Abstract: Provided are crystalline forms of a KRAS G12C inhibitor compound and to processes for their preparation. Furthermore, provided is pharmaceutical composition comprising said crystalline forms, and at least one pharmaceutically acceptable excipient. The pharmaceutical composition can be used as a medicament, in particular for the treatment of cancer, and KRAS G12C-mutant cancer.

Abstract: A design and a production method of a front floor reinforcement structure 1 for a vehicle 3 having a battery pack 5 in the tunnel 7 designed to improve the energy absorption of the vehicle during a side impact by involving the front floor panel 11 in the energy absorption during the side impact. The front floor reinforcement structure 1 includes a front floor cross member 13 having a non-deformable portion 14 located on the end of the front floor cross member 13 closest to the side sill 9 and a deformable portion 16 located on the end of the front floor cross member 13 closest to the tunnel 7. The resistance to plastic deformation of the non-deformable portion 14 is greater than the resistance to plastic deformation of the deformable portion 16, which is itself greater than the resistance to plastic deformation of the front floor panel 11.

Abstract: It relates to a pharmaceutical combination comprising a KRAS G12C inhibitor, in particular 1-{6-[(4M)-4-(5-Chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methyl-1H-indazol-5-yl)-1H-pyrazol-1-yl]-2-azaspiro [3.3] heptan-2-yl} prop-2-en-1-one (Compound A) and one or more therapeutically active agents selected from a SHP2 inhibitor (e.g. TNO155) and a PD-1 inhibitor, pharmaceutical compositions comprising the same; and methods of using such combinations and compositions in the treatment or prevention of a cancer or a tumor, in particular wherein the cancer or tumor is KRAS G12C mutated.

Abstract: A method, in particular a computer-implemented method, for session-based and secure access control to a data storage system, comprising: detecting an activation signal for initiating access to the data storage system; and at least one write session to write write session-related data to the data storage system.

Abstract: A protective element (1) named shield element for a battery pack of an electric or hybrid vehicle, wherein the protective element (1) includes a securing device (2) configured to removably secure the shield element (1) both to the battery pack and to a body (11) of the vehicle.

Abstract: A method is for producing a three-dimensional vehicle door frame inner reinforcement element (52) including an inner center pillar part (66), an inner front pillar part (68) and an inner side rail part (64) joining the inner center pillar part (66) and the inner front pillar part (68). The method includes providing an inner center pillar blank, an inner front pillar blank and an inner side rail blank, said inner blanks being substantially planar, assembling the inner center pillar blank and the inner front pillar blank to the inner side rail blank in order to form a substantially planar door frame inner reinforcement blank, and hot stamping the door frame inner reinforcement blank to shape the three-dimensional door frame inner reinforcement element (52).

Abstract: A carrier device including a reinforcement arrangement (9) including: at least two adjacent reinforcement hollow portions (24, 25) both being traversed by the side wall (3) of the carrier device (2) and each made of an inner reinforcement hollow section (26, 27) of the inner reinforcement piece (14) and an outer reinforcement hollow (28, 29) section of the outer reinforcement piece (19), both reinforcement hollow sections being at least partially facing each other, and a longitudinal reinforcement fastening portion (30) located between the adjacent reinforcement hollow portions (24, 25), secured to the side wall (3), and made of an inner reinforcement fastening section (31) of the inner reinforcement piece (14) and an outer reinforcement fastening section (32) of the outer reinforcement piece (19), both reinforcement fastening sections (31, 32) being at least partially facing each other.

Abstract: Rear structure for an electric vehicle having a rear rail which includes a rear portion, a front portion and a transition zone, such that in the event of a rear crash the rear portion and the transition zone are both able to deform to maximize the amount of energy absorption.

Abstract: Front structure for an electric vehicle including a lower dash panel, a seat cross-member and a tunnel nose, such that the tunnel nose is designed to absorb energy in its front portion while resisting intrusion in its rear portion, optimizing the energy absorption in the part during a front crash and protecting the battery pack from being breached by the downward pushing effect of the lower dash panel.

Abstract: A side sill part (6) for an automotive vehicle comprises an outer sill member (10) and an inner sill member (12), and defining between them an outer volume (47). The side sill part also includes an external profile part (68), defining with the inner sill member (12) an inner volume (74), and a first profile part (48) extending in the outer volume (47). The first profile part comprising at least one outer contact portion (50), at least one inner contact portion (52), and at least one joining wall (54) joining the outer contact portion (50) and the inner contact portion (52). The side sill part further includes a second profile part (88) extending in the inner volume (74), comprising at least one outer contact portion (90), at least one inner contact portion (92), and at least one joining wall (94) joining the outer contact portion (90) and the inner contact portion (92).

