Patents by Inventor Nicholas Lawrence
Nicholas Lawrence has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240155786Abstract: An exterior display system can be configured and arranged around a structure. The exterior display system includes a mechanical supporting structure configured and arranged about the exterior surface of the structure. This mechanical supporting structure can include various supporting structures and/or mounting structures which are configured and arranged to form a mechanical lattice framework. An electronic visual display device can be connected to the mechanical lattice framework to form the exterior display system. The electronic visual display device can include multiple electronic visual display panels which are connected to the mechanical lattice framework. Each of these multiple electronic visual display panels can include multiple groups of multiple light-emitting diodes (LEDs), also referred to electronic LED disc assemblies, that are configured and arranged in a series of one or more rows and/or a series of one or more columns.Type: ApplicationFiled: November 9, 2023Publication date: May 9, 2024Applicant: MSG Entertainment Group, LLCInventors: Alex Luthwaite, Miguel Fontgivell Ariño, Jonathan Lawrence Mallie, Aric Gabriel Braselton, Nicholas Craig Reynolds, Maria Charlotta Knutsson-Hall, Cawsie Jijina
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Publication number: 20240140952Abstract: The present disclosure provides inhibitors of Janus Kinase 2 (JAK2) which may be used in the treatment of medical disorders such as cancer.Type: ApplicationFiled: January 18, 2022Publication date: May 2, 2024Inventors: Nicholas LAWRENCE, Harshani LAWRENCE, Ernst SCHÖNBRUNN, Gary REUTHER
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Patent number: 11938295Abstract: Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.Type: GrantFiled: September 15, 2022Date of Patent: March 26, 2024Assignee: Biora Therapeutics, Inc.Inventors: Jeffrey A. Shimizu, Mitchell Lawrence Jones, Mark Sasha Drlik, Iman Niknia, Nathan John Muller, Tuyen Nguyen, Christopher Loren Wahl, Edward Mudge, Nicholas Mark Salt, Nia Eleri Stevens, Stuart Robert Abercrombie, Christopher Ian Bunce, Ryan Elliott Jones, Kevin Howe, Pejman Rahimian, Nelson Quintana
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Patent number: 11729180Abstract: Methods and systems for using block chain technology to verify transaction data are described herein. A computing platform may receive data about events related to transactions, personal or corporate information, supply chains, and other relevant information about a person or corporate entity. The event information may be received, aggregated, and processed to determine metadata about the person or corporate entity. The metadata may indicate, for example, a trustworthiness of the person or corporate entity for various purposes. Such event information and/or metadata may be stored as transactions in a block chain that may be accessible by counterparties to a potential transaction involving the person or corporate entity. The automated event processing computing platform may further use automated techniques to implement smart transactions between the person/entity and counterparty based on the trust metadata.Type: GrantFiled: December 21, 2021Date of Patent: August 15, 2023Assignee: Bank of America CorporationInventors: Jisoo Lee, John C. Checco, William August Stahlhut, Joseph Castinado, Brad Romano, Suki Ramasamy, Patrick Nicholas Lawrence, Lekha Ananthakrishnan
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Publication number: 20230150948Abstract: Disclosed herein are compounds and methods for reducing the risk of developing, preventing, or treating graft versus host disease (GVHD) in a subject. The compounds can concurrently block Aurora kinase A and JAK2 signal transduction which synergistically suppresses alloreactive human T-cells in vitro, prevents xenogeneic graft-versus-host disease without impairing anti-tumor responses, and promotes the development and suppressive potency of CD39+ inducible Treg. In certain aspects, disclosed are compounds of Formula I-V.Type: ApplicationFiled: January 19, 2023Publication date: May 18, 2023Inventors: Brian Betts, Said M. Sebti, Harshani Lawrence, Nicholas Lawrence, Claudio Anasetti, Joseph Pidala
