Abstract: Abstract: A device and method for cutting and collecting bone debris. The device comprises a receptacle having an opening, the receptacle opening being disposed with respect to a cutting tool such that, in use, bone debris produced by the cutting tool is received by the receptacle. The opening of the receptacle may have dimensions corresponding to those of the cutting tool. The receptacle may be shaped so that it does not extend beyond the outer periphery of the cutting tool.

Abstract: The present invention relates to a method for the deracemisation or chiral inversion of chiral amines by enzymatic treatment. The method employs a stereoselective enzymatic conversion and either a non-selective or partially selective chemical or enzymatic conversion, simultaneously or sequentially. The invention also provides a method for selecting a suitable enzyme, particularly a suitable amine oxidase, and for the generation of novel enzymes suitable for use in the deracemisation method.

Abstract: The present invention relates to a test blade for a blade-release test. The blade is arranged in use to be mounted on a hub for rotation, and to be released therefrom by the action of a controlled explosion. The blade is arranged to receive at least one explosive charge and at least one detonator for detonating the charge. The blade further comprises a cut-through portion extending completely through the blade from a front face to a rear face, the cut-through portion also extending part way along the blade in an axial direction between a leading edge and a trailing edge of the blade.

Abstract: An artillery charge includes a generally cylindrical body with a hollow core; propellant disposed in the body and first energetic material disposed in the hollow core; and a seal disposed over one end of the hollow core, the seal including second energetic material disposed therein. A laser igniter ignites the second energetic material in the seal, thereby providing more reliable ignition of the first energetic material and the propellant. The artillery charge reliably ignites using a lower powered laser than known charges.

Abstract: An optical device has a photodiode placed on a substrate. A guide is formed on the substrate so that it surrounds the photodiode with concentric positioning to an accuracy better than 5 ?m. A ferrule of a ferrule assembly engages within the guide for automatic alignment with the photodiode without need for active alignment with monitoring of light signals.

Abstract: Methods are described for the deracemisation or chiral inversion of chiral amines by enzymatic treatment, such as by a stereoselective enzymatic conversion and either a non-selective or partially selective chemical or enzymatic conversion, simultaneously or sequentially. Also described are methods for selecting a suitable enzyme, particularly a suitable amine oxidase, and for the generation of novel enzymes suitable for use in the deracemisation method.

Abstract: An optical device has a photodiode placed on a substrate. A guide is formed on the substrate so that it surrounds the photodiode with concentric positioning to an accuracy better than 5 ?m. A ferrule of a ferrule assembly engages within the guide for automatic alignment with the photodiode without need for active alignment with monitoring of light signals.

Abstract: The present invention relates to a method for the deracemisation or chiral inversion of chiral amines by enzymatic treatment. The method employs a stereoselective enzymatic conversion and either a non-selective or partially selective chemical or enzymatic conversion, simultaneously or sequentially. The invention also provides a method for selecting a suitable enzyme, particularly a suitable amine oxidase, and for the generation of novel enzymes suitable for use in the deracemisation method.

Abstract: An optical fibre connector includes a connector having a receptacle or socket with a recessed optical fibre ferrule assembly for aligning an optical fibre within the connector. An optical socket has recessed therein a sleeve for receiving and bringing into optical alignment an optical fibre ferrule assembly at an internal end of the socket with a similar optical fibre ferrule assembly of an optical plug connected to the optical socket. The optical connector has a housing with at least two portions that are removably secured to one another. A method of cleaning such a recessed assembley includes removing at least one of said portions from the remainder of the housing. Contamination is then cleaned from the optical fibre ferrule assembly. Then, the the removed portion(s) are reassembled with the remainder of the housing.

