Abstract: Disclosed are CCR1 receptor antagonists of the formula (I) wherein Ar1, Ar2, R1-R3, X and L are disclosed herein. Also disclosed are compositions, methods of making and using compounds of the formula (I).

Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

Abstract: A media cassette loader is described. The media cassette loader comprises a base; a media loading surface inclined at an angle to the base; and an end wall upstanding from a lower end of the media loading surface. The end wall supports media items stacked on the media loading surface. The media loading surface and the end wall are dimensioned to be accommodated within a media cassette body. This allows the media cassette body to be placed over the media loading surface when stacked with media items so that the cassette body surrounds the stacked media items.

Abstract: Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.

Abstract: An apparatus and method are disclosed for temporarily storing at least one item of media. The apparatus includes a rotatable item support member arranged to rotate about a support member axis of rotation and comprising an outer support surface. The apparatus also includes a pair of drive tape members, each arranged along a respective tape pathway, each tape pathway comprising a pathway portion in which the tape members extend in a co-operating relationship supported by said outer support surface. The outer support surface includes at least one support region that supports the tape members and an item located therebetween in a flat orientation.

Abstract: An apparatus and method are disclosed for removing at least one item of media from a rotating drum element. The apparatus includes a scraper element comprising a blade edge region locatable at an effective outer surface of a rotating drum element and a scraper element support that locates the blade edge region at a desired position at the effective outer surface responsive to a diameter of the effective outer surface. The scraper element rotates and moves laterally with respect to the support responsive to the diameter.

Abstract: An apparatus and method are disclosed for temporarily storing at least one item of media. The apparatus includes a rotatable item support member arranged to rotate about a support member axis of rotation and comprising an outer support surface. The apparatus also includes a pair of drive tape members, each arranged along a respective tape pathway, each tape pathway comprising a pathway portion in which the tape members extend in a co-operating relationship supported by said outer support surface. The outer support surface includes at least one support region that supports the tape members and an item located therebetween in a flat orientation.

Abstract: Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.

Abstract: A rotary storage device is described. The device comprises a rotatable drum around which media items may be stored, and a tape reel rotatably mounted on a tape reel shaft and partially wound with tape extending from the tape reel to the rotatable drum. The device further comprises a motor coupled to both the rotatable drum and the tape reel shaft. The motor is operable to rotate in a deposit direction and in a dispense direction. The device comprises a friction clutch coupled to both the tape reel shaft and the tape reel to provide some resistance to rotation of the tape reel relative to the tape reel shaft so that the tape reel cannot rotate freely about the tape reel shaft. The device also comprises a one-way clutch coupled to the tape reel shaft to allow the tape reel shaft to rotate in the dispense direction and to prevent the tape reel shaft from rotating in the deposit direction.

Abstract: Disclosed are CCR1 receptor antagonists of the formula (I) wherein Ar1, Ar2, R1-R3, X and L are disclosed herein. Also disclosed are compositions, methods of making and using compounds of the formula (I).

Abstract: Diclosed are CCR1 receptor antagonists of the formula (I) wherein Ar1, Ar2, R1, X and G are disclosed herein. Also disclosed are compositions, methods of making and using compounds of the formula (I).

Abstract: Disclosed are compounds of the formula (I) which block the interaction of CCR1 and its ligands and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

Abstract: Compounds of the formula (I) wherein R1, R2, R3, R4, R5, R6, W, and Y are as described herein, or a tautomer, prodrug, solvate, or salt thereof. These compounds are useful as inhibitors of Urotensin II and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the interaction of Urotensin II with its receptor, including cardiovascular diseases. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds, and intermediates useful in these processes.

Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

Abstract: Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are intermediates thereof, and methods of making and methods of using same.

Abstract: Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are intermediates thereof, and methods of making and methods of using same.

Abstract: Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.

Abstract: Disclosed are compounds of the formula (I) which block the interaction of CCR1 and its ligands and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

Abstract: Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.

Abstract: Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.