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Patent number: 11520910Abstract: A system for classifying a data item to communicate to authorized users extracts features from the data item, where the features comprise a responsibility feature and a sensitivity feature. The responsibility feature indicates a job responsibility associated with the data item. The sensitivity feature indicates a sensitivity level of the data item. The system determines, based on the responsibility feature, that the data item belongs to a particular responsibility class. The system determines, based on the sensitivity feature, that the data item belongs to a particular sensitivity class. The system determines whether a user to whom the data item is directed belongs to the particular responsibility class and sensitivity class to which the data item belongs. The system sends the data item to the user, if is it determined that the user belongs to the particular responsibility class and sensitivity class to which the data item belongs.Type: GrantFiled: February 9, 2021Date of Patent: December 6, 2022Assignee: Bank of America CorporationInventors: Christopher Lee Danielson, Marcus Raphael Matos, Daniel Joseph Serna, Patrick Nicholas Lawrence
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Publication number: 20220281828Abstract: Disclosed herein are compounds and methods for reducing the risk of developing, preventing, or treating graft versus host disease (GVHD) in a subject. The compounds can concurrently block Aurora kinase A and JAK2 signal transduction which synergistically suppresses alloreactive human T-cells in vitro, prevents xenogeneic graft-versus-host disease without impairing anti-tumor responses, and promotes the development and suppressive potency of CD39+ inducible Treg. In certain aspects, disclosed are compounds of Formula I-V.Type: ApplicationFiled: December 20, 2021Publication date: September 8, 2022Inventors: Brian Betts, Said M. Sebti, Harshani Lawrence, Nicholas Lawrence, Claudio Anasetti, Joseph Pidala
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Publication number: 20220253539Abstract: A system for classifying a data item to communicate to authorized users extracts features from the data item, where the features comprise a responsibility feature and a sensitivity feature. The responsibility feature indicates a job responsibility associated with the data item. The sensitivity feature indicates a sensitivity level of the data item. The system determines, based on the responsibility feature, that the data item belongs to a particular responsibility class. The system determines, based on the sensitivity feature, that the data item belongs to a particular sensitivity class. The system determines whether a user to whom the data item is directed belongs to the particular responsibility class and sensitivity class to which the data item belongs. The system sends the data item to the user, if is it determined that the user belongs to the particular responsibility class and sensitivity class to which the data item belongs.Type: ApplicationFiled: February 9, 2021Publication date: August 11, 2022Inventors: Christopher Lee Danielson, Marcus Raphael Matos, Daniel Joseph Serna, Patrick Nicholas Lawrence
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Publication number: 20220116401Abstract: Methods and systems for using block chain technology to verify transaction data are described herein. A computing platform may receive data about events related to transactions, personal or corporate information, supply chains, and other relevant information about a person or corporate entity. The event information may be received, aggregated, and processed to determine metadata about the person or corporate entity. The metadata may indicate, for example, a trustworthiness of the person or corporate entity for various purposes. Such event information and/or metadata may be stored as transactions in a block chain that may be accessible by counterparties to a potential transaction involving the person or corporate entity. The automated event processing computing platform may further use automated techniques to implement smart transactions between the person/entity and counterparty based on the trust metadata.Type: ApplicationFiled: December 21, 2021Publication date: April 14, 2022Inventors: Jisoo Lee, John C. Checco, William August Stahlhut, Joseph Castinado, Brad Romano, Suki Ramasamy, Patrick Nicholas Lawrence, Lekha Ananthakrishnan
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Patent number: 11265326Abstract: Methods and systems for using block chain technology to verify transaction data are described herein. A computing platform may receive data about events related to transactions, personal or corporate information, supply chains, and other relevant information about a person or corporate entity. The event information may be received, aggregated, and processed to determine metadata about the person or corporate entity. The metadata may indicate, for example, a trustworthiness of the person or corporate entity for various purposes. Such event information and/or metadata may be stored as transactions in a block chain that may be accessible by counterparties to a potential transaction involving the person or corporate entity. The automated event processing computing platform may further use automated techniques to implement smart transactions between the person/entity and counterparty based on the trust metadata.Type: GrantFiled: September 25, 2019Date of Patent: March 1, 2022Assignee: Bank of America CorporationInventors: Jisoo Lee, John C. Checco, William August Stahlhut, Joseph Castinado, Brad Romano, Suki Ramasamy, Patrick Nicholas Lawrence, Lekha Ananthakrishnan