Abstract: A design and a production method of a front floor reinforcement structure 1 for a vehicle 3 having a battery pack 5 in the tunnel 7 designed to improve the energy absorption of the vehicle during a side impact by involving the front floor panel 11 in the energy absorption during the side impact. The front floor reinforcement structure 1 includes a front floor cross member 13 having a non-deformable portion 14 located on the end of the front floor cross member 13 closest to the side sill 9 and a deformable portion 16 located on the end of the front floor cross member 13 closest to the tunnel 7. The resistance to plastic deformation of the non-deformable portion 14 is greater than the resistance to plastic deformation of the deformable portion 16, which is itself greater than the resistance to plastic deformation of the front floor panel 11.

Abstract: The present invention provides antibodies having improved stability. Included are antibodies that are capable of binding to KIR3DL2 polypeptides. The antibodies are suitable for the treatment of disorders characterized by KIR3DL2-expressing cells, particularly CD4+ T cells, including malignancies such as Mycosis Fungoides and Sezary Syndrome, and KIR3DL2-expressing autoimmune disorders.

Abstract: The present invention provides antibodies having improved stability. Included are antibodies that are capable of binding to KIR3DL2 polypeptides. The antibodies are suitable for the treatment of disorders characterized by KIR3DL2-expressing cells, particularly CD4+ T cells, including malignancies such as Mycosis Fungoides and Sezary Syndrome, and KIR3DL2-expressing autoimmune disorders.

Abstract: The reinforcement element for reinforcing the structure of a door of a vehicle extends along a main direction and comprises at least a main portion having a reinforcing cross-section (40) extending in a plane substantially perpendicular to the main direction. The reinforcing cross-section (40) includes at least four adjacent branches (42a, 42b, 42c, 42d, 42e, 42f, 42g), each extending in different directions, two successive branches forming a non-zero angle, at least two of the non-zero angles being of opposite signs.

Abstract: A method is for producing a three-dimensional vehicle door frame inner reinforcement element (52) including an inner center pillar part (66), an inner front pillar part (68) and an inner side rail part (64) joining the inner center pillar part (66) and the inner front pillar part (68). The method includes providing an inner center pillar blank, an inner front pillar blank and an inner side rail blank, said inner blanks being substantially planar, assembling the inner center pillar blank and the inner front pillar blank to the inner side rail blank in order to form a substantially planar door frame inner reinforcement blank, and hot stamping the door frame inner reinforcement blank to shape the three-dimensional door frame inner reinforcement element (52).

Abstract: The reinforcement element for reinforcing the structure of a door of a vehicle extends along a main direction and comprises at least a main portion having a reinforcing cross-section (40) extending in a plane substantially perpendicular to the main direction. The reinforcing cross-section (40) includes at least four adjacent branches (42a, 42b, 42c, 42d, 42e, 42f, 42g), each extending in different directions, two successive branches forming a non-zero angle, at least two of the non-zero angles being of opposite signs.

Abstract: A reinforcement structure containing: at least one elevation reinforcement profile extending along an elevation direction; at least one transversal reinforcement profile extending along a transversal direction, substantially perpendicular to the elevation direction and at least one compartment panel extending against the elevation reinforcement profile and transversal reinforcement profile; and at least one reinforcement member extending along at least part of the elevation reinforcement profile between the elevation reinforcement profile and the compartment panel, the reinforcement member made of a material having a tensile strength greater than the tensile strength of the material forming the elevation reinforcement profile.

Abstract: Methods for producing a three-dimensional vehicle door frame inner reinforcement element, for producing a vehicle door frame and for producing a vehicle reinforcement structure A method for producing a three-dimensional vehicle door frame inner reinforcement element (52) comprising an inner center pillar part (66), an inner front pillar part (68) and an inner side rail part (64) joining the inner center pillar part (66) and the inner front pillar part (68). The method comprises: providing an inner center pillar blank, an inner front pillar blank and an inner side rail blank, said inner blanks being substantially planar, assembling the inner center pillar blank and the inner front pillar blank to the inner side rail blank in order to form a substantially planar door frame inner reinforcement blank, hot stamping the door frame inner reinforcement blank to shape the three-dimensional door frame inner reinforcement element (52).

Abstract: The reinforcement member includes a body made of a press hardened steel having a tensile strength greater or equal to 1200 MPa. The body is coated with a zinc-based coating or with an aluminum-based coating and extends along a main direction. The reinforcement member also includes at least one tab extending from the body along a transversal direction forming a non-zero angle with the main direction. The bend between the body and the tab defines an intrados and an extrados. The tab is made of a cold bent part of the body, and the elongation of the extrados is between 10% and 25%.

Abstract: A longitudinal member is provided. The longitudinal member includes a front end provided with a hinge element for attaching the longitudinal member in an articulated manner to a heavy goods vehicle body, and a rear end including an attachment element for attaching the longitudinal member in a non-permanent manner to the heavy goods vehicle body. The longitudinal member includes a front part extending from the front end to an intermediate area of the longitudinal member and a rear part extending from the intermediate area to the rear end of the longitudinal member. The product (PF) of the wall thickness (tF) of the front part by the yield strength (YsF) of the material of the front part is greater than the product (PR) of the wall thickness (tR) of the rear part by the yield strength (YsR) of the material of the rear part.