Abstract: The present invention provides a compound of formula (1) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: A skateboard truck mounting apparatus is provided. The skateboard truck mounting apparatus includes a rigid body, having a first hole and a second hole, where the holes are configured to interface with the holes on a skateboard deck. Both the first hole and the second hole are equipped with self-locking mechanisms.

Abstract: One example of an inspection system includes a laser, a magnification changer, and a first camera. The laser projects a line onto a wafer to be inspected. The magnification changer includes a plurality of selectable lenses of different magnification. The first camera images the line projected onto the wafer and outputs three-dimensional line data indicating the height of features of the wafer. Each lens of the magnification changer provides the same nominal focal plane position of the first camera with respect to the wafer.

Abstract: A tailgate enclosure for use with a vehicle can include a plurality of cross-members, a first upright, a second upright, and only one additional upright. Each of the cross-members can be vertically spaced apart from an adjacent one of the cross-members and can include a first beam, a second beam, and a central beam having a first end and a second end, the central beam positioned at least partially between the first and second beams. The first upright can secure the first beam of each of the cross-members to a first sidewall of the vehicle and the second upright can secure the second beam of each of the cross-members to a second sidewall of the vehicle. The additional upright can be positioned along the central beam of each of the cross-members between the first and second ends of the central beam.

Abstract: A retractable step and side bar assembly that can be used for raised vehicles, such as trucks. The retractable step can be configured to provide for significant reach in a deployed position to allow for a user to enter the raised vehicle. Further, in the stowed position the retractable step can be located within the side bar, thereby providing a low profile as well as an enhanced aesthetic appearance.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: Disclosed herein are methods, systems, and devices for facilitating in determining, logging, and analyzing intelligence, surveillance, and reconnaissance (ISR) information in near real-time. According to one embodiment, a method is implemented on a server for facilitating identification tagging and logging of ISR information. The method includes receiving georeferenced map data and receiving image data. The method further includes transmitting the georeferenced map data and image data to a client device. The method also includes receiving ISR data from the client device and storing the ISR data. In another embodiment, a method implemented on a client device for facilitating an analyst in determining and logging ISR information is disclosed. The method includes receiving georeferenced map data, displaying the georeferenced map data on a GUI implemented on the client device, receiving analyst provided input from the GUI, and transmitting ISR data to a server.

Abstract: Apparatus, systems, and methods are disclosed for tracking movement over the ground or other surfaces using two or more spaced apart cameras and an associated processing element to detect ground features in images from the cameras and determine tracking parameters based on the position of the detected ground features in the images.

Abstract: A separable footwear article comprising an outsole oriented at a bottom of the footwear and configured for ground contact, the outsole comprising a first material, an upper portion comprising a second material different from the first material, and a welt positioned between the outsole and the upper. The welt is releasably coupled to the outsole with a first thread using a first stitching technique, and releasably coupled to the upper portion with a second thread using a second stitching technique. The outsole, the upper portion, and the welt are configured to be separated upon receipt of a pulling force upon the first thread and the second thread sufficient to remove the first thread and the second thread from the footwear article.

Abstract: One example of an inspection system includes a laser, a magnification changer, and a first camera. The laser projects a line onto a wafer to be inspected. The magnification changer includes a plurality of selectable lenses of different magnification. The first camera images the line projected onto the wafer and outputs three-dimensional line data indicating the height of features of the wafer. Each lens of the magnification changer provides the same nominal focal plane position of the first camera with respect to the wafer.

Abstract: A separable footwear article may comprise an outsole oriented at the bottom of the footwear and configured for ground contact, the outsole comprising a first material; an upper portion releasably coupled to the outsole with thread using chain stitching, the upper portion comprising a second material different from the first material; and an insole removeably disposed adjacent the upper portion and the outsole, the insole comprising a third material different from the first material and the second material; wherein the outsole, the upper portion, and insole are capable of being separated by releasing the thread and hand pulling the thread from the footwear article.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; Wherein R1, R3-R6, X2 and X3 are as defined herein, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: A tailgate enclosure for use with a vehicle can include a plurality of cross-members, a first upright, a second upright, and only one additional upright. Each of the cross-members can be vertically spaced apart from an adjacent one of the cross-members and can include a first beam, a second beam, and a central beam having a first end and a second end, the central beam positioned at least partially between the first and second beams. The first upright can secure the first beam of each of the cross-members to a first sidewall of the vehicle and the second upright can secure the second beam of each of the cross-members to a second sidewall of the vehicle. The additional upright can be positioned along the central beam of each of the cross-members between the first and second ends of the central beam.

Abstract: A printing system comprises one or more printheads arranged to eject ink to a deposition region. Print media are held by vacuum suction against a movable support surface, which transports the print media though the deposition region. The vacuum suction is communicated from a vacuum source to the movable support surface via a vacuum plenum. An airflow control system comprises one or more dampers arranged in the vacuum plenum to control airflow between the vacuum source and the movable support surface. The dampers have an adjustable impedance to airflow through the damper. The airflow control system is configured to adjust the impedance of the damper based on a detected condition of the printing system. A detected condition of the printing system may include, for example, a sensed pressure in the vacuum plenum.

Abstract: The invention relates to heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification; capable of modulating the ctivity of TMEM16a. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including COPD, bronchiectasis, asthma, cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, cystic fibrosis, primary ciliary dyskinesia, respiratory tract infections (acute and chronic; viral and bacterial), lung carcinoma.

Abstract: Camera heads including multiple imaging elements with overlapping Fields of View (FOV) for inspecting pipes or cavities are disclosed.

Abstract: The invention provides a system for containing irradiated particles, the system having a housing having a closed upstream end and an open downstream end; an axially disposed tunnel extending from the downstream end to the upstream end, wherein longitudinally extending regions of the tunnel define a plurality of threaded surfaces; a sample cup positioned within the tunnel and proximal to the closed upstream end; threaded plugs matingly received by the threaded surfaces so as to provide at least one seal between the sample cup and the atmosphere external of the housing; and a plurality of deformable substrates disposed between the plugs.

Abstract: A wire passer system for passing a surgical wire around a bone. The wire passer system broadly comprises a gun assembly, a flexible push member, and a surgical wire. The gun assembly can comprise a handle, a trigger, a rigid guide section, a support guide, a push rod, and tensioner.

Abstract: A tailgate enclosure for use with a vehicle can include a plurality of cross-members, a first upright, a second upright, and only one additional upright. Each of the cross-members can be vertically spaced apart from an adjacent one of the cross-members and can include a first beam, a second beam, and a central beam having a first end and a second end, the central beam positioned at least partially between the first and second beams. The first upright can secure the first beam of each of the cross-members to a first sidewall of the vehicle and the second upright can secure the second beam of each of the cross-members to a second sidewall of the vehicle. The additional upright can be positioned along the central beam of each of the cross-members between the first and second ends of the central beam.

Abstract: Camera head apparatus, systems, and methods for providing wide angle/panoramic images and/or video of the interior of pipes or other cavities using multiple imaging and illumination modules are disclosed.