Abstract: An injection device (10) comprises an injection solution receptacle (30) and a plunger (70) at feast a portion of which is slidably received in the injection solution receptacle (30), wherein the plunger (70) is displaceable relative to the injection solution receptacle (30) in a distal direction in order to expel an injection solution contained in the injection solution receptacle (30) from the injection solution receptacle (30). A first plunger stop mechanism (140) is adapted to stop a displacement of the plunger (70) relative to the injection solution receptacle (30) in the distal direction at a first dosing position (P1).

Abstract: An inbound message including medical record content may be received. The inbound message may indicate a healthcare entity and a vendor entity. It may be determined, from the healthcare entity and stored correspondences between medical record formats and healthcare entities, that the medical record content of the inbound message is in a first medical record format. Which configuration record of stored configuration records specifying combinations of sets of rules may be determined to apply as a translation to the inbound message based upon the medical record content of the inbound message and the first medical record format. The sets of rules as indicated by the configuration record may be accessed and applied to the inbound message to translate the medical record content in the inbound message from the first medical record format to the standardized format. The standardized format may be transmitted to the vendor entity.

Abstract: The present disclosure provides novel 15-hydroxy-prostaglandin dehydrogenase inhibitors, pharmaceutical compositions comprising such compounds, and methods of using such compounds and compositions in treating 15-hydroxy-prostaglandin dehydrogenase-mediated disease. Also provided are methods of making such compounds and intermediates thereof. The compounds have a general Formula (A). Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (A).

Abstract: Embodiments disclosed relate to methods of treating amyotrophic lateral sclerosis (ALS), including: selecting a therapeutic compound: treating an aberrant arachidonic acid (AA) metabolic pathway in an ALS cell.

Abstract: An improved, efficient method for mapping world points from an environment (e.g., points generated by a LIDAR sensor of an autonomous vehicle) to locations (e.g., pixels) within rolling-shutter images taken of the environment is provided. This improved method allows for accurate localization of the world point in a rolling-shutter image via an iterative process that converges in very few iterations. The method poses the localization process as an iterative process for determining the time, within the rolling-shutter exposure period of the image, at which the world point was imaged by the camera. The method reduces the number of times the world point is projected into the normalized space of the camera image, often converging in three or fewer iterations.

Abstract: A spray pattern monitoring system includes a spray sensor disposed proximate an outlet of a spray nozzle. The spray sensor has one or more optical sensors configured to emit directional light, such as laser pulses, towards the expected position of a liquid spray emitted from the nozzle. The spray sensor can detect the absence or presence of the liquid spray based on returns of the directional light to the optical sensor.

Abstract: A spray pattern monitoring system includes a spray sensor disposed proximate an outlet of a spray nozzle. The spray sensor has one or more optical sensors configured to emit directional light, such as laser pulses, towards the expected position of a liquid spray emitted from the nozzle. The spray sensor can detect the absence or presence of the liquid spray based on returns of the directional light to the optical sensor.

Abstract: An improved, efficient method for mapping world points from an environment (e.g., points generated by a LIDAR sensor of an autonomous vehicle) to locations (e.g., pixels) within rolling-shutter images taken of the environment is provided. This improved method allows for accurate localization of the world point in a rolling-shutter image via an iterative process that converges in very few iterations. The method poses the localization process as an iterative process for determining the time, within the rolling-shutter exposure period of the image, at which the world point was imaged by the camera. The method reduces the number of times the world point is projected into the normalized space of the camera image, often converging in three or fewer iterations.

Abstract: A spray pattern monitoring system includes a spray sensor disposed proximate an outlet of a spray nozzle. The spray sensor has one or more optical sensors configured to emit directional light, such as laser pulses, towards the expected position of a liquid spray emitted from the nozzle. The spray sensor can detect the absence or presence of the liquid spray based on returns of the directional light to the optical sensor.

Abstract: Three-dimensional imagers have conventionally been constrained by size, weight, and power (“SWaP”) limitations, readout circuitry bottlenecks, and the inability to image in sunlit environments. As described herein, an imager can illuminate a scene with spatially and temporally modulated light comprising a viewpoint-invariant pattern. The imager can detect diffuse reflections from the illuminated scene to produce a first image. The first image is background-corrected and compared with respect to a known reference image to produce a depth image. The imager can perform in sunlit environments and has improved SWaP and signal-to-noise (SNR) characteristics over existing technologies.

Abstract: Three-dimensional imagers have conventionally been constrained by size, weight, and power (“SWaP”) limitations, readout circuitry bottlenecks, and the inability to image in sunlit environments. As described herein, an imager can illuminate a scene with spatially and temporally modulated light comprising a viewpoint-invariant pattern. The imager can detect diffuse reflections from the illuminated scene to produce a first image. The first image is background-corrected and compared with respect to a known reference image to produce a depth image. The imager can perform in sunlit environments and has improved SWaP and signal-to-noise (SNR) characteristics over existing technologies.

