Patents by Inventor Nicholas D. Smith

Nicholas D. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Androgen receptor modulator and uses thereof
    Patent number: 9340524
    Abstract: Described herein is the androgen receptor modulator of formula (I) in the treatment of prostate cancer in combination with other therapeutic options and in the treatment of diseases or conditions that are amenable to treatment with the androgen receptor modulator, as well as pharmaceutical compositions and medicaments that include such compound.
    Type: Grant
    Filed: January 9, 2014
    Date of Patent: May 17, 2016
    Assignee: Aragon Pharmaceuticals, Inc.
    Inventors: Isan Chen, Jeffrey H Hager, Edna Chow Maneval, Mark R Herbert, Nicholas D Smith
  • ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
    Publication number: 20160090378
    Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
    Type: Application
    Filed: December 9, 2015
    Publication date: March 31, 2016
    Applicant: Genentech, Inc.
    Inventors: Mehmet Kahraman, Steven P. Govek, Nicholas D. Smith, Jeffrey H. Hager, Edna Chow Maneval
  • AZETIDINE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
    Publication number: 20160090377
    Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
    Type: Application
    Filed: December 9, 2015
    Publication date: March 31, 2016
    Applicant: Genentech, Inc.
    Inventors: Steven P. Govek, Mehmet Kahraman, Nicholas D. Smith, Jeffrey H. Hager, Edna Chow Maneval
  • CRYSTALLINE FORMS OF AN ESTROGEN RECEPTOR MODULATOR
    Publication number: 20160039770
    Abstract: Described herein are amorphous and crystalline forms of pharmaceutically acceptable salts of the estrogen receptor modulator (E)-3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylic acid. Also described are pharmaceutical compositions suitable for administration to a mammal that include the estrogen receptor modulator, and methods of using the estrogen receptor modulator, alone and in combination with other compounds, for treating diseases or conditions that are associated with estrogen receptor activity.
    Type: Application
    Filed: August 10, 2015
    Publication date: February 11, 2016
    Applicant: GENENTECH, INC.
    Inventors: Nicholas D. Smith, Mark R. Herbert
  • Fluorinated estrogen receptor modulators and uses thereof
    Patent number: 9193714
    Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: November 24, 2015
    Assignee: SERAGON PHARMACEUTICALS, INC.
    Inventors: Nicholas D. Smith, Steven P. Govek, Mehmet Kahraman, Johnny Y. Nagasawa, Andiliy G. Lai, Celine Bonnefous
  • Estrogen receptor modulators and uses thereof
    Patent number: 9187460
    Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: November 17, 2015
    Assignee: SERAGON PHARMACEUTICALS, INC.
    Inventors: Nicholas D. Smith, Steven P. Govek, Mehmet Kahraman, Jackaline D. Julien, Johnny Y. Nagasawa, Andiliy G. Lai
  • METHODS AND COMPOSITIONS FOR MODULATING ESTROGEN RECEPTOR MUTANTS
    Publication number: 20150258099
    Abstract: Described herein are methods and compositions for treating an ER-related disease condition characterized by a mutation in the ESR1 gene by administering an estrogen receptor modulator. Also described herein are methods of treating hormone resistant-estrogen receptor (ER) positive breast cancers characterized by a mutation in the ESR1 gene by administering an estrogen receptor modulator.
    Type: Application
    Filed: March 12, 2015
    Publication date: September 17, 2015
    Applicant: GENENTECH, INC.
    Inventors: Jeffrey J. Hager, James D. Joseph, Jing Qian, Nicholas D. Smith, Edna Chow Maneval, Debasish F. ROYCHOWDHURY, Lori Friedman, Deepak Sampath
  • THERAPEUTIC COMBINATIONS WITH ESTROGEN RECEPTOR MODULATORS
    Publication number: 20150258080
    Abstract: Described herein are therapeutic combinations with estrogen receptor modulators for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
    Type: Application
    Filed: March 12, 2015
    Publication date: September 17, 2015
    Applicant: Genentech, Inc.
    Inventors: Jeffrey J. Hager, Edna Chow Maneval, Nicholas D. Smith, Lori Friedman, Deepak Sampath
  • METHODS AND COMPOSITIONS FOR DETERMINING RESISTANCE TO ANDROGEN RECEPTOR THERAPY
    Publication number: 20150252426
    Abstract: Described herein are modified androgen receptor polypeptides that are resistant to inhibition by an androgen receptor inhibitor. Described herein are compositions, combinations, and kits containing the modified androgen receptor polypeptides and methods of using the modified androgen receptor polypeptides. Also described herein are methods of using the modified androgen receptor polypeptides as screening agents for the identification and design of third-generation androgen receptor modulators. Also described herein are third-generation androgen receptor modulators that inhibit the activity of the modified androgen receptor polypeptides. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such androgen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions, including cancers, such as castration resistant prostate cancers, that are mediated or dependent upon androgen receptors.
