Patents by Inventor Nicola Gail Wallis

Nicola Gail Wallis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Response regulator polypeptides of Streptococcus pheunoniae
    Patent number: 6217861
    Abstract: The invention provides Response Regulator and Histidine Kinase polypeptides and DNA (RNA) encoding such polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: June 29, 1999
    Date of Patent: April 17, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventor: Nicola Gail Wallis
  • GlmU
    Patent number: 6204042
    Abstract: The invention provides GlmU polypeptides and polynucleotides encoding GlmU polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing GlmU polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 10, 1999
    Date of Patent: March 20, 2001
    Assignee: SMithKline Beecham Corporation
    Inventors: Christine Debouck, Deborah Dee Jaworski, Jeffrey L Mooney, Lisa Kathleen Shilling, Nicola Gail Wallis, Min Wang, Yi Yi Zhong
  • MurF of Streptococcus pneumoniae
    Patent number: 6194170
    Abstract: The invention provides MurF polypeptides and polynucleotides encoding MurF polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurF polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 31, 1998
    Date of Patent: February 27, 2001
    Assignee: SmithKline Beecham Corporation
    Inventor: Nicola Gail Wallis
  • Sensor histidine kinase of streptococcus pneumoniae
    Patent number: 6162619
    Abstract: The invention provides Histidine kinase polypeptides and polynucleotides encoding Histidine kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Histidine kinase polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 20, 1998
    Date of Patent: December 19, 2000
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Sanjoy Biswas, Alexander Bryant, Yigong Ge, David John Holmes, Karen A Ingraham, Deborah Dee Jaworski, Andrea Marra, Lisa Kathleen Shilling, John P. Throup, Min Wang, Nicola Gail Wallis, Magdalena Zalacain
  • Response regulator
    Patent number: 6140061
    Abstract: The invention provides response regulator polypeptides and polynucleotides encoding response regulator polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing response regulator polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: June 9, 1998
    Date of Patent: October 31, 2000
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Nicola Gail Wallis, Magdalena Zalacain, John Throup, Sanjoy Biswas
  • TCTS response regulator
    Patent number: 6136556
    Abstract: Novel response regulator polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides and polypeptides for the treatment of infection, particularly bacterial infections. Antagonists against such the polypeptides of the invention and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence the nucleic acid sequences and the polypeptides of the invention in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding response regulators and for detecting the polypeptide in a host.
    Type: Grant
    Filed: December 20, 1996
    Date of Patent: October 24, 2000
    Assignee: SmithKline Beecham p.I.c.
    Inventors: John Edward Hodgson, Nicola Gail Wallis
  • Sensor histidine kinase of Staphylococcus Aureus
    Patent number: 6127147
    Abstract: The invention provides histidine kinase polypeptides and DNA (RNA) encoding histidine kinase polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing histidine kinase polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: March 23, 1998
    Date of Patent: October 3, 2000
    Assignee: SmithKline Beecham Corporation
    Inventor: Nicola Gail Wallis
  • Mure
    Patent number: 6120771
    Abstract: The invention provides MurE polypeptides and DNA (RNA) encoding MurE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurE polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: September 17, 1999
    Date of Patent: September 19, 2000
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventor: Nicola Gail Wallis
  • MurE
    Patent number: 6121028
    Abstract: The invention provides MurE polypeptides and DNA (RNA) encoding MurE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurE polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: October 10, 1997
    Date of Patent: September 19, 2000
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventor: Nicola Gail Wallis
  • TCTS response regulator
    Patent number: 6107463
    Abstract: Novel response regulator polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides and polypeptides for the treatment of infection, particularly bacterial infections. Antagonists against such the polypeptides of the invention and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence the nucleic acid sequences and the polypeptides of the invention in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding response regulators and for detecting the polypeptide in a host.
