Abstract: The present invention relates to an inhibitor of the interaction between the ROCK and PDK1 protein kinases. The present invention also relates to a pharmaceutical composition comprising at least one inhibitor of the interaction between the ROCK and PDK1 protein kinases as an active ingredient and at least one pharmaceutically acceptable excipient and/or support and/or a diluent and/or a pharmaceutically acceptable carrier. The invention also relates to the use of said pharmaceutical composition in the prevention and/or treatment of inflammatory diseases, viral and/or bacterial infections and autoimmune diseases.

Abstract: A protective element (1) named shield element for a battery pack of an electric or hybrid vehicle, wherein the protective element (1) includes a securing device (2) configured to removably secure the shield element (1) both to the battery pack and to a body (11) of the vehicle.

Abstract: The present invention provides antibodies having improved stability. Included are antibodies that are capable of binding to KIR3DL2 polypeptides. The antibodies are suitable for the treatment of disorders characterized by KIR3DL2-expressing cells, particularly CD4+ T cells, including malignancies such as Mycosis Fungoides and Sezary Syndrome, and KIR3DL2-expressing autoimmune disorders.

Abstract: Front structure for an electric vehicle including a lower dash panel, a seat cross-member and a tunnel nose, such that the tunnel nose is designed to absorb energy in its front portion while resisting intrusion in its rear portion, optimizing the energy absorption in the part during a front crash and protecting the battery pack from being breached by the downward pushing effect of the lower dash panel.

Abstract: A computerized method to determine the aptitude of a metallic part to be manufactured by roll forming and to classify metallic parts into one of the following categories: roll-formable without modification, roll-formable with modifications, not roll-formable. It also provides for a computerized method to compute the roll forming direction of a part. It further provides a method for determining the aptitude to roll forming of a large set of parts, such as for example part of the set of parts making up an automotive vehicle. The purpose of the current invention is further to provide a manufacturing method for a metallic part.

Abstract: A side sill part (6) for an automotive vehicle comprises an outer sill member (10) and an inner sill member (12), and defining between them an outer volume (47). The side sill part also includes an external profile part (68), defining with the inner sill member (12) an inner volume (74), and a first profile part (48) extending in the outer volume (47). The first profile part comprising at least one outer contact portion (50), at least one inner contact portion (52), and at least one joining wall (54) joining the outer contact portion (50) and the inner contact portion (52). The side sill part further includes a second profile part (88) extending in the inner volume (74), comprising at least one outer contact portion (90), at least one inner contact portion (92), and at least one joining wall (94) joining the outer contact portion (90) and the inner contact portion (92).

Abstract: A design and a production method of a front floor reinforcement structure 1 for a vehicle 3 having a battery pack 5 in the tunnel 7 designed to improve the energy absorption of the vehicle during a side impact by involving the front floor panel 11 in the energy absorption during the side impact. The front floor reinforcement structure 1 includes a front floor cross member 13 having a non-deformable portion 14 located on the end of the front floor cross member 13 closest to the side sill 9 and a deformable portion 16 located on the end of the front floor cross member 13 closest to the tunnel 7. The resistance to plastic deformation of the non-deformable portion 14 is greater than the resistance to plastic deformation of the deformable portion 16, which is itself greater than the resistance to plastic deformation of the front floor panel 11.

Abstract: A method, in particular a computer-implemented method, for session-based and secure access control to a data storage system, comprising: detecting an activation signal for initiating access to the data storage system; and at least one write session to write write session-related data to the data storage system.

Abstract: A protective element (1) named shield element for a battery pack of an electric or hybrid vehicle, wherein the protective element (1) includes a securing device (2) configured to removably secure the shield element (1) both to the battery pack and to a body (11) of the vehicle.

Abstract: A method is for producing a three-dimensional vehicle door frame inner reinforcement element (52) including an inner center pillar part (66), an inner front pillar part (68) and an inner side rail part (64) joining the inner center pillar part (66) and the inner front pillar part (68). The method includes providing an inner center pillar blank, an inner front pillar blank and an inner side rail blank, said inner blanks being substantially planar, assembling the inner center pillar blank and the inner front pillar blank to the inner side rail blank in order to form a substantially planar door frame inner reinforcement blank, and hot stamping the door frame inner reinforcement blank to shape the three-dimensional door frame inner reinforcement element (52).