Abstract: The present invention relates to compounds of formula I, or pharmaceutically acceptable salt thereof, wherein: Z is CR10 or N; one of R1 and R2 is selected from (CH2)mR11, (CH2)mR12, (CH2)mNR12R13, (CH2)mOR12, (CH2)mNR13CO(CH2)nR11, (CH2)mNR13COR12, (CH2)mCONR13(CH2)nR11, (CH2)mCONR12R13, (CH2)mCO(CH2)nR11 and (CH2)mCOR12; where m is 0, 1, 2, 3 or 4 and n is 1, 2, 3 or 4; the other of R1 and R2 is H or R11; R3 and R5 are both H; R4 is H or R11; R6is H or (CH2)pR11, where p is 0 or 1; R7, R9 and R10 are each independently H or R11; R8 is selected from H, halogen, NO2, CN, OR13, NR13R14, NHCOR13, CF3, COR13, R13, CONR13R15, SO2NR13R14, SO2R13, NR13SO2R14, OCH2CH2OH, OCH2CH2OMe, morpholine, piperidine, and piperazine; each R11 is independently halogen, NO2, CN, (CH2)qOR13(CH2)rNR13R14, NHCOR13, CF3, COR13, R13, CONR13R14, SO2NR13R14, SO2R13, OR12, NR13SO2R14, OCH2CH2OH, OCH2CH2OMe, NR13SO2R12, (CH2)sNR12R13, morpholine, piperidine or piperazine, where q, r and s are each independently 0, 1, 2, 3 or

Abstract: The present invention relates to a method for the deracemisation or chiral inversion of chiral amines by enzymatic treatment. The method employs a stereoselective enzymatic conversion and either a non-selective or partially selective chemical or enzymatic conversion, simultaneously or sequentially. The invention also provides a method for selecting a suitable enzyme, particularly a suitable amine oxidase, and for the generation of novel enzymes suitable for use in the deracemisation method.

Abstract: The present invention relates to an optical fibre connector (2), and particularly a connector having a receptacle or socket with a recessed optical fibre/ferrule assembly (30,33) for aligning an optical fibre within the connector (2), and to a method of cleaning such a recessed assembly (30,33). An optical socket (11) has recessed therein a sleeve (24) for receiving and bringing into optical alignment an optical fibre/ferrule (30,33) assembly at an internal end of the socket (11) with a similar optical fibre/ferrule assembly of an optical plug connected to the optical socket (11). The optical connector (2) has a housing (4) with at least two portions (14,16) that are removably secured to one another. At least one of said portions (16) is removed from the remainder of the housing (14). Contamination is then cleaned from the optical fibre/ferrule assembly (30,33). Then, the removed portion(s) (16) are reassembled with the remainder of the housing (14).

Abstract: The present invention relates to the use of bisarylsulfonamide compounds of formula I wherein W is a C1-5 branched or unbranched alkyl group or a C2-5 alkenyl group; n is 0 or 1; R1 is H, a C1-8 branched or unbranched alkyl group, a C2-8 alkenyl group, or an aryl or aralkyl group; Ar1 is a substituted thienyl, furyl, pyrrolyl, imidazothiazolyl, thiazolyl, pyridyl or phenyl group; and Ar2 is a substituted phenyl, indolyl or benzoimidazolyl group; in the preparation of a medicament for treating proliferative disorders. Further aspects of the invention relate to compounds of formula I, pharmaceutical compositions thereof, and an assay for determining binding to HDM2.

Abstract: There is disclosed a medical device for implantation in a body comprising: one or more sensors for sensing a physiologically or clinically relevant parameter; and telemetric communications means for telemetrically transmitting data related to a parameter sensed by the one or more sensors to a remote device.

Abstract: There is disclosed a medical device adapted to be implanted in the heart of a patient and operable therein i) as a heart valve; or ii) to assist in the functioning of one of the patient's heart valves; or iii) to monitor the functioning of one of the patient's heart valves. The device includes one or more sensors for sensing a physiologically or clinically relevant parameter of a patient. A telemetric communication device telemetrically transmits data related to a parameter sensed by the sensor to a remote device.

Abstract: Azlactone (3), or the opposite enantiomer thereof, undergoes biotransformation, using suitable enzymatic activity, in the presence of a compound YH to form a N-acyl-amino acid (2), wherein R1, R2 and R3 are each not hydrogen and are independently selected from groups containing up to 20 carbon atoms, optionally with any combination of R1, R2 and R3 being joined together to form at least one ring, X is selected from groups containing up to 20 carbon atoms, and Y is selected from the group consisting of —OH, -Oalkyl and -Nalkyl. Amino acid (1), or the opposite enantiomer thereof, can be prepared in high enantiomeric excess from N-acyl amino acid (2), by converting Y to OH.