    Type: Grant
    Filed: May 12, 1998
    Date of Patent: August 22, 2000
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: John Edward Hodgson, Nicola Gail Wallis
  • MurE
    Patent number: 6103507
    Abstract: The invention provides MurE polypeptides and polynucleotides encoding MurE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurE polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 30, 1999
    Date of Patent: August 15, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Lisa Kathleen Shilling, Nicola Gail Wallis, Susan Zabierowski
  • TCSTS polynucleotides
    Patent number: 6084086
    Abstract: Novel response regulator polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides and polypeptides for the treatment of infection, particularly bacterial infections. Antagonists against such the polypeptides of the invention and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence the nucleic acid sequences and the polypeptides of the invention in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding response regulators and for detecting the polypeptide in a host.
    Type: Grant
    Filed: December 20, 1996
    Date of Patent: July 4, 2000
    Assignee: SmithKline Beecham, p.l.c.
    Inventors: John Edward Hodgson, Nicola Gail Wallis
  • Sensor histidine kinase of Staphylococcus aureus
    Patent number: 6071894
    Abstract: The invention provides Histidine Kinase polypeptides and polynucleotides encoding Histidine Kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Histidine Kinase polypeptides or polynucleotides to screen for antibacterial compounds.
    Type: Grant
    Filed: February 12, 1998
    Date of Patent: June 6, 2000
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham, p.l.c.
    Inventor: Nicola Gail Wallis
  • Response regulator in a two component signal transduction system
    Patent number: 6051691
    Abstract: The invention provides response regulator polypeptides and DNA (RNA) encoding response regulator polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing response regulator polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: December 31, 1998
    Date of Patent: April 18, 2000
    Assignee: SmithKline Beecham Corporation
    Inventor: Nicola Gail Wallis
  • GlmU
    Patent number: 6043071
    Abstract: The invention provides GlmU polypeptides and polynucleotides encoding GlmU polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing GlmU polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 17, 1997
    Date of Patent: March 28, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Christine DeBouck, Deborah Dee Jaworski, Jeffrey L Mooney, Lisa Kathleen Shilling, Nicola Gail Wallis, Min Wang, Yi Yi Zhong
  • MurE
    Patent number: 6013497
    Abstract: The invention provides MurE polypeptides and polynucleotides encoding MurE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurE polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: December 10, 1997
    Date of Patent: January 11, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Lisa Kathleen Shilling, Nicola Gail Wallis, Susan Zabierowski
  • Compounds
    Patent number: 6001362
    Abstract: The invention provides Response regulator polypeptides and DNA (RNA) encoding Response regulator polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Response regulator polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: June 8, 1998
    Date of Patent: December 14, 1999
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventor: Nicola Gail Wallis
  • DNA encoding tests polypeptides
    Patent number: 6001600
    Abstract: Novel response regulator polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides and polypeptides for the treatment of infection, particularly bacterial infections. Antagonists against such the polypeptides of the invention and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence the nucleic acid sequences and the polypeptides of the invention in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding response regulators and for detecting the polypeptide in a host.
    Type: Grant
    Filed: December 20, 1996
    Date of Patent: December 14, 1999
    Assignee: SmithKline Beecham plc
    Inventors: John Edward Hodgson, Nicola Gail Wallis
  • Response regulator polynucleotides
    Patent number: 5962259
    Abstract: Novel response regulator polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides and polypeptides for the treatment of infection, particularly bacterial infections. Antagonists against such the polypeptides of the invention and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence the nucleic acid sequences and the polypeptides of the invention in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding response regulators and for detecting the polypeptide in a host.
    Type: Grant
    Filed: December 20, 1996
    Date of Patent: October 5, 1999
    Assignee: SmithKline Beecham plc
    Inventors: John Edward Hodgson, Nicola Gail Wallis
  • Recombinant expression of polynucleotides encoding the UDP-N-acetylmuramoylalanine:D-glutamate ligase (MurD) of Streptococcus pneumoniae
    Patent number: 5929045
    Abstract: The invention provides MurD polypeptides and DNA (RNA) encoding MurD polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurD polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: September 19, 1997
    Date of Patent: July 27, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Nicola Gail Wallis, Joanna Lynn Fueyo, Michael Arthur Lonetto