Abstract: This invention relates to compounds of Formula (I): and enantiomers thereof, and to pharmaceutically acceptable salts of Formula (I) and said enantiomers, wherein L1, L2, R1, R2, R3 and n are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof.

Abstract: Methods and systems are provided for detecting a trip of a user in a vehicle. A method includes: receiving by a processor of a user device, device scan data from one or more communication enabled devices; determining, by the processor, whether the devices listed in the device scan data is a vehicle device; in response to the determining, identifying, by the processor, the vehicle device as a found device; determining, by the processor, whether the found device is listed in a known device list; and generating, by the processor, at least one of a trip start signal and a trip end signal based on whether the found device is listed in the known device list.

Abstract: Authentication tokens, systems, and methods are described. An illustrative method is disclosed to include receiving an electronic file including a digital image, receiving biometric information that is associated with a person, modifying the electronic file with the biometric information such that one or more pixels in the digital image are replaced with the biometric information, and storing the modified electronic file as a digital authentication token to be used in connection with authorized publications of original digital work.

Abstract: The instant disclosure is directed to methods for generating stem cell-derived immune cells with enhanced function. Disclosed herein are methods for modifying a stem or progenitor cell capable of differentiating into an immune cell to inhibit the function of at least one gene selected from DGK? and DGK?, and directing differentiation of that stem or progenitor cells towards enhanced immune cells. Also disclosed herein are immune cells or stem cells made by the present methods, as well as the use of immune cells in therapeutic treatment.

Abstract: An aerospace vehicle system, preferably including one or more capsules, and optionally including one or more propulsion modules and/or safety modules. A capsule, preferably including a pressure vessel including a structural frame and one or more windows, and optionally including a cabin. In alternate embodiments, the system can additionally or alternatively function as a terrestrial vehicle, a watercraft, and/or any other suitable vehicle. A method of operation, preferably including operating the aerospace vehicle system in flight, while maintaining a pressure differential between the pressure vessel interior and an environment surrounding the system.

Abstract: An immersed membrane cassette has a high tank intensity achieved by one or more of: reduced module to module gap; using structural hollow tubing in at least parts of a frame in place of separate permeate and/or air pipes; and, using vertical permeate port connections. The cassette has a tank intensity over 650 m2/m2. The cassette may be combined with a fine screen. This specification also describes an immersed membrane module having a permeate port and/or connector on the top of a header. The permeate connection between the module and a permeate collection tube may be vertical, i.e. perpendicular to the length of the header. A piston seal may be used between the permeate port of the header and the permeate collection tube. The permeate collection tube may be a horizontal structural member on the periphery of a frame that holds the module.

Abstract: A display processing device includes a display device interface and a processing unit. The processing is configured to transition at least a first component of the display processing system into a low-power state in response to an active region of a first video frame of a plurality of video frames having completed. A second component of the display processing device is configured to maintain a temporal count value corresponding to a current frame line of the plurality of video frames, and further to generate a first signal in response to the temporal count value corresponding to a first trigger value. The first signal causes the at least first component to transition out of the low-power state.

Abstract: A system and method for intent-based active callback management using enhanced callback objects, utilizing a cloud callback system comprising at least a profile manager, callback manager, interaction manager, media server, and environment analyzer, allowing users to call businesses, agents in contact centers, or other users who are connected to a cloud callback system, and, failing to connect to the individual they called, allow for an automatic callback object to be created, whereby the two users may be automatically called and bridged together at a time when both users are available.

Abstract: A retractable fuselage mounted landing gear assembly is disclosed. The landing gear assembly includes a main strut, a drag stay and a landing gear main fitting. A first end of the drag stay is attached to the main strut and a second end of the drag stay is connected to the fuselage. A first end of the landing main fitting is attached to the main strut and a second end of the main fitting is connected to the fuselage. When the landing gear is extended, substantially all the landing gear loads are transferred from the landing gear to the fuselage via one or more of the drag stay and the main fitting.

Abstract: A shell extractor tool for removing a jammed ammunition shell from a firearm comprises a handle portion and a shaft portion. The shaft portion is adapted to be inserted through a firearm port and terminates at a proximal end and wherein the proximal end is angled relative to a remainder of the shaft portion to permit engagement of the jammed ammunition shell in a chamber of a firearm. The handle portion is adapted to be grasped by a user and to apply leverage to the jammed ammunition shell, to allow removal of the ammunition shell from the firearm with the shell extractor tool. The shell extractor tool may be provided with a sheath to provide a shell extractor tool kit. The sheath comprises a first structural portion and a second structural portion. The first structural portion and second structural portion are secured together to form a pocket to receive and reversibly secure the extractor tool. The sheath may optionally comprise a third structural portion.

