Patents by Inventor Nicholas D. Smith

Nicholas D. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Farnesoid X receptor agonists and uses thereof
    Patent number: 11084817
    Abstract: Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.
    Type: Grant
    Filed: September 17, 2019
    Date of Patent: August 10, 2021
    Assignee: METACRINE, INC.
    Inventors: Nicholas D. Smith, Steven P. Govek, Karensa L. Douglas, Andiliy G. Lai
  • Androgen Receptor Modulator And Uses Thereof
    Publication number: 20210177821
    Abstract: Described herein is the androgen receptor modulator of formula (I) in the treatment of prostate cancer in combination with other therapeutic options and in the treatment of diseases or conditions that are amenable to treatment with the androgen receptor modulator, as well as pharmaceutical compositions and medicaments that include such compound.
    Type: Application
    Filed: February 25, 2021
    Publication date: June 17, 2021
    Inventors: Isan Chen, Jeffrey H. Hager, Edna Chow Maneval, Mark R. Herbert, Nicholas D. Smith
  • Crystalline Forms Of An Androgen Receptor Modulator
    Publication number: 20210163441
    Abstract: Described herein are amorphous and crystalline forms of the androgen receptor modulator 4-[7-(6-cyano-5-trifluoromethylpyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-N-methylbenzamide. Also described are pharmaceutical compositions suitable for administration to a mammal that include the androgen receptor modulator, and methods of using the androgen receptor modulator, alone and in combination with other compounds, for treating diseases or conditions that are associated with androgen receptor activity.
    Type: Application
    Filed: January 26, 2021
    Publication date: June 3, 2021
    Inventors: Anna Dihas, Mark R. Herbert, Ouathek Ouerfelli, Nicholas D. Smith
  • Farnesoid X receptor agonists and uses thereof
    Patent number: 10961198
    Abstract: Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: March 30, 2021
    Assignee: METACRINE, INC.
    Inventors: Nicholas D. Smith, Steven P. Govek, Johnny Y. Nagasawa
  • Crystalline forms of an androgen receptor modulator
    Patent number: 10934271
    Abstract: Described herein are amorphous and crystalline forms of the androgen receptor modulator 4-[7-(6-cyano-5-trifluoromethylpyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-N-methylbenzamide. Also described are pharmaceutical compositions suitable for administration to a mammal that include the androgen receptor modulator, and methods of using the androgen receptor modulator, alone and in combination with other compounds, for treating diseases or conditions that are associated with androgen receptor activity.
    Type: Grant
    Filed: July 29, 2020
    Date of Patent: March 2, 2021
    Assignees: Aragon Pharmaceuticals, Inc., Sloan-Kettering Institute For Cancer Research
    Inventors: Anna Dihas, Mark R. Herbert, Ouathek Ouerfelli, Nicholas D. Smith
  • Farnesoid X receptor agonists and uses thereof
    Patent number: 10927082
    Abstract: Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: February 23, 2021
    Assignee: METACRINE, INC.
    Inventors: Nicholas D. Smith, Stephen P. Govek, Johnny Y. Nagasawa
  • FARNESOID X RECEPTOR AGONISTS AND USES THEREOF
    Publication number: 20210032195
    Abstract: Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.
    Type: Application
    Filed: May 12, 2020
    Publication date: February 4, 2021
    Inventors: Nicholas D. SMITH, Steven P. GOVEK, Johnny Y. NAGASAWA
  • Crystalline Forms Of An Androgen Receptor Modulator
    Publication number: 20200354335
    Abstract: Described herein are amorphous and crystalline forms of the androgen receptor modulator 4-[7-(6-cyano-5-trifluoromethylpyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-N-methylbenzamide. Also described are pharmaceutical compositions suitable for administration to a mammal that include the androgen receptor modulator, and methods of using the androgen receptor modulator, alone and in combination with other compounds, for treating diseases or conditions that are associated with androgen receptor activity.
    Type: Application
    Filed: July 29, 2020
    Publication date: November 12, 2020
    Inventors: Anna Dihas, Mark R. Herbert, Ouathek Ouerfelli, Nicholas D. Smith
  • FARNESOID X RECEPTOR AGONISTS AND USES THEREOF
    Publication number: 20200290973
    Abstract: Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.
