Patents by Inventor Nicolaas Smit

Nicolaas Smit has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of manufacturing a plurality of uniform microfabricated sensing devices having an immobilized ligand receptor
    Patent number: 5063081
    Abstract: A plurality of uniform microfabricated sensing devices are produced by establishing a plurality of base sensors on a substrate wafer, forming over at least a portion of each base sensor a permselective layer, superimposing a photoformable proteinaceous photoresist layer over a substantial portion of the permselective layer, and forming a topmost layer of an immobilized ligand receptor. The ligand receptor and corresponding ligand may be immunoreactive species.
    Type: Grant
    Filed: August 15, 1990
    Date of Patent: November 5, 1991
    Assignee: I-Stat Corporation
    Inventors: Stephen N. Cozzette, Graham Davis, Jeanne Itak, Imants R. Lauks, Randall M. Mier, Sylvia Piznik, Nicolaas Smit, Susan Steiner, Paul Van Der Werf, Henry J. Wieck