Abstract: The disclosure relates to a tank for storing volatile gas under pressure and a structure comprising the tank. The tank has a wall formed of a filament wound carbon fibre reinforced polymer (CFRP). The CFRP may have a graphene nanomaterial filler dispersed in the polymer adhesive matrix. The structure includes a frame for bearing static and dynamic forces from internal and external loads, the frame including the tank, the tank being an active load bearing structural element configured as a stressed member in the frame such that, in the structure in use, the tank bears static and dynamic forces from internal and external loads. One or more of: the filament winding pattern of the carbon fibre, the wall thickness, the wall shape, or the material properties of the polymer matrix including the dispersed graphene; is configured such that the tank has mechanical properties required by the design of the structure.

Abstract: Described herein are photonic communication platforms that permit use by multiple users in a secure way. A platform comprises a substrate, a first photonic circuit monolithically integrated with the substrate, and a second photonic circuit monolithically integrated with the substrate. The first photonic circuit is patterned with a first plurality of photonic modules, the photonic modules of the first plurality being copies of a common template photonic module The second photonic circuit is patterned with a second plurality of photonic modules, the photonic modules of the second plurality being copies of the common template photonic module. A photonic link couples the first photonic circuit to the second photonic circuit. A controller optically isolates the first photonic circuit from the second photonic circuit by optically interrupting the photonic link.

Abstract: Modified connecting rod journals containing a first cylindrical portion and a second cylindrical portion can be used in a crankshaft of an internal combustion engine used in a gas compression system. These modified journals allow multiple stroke lengths for the pistons of the system thereby increasing system efficiency.

Abstract: Deselect times can be specified for transactions that are to utilize a communication bus shared by multiple devices. A host can communicate with a multiplexer to select a channel for communication on that bus. If this host communicates with the multiplexer over the bus as well, the host can be prevented from instructing the multiplexer to deselect a channel if the bus is hung. To provide for recovery in such situations, one or more deselect times can be specified for one or more channels of a bus. If a transaction for a device on one of these channels is ongoing when the deselect time is reached, the multiplexer can automatically deselect that channel in order to enable other devices to communicate over other channels on that bus. In some embodiments, a riskiness of a transaction or device can be determined for purposes of applying or determining a relevant deselect time.

Abstract: A modular omnidirectional hygienic conveyor belt constructed of a series of similar conveyor belt modules connected by pivot pins. Each conveyor belt module includes a modular laterally extending body having first spaced apart hinge eyes extending in a first direction and being connected to a first pivot pin and laterally offset second spaced apart hinge eyes extending in an opposed second direction and being connected to a second pivot pin. A plurality of spheres are captured by, engage and rotate omnidirectionally relative to upper and lower arcuate sphere contact surfaces of the body, which define for the spheres openly exposed opposed upper and lower spherical cap regions and openly exposed spherical segment regions therebetween, wherein openings in the body provide access for hygienic cleaning. A directional control system may drive the omnidirectional rotation of the spheres.

Abstract: The present invention relates to novel process for the production of ketoisophorone via biocatalytic conversion of isophorone, in particular a one-pot biocatalytic system for conversion of ?-isophorone in a two-step oxidation process, with a first oxidation being catalyzed by a heme containing oxidoreductase such as a cytochrome P450 monooxygenase followed by another oxidation which can be either a chemical reaction or a biocatalytic reaction, in particular wherein the oxidation is catalyzed by an NAD(P) or NADP(H)-dependent oxidoreductase. The invention further provides polypeptides and nucleic acid sequences coding for cytochrome P450 monooxygenase with modified (higher) substrate selectivity, total turnover numbers and/or (re)activity compared to the wild-type enzyme. Ketoisophorone is useful as building block in the synthesis of vitamins and carotenoids.

Abstract: The present disclosure relates to isolated enzyme complexes comprising a tethered cofactor and at least two enzymes paired to catalyse an enzymatic reaction and recycle the cofactor.

Abstract: The present invention relates to a novel biocatalytic method for the production of primary and secondary amines, comprising coupled enzymatic oxidation and reduction processes simultaneously regenerating the required cofactor; making use of two enzymes—i.e. an alcohol dehydrogenase and an amine dehydrogenase—operating simultaneously in a one pot process (i.e. biocatalytic cascade). Furthermore, the overall process is redox neutral, since the hydride generated from the first oxidative step is internally recycled in the second reductive step. The invention also relates to recombinant expression systems and microorganisms procuring the required enzyme activities; and bioreactors for performing such methods.

Abstract: A device (1) for indicating on an object to be cut the cutting depth of a cutting tool, the device comprising: a first arm (2) having a first end (3) and a second end (4), a second arm (5) having a first end (6) and a second end (7), wherein the first arm (2) and the second arm (5) are joined together such that the distance between the first end (3) of the first arm (2) and the first end (6) of the second arm (5) is equal to the length of the cutting tool so that when, in use, the device (1) is aligned with an object to be cut the device indicates the cutting depth of the cutting tool. A method of indicating on an object to be cut the cutting depth of a cutting tool using such a device.

Abstract: A device (1, 7) for separating a sleeve from an implant head, comprising a drive shaft (2) having a proximal end (3) and a distal end (4), the distal end having a cam (6), wherein the cam is disposed such that when, in use, a torque is applied to the drive shaft via the proximal end the cam acts in a direction substantially parallel to the axis of the drive shaft. A method of separating a sleeve from an implant head using such a device.

