Patents by Inventor Nicholas L. Abbott

Nicholas L. Abbott has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190136033
    Abstract: Methods are provided for fabricating functional nanostructures (e.g., nanowires/nanofibers) via chemical vapor deposition polymerization of paracyclophanes or substituted paracyclophanes onto and through a structured fluid, such as a film of liquid crystals, on a substrate. A one-step process is provided that does not require the use of any solid templates, nor does it require any volatile solvents, additives or catalysts. The resulting nanowires/nanofibers can be in the form of aligned nanowires/nanofibers arrays supported on any solid material, in the form of nanofibers mats supported on porous materials, or as individual free-standing nanowires/nanofibers. By using chiral liquid crystals, chiral nanofibers can be fabricated. The functional nanowires/nanofibers can contain one or more type of surface reactive groups that allows for post surface chemical modifications on the nanowires/nanofibers. Such nanostructures can be used in a range of different applications, including in biomedical applications.
    Type: Application
    Filed: April 14, 2017
    Publication date: May 9, 2019
    Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Marco A. BEDOLLA PANTOJA, Nicholas L. ABBOTT, Kenneth CHENG, Joerg LAHANN
  • Publication number: 20180325378
    Abstract: The present invention relates to methods and devices for characterizing wounds, and in particular to the use of Raman spectroscopy to characterize the state of healing of a wound.
    Type: Application
    Filed: July 17, 2018
    Publication date: November 15, 2018
    Inventors: Christopher J. Murphy, Nicholas L. Abbott, Jonathan McAnulty, Rishabh Jain
  • Publication number: 20180271798
    Abstract: The present invention relates to methods and compositions for modifying mucous membranes. In particular, the present invention relates to treating diseases associated with mucous membranes by changing the intrinsic chemical composition and/or physical features of a target mucous membrane.
    Type: Application
    Filed: June 5, 2018
    Publication date: September 27, 2018
    Inventors: Nicholas L. Abbott, Christopher J. Murphy
  • Patent number: 10022052
    Abstract: The present invention relates to methods and devices for characterizing wounds, and in particular to the use of Raman spectroscopy to characterize the state of healing of a wound.
    Type: Grant
    Filed: July 25, 2014
    Date of Patent: July 17, 2018
    Inventors: Christopher J. Murphy, Nicholas L. Abbott, Jonathan McAnulty, Rishabh Jain
  • Patent number: 9987235
    Abstract: The present invention relates to methods and compositions for modifying mucous membranes. In particular, the present invention relates to treating diseases associated with mucous membranes by changing the intrinsic chemical composition and/or physical features of a target mucous membrane.
    Type: Grant
    Filed: July 28, 2014
    Date of Patent: June 5, 2018
    Inventors: Nicholas L. Abbott, Christopher J. Murphy
  • Publication number: 20180080912
    Abstract: Methods and compositions for detecting a targeted analyte, such as volatile organic compound (VOCs), are disclosed. Specifically, a cholesteric liquid crystal composition comprising a nematic liquid crystal and a chiral dopant transitions to a liquid crystal blue phase or undergoes other optical changes when in contact with a sample containing the analyte. The phase transition can be readily detected with the naked eye. The disclosed methods and compositions may be used in, for example, dosimeters for detecting analyte (e.g., VOC) exposure. Methods and compositions for producing arrays of liquid crystal thin films are also disclosed. The surface between the microwells in a microwell array is coated with a liquid-crystal-phobic material, such as a fluorinated polymer or a fluorinated silane, creating isolated microwell domains that are preferentially wetted by liquid crystal. Liquid crystal can be added to the microwell domains by simple techniques such as spin coating.
    Type: Application
    Filed: November 29, 2017
    Publication date: March 22, 2018
    Inventors: Nicholas L. Abbott, Marco Antonio Bedolla Pantoja, Xiaoguang Wang
  • Publication number: 20180028713
    Abstract: The present invention relates to large scale manufacture of nanoscale microsheets for use in applications such as wound healing or modification of a biological or medical surface.