Abstract: A barrier for reduction of a shock wave. The barrier has a spatially graded structure in which a density of the structure varies across a thickness thereof. The graded structure includes a polymer having hollow containers dispersed in the polymer to provide the density of the graded structure. The barrier can be included in at least one of 1) an explosive device, 2) a war head, 3) a demolition charge, and 4) an explosive containment. These devices have an exterior housing and at least one partitioned segment inside the housing with the partitioned segment including the barrier for reduction of the shock wave. Partitioned sections of the explosive devices are selectively or in total detonated.

Abstract: A barrier for reduction of a shock wave. The barrier has a spatially graded structure in which a density of the structure varies across a thickness thereof. The graded structure includes a polymer having hollow containers dispersed in the polymer to provide the density of the graded structure. The barrier can be included in at least one of 1) an explosive device, 2) a war head, 3) a demolition charge, and 4) an explosive containment. These devices have an exterior housing and at least one partitioned segment inside the housing with the partitioned segment including the barrier for reduction of the shock wave. Partitioned sections of the explosive devices are selectively or in total detonated.

Abstract: A barrier for reduction of a shock wave. The barrier has a spatially graded structure in which a density of the structure varies across a thickness thereof. The graded structure includes a polymer having hollow containers dispersed in the polymer to provide the density of the graded structure. The barrier can be included in at least one of 1) an explosive device, 2) a war head, 3) a demolition charge, and 4) an explosive containment. These devices have an exterior housing and at least one partitioned segment inside the housing with the partitioned segment including the barrier for reduction of the shock wave. Partitioned sections of the explosive devices are selectively or in total detonated.

Abstract: The problem of noxious fume generation during chemical treatment of hair using a hair iron is solved by providing a fume intake on the hair iron near the point of fume generation, preferably near the iron's heating elements. The fume intake receives the fumes and delivers them to the fume removal passage under vacuum flow generated by a vacuum source, then transported to a filtration system or exhausted to the outside environment. Optionally, the fume intake may extend along the length of the heating element and may be directed downward, towards the hair. Optionally, the fume removal device may be attachable as a retrofit to a standard hair iron. The present invention advantageously prevents the spread of the noxious fumes to the rest of the salon and protects both the stylist and client from discomfort and irritation, thus permitting the more widespread use of these beneficial hair treatments.

Abstract: A railway rail fastening apparatus has a baseplate for receiving a railway rail to be fastened thereto and baseplate securing elements for securing the baseplate to a baseplate seat area of a concrete railway foundation. The baseplate securing elements carry first and second fastening assemblies configured for location on the concrete rail foundation on opposite sides of the baseplate seat area. Each of the first and second fastening assemblies including fixing member having a first part that extends from the baseplate member for retention within the concrete rail foundation. Only the fixing member of one fastening assembly includes a screw-threaded fastener.

Abstract: A method of calibrating an optical detector arrangement (38,42) comprises simultaneously generating a plurality of entangled photon pairs, such that one photon from each pair traverses a first path (36-38-42) and the other photon from each pair traverses a second path (36-40-44). The number of photons received along the first path is calculated using the detector arrangement (38,42), while the number of simultaneously-generated photons received along the second path is calculated using a second detector arrangement (40,44). These photon numbers are used to calculated an estimate of the detection efficiency (50) of the first detector arrangement (38,42).

Abstract: A device that can be used to moor, tether or suspend an article has a spool mounted in a support frame. A flange of the spool may have holes or cleats so that a free end of a tape, rope, webbing, strap or the like wound on to a hub of the spool can be attached to the flange preferably by a clipping mechanism such as a carabiner attached to the free end thereby preventing the spool from rotating further. In this way the length of tape withdrawn from the spool remains fixed. Alternatively the end of the tape may be passed via a hole or cleat or the like and tensioned before being tied off.

Abstract: A railway rail fastening apparatus has a baseplate for receiving a railway rail to be fastened thereto and baseplate securing elements for securing the baseplate to a baseplate seat area of a concrete railway foundation. The baseplate securing elements carry first and second fastening assemblies configured for location on the concrete rail foundation on opposite sides of the baseplate seat area. Each of the first and second fastening assemblies including fixing member having a first part that extends from the baseplate member for retention within the concrete rail foundation. Only the fixing member of one fastening assembly includes a screw-threaded fastener.

Abstract: A barrier for reduction of a shock wave. The barrier has a spatially graded structure in which a density of the structure varies across a thickness thereof. The graded structure includes a polymer having hollow containers dispersed in the polymer to provide the density of the graded structure. The barrier can be included in at least one of 1) an explosive device, 2) a war head, 3) a demolition charge, and 4) an explosive containment. These devices have an exterior housing and at least one partitioned segment inside the housing with the partitioned segment including the barrier for reduction of the shock wave. Partitioned sections of the explosive devices are selectively or in total detonated.