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Patent number: 11203576Abstract: Disclosed herein are compounds and methods for reducing the risk of developing, preventing, or treating graft versus host disease (GVHD) in a subject. The compounds can concurrently block Aurora kinase A and JAK2 signal transduction which synergistically suppresses alloreactive human T-cells in vitro, prevents xenogeneic graft-versus-host disease without impairing anti-tumor responses, and promotes the development and suppressive potency of CD39+ inducible Treg. In certain aspects, disclosed are compounds of Formula I-V.Type: GrantFiled: March 13, 2017Date of Patent: December 21, 2021Assignee: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.Inventors: Brian Betts, Said M. Sebti, Harshani Lawrence, Nicholas Lawrence, Claudio Anasetti, Joseph Pidala
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Patent number: 11196747Abstract: Methods and systems for using block chain technology to verify transaction data are described herein. A computing platform may receive data about events related to transactions, personal or corporate information, supply chains, and other relevant information about a person or corporate entity. The event information may be received, aggregated, and processed to determine metadata about the person or corporate entity. The metadata may indicate, for example, a trustworthiness of the person or corporate entity for various purposes. Such event information and/or metadata may be stored as transactions in a block chain that may be accessible by counterparties to a potential transaction involving the person or corporate entity. The automated event processing computing platform may further use automated techniques to implement smart transactions between the person/entity and counterparty based on the trust metadata.Type: GrantFiled: December 7, 2017Date of Patent: December 7, 2021Assignee: Bank of America CorporationInventors: Jisoo Lee, John C. Checco, William August Stahlhut, Joseph Castinado, Brad Romano, Suki Ramasamy, Patrick Nicholas Lawrence, Lekha Ananthakrishnan
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Patent number: 11185229Abstract: A method for authenticating to a network comprising a plurality of Internet of Things (“IoT”) devices is provided. The method may include using a mobile telephone apparatus, a wrist-worn apparatus and a head-worn apparatus to monitor the level of at least one of a wearer's pulse, body temperature, voice, gait and/or other biorhythmic indicator. One of the aforementioned apparatus may operate as a hub apparatus. The method may further include using the hub apparatus to assign a federated biometric marker based at least in part on the first, second and third biometric markers. The method may also include using artificial intelligence to monitor for one or more outliers with respect to historical monitoring. Each of the one or more outliers may include a magnitude that exceeds a security threshold difference between the current magnitude and the historically monitored magnitude.Type: GrantFiled: February 27, 2020Date of Patent: November 30, 2021Assignee: Bank of America CorporationInventors: Patrick Nicholas Lawrence, Jesse Strickland Newsom, III, Victoria Lynn Dravneek, John Christopher Checco, Hitesh J. Shah
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Patent number: 11188909Abstract: Methods and systems for using block chain technology to verify transaction data are described herein. A computing platform may receive data about events related to transactions, personal or corporate information, supply chains, and other relevant information about a person or corporate entity. The event information may be received, aggregated, and processed to determine metadata about the person or corporate entity. The metadata may indicate, for example, a trustworthiness of the person or corporate entity for various purposes. Such event information and/or metadata may be stored as transactions in a block chain that may be accessible by counterparties to a potential transaction involving the person or corporate entity. The automated event processing computing platform may further use automated techniques to implement smart transactions between the person/entity and counterparty based on the trust metadata.Type: GrantFiled: September 27, 2019Date of Patent: November 30, 2021Assignee: Bank of America CorporationInventors: Jisoo Lee, John C. Checco, William August Stahlhut, Joseph Castinado, Brad Romano, Suki Ramasamy, Patrick Nicholas Lawrence, Lekha Ananthakrishnan