    Type: Application
    Filed: July 28, 2017
    Publication date: February 1, 2018
    Inventors: Ankit Agarwal, Gaurav Pranami, Tyler B. Nelson, Anna M. O'Keefe, Nicholas L. Abbott, Eric Crawford
  • Patent number: 9863923
    Abstract: Methods and compositions for detecting a targeted analyte, such as volatile organic compound (VOCs), are disclosed. Specifically, a cholesteric liquid crystal composition comprising a nematic liquid crystal and a chiral dopant transitions to a liquid crystal blue phase or undergoes other optical changes when in contact with a sample containing the analyte. The phase transition can be readily detected with the naked eye. The disclosed methods and compositions may be used in, for example, dosimeters for detecting analyte (e.g., VOC) exposure. Methods and compositions for producing arrays of liquid crystal thin films are also disclosed. The surface between the microwells in a microwell array is coated with a liquid-crystal-phobic material, such as a fluorinated polymer or a fluorinated silane, creating isolated microwell domains that are preferentially wetted by liquid crystal. Liquid crystal can be added to the microwell domains by simple techniques such as spin coating.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: January 9, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Nicholas L. Abbott, Marco Antonio Bedolla Pantoja, Xiaoguang Wang
  • Patent number: 9592300
    Abstract: The present invention provides methods utilizing redox-active surfactants to provide electrochemical control over polymer interactions. In one embodiment, the invention is directed to a transfection method using a redox-active transfection agent that preferentially promotes transfection dependent on the oxidation state of the transfection agent. Accordingly, certain methods according to the invention provide spatial and/or temporal control of cell transfection.
    Type: Grant
    Filed: June 9, 2006
    Date of Patent: March 14, 2017
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Nicholas L. Abbott, David M. Lynn, Yukishige Kondo, Christopher M. Jewell, Melissa E. Hays
  • Patent number: 9547018
    Abstract: Devices and methods for using changes in the defects in micrometer sized dispersed liquid crystal domains to detect or quantify analytes in a test sample, including endotoxin lipopolysaccharide (LPS), are disclosed. The dispersed liquid crystal microdomains are exposed to the test sample, and any changes in the number of defects in the liquid crystal microdomains are detected by detecting changes in the anchoring configuration of the microdomains. Such changes in anchoring configuration indicate the presence of analyte in the test sample.
    Type: Grant
    Filed: April 12, 2016
    Date of Patent: January 17, 2017
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Nicholas L. Abbott, I-Hsin Lin, Christopher J. Murphy, Jugal Gupta
  • Publication number: 20160223573
    Abstract: Devices and methods for using changes in the defects in micrometer sized dispersed liquid crystal domains to detect or quantify analytes in a test sample, including endotoxin lipopolysaccharide (LPS), are disclosed. The dispersed liquid crystal microdomains are exposed to the test sample, and any changes in the number of defects in the liquid crystal microdomains are detected by detecting changes in the anchoring configuration of the microdomains. Such changes in anchoring configuration indicate the presence of analyte in the test sample.
    Type: Application
    Filed: April 12, 2016
    Publication date: August 4, 2016
    Inventors: Nicholas L. Abbott, I-Hsin Lin, Christopher J. Murphy, Jugal Gupta
  • Patent number: 9400244
    Abstract: Devices and methods for immobilizing micrometer sized liquid domains onto a chemically functionalized substrate surface are disclosed. A multifunctional polymer is adsorbed at the surface interface of the liquid microdomains, and the liquid microdomains are immobilized by covalent bonding or non-covalent forces such as electrostatic attraction between the adsorbed multifunctional polymer and the functionalized substrate surface.
    Type: Grant
    Filed: April 15, 2011
    Date of Patent: July 26, 2016
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: David M. Lynn, Nicholas L. Abbott, Maren E. Buck, Michael I. Kinsinger
  • Publication number: 20160198994
    Abstract: The present invention relates to methods and devices for characterizing wounds, and in particular to the use of Raman spectroscopy to characterize the state of healing of a wound.
    Type: Application
    Filed: July 25, 2014
    Publication date: July 14, 2016
    Inventors: Christopher J. MURPHY, Nicholas L. ABBOTT, Jonathan MCANULTY, Rishabh JAIN
  • Publication number: 20160175261
    Abstract: The present invention relates to methods and compositions for modifying mucous membranes. In particular, the present invention relates to treating diseases associated with mucous membranes by changing the intrinsic chemical composition and/or physical features of a target mucous membrane.
