Patents by Inventor Nicola Gail Wallis

Nicola Gail Wallis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENHANCEMENT OF ANTI-TUMOR ACTIVITY OF SHP2 INHIBITOR PYRIMIDINONE IN COMBINATION WITH NOVEL CANCER MEDICINES IN CANCERS
    Publication number: 20230146795
    Abstract: The present invention provides a combination drug for the treatment of a malignant tumor comprising 2-((1R,2R,4S)-2-amino-7-azabicyclo[2.2.1]heptan-7-yl)-5-(3,4-dichloro-2-methyl-2H-indazol-5-yl)-3-methyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one or a pharmaceutically acceptable salt thereof, and at least one additional compound having an antitumor effect or at least one pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising both the active ingredients.
    Type: Application
    Filed: January 22, 2021
    Publication date: May 11, 2023
    Applicants: TAIHO PHARMACEUTICAL CO., LTD., OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Takuya HOSHINO, Yu KOMIYA, Yoko NAKATSURU, Nicola Gail WALLIS
  • FabK variant
    Patent number: 7056697
    Abstract: The invention provides FabK polypeptides and polynucleotides encoding FabK polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing FabK polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 26, 2002
    Date of Patent: June 6, 2006
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Walter E. DeWolf, Jr., David John Payne, Nicola Gail Wallis, Joshua M. West
  • FabK variant
    Patent number: 7033795
    Abstract: The invention provides FabK polypeptides and polynucleotides encoding FabK polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing FabK polypeptides and polynucleotides as diagnostic reagents and in diagnostic assays to screen for microbial infections in organisms and infestations in materials.
    Type: Grant
    Filed: November 26, 2002
    Date of Patent: April 25, 2006
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Walter E. DeWolf, Jr., David John Payne, Nicola Gail Wallis, Joshua M. West
  • MurC
    Patent number: 6838255
    Abstract: The invention provides MurC polypeptides and polynucleotides encoding MurC polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurC polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: June 23, 1998
    Date of Patent: January 4, 2005
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Martin Karl Russell Burnham, Nicola Gail Wallis
  • Methods of screening for FabK antagonists and agonists
    Patent number: 6821746
    Abstract: The invention provides methods for identifying agonists and antagonists of FabK polypeptides.
    Type: Grant
    Filed: October 1, 2001
    Date of Patent: November 23, 2004
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Walter E. DeWolf, Jr., David John Payne, Nicola Gail Wallis, Joshua M. West
  • METHODS OF SCREENING FOR FABK ANTAGONISTS AND AGONISTS
    Publication number: 20040137548
    Abstract: The invention provides methods for identifying agonists and antagonists of FabK polypeptides.
    Type: Application
    Filed: October 1, 2001
    Publication date: July 15, 2004
    Inventors: Walter E. DeWolf, David John Payne, Nicola Gail Wallis, Joshua M. West
  • FabK variant
    Publication number: 20030175758
    Abstract: The invention provides FabK polypeptides and polynucleotides encoding FabK polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing FabK polypeptides and polynucleotides as diagnostic reagents and in diagnostic assays to screen for microbial infections in organisms and infestations in materials.
