    Filed: March 14, 2012
    Date of Patent: January 27, 2015
    Assignee: Board of Regents, The University of Texas System
    Inventors: Nicholas A. Peppas, Edgar Perez-Herrero
  • Method and process for the production of multi-coated recognitive and releasing systems
    Patent number: 8821899
    Abstract: The present invention includes compositions, methods, systems for the controlled delivery of an active agent within a polymeric network upon the binding of a molecule that decreases the structural integrity of the polymeric network at one or more micro- or nanovacuoles.
    Type: Grant
    Filed: December 4, 2008
    Date of Patent: September 2, 2014
    Assignee: Board of Regents, The University of Texas System
    Inventors: Nicholas A. Peppas, Barbara Ekerdt, Marta Gomez-Burgaz
  • Method and process for the production of multi-coated recognitive and releasing systems
    Patent number: 8771713
    Abstract: The present invention includes compositions, methods, systems for the controlled delivery of an active agent in a tablet polymer comprising two or more layers, wherein each of the two or more layers comprises at least one active agent and at least one molecular recognition polymer, wherein the two or more layers are compressed into a single tablet.
    Type: Grant
    Filed: March 3, 2009
    Date of Patent: July 8, 2014
    Assignee: Board of Regents, The University of Texas System
    Inventors: Nicholas A. Peppas, Barbara Ekerdt, Marta Gomez-Burgaz
  • Highly porous, recognitive polymer systems
    Patent number: 8741316
    Abstract: The present invention includes compositions, methods, systems of making a composition that includes one or more active agent; a recognitive polymeric matrix; and a porosigen, wherein the composition comprises a porous recognitive, swellable hydrogel that dissociates under conditions of low water or humidity.
    Type: Grant
    Filed: December 4, 2008
    Date of Patent: June 3, 2014
    Assignee: Board of Regents, The University of Texas System
    Inventors: Nicholas A. Peppas, Aditya Durgam