Abstract: Devices, methods and systems for transmitting signals through a device located in a blood vessel of an animal, for stimulating and/or sensing activity of media proximal to the device, wherein the media includes tissue and/or fluid.

Abstract: An example system for performing segmentation of data based on tensor inputs includes memory storing computer-executable instructions defining a learning network, where the learning network includes a plurality of sequential encoder down-sampling blocks. A processor is configured to execute the computer-executable instructions to receive a multi-dimensional input tensor including at least a first dimension, a second dimension and a plurality of channels. The processor is also configured to process the received multi-dimensional input tensor by passing the received multi-dimensional input tensor through the plurality of sequential encoder down-sampling blocks of the learning network, and to generate an output tensor in response to processing the received multi-dimensional input tensor. The output tensor includes at least one segmentation classification.

Abstract: Devices, methods and systems for transmitting signals through a device located in a blood vessel of an animal, for stimulating and/or sensing activity of media proximal to the device, wherein the media includes tissue and/or fluid.

Abstract: An administration device for intravitreal administration of a fluid wherein a second actuation part of the administration device is configured to axially block a plunger rod and/or a first actuation part of the administration device, where in the second actuation part is to be actuated in order to axially release the plunger rod and/or the first actuation part such that the first actuation part can be actuated. The administration device has a securing member that is configured to block a back-movement of the plunger rod and/or the first actuation part at least in an initial position and/or in an administration position of the plunger rod and wherein the securing member is configured to block actuation of the second actuation part before reaching the administration position of the plunger rod.

Abstract: Systems and methods for tracking biological samples are presented. Intrinsic and extrinsic biological sample data and/or intrinsic and extrinsic patient data may be used to label a biological sample obtained at a point-of-care facility, which may be sent to a processing facility, wherein the labeled biological sample undergoes analysis and/or processing into a labeled therapeutic. The labeled therapeutic is delivered back to the point-of-care facility, wherein the labeled therapeutic is tested for the presence of the additives prior to administration to a patient. Multi-factor validation is performed, including validating the identity of the patient to a container, validating the identity of the labeled biological sample/therapeutic to the container, and thus, validating the identity of the labeled therapeutic to the patient. The entire life cycle of a biological sample used to generate a personalized therapeutic is validated, and ensures that mix-ups or errors in administration are reduced or eliminated.

Abstract: An automated damping system including a damping device arranged and disposed to provide variable resistance to a load. The variable resistance provides resistance values corresponding to a displacement position of the damping device. The system includes a damping profile generator that calculates a damping profile and a sensor is arranged and disposed to measure one or more damping affecting properties. The sensor provides the one or more damping affecting properties to the damping profile generator. The damping profile provides the variable resistance based upon the one or more damping affecting properties of the load.

Abstract: A server-implemented method is disclosed. The method includes: receiving a request from an IP Multimedia Subsystem (IMS) network node of an IMS network; and in response to receiving the request, providing NAS registration state information associated with a user equipment (UE) to the IMS network node, the NAS registration state information indicating at least one of fourth-generation (4G) single radio voice call continuity (SRVCC) capability of the UE or fifth-generation (5G) SRVCC capability of the UE that is applicable when using an access network supported by a core network, wherein the server is configured to store separate instances of UE SRVCC capabilities, the separate instances including indications of at least one of 4G UE SRVCC capability or 5G UE SRVCC capability that is applicable when using the access network supported by the core network, and wherein the UE is registered with the IMS network using a session initiation protocol (SIP) via the access network.

Abstract: A lubrication system for an internal combustion engine includes a fluid flow control device at an outlet side of the pump that regulates pressure conditions at the outlet side of the pump upstream of the lubrication circuit in the engine. The fluid flow control device is located in a recirculation path, and opens in response to a fluid pressure at the outlet of the pump exceeding a first threshold to allow the fluid to pass from the outlet side of the pump back to an inlet side of the pump. The recirculation path includes a tuning device that maintains the fluid pressure at engine speeds above the first threshold. In response to engine speeds above a second threshold, the tuning device restricts fluid flow in the recirculation path so that the fluid pressure in the fluid flow path increases.