    Type: Application
    Filed: July 28, 2014
    Publication date: June 23, 2016
    Inventors: Nicholas L. ABBOTT, Christopher J. MURPHY
  • Publication number: 20160178588
    Abstract: Methods and compositions for detecting a targeted analyte, such as volatile organic compound (VOCs), are disclosed. Specifically, a cholesteric liquid crystal composition comprising a nematic liquid crystal and a chiral dopant transitions to a liquid crystal blue phase or undergoes other optical changes when in contact with a sample containing the analyte. The phase transition can be readily detected with the naked eye. The disclosed methods and compositions may be used in, for example, dosimeters for detecting analyte (e.g., VOC) exposure. Methods and compositions for producing arrays of liquid crystal thin films are also disclosed. The surface between the microwells in a microwell array is coated with a liquid-crystal-phobic material, such as a fluorinated polymer or a fluorinated silane, creating isolated micowell domains that are preferentially wetted by liquid crystal. Liquid crystal can be added to the microwell domains by simple techniques such as spin coating.
    Type: Application
    Filed: December 16, 2015
    Publication date: June 23, 2016
    Inventors: Nicholas L. Abbott, Marco Antonio Bedolla Pantoja, Xiaoguang Wang
  • Patent number: 9372142
    Abstract: Methods and devices for assaying the effectiveness of a cleaning composition in removing a protein or a biofilm from a surface are disclosed. Such methods include the steps of providing one or more proteins at an interface between an aqueous phase and a liquid crystal phase or at the surface of a liquid crystal, contacting the interface or liquid crystal surface with a cleaning composition, and observing the orientational ordering of the liquid crystal at the interface or liquid crystal surface. A continuous change in the orientational ordering of the liquid crystal at the interface or liquid crystal surface indicates that the proteins are being removed from the interface, and the rate of change in orientational ordering, the extent of the change in orientational ordering, or both, are correlated with the effectiveness of the cleaning composition.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: June 21, 2016
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Nicholas L. Abbott, Lie Na Tan
  • Patent number: 9341570
    Abstract: Devices and methods for using changes in the defects in micrometer sized dispersed liquid crystal domains to detect or quantify analytes in a test sample, including endotoxin lipopolysaccharide (LPS), are disclosed. The dispersed liquid crystal microdomains are exposed to the test sample, and any changes in the number of defects in the liquid crystal microdomains are detected by detecting changes in the anchoring configuration of the microdomains. Such changes in anchoring configuration indicate the presence of analyte in the test sample.
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: May 17, 2016
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Nicholas L. Abbott, I-Hsin Lin, Christopher J. Murphy, Jugal Gupta
  • Publication number: 20160030624
    Abstract: The present invention relates to methods and compositions for wound healing. In particular, the present invention relates to promoting and enhancing wound healing by utilizing cross-linker covalent modification molecules to attach and deliver wound active agents to a wound. In addition, the present invention provides methods and compositions utilizing oppositely charged polyelectrolytes to form a polyelectrolyte layer on a wound surface. The invention further relates to incorporating wound active agents into a polyelectrolyte layer for delivery to a wound.
    Type: Application
    Filed: October 14, 2015
    Publication date: February 4, 2016
    Inventors: Nicholas L. Abbott, Ankit Agarwal, Christopher J. Murphy, Jonathan F. McAnulty
  • Patent number: 9174839
    Abstract: The present invention relates to methods and compositions for wound healing. In particular, the present invention relates to promoting and enhancing wound healing by utilizing cross-linker covalent modification molecules to attach and deliver wound active agents to a wound. In addition, the present invention provides methods and compositions utilizing oppositely charged polyelectrolytes to form a polyelectrolyte layer on a wound surface. The invention further relates to incorporating wound active agents into a polyelectrolyte layer for delivery to a wound.
    Type: Grant
    Filed: February 10, 2011
    Date of Patent: November 3, 2015
    Assignee: IMBED BIOSCIENCES, INC.
    Inventors: Nicholas L. Abbott, Ankit Agarwal, Christopher J. Murphy, Jonathan F. McAnulty
  • Publication number: 20150283287
    Abstract: The present invention relates to methods and compositions for wound healing. In particular, the present invention relates to promoting and enhancing wound healing by utilizing cross-linker covalent modification molecules to attach and deliver wound active agents to a wound. In addition, the present invention provides methods and compositions utilizing oppositely charged polyelectrolytes to form a polyelectrolyte layer on a wound surface. The invention further relates to incorporating wound active agents into a polyelectrolyte layer for delivery to a wound.
    Type: Application
    Filed: November 5, 2013
    Publication date: October 8, 2015
    Inventors: Ankit Agarwal, Nicholas L. Abbott