Abstract: A carrier device including a reinforcement arrangement (9) including: at least two adjacent reinforcement hollow portions (24, 25) both being traversed by the side wall (3) of the carrier device (2) and each made of an inner reinforcement hollow section (26, 27) of the inner reinforcement piece (14) and an outer reinforcement hollow (28, 29) section of the outer reinforcement piece (19), both reinforcement hollow sections being at least partially facing each other, and a longitudinal reinforcement fastening portion (30) located between the adjacent reinforcement hollow portions (24, 25), secured to the side wall (3), and made of an inner reinforcement fastening section (31) of the inner reinforcement piece (14) and an outer reinforcement fastening section (32) of the outer reinforcement piece (19), both reinforcement fastening sections (31, 32) being at least partially facing each other.

Abstract: Rear structure for an electric vehicle having a rear rail which includes a rear portion, a front portion and a transition zone, such that in the event of a rear crash the rear portion and the transition zone are both able to deform to maximize the amount of energy absorption.

Abstract: Front structure for an electric vehicle including a lower dash panel, a seat cross-member and a tunnel nose, such that the tunnel nose is designed to absorb energy in its front portion while resisting intrusion in its rear portion, optimizing the energy absorption in the part during a front crash and protecting the battery pack from being breached by the downward pushing effect of the lower dash panel.

Abstract: A side sill part (6) for an automotive vehicle comprises an outer sill member (10) and an inner sill member (12), and defining between them an outer volume (47). The side sill part also includes an external profile part (68), defining with the inner sill member (12) an inner volume (74), and a first profile part (48) extending in the outer volume (47). The first profile part comprising at least one outer contact portion (50), at least one inner contact portion (52), and at least one joining wall (54) joining the outer contact portion (50) and the inner contact portion (52). The side sill part further includes a second profile part (88) extending in the inner volume (74), comprising at least one outer contact portion (90), at least one inner contact portion (92), and at least one joining wall (94) joining the outer contact portion (90) and the inner contact portion (92).

Abstract: A design and a production method of a front floor reinforcement structure 1 for a vehicle 3 having a battery pack 5 in the tunnel 7 designed to improve the energy absorption of the vehicle during a side impact by involving the front floor panel 11 in the energy absorption during the side impact. The front floor reinforcement structure 1 includes a front floor cross member 13 having a non-deformable portion 14 located on the end of the front floor cross member 13 closest to the side sill 9 and a deformable portion 16 located on the end of the front floor cross member 13 closest to the tunnel 7. The resistance to plastic deformation of the non-deformable portion 14 is greater than the resistance to plastic deformation of the deformable portion 16, which is itself greater than the resistance to plastic deformation of the front floor panel 11.

Abstract: The present invention provides antibodies having improved stability. Included are antibodies that are capable of binding to KIR3DL2 polypeptides. The antibodies are suitable for the treatment of disorders characterized by KIR3DL2-expressing cells, particularly CD4+ T cells, including malignancies such as Mycosis Fungoides and Sezary Syndrome, and KIR3DL2-expressing autoimmune disorders.

Abstract: The present invention provides antibodies having improved stability. Included are antibodies that are capable of binding to KIR3DL2 polypeptides. The antibodies are suitable for the treatment of disorders characterized by KIR3DL2-expressing cells, particularly CD4+ T cells, including malignancies such as Mycosis Fungoides and Sezary Syndrome, and KIR3DL2-expressing autoimmune disorders.

Abstract: The reinforcement element for reinforcing the structure of a door of a vehicle extends along a main direction and comprises at least a main portion having a reinforcing cross-section (40) extending in a plane substantially perpendicular to the main direction. The reinforcing cross-section (40) includes at least four adjacent branches (42a, 42b, 42c, 42d, 42e, 42f, 42g), each extending in different directions, two successive branches forming a non-zero angle, at least two of the non-zero angles being of opposite signs.

Abstract: A method is for producing a three-dimensional vehicle door frame inner reinforcement element (52) including an inner center pillar part (66), an inner front pillar part (68) and an inner side rail part (64) joining the inner center pillar part (66) and the inner front pillar part (68). The method includes providing an inner center pillar blank, an inner front pillar blank and an inner side rail blank, said inner blanks being substantially planar, assembling the inner center pillar blank and the inner front pillar blank to the inner side rail blank in order to form a substantially planar door frame inner reinforcement blank, and hot stamping the door frame inner reinforcement blank to shape the three-dimensional door frame inner reinforcement element (52).

Abstract: The reinforcement element for reinforcing the structure of a door of a vehicle extends along a main direction and comprises at least a main portion having a reinforcing cross-section (40) extending in a plane substantially perpendicular to the main direction. The reinforcing cross-section (40) includes at least four adjacent branches (42a, 42b, 42c, 42d, 42e, 42f, 42g), each extending in different directions, two successive branches forming a non-zero angle, at least two of the non-zero angles being of opposite signs.