    Type: Application
    Filed: July 26, 2013
    Publication date: September 10, 2015
    Inventors: James David Joseph, Jeffrey H. Hager, John Lee Sensintaffar, Nhin Lu, Jing Qian, Nicholas D. Smith
  • Androgen receptor modulators and uses thereof
    Patent number: 9108944
    Abstract: Described herein are compounds that are androgen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such androgen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon androgen receptors.
    Type: Grant
    Filed: February 16, 2011
    Date of Patent: August 18, 2015
    Assignee: ARAGON PHARMACEUTICALS, INC.
    Inventors: Nicholas D. Smith, Celine Bonnefous, Jackaline D. Julien
  • Estrogen receptor modulators and uses thereof
    Patent number: 9078871
    Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: July 14, 2015
    Assignee: SERAGON PHARMACEUTICALS, INC.
    Inventors: Mehmet Kahraman, Steven P. Govek, Johnny Y. Nagasawa, Nicholas D. Smith
  • ANDROGEN RECEPTOR MODULATORS AND USES THEREOF
    Publication number: 20150182529
    Abstract: Described herein are compounds that are androgen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such androgen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon androgen receptors.
    Type: Application
    Filed: March 12, 2015
    Publication date: July 2, 2015
    Inventors: NICHOLAS D. SMITH, CELINE BONNEFOUS, JACKALINE D. JULIEN
  • CRYSTALLINE FORMS OF AN ANDROGEN RECEPTOR MODULATOR
    Publication number: 20150133481
    Abstract: Described herein are amorphous and crystalline forms of the androgen receptor modulator 4-[7-(6-cyano-5-trifluoromethylpyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-N-methylbenzamide. Also described are pharmaceutical compositions suitable for administration to a mammal that include the androgen receptor modulator, and methods of using the androgen receptor modulator, alone and in combination with other compounds, for treating diseases or conditions that are associated with androgen receptor activity.
    Type: Application
    Filed: June 4, 2013
    Publication date: May 14, 2015
    Applicant: Aragon Pharmaceuticals, Inc.and Sloan -Kettering Institute for Cancer Research
    Inventors: Anna Dilhas, Mark R. Herbert, Ouathek Ouerfelli, Nichola D. Smith
  • ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
    Publication number: 20150105403
    Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
    Type: Application
    Filed: March 14, 2013
    Publication date: April 16, 2015
    Inventors: Nicholas D. Smith, Steven P. Govek, Mehmet Kahraman, Jackaline D. Julien, Johnny Y. Nagasawa, Karensa L. Douglas, Celine Bonnefous, Andiliy G. Lai
  • FLUORINATED ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
    Publication number: 20150005286
    Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
    Type: Application
    Filed: December 14, 2012
    Publication date: January 1, 2015
    Inventors: Nicholas D. Smith, Steven P. Govek, Mehmet Kahraman, Johnny Y. Nagasawa, Andiliy G. Lai, Celine Bonnefous
  • ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
    Publication number: 20140364427
    Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
    Type: Application
    Filed: December 14, 2012
    Publication date: December 11, 2014
    Inventors: Nicholas D. Smith, Steven P. Govek, Mehmet Kahraman, Jackaline D. Julien, Johnny Y. Nagasawa, Andiliy G. Lai
  • Indane estrogen receptor modulators and uses thereof
    Patent number: 8853423
    Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
    Type: Grant
    Filed: June 15, 2011
    Date of Patent: October 7, 2014
    Assignee: Seragon Pharmaceuticals, Inc.
    Inventors: Steven P. Govek, Nicholas D. Smith
  • ANDROGEN RECEPTOR MODULATOR AND USES THEREOF
    Publication number: 20140199236
    Abstract: Described herein is the androgen receptor modulator of formula (I) in the treatment of prostate cancer in combination with other therapeutic options and in the treatment of diseases or conditions that are amenable to treatment with the androgen receptor modulator, as well as pharmaceutical compositions and medicaments that include such compound.
    Type: Application
    Filed: January 9, 2014
    Publication date: July 17, 2014
    Applicant: ARAGON PHARMACEUTICALS, INC.
    Inventors: ISAN CHEN, JEFFREY H. HAGER, EDNA CHOW MANEVAL, MARK R. HERBERT, NICHOLAS D. SMITH
  • Estrogen receptor modulators and uses thereof
    Patent number: 8703810
    Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
    Type: Grant
    Filed: June 8, 2011
    Date of Patent: April 22, 2014
    Assignee: Seragon Pharmaceuticals, Inc.
    Inventors: Mehmet Kahraman, Steven P. Govek, Johnny Y. Nagasawa, Nicholas D. Smith
  • ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
    Publication number: 20140107095
    Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
    Type: Application
    Filed: December 20, 2013
    Publication date: April 17, 2014
    Applicant: SERAGON PHARMACEUTICALS, INC.
    Inventors: Mehmet Kahraman, Steven P. Govek, Johnny Y. Nagasawa, Nicholas D. Smith