    Type: Application
    Filed: May 28, 2020
    Publication date: September 17, 2020
    Inventors: Nicholas D. SMITH, Stephen P. GOVEK, Johnny Y. NAGASAWA
  • Crystalline forms of an androgen receptor modulator
    Patent number: 10766875
    Abstract: Described herein are amorphous and crystalline forms of the androgen receptor modulator 4-[7-(6-cyano-5-trifluoromethylpyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-N-methylbenzamide. Also described are pharmaceutical compositions suitable for administration to a mammal that include the androgen receptor modulator, and methods of using the androgen receptor modulator, alone and in combination with other compounds, for treating diseases or conditions that are associated with androgen receptor activity.
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: September 8, 2020
    Assignees: Aragon Pharmaceuticals, Inc., Sloan-Kettering Institute for Cancer Research
    Inventors: Anna Dihas, Mark R. Herbert, Ouathek Ouerfelli, Nicholas D. Smith
  • Farnesoid X receptor agonists and uses thereof
    Patent number: 10703712
    Abstract: Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: July 7, 2020
    Assignee: METACRINE, INC.
    Inventors: Nicholas D. Smith, Steven P. Govek, Johnny Y. Nagasawa
  • SSAO INHIBITORS AND USES THEREOF
    Publication number: 20200181104
    Abstract: Described herein are compounds that are semicarbazide-sensitive amine oxidase (SSAO) inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in treating or preventing a liver disease or condition.
    Type: Application
    Filed: February 14, 2020
    Publication date: June 11, 2020
    Inventors: Nicholas D. Smith, Andrew R. Hudson, Mi Chen, Johnny Y. Nagasawa, Iriny Botrous
  • FARNESOID X RECEPTOR AGONISTS AND USES THEREOF
    Publication number: 20200131129
    Abstract: Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.
    Type: Application
    Filed: March 14, 2018
    Publication date: April 30, 2020
    Inventors: Nicholas D. SMITH, Steven P. GOVEK, Johnny Y. NAGASAWA, Andiliy G. LAI
  • FARNESOID X RECEPTOR AGONISTS AND USES THEREOF
    Publication number: 20200131132
    Abstract: Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.
    Type: Application
    Filed: March 14, 2018
    Publication date: April 30, 2020
    Inventors: Nicholas D. SMITH, Steven P. GOVEK, Johnny Y. NAGASAWA
  • FARNESOID X RECEPTOR AGONISTS AND USES THEREOF
    Publication number: 20200131134
    Abstract: Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.
    Type: Application
    Filed: March 14, 2018
    Publication date: April 30, 2020
    Inventors: Nicholas D. SMITH, Steven P. GOVEK, Johnny Y. NAGASAWA
  • FARNESOID X RECEPTOR AGONISTS AND USES THEREOF
    Publication number: 20200131142
    Abstract: Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.
    Type: Application
    Filed: March 14, 2018
    Publication date: April 30, 2020
    Inventors: Nicholas D. SMITH, Steven P. GOVEK, Johnny Y. NAGASAWA, Karensa L. Douglas
  • Farnesoid X receptor agonists and uses thereof
    Patent number: 10626081
    Abstract: Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: April 21, 2020
    Assignee: METACRINE, INC.
    Inventors: Nicholas D. Smith, Steven P. Govek, Johnny Y. Nagasawa
  • Crystalline Forms Of An Androgen Receptor Modulator
    Publication number: 20200115361
    Abstract: Described herein are amorphous and crystalline forms of the androgen receptor modulator 4-[7-(6-cyano-5-trifluoromethylpyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-N-methylbenzamide. Also described are pharmaceutical compositions suitable for administration to a mammal that include the androgen receptor modulator, and methods of using the androgen receptor modulator, alone and in combination with other compounds, for treating diseases or conditions that are associated with androgen receptor activity.
    Type: Application
    Filed: December 11, 2019
    Publication date: April 16, 2020
    Inventors: Anna Dihas, Mark R. Herbert, Ouathek Ouerfelli, Nicholas D. Smith
  • FARNESOID X RECEPTOR AGONISTS AND USES THEREOF
    Publication number: 20200102308
    Abstract: Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.
    Type: Application
    Filed: September 17, 2019
    Publication date: April 2, 2020
    Inventors: Nicholas D. SMITH, Steven P. GOVEK, Karensa L. DOUGLAS, Andiliy G. LAI
  • Computer display screen or portion thereof with graphic
    Patent number: D906348
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: December 29, 2020
    Assignee: Intergraph Corporation
    Inventors: Claudia Blackwell, Nicholas D. Smith, Bryan K. Layton