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Publication number: 20210309630Abstract: Disclosed is a method for selecting a cancer therapeutic for a patient that involves assaying a tumor biopsy sample from the subject to detect PAXIP1 expression, and selecting a WEE1 inhibitor as the cancer therapeutic if PAXIP1 is detected in the tumor biopsy sample.Type: ApplicationFiled: August 2, 2019Publication date: October 7, 2021Inventors: Nupam MAHAJAN, Nicholas LAWRENCE
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Patent number: 11136283Abstract: The present invention relates to a process for recovering and purifying resveratrol produced by microbial fermentation. More particularly, the present invention relates to a process for recovering and purifying resveratrol produced by yeast fermentation.Type: GrantFiled: January 31, 2018Date of Patent: October 5, 2021Assignee: EVOLVA SAInventors: Nicholas Lawrence Ohler, Satish Kumar Bachu, Oliver Frankovic
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Publication number: 20210121427Abstract: The present invention concerns compounds, compositions containing these compounds, and methods of using these compounds and compositions as inhibitors of Stat3 signaling, Stat3 dimerization, Stat3-DNA binding, Stat5-DNA binding, and/or aberrant cell growth in vitro or in vivo, e.g., as anti-cancer agents for treatment of cancer, such as breast cancer. The compounds of the invention include, but are not limited to, NSC 74859 (S3I-201), NSC 42067, NSC 59263, NSC 75912, NSC 11421, NSC 91529, NSC 263435, and pharmaceutically acceptable salts and analogs of the foregoing. Other non-malignant diseases characterized by proliferation of cells that may be treated using the compounds of the invention, but are not limited to, cirrhosis of the liver; graft rejection; restenosis; and disorders characterized by a proliferation of T cells such as autoimmune diseases, e.g., type 1 diabetes, lupus and multiple sclerosis.Type: ApplicationFiled: October 19, 2020Publication date: April 29, 2021Inventors: JAMES TURKSON, SAID M. SEBTI, WAYNE GUIDA, MAN LUN YIP, NICHOLAS LAWRENCE, HARSHANI RITHMA LAWRENCE, BENJAMIN GREEDY
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Patent number: 10965445Abstract: Methods, systems, and apparatuses for blockchain-based unexpected data detection are described herein. In some arrangements, a node within a decentralized peer-to-peer (e.g., P2P) network may receive a plurality of network function requests corresponding to the decentralized network. The node may analyze the plurality of network function requests to identify whether the requests included unexpected data and/or irregular data, and/or are associated with flagged wallets and/or smart contracts.Type: GrantFiled: September 27, 2019Date of Patent: March 30, 2021Assignee: Bank of America CorporationInventors: Joseph Castinado, John C. Checco, Patrick Nicholas Lawrence
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Patent number: 10846485Abstract: A system, computer program product, and method are provided to automate a framework for knowledge graph based persistence of data, and to resolve temporal changes and uncertainties in the knowledge graph. Natural language understanding, together with one or more machine learning models (MLMs), is used to extract data from unstructured information, including entities and entity relationships. The extracted data is populated into a knowledge graph. As the KG is subject to change, the KG is used to create new and retrain existing machine learning models (MLMs). Weighting is applied to the populated data in the form of veracity value. Blockchain technology is applied to the populated data to ensure reliability of the data and to provide auditability to assess changes to the data.Type: GrantFiled: September 20, 2019Date of Patent: November 24, 2020Assignee: International Business Machines CorporationInventors: David Bacarella, James H. Barnebee, IV, Nicholas Lawrence, Sumit Patel
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Publication number: 20200354331Abstract: Disclosed are derivatives of icariin. Disclosed are compounds having Formula I-VIII as defined herein. Methods of using these compounds for the treatment of cancer and inflammation are also disclosed.Type: ApplicationFiled: June 18, 2019Publication date: November 12, 2020Inventors: Sheng Wei, Alan List, Nicholas Lawrence