    Type: Application
    Filed: November 26, 2002
    Publication date: September 18, 2003
    Applicant: SmithKline Beecham Corporation
    Inventors: Walter E. DeWolf, David John Payne, Nicola Gail Wallis, Joshua M. West
  • FabK variant
    Publication number: 20030175757
    Abstract: The invention provides FabK polypeptides and polynucleotides encoding FabK polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing FabK polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: November 26, 2002
    Publication date: September 18, 2003
    Applicant: SmithKline Beecham Corporation
    Inventors: Walter E. DeWolf, David John Payne, Nicola Gail Wallis, Joshua M. West
  • Histidine kinase
    Patent number: 6548281
    Abstract: The invention provides Histidine Kinase polypeptides and polynucleotides encoding Histidine Kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Histidine Kinase polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 18, 2000
    Date of Patent: April 15, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Karen M O'Dwyer, Deborah D Jaworski, Jeffrey L Mooney, Lisa K Shilling, John Peter Throup, Nicola Gail Wallis, Yi Yi Zhong, Min Wang
  • Novel histidine kinase
    Publication number: 20030049812
    Abstract: The invention provides histidine kinase polypeptides and DNA (RNA) encoding histidine kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing histidine kinase polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: June 11, 2001
    Publication date: March 13, 2003
    Inventor: Nicola Gail Wallis
  • Novel histidine kinase
    Publication number: 20030049706
    Abstract: The invention provides Histidine kinase polypeptides and polynucleotides encoding Histidine kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Histidine kinase polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: June 8, 2001
    Publication date: March 13, 2003
    Inventors: Anna Lisa Kosmatka, Lisa Kathleen Shilling, Christopher Michael Traini, Nicola Gail Wallis, Richard Lloyd Warren
  • Compounds
    Patent number: 6498234
    Abstract: The invention provides histidine kinase polypeptides and DNA (RNA) encoding histidine kinase polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing histidine kinase polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: March 14, 2000
    Date of Patent: December 24, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventor: Nicola Gail Wallis
  • MurF
    Publication number: 20020146790
    Abstract: The invention provides MurF polypeptides and polynucleotides encodihng MurF polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurF polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: August 17, 2001
    Publication date: October 10, 2002
    Inventor: Nicola Gail Wallis
  • Novel histidine kinase
    Publication number: 20020123119
    Abstract: The invention provides histidine kinase polypeptides and DNA (RNA) encoding histidine kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing histidine kinase polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: September 10, 2001
    Publication date: September 5, 2002
    Inventors: James Raymond Brown, Nicola Gail Wallis, Magdalena Zalacain, Sanjoy Biswas, John Throup
  • Histidine kinase
    Patent number: 6410263
    Abstract: The invention provides histidine kinase polypeptides and polynucleotides encoding histidine kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing histidine kinase polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 29, 1998
    Date of Patent: June 25, 2002
    Assignees: Smithkline Beecham Corporation, Smithkline Beecham p.l.c.
    Inventors: Nicola Gail Wallis, Lisa Kathleen Shilling, Richard Lloyd Warren
  • Novel TCTS response regulator
    Publication number: 20020076776
    Abstract: Novel response regulator polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides and polypeptides for the treatment of infection, particularly bacterial infections. Antagonists against such the polypeptides of the invention and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence the nucleic acid sequences and the polypeptides of the invention in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding response regulators and for detecting the polypeptide in a host.
    Type: Application
    Filed: April 5, 2001
    Publication date: June 20, 2002
    Inventors: John Edward Hodgson, Nicola Gail Wallis
  • Novel compounds
    Publication number: 20020065395
    Abstract: The invention provides response regulator polypeptides and DNA (RNA) encoding response regulator polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing response regulator polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: March 6, 2001
    Publication date: May 30, 2002
    Inventor: Nicola Gail Wallis
  • Histidine kinase
    Publication number: 20020061572
    Abstract: The invention provides histidine kinase polypeptides and polynucleotides encoding histidine kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing histidine kinase polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: May 25, 2001
    Publication date: May 23, 2002
    Inventor: Nicola Gail Wallis
  • UDP-N-acetylenolpyruvylglucosamine reductase
    Patent number: 6355463
    Abstract: The invention provides MurB polypeptides and polynucleotides encoding MurB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurB polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: March 12, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Nicola Gail Wallis, Jason Craig Fedon, Leslie Marie Palmer, Lisa Kathleen Shilling
  • MurD
    Patent number: 6350598
    Abstract: The invention provides MurD polypeptides and DNA (RNA) encoding MurD polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurD polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: April 13, 1999
    Date of Patent: February 26, 2002
    Assignee: SmithKline Beecham Corp.
    Inventors: Nicola Gail Wallis, Joanna Lynn Fueyo, Michael Arthur Lonetto