Abstract: A device (1) for connecting an instrument to a driver, the device comprising: a first connector (3) having at least two protrusions connectable, in use, to the instrument; a mechanism for moving the protrusions between a connected and a disconnected position; and a second connector (17) for connecting the device (1) to the driver, in use. Also disclosed is a method of connecting an instrument to a driver.

Abstract: Devices, systems, and methods are provided for cutting bone and collecting bone debris. A disclosed device includes a receptacle having a proximal opening, a cutting tool having a connector on a proximal end, and a space between the cutting tool and receptacle. In use, bone debris produced by the cutting tool is received by the receptacle into the space. A distal opening of the receptacle may have dimensions corresponding to those of the cutting tool. The receptacle may be shaped so that it does not extend beyond the outer periphery of the cutting tool.

Abstract: The present invention relates to a test blade for a blade-release test. The blade is arranged in use to be mounted on a hub for rotation, and to be released therefrom by the action of a controlled explosion. The blade is arranged to receive at least one explosive charge and at least one detonator for detonating the charge. The blade further comprises a cut-through portion extending completely through the blade from a front face to a rear face, the cut-through portion also extending part way along the blade in an axial direction between a leading edge and a trailing edge of the blade.

Abstract: The present invention relates to a process for the preparation of a compound of the general Formula (I), comprising: a) reacting a compound of the general Formula (II) with a compound of the Formula III R2COOH and a compound of the general Formula IV R3NC under such conditions that compound I is formed, wherein R1 represents a substituted or unsubstituted alkyl, alkenyl, alkynyl, aromatic or non-aromatic, mono-, di- or tricyclic, or heterocyclic structure, and R2 represents a substituted or unsubstituted alkyl, alkenyl, alkynyl, aromatic or non-aromatic, mono-, di- or tricyclic, or heterocyclic structure, and R3 represents a substituted or unsubstituted alkyl, alkenyl, or alkynyl structure. In further aspect the subject invention relates to the use of the the obtained products as intermediates for various peptidomimetics, and preferably as a building block in a convergent synthesis of prolyl dipeptide structures.

Abstract: The present invention relates to a process for the preparation of a compound of the general Formula (I), comprising: a) reacting a compound of the general Formula (II) with a compound of the Formula III R2COOH and a compound of the general Formula IV R3NC under such conditions that compound I is formed, wherein R1 represents a substituted or unsubstituted alkyl, alkenyl, alkynyl, aromatic or non-aromatic, mono-, di- or tricyclic, or heterocyclic structure, and R2 represents a substituted or unsubstituted alkyl, alkenyl, alkynyl, aromatic or non-aromatic, mono-, di- or tricyclic, or heterocyclic structure, and R3 represents a substituted or unsubstituted alkyl, alkenyl, or alkynyl structure. In further aspect the subject invention relates to the use of the obtained products as intermediates for various peptidomimetics, and preferably as a building block in a convergent synthesis of prolyl dipeptide structures.

Abstract: The present invention relates to a process for the stereoselective preparation of a compound having the general formula (I) or its respective diastereomers: comprising reacting a compound having the general formula (II) or its diastereomers: with a compound of the general formula III: R3—COOH and a compound of the general formula IV: R4—NC wherein R1 represents each independently, or jointly a substituted or unsubstituted alkyl, alkenyl, alkynyl, aromatic or non-aromatic, mono-, di- or tricyclic, or heterocyclic structure, and R2 represents a hydrogen atom, a substituted or unsubstituted alkyl, alkenyl, alkynyl, aromatic or non-aromatic, mono-, di- or tricyclic, or heterocyclic structure, and R3 represents a substituted or unsubstituted alkyl, alkenyl, or alkynyl, or an aromatic or non-aromatic aromatic or non-aromatic, mono-, di- or tricyclic, or heterocyclic structure.

Abstract: The present invention relates to a process for the preparation of a compound of the general Formula (I), comprising: a) reacting a compound of the general Formula (II) with a compound of the Formula III R2COOH and a compound of the general Formula IV R3NC under such conditions that compound I is formed, wherein R1 represents a substituted or unsubstituted alkyl, alkenyl, alkynyl, aromatic or non-aromatic, mono-, di- or tricyclic, or heterocyclic structure, and R2 represents a substituted or unsubstituted alkyl, alkenyl, alkynyl, aromatic or non-aromatic, mono-, di- or tricyclic, or heterocyclic structure, and R3 represents a substituted or unsubstituted alkyl, alkenyl, or alkynyl structure. In further aspect the subject invention relates to the use of the obtained products as intermediates for various peptidomimetics, and preferably as a building block in a convergent synthesis of prolyl dipeptide structures.

Abstract: The present invention relates to a method for the deracemization or chiral inversion of chiral amines by enzymatic treatment. The method employs a stereoselective enzymatic conversion and either a non-selective or partially selective chemical or enzymatic conversion, simultaneously or sequentially. The invention also provides a method for selecting a suitable enzyme, particularly a suitable amine oxidase, and for the generation of novel enzymes suitable for use in the deracemization method.

Abstract: A device (1) for connecting an instrument to a driver, the device comprising: a first connector (3) having at least two protrusions connectable, in use, to the instrument; a mechanism for moving the protrusions between a connected and a disconnected position; and a second connector (17) for connecting the device (1) to the driver, in use. A method of connecting an instrument to a driver.