Abstract: Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

Abstract: The invention relates to an apparatus for vapour decontamination of an enclosed space. The apparatus comprises: (a) a reservoir comprising a supply of a liquid decontaminant; and (b) a vaporiser unit in fluid communication with the reservoir. The vaporiser unit comprises: a body that defines a lumen that passes along the length of the body, the lumen comprising a first end and a second end, wherein the first end receives liquid decontaminant from the reservoir; and a heating element that is configured to deliver sufficient thermal energy to effect rapid boiling of the liquid decontaminant within the lumen so that it exits the lumen via an exit port at the second end of the lumen as a vapour. The exit port is configured to deliver the vapour into a flow of a non-heated carrier gas, thereby facilitating distribution of the decontaminant vapour within the enclosed space. The invention also relates to a method for decontaminating surfaces within an enclosed space.

Abstract: Embodiments of the present disclosure are drawn to systems and methods for adjusting a three-dimensional (3D) model used in metal additive manufacturing to maintain dimensional accuracy and repeatability of a fabricated 3D part. These embodiments may be used to reduce or remove geometric distortions in the fabricated 3D part. One exemplary method may include: receiving, via one or more processors, a selection made by a user; receiving a 3D model of a desired part; retrieving at least one model constant based on the user's selection; receiving an input of at least one process variable setting from a set of process variable settings; generating transformation factors based on the at least one process variable parameter and the at least one model constant; transforming the 3D model of the desired part based on the transformation factors; and generating processing instructions for fabricating the transformed 3D model of the desired part.

Abstract: An optical module comprising: at least three lens elements, wherein the lens elements collectively set a numerical aperture NA, a field height FH, and a system effective focal length EFLsys for directing the light rays between first and second planes, wherein NA, FH, and EFLsys satisfy 0<NA<0.25 and 0<FH<(0.4)·(EFLsys); wherein first and second adjacent lens elements having effective focal lengths EFL1 and EFL2, respectively, satisfies (1.5)·(EFLsys)<EFL1<3·(EFLsys) and (1.5)·(EFLsys)<EFL2<3·(EFLsys); wherein an air-distance between the first and second lens elements A12 satisfies 0<A12<EFLsys; wherein a third lens element adjacent the second lens elements opposite the first lens element and having an effective focal length EFL3 satisfies (?20)·EFLsys<EFL3<(?1)·EFLsys; and wherein an air-distance between the second and third lens elements A23 satisfies 0<A23<EFLsys.

Abstract: This disclosure features methods and devices for treating diseases with orally-delivered biotherapeutics.

Abstract: Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

Abstract: The present invention relates generally to the field of industrial biotechnology and particularly to an improved hydrolysis method for increasing sugar production from a high solids concentration of lignocellulosic biomass, especially one derived from Municipal Solid Waste (MSW) by enzymatic hydrolysis of a lignocellulosic biomass to obtain a slurry, wherein the hydrolysis comprises aliquot additions of enzyme and lignocellulosic biomass; and removal of sugars from the slurry and washing of the residual lignocellulosic biomass.

Abstract: The present invention relates to methods of screening in vitro fertilization (IVF) embryos for pathogenic genetic variations, such as single nucleotide polymorphisms. In particular, the present invention relates to methods of screening IVF embryos using whole genome sequencing (WGS) data. The present invention also relates to methods of screening in vitro fertilization (IVF) embryos for phenotypic traits.

Abstract: Described herein is an animal handling device in the form of a cattle crush with automated headbail capture, back bar operation and positional sensing along with methods of use thereof. The crush and method offer automation for functions that in the art have been largely manual and inherently labour intensive, physical and even potentially dangerous for the operator and/or animal.

Abstract: The present invention relates generally to the field of waste processing. The method comprises separating waste into at least two parts, comprising: (i) mainly food waste (fines) and (ii) mainly paper and other recyclable material (overs). The overs are pulped and washed to obtain a cellulose-rich biomass and the fines are optionally processed separately to recover a cellulose-rich biomass and the cellulose-rich biomass from both the fines and the overs may be combined.

Abstract: A method of treating a disease or condition in a subject in need thereof is disclosed. The method comprising: trans-epithelially administering a dispensable substance to the gastrointestinal (GI) tract of the subject by orally administering an ingestible device comprising the dispensable substance to the subject. The ingestible device is configured for trans-epithelial delivery of the dispensable substance to the GI tract of the subject and the dispensable substance comprises a pharmaceutical formulation comprising a therapeutically effective amount of a glucagon receptor agonist or a glucagon-like peptide-1 (GLP-1) receptor agonist. The ingestible device releases the dispensable substance as at least one jet to a desired location of the GI tract of the subject.

Abstract: Described herein is an animal handling device in the form of a cattle crush with automated headbail capture, back bar operation and positional sensing along with methods of use thereof. The crush and method offer automation for functions that in the art have been largely manual and inherently labour intensive, physical and even potentially dangerous for the operator and/or animal.

Abstract: This disclosure features methods and devices for treating diseases with orally-delivered biotherapeutics.

Abstract: The present disclosure relates to methods and systems for assessing the risk of a human subject developing a severe response to a Coronavirus infection, such as a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus infection.

Abstract: Adjustable package flow stop wall systems and associated methods may operate as part of package processing stations, in order to facilitate accumulation and transfer of packages from inbound collection areas to outbound conveyances. For example, an adjustable package flow stop wall may include a wall assembly, a frame assembly, a pedal assembly, and/or a handle assembly. The wall assembly may selectively extend above the upper surface of a station between a plurality of positions, e.g., a closeout position, an active position, and a flush position, and the pedal and/or handle assemblies may be actuated to cause movement of the wall assembly. Further, the adjustable package flow stop wall may include one or more sensors, actuators, and/or input elements to enable movement of the wall assembly at least partially or fully automatically, which movements may be based on detected agents and/or packages and associated characteristics.

Abstract: Systems and methods are disclosed herein for obtaining data about a network having at least a first node and a second node. A server transmits to the first node a request for the first node to send a communication to the second node. The server is outside of the network. The server receives, from the first node, an indication of whether the communication to the second node is successful. The server receives, from the first node, a second request for access to a file stored on the server, determines that the second file has been previously accessed at the second node, and instructs the first node to obtain the second file from the second node.

Abstract: A color correction mask programmatically generated in software on an HMD device is applied to a gaze region on a display field of view (FOV) on a head-mounted display (HMD) device to optimize system resources while rendering a display. Eye monitoring sensors are utilized to track movement of a user's eyes while the user operates the HMD device to determine a gaze position of the user's eyes on the display FOV. Using the determined gaze position, a dynamic foveal gaze region is sized around the gaze position so that the foveal portion of the display FOV is color-corrected, that is, color non-uniformities are reduced or eliminated. In other implementations, a gaze-based weighting mode is implemented in which measurements of the user's full eye or eye orbit are utilized to color correct a larger surface area of the display FOV relative to the foveal color correction mode.

Abstract: The present disclosure relates to methods and systems for assessing the risk of a human subject developing a severe response to a Coronavirus infection, such as a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus infection.

Abstract: The current document is directed to methods and systems for simulation-based training of automated reinforcement-learning-based application managers. Simulators are generated from data collected from controlled computing environments controlled and may employ any of a variety of different machine-learning models to learn state-transition and reward models. The current disclosed methods and systems provide facilities for visualizing aspects of the models learned by a simulator and for initializing simulator models using domain information. In addition, the currently disclosed simulators employ weighted differences computed from simulator-generated and training-data state transitions for feedback to the machine-learning models to address various biases and deficiencies of commonly employed difference metrics in the context of training automated reinforcement-learning-based application managers.

Abstract: Systems and methods are disclosed herein for obtaining data about a network having at least a first node and a second node. A server transmits to the first node a request for the first node to send a communication to the second node. The server is outside of the network. The server receives, from the first node, an indication of whether the communication to the second node is successful. The server receives, from the first node, a second request for access to a file stored on the server, determines that the second file has been previously accessed at the second node, and instructs the first node to